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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 394-398页

作者： Farhadul Islam Hasina Khatun Soby Ghosh MM Ali ja Khanam Department of Biochemistry and Molecular Biology Faculty of ScienceUniversity of Rajshahi Department of Applied Chemistry and Chemical engineering Faculty of EngineeringUniversity of Rajshahi

Objective:To evaluate the antineoplastic activity of Eucalyptus extract(EUE) against Ehrlich ascites carcinoma(EAC)in Swiss albino ***:Preliminary examination of four plant extracts(namely Eucalyptus,Costus,*** has been done by observing the reduction ability of number of EAC cells in previously inoculated Swiss alliino *** them as EuE showed maximum capability,the whole study has been conducted with EuE only. Important parameters *** of life span,reduction of average tumor weight *** been *** addition the effects of EuE on hematological parameters in both normal and EAC inoculated mice have been *** of EuE on normal peritoneal cells has also been ***:EuE reduced tumor burden *** reduced the tumor growth rate and enhanced the life span of EAC bearing mice *** reversed back the hematological parameters towards normal,reduced the Irasplanlability of EAC cells and enhanced the immunomodulatory effects in *** host toxic effect of EuE in mice is minimum and mostly reversible with *** such data have been compared with those obtained by running parallel experiments with bleomycin at dose 0.3 mg/kg(i.p.).Conclusions:The Eucalyptus extract may be considered as a potent anticancer agent for advanced researches.

关键词： Antineoplastic activity Eucalyptus extract Ehrlich ascites carcinoma cells Swiss albino mice

The Challenge of Implementing Information Security Standards in Small and Medium e-Business Enterprises

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Journal of Software Engineering and Applications 2014年第10期7卷 883-890页

作者： ja’far Alqatawna King Abdulla II School of Information Technology The University of Jordan Amman Jordan

The dynamic nature of online systems requires companies to be proactive with thwarting information security threats, and to follow a systematic way for managing and evaluating the security of their online services. The existence of security standards is an important factor that helps organisations to evaluate and manage security by providing guidelines and best practices that enable them to follow a standard and systematic way to protect their e-Business activities. However, the suitability of available information security standards for Small and Medium e-Business Enterprises (e-SME) is worth further investigation. In this paper three major security standards including Common Criteria, System Security Engineering-Capability and Maturity Model and ISO/IEC 27001 were analysed. Accordingly, several challenges associated with these standards that may render them difficult to be implemented in e-SME have been identified.

关键词： Information Security Standards e-Business Small and Medium Enterprises

Pulsar B0531 + 21 in the Crab Nebula

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International Journal of Astronomy and Astrophysics 2021年第4期11卷 470-480页

作者： Boris ja. Losovsky Physical Institute of the Russian Academy of Science Pushchino Radio Astronomy Observatory Moscow Russia

The Crab Nebula and its pulsar PSR B0531 + 21 is the space laboratory for the study of fundamental physical processes. From the beginning of the current century up to date, the giant pulses of the pulsar in the Crab Nebula are regularly observed on the Large Phased Array of the Pushchino Radio Astronomy Observatory of the Lebedev Physical Institute at a frequency 111 MHz. The connection between the scattering time scale of radio pulses and the dispersion measure of the pulsar, which was established earlier together with Jodrell Bank, is confirmed. The observed variations in the scattering of radio pulses and their partial correlation with the dispersion measure are explained by the eclipse of the pulsar by dense plasma clouds with fluctuations in the electron density significantly exceeding the corresponding fluctuations in the interstellar medium. The question of a possible connection between period failers (glitches), dispersion measure variations, radio pulses scattering and gamma-ray flares is discussed.

关键词： Pulsar Giant Pulses Dispersion Measure Braking Index Glitches Gamma-Ray Flares

Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy

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World Journal of Gastroenterology 2012年第30期18卷 4044-4050页

作者： Hyung Hun Kim Moo In Park Sang Ho Lee Hyun Yong Hwang Sung Eun Kim Seun ja Park Won Moon Departments of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea Departments of Surgery Kosin University College of MedicineBusan 602-702South Korea Departments of Laboratory Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal ***:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric *** surgeries were performed by a single skilled *** measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after ***:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36.

关键词： Peptide YY Ghrelin Vagotomy Gastrectomy Body weight

Fractures around the shoulder in the skeletally immature:A scoping review

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世界骨科杂志:英文版 2023年第8期14卷 604-611页

作者： Tim Kraal Peter AA Struijs Lisette C Langenberg Christiaan ja van Bergen Department of Orthopedic Surgery and Sports Medicine Amsterdam University Medical CentersAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery NoordWest ZiekenhuisgroepAlkmaar 1815 JDNetherlands Department of Orthopedic Surgery and Sports Medicine Erasmus University Medical Center-Sophia Children’s HospitalRotterdam 3015 GDNetherlands Department of Orthopedic Surgery AmphiaBreda 4818 CKNetherlands

Fractures around the shoulder girdle in children are mainly caused by sports *** clavicle and the proximal humerus are most commonly *** the clavicle and the proximal humerus have a remarkable potential for remodeling,which is why most of these fractures in children can be treated ***,the key is to understand when a child benefits from surgical *** indications for surgery of these fractures are *** review focuses on the available evidence on the management of clavicle and proximal humerus fractures in *** only strict indications for surgery for diaphyseal clavicle fractures in children are open fractures,tenting of the skin with necrosis,associated neurovascular injury,or a floating *** is no evidence to argue for surgery of displaced clavicle fractures to prevent malunion since most malunions are *** the rare case of a symptomatic malunion of the clavicle in children,corrective osteosynthesis is a viable treatment *** proximal humerus fractures in children,treatment is dictated by the patient's age(and thus remodeling potential)and the amount of fracture *** ten years of age,even severely displaced fractures can be treated *** the age of 13 and onwards,surgery has better outcomes for severely displaced(Neer types III and IV)*** 10 and 13 years of age,the indications for surgical treatment are less clear,with varying cut-off values of angulation(30-60 degrees)or displacement(1/3–2/3 shaft width)in the current literature.

关键词： Clavicle fracture Proximal humerus fracture Pediatric Skeletally immature Children Shoulder

Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee Sung Yong Ahn Young‐Ho Ahn Jihee Lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

Impact of the microenvironment on the pathogenesis of mucosaassociated lymphoid tissue lymphomas

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 153-162页

作者： Barbara Uhl Katharina T Prochazka Karoline Fechter Katrin Pansy Hildegard T Greinix Peter Neumeister Alexander ja Deutsch Division of Hematology Medical University of GrazGraz 8036Austria

Approximately 8%of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue(MALT),also known as MALT *** arise at a wide range of different extranodal sites,with most cases affecting the stomach,the lung,the ocular adnexa and the *** small intestine is involved in a lower percentage of *** growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections(e.g.,Helicobacter pylori or Chlamydia psittaci infections)or autoimmune conditions(e.g.,Sjögren’s syndrome or Hashimoto thyroiditis).While these inflammatory processes trigger lymphoma cell proliferation and/or survival,they also shape the ***,activated immune cells are actively recruited to the lymphoma,resulting in either direct lymphoma cell stimulation via surface receptor interactions and/or indirect lymphoma cell stimulation via secretion of soluble factors like *** addition,chronic inflammatory conditions cause the acquisition of genetic alterations resulting in autonomous lymphoma cell ***,novel agents targeting the microenvironment have been developed and clinically tested in MALT lymphomas as well as other lymphoid *** this review,we aim to describe the composition of the microenvironment of MALT lymphoma,the interaction of activated immune cells with lymphoma cells and novel therapeutic approaches in MALT lymphomas using immunomodulatory and/or microenvironmenttargeting agents.

关键词： Mucosa-associated lymphoid tissue lymphoma Tumor microenvironment Microenvironment Helicobacter pylori Activated immune cells

Assessment of oxidative stress in chronic pancreatitis patients

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World Journal of Gastroenterology 2006年第35期12卷 5705-5710页

作者： Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert ja Wanten jan BMJ jansen Wilbert HM Peters Joost PH Drenth Department of Gastroenterology Radboud University Nijmegen Medical Centre The Netherlands

AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy.

关键词： Chronic pancreatitis Oxidative stress Thiols Ferric reducing ability of plasma Protein carbonyls Thiobarbituric acid reactive substances Reactive oxygen species

Congenital absence of the splenic artery and splenic vein accompanied with a duodenal ulcer and deformity

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World Journal of Gastroenterology 2009年第11期15卷 1401-1403页

作者： Eun Kyung Shin Won Moon Seun ja Park Moo In Park Kyu Jong Kim Jee Suk Lee Jin Hwan Kwon Department of Gastroenterology Kosin University College of MedicineBusanSouth Korea Department of Radiology Kosin University College of MedicineBusanSouth Korea

Congenital absence of the splenic artery is a very rare *** the best of our knowledge, congenital absence of the splenic artery accompanied with absence of the splenic vein has not been *** report a case of the absence of the splenic artery and vein in a 61-year-old woman who presented with postprandial epigastric discomfort. Upper gastrointestinal endoscopy showed a dilated, pulsatile vessel in the fundus and duodenal stenosis. An abdominal computed tomography(CT)scan revealed absence of the splenic vein with a tortuously engorged gastroepiploic ***-dimensional CT demonstrated the tortuously dilated left gastric artery and the left gastroepiploic artery with non-visualization of the splenic *** administration of a proton pump inhibitor,abdominal symptoms resolved without any recurrence of symptoms during 6 mo of follow-up.

关键词： Congenital Anomaly Splenic artery Splenic vein Duodenum Ulcer Deformity

叉头转录因子FoxO1的生物遗传信息学分析

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中国牛业科学 2024年第1期50卷 29-34页

作者：刘勇朱文科吴欣苡陆萌萌孙雨佳盱胎县动物疫病预防控制中心江苏准安211700 扬州大学农业科技发展研究院(国际联合实验室) 江苏扬州225009 扬州大学动物科学与技术学院江苏扬州225009

叉头转录因子FoxO1是一种重要的调控因子,其广泛参与机体的各项生命活动,对其生物信息学的分析,可以更清楚和直观的了解FoxO1基因的结构和功能,为后期发育、分化、代谢和进化等作用机制的深入研究提供重要的理论基础。本试验运用生物信... 详细信息

叉头转录因子FoxO1是一种重要的调控因子,其广泛参与机体的各项生命活动,对其生物信息学的分析,可以更清楚和直观的了解FoxO1基因的结构和功能,为后期发育、分化、代谢和进化等作用机制的深入研究提供重要的理论基础。本试验运用生物信息学手段对牛FoxO1基因的结构和功能进行预测分析,结果表明FoxO1蛋白为不稳定的亲水性酸性蛋白质,主要定位在细胞核,含有七个半胱氨酸残基,其中六个半胱氨酸形成三个二硫键,3个氨基酸具有59个潜在磷酸化位点,作为非分泌型蛋白,无信号肽和跨膜区域,其二级结构中,无规则卷曲所占比例高达75.42%,且在第165-259位氨基酸之间,其叉头域有95个保守的氨基酸残基。

关键词：牛 FoxO1基因遗传结构生物化学信息