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Longitudinal Analysis of Inter-Limb Coordination Before and After Anterior Cruciate Ligament Injury: The JUMP-ACL Study

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Journal of Science in Sport and Exercise 2020年第3期2卷 265-271页

作者： Benjamin M.Goerger stephen W.Marshall Anthony I.Beutler J.Troy Blackburn John H.Wilckens Darin A.Padua Department of Exercise and Sport Science The University of North Carolina at Chapel HillChapel HillNCUSA Department of Epidemiology The University of North Carolina at Chapel HillChapel HillNCUSA Musculoskeletal Clinical Program Intermountain HealthcareProvoUTUSA Department of Orthopaedic Surgery Johns Hopkins UniversityBaltimoreMDUSA

Purpose Inter-limb coordination may provide insight into why patients with anterior cruciate ligament reconstructive sur-gery(ACLR)have an increased risk for future injury and *** purpose of this study was to compare inter-limb coordination prior-to anterior cruciate ligament(ACL)injury and following *** Unilateral lower extremity biomechanics during a double-leg jump landing were collected prior-to ACL injury(baseline)and after ACLR,rehabilitation,and return to physical activity(follow-up).Sixty-nine participants were included in this analysis:31 participants suffered an ACL injury since baseline:12 injured the leg tested at baseline[ACLR-injured leg(ACLR-INJ),n=12]and 19 injured the leg that was not tested at baseline[ACLR-uninjured leg(ACLR-UNINJ)n=19];38 participants served as matched ***-limb coordination-calculated as the mean coupling angle-between the hip and knee were measured in the respective leg of each defined group and compared amongst groups at baseline and *** We observed no significant change in sagittal or frontal plane inter-limb coordination amongst groups or across time(P>0.05).A significant decrease in inter-limb coordination in the transverse plane from baseline and follow-up was observed but limited to the ACLR-INJ group(P=0.016).Conclusion The primary finding of this study is that inter-limb coordination between the hip and knee in the sagittal and frontal plane is unchanged by ACL injury and *** may help explain previous observations of changes in kinemat-ics at both the hip and knee in this *** observation of alterations in the transverse plane should be interpreted with caution,but may provide additional evidence for potential mechanisms that lead to the development of osteoarthritis in ACLR patients.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Knee Injury Inter-limb coordination

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气喘和支气管炎自学问题解答

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药学实践杂志 1984年第1期 65-66页

作者： F.G.prior C.J.Cairns B.G.Moore 魏玲

(一)在全身感染时,可出现哪类免疫球蛋白? *** *** *** ***(二)下列哪种微生物常与慢性支气管炎的发病过程相联系?

关键词：气喘病病人哮喘慢性支气管炎流感嗜血杆菌流感杆菌嗜血杆菌属色甘酸钠舒喘宁异丙阿托品抗胆碱能药

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通过等通道弯角挤压至高剪切应变的多晶冰的晶体优选取向的演变

通过等通道弯角挤压至高剪切应变的多晶冰的晶体优选取向的演变

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2023年中国地球科学联合学术年会

作者：王钦宇綦超 David J.prior 范绳中国科学院地质与地球物理研究所中国科学院大学地球与行星科学学院奥塔哥大学地质系

多晶冰在塑性变形过程中会产生晶体择优取向(CPO),从而导致冰的粘度产生各向异性,进而对冰川和冰盖的流动产生强烈影响。CPO的发展主要受两个关键机制控制:以晶格旋转为主的重结晶和以晶界迁移(GBM)为主的重结晶。为了研究应变对机制转... 详细信息

多晶冰在塑性变形过程中会产生晶体择优取向(CPO),从而导致冰的粘度产生各向异性,进而对冰川和冰盖的流动产生强烈影响。CPO的发展主要受两个关键机制控制:以晶格旋转为主的重结晶和以晶界迁移(GBM)为主的重结晶。为了研究应变对机制转变的影响,我们采用等通道角挤压技术对合成冰进行剪切变形,通过对同一样品的多次剪切变形已达到较大的剪切应变。在-5℃的变形温度下,样品的剪切应变高达6.2,相当于von Mises应变ε≈3.6。

关键词：等通道弯角挤压剪切应变 CPO 多晶冰

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多普勒组织成像评价扩张型心肌病患者右心室收缩功能

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中国超声诊断杂志 2006年第4期7卷 257-259页

作者：张连仲谢明星范闽延王新房 David prior 华中科技大学同济医学院附属协和医院超声影像科武汉市430022 现在河南省人民医院超声科河南省人民医院超声科不详

目的探讨多普勒组织成像(DTI)评价扩张型心肌病(DCM)患者右心室收缩功能的价值。方法应用DTI检测了28例DCM患者和30例正常人三尖瓣环处射血期波(S)峰值速度(Vs)、速度时间积分(VTIs)、持续时间(Ts)、心电图Q波至S波起点处间期(Q-S)等,... 详细信息

目的探讨多普勒组织成像(DTI)评价扩张型心肌病(DCM)患者右心室收缩功能的价值。方法应用DTI检测了28例DCM患者和30例正常人三尖瓣环处射血期波(S)峰值速度(Vs)、速度时间积分(VTIs)、持续时间(Ts)、心电图Q波至S波起点处间期(Q-S)等,并与二维超声心动图所测三切面平均右心室面积变化率(MRVPCA)、胸骨旁左心长轴切面所测右心室前后径(RVD)等对比分析。结果DCM患者三尖瓣环处Vs、VTIs均较对照组明显减低(P0.05)。结论DCM患者右心室收缩功能存在一定程度减退,应用三尖瓣环处DTI所测收缩期运动指标,可对其进行正确评价。

关键词：多普勒组织成像收缩功能右心室三尖瓣环

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Initial Antibiotic Selection of Patients Presenting with Infection after Transrectal Prostate Biopsy Leading to a Quality Improvement Initiative

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Open Journal of Urology 2017年第8期7卷 131-137页

作者： Steven R. Madsen Elizabeth Rourke stephen Overholser Michael A. Liss Department of Urology University of Texas Health Science Center San Antonio South Texas Veterans Affairs Healthcare San Antonio TX USA

Background: The incidence of infection associated with transrectal prostate biopsy has been increasing largely due to fluoroquinolone resistance (FQR). Purpose: To identify the antibiotic prescribing patterns employed when men seek medical professionals due to infectious complications of prostate biopsy, and employ a quality improvement initiative to improve antibiotic selection. Methods: A retrospective review determined the percentage of patients who presented to the emergency department (ED) after TRUS biopsy, and whether they were given appropriate antibiotic therapy. Prospective quality improvement was initiated by obtaining cultures via rectal swab at the time of transrectal biopsy in order to allow culture results and fluoroquinolone sensitivities to be available in the electronic medical record. The provider to guide antibiotic selection if the patient returned with infection symptoms could utilize the data. Findings: From 10/2009 to 6/2014, 0.5% (9/1724) of patients who underwent TRUS prostate biopsy returned to the ED with infection. Seven patients had complete data and 4 (0.57%) were given appropriate initial antibiotic treatment. To improve antibiotic selection, the 119 men who underwent rectal swab culture prior to biopsy 19.3% (23/119) showed FQR on rectal culture. 4% (5/119) were hospitalized with infection, demonstrating a significant increase in infection incidence from retrospective chart review (0.5% to 4%, p = 0.0013). Of these 5 men, 60% (3/5) had FQR on rectal culture. Conclusions: Rectal culture at the time of biopsy may lead to faster recognition of resistant bacteria when presented with prostate biopsy infection.

关键词： Prostate Biopsy Infection Antibiotic Resistance Fluoroquinolone

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Assessing insulin effectiveness at the end of the day: Once-daily versus twice-daily insulin glargine injection

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Journal of Diabetes Mellitus 2012年第2期2卷 203-207页

作者： Mark R. Burge Eric R. Schroeder stephen Mitchell Department of Medicine Endocrinology The Vancouver Clinic Vancouver USA Division of Cardiovascular Medicine South Miami Hospital Miami USA University of New Mexico Health Sciences Center Department of Medicine Division of Endocrinology and Metabolism Albuquerque USA

Objective: Evidence supporting the twice-daily administration of insulin glargine as an approach to address its waning effectiveness at the end of a 24 hour period is sparse. We hypothesized that insulin concentrations determined during the last four hours of a 24 hour period would be greater when identical doses of insulin glargine were administered twice-daily as compared to once-daily among type 1 diabetes patients. Research Methods: Ten subjects with insulin deficient type 1 diabetes were admitted for two 38-hour studies at least one week apart. Patients received full-dose insulin glargine once daily at 0800 and half-dose insulin glargine twice-daily at 0800 and 2000 for at least one week in random order prior to overnight studies. Overnight glucose was stabilized with intravenous insulin on the evening prior to study, and subjects fasted and did not receive short acting insulin during the study period. Insulin concentrations were assessed every 30 minutes with an ultrasensitive assay between study hours 20 and 24. Results: Insulin concentrations for the final four hours of study period did not differ between once-daily and twice-daily insulin glargine administration (p = 0.38). Home glucose testing results and overnight plasma glucose concentrations did not differ between study conditions. Conclusions: These results demonstrate that insulin concentrations are equivalent during the last four hours of a 24-hour period when insulin glargine is administered once- or twice-daily. These findings do not support a role for twice-daily insulin glargine in the management of patients with type 1 diabetes.

关键词： Insulin Injection Timing Insulin Glargine Basal Insulin Type 1 Diabetes

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^(18)F-FDG PET/CT肿瘤显像报告书写指南

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中华核医学与分子影像杂志 2021年第2期41卷 124-128页

作者：黎翔(译) 杨卫东汪静(审校) Ryan D.Niederkohr Bennett S.Greenspan John O.prior Heiko Schöder Marc A.Seltzer Katherine A.Zukotynski Eric M.Rohren 空军军医大学第一附属医院西安710032 Department of Nuclear Medicine Kaiser Permanente Medical CenterSanta ClaraCalifornia Department of Radiology Medical College of Georgia/Georgia Regents UniversityAugustaGeorgia Department of Nuclear Medicine Lausanne University HospitalLausanneSwitzerland Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNew York Department of Radiology Dartmouth-Hitchcock Medical CenterLebanonNew Hampshire Department of Medical Imaging University of TorontoTorontoOntarioCanada Department of Radiology Harvard Medical SchoolBostony Massachusetts Department of Diagnostic Radiology and Nuclear Medicine University of Texas M.D.Anderson Cancer CenterHoustonTexas

纸质报告或其电子版报告是影像医师与转诊医师的主要沟通方式。报告的内容不仅影响患者的管理和临床结果,而且可以作为法律性文件用于医疗纠纷的评判,用于证明医疗的必要性、计费的准确性和监管的合规性。融合显像的复杂性使得完成一份... 详细信息

纸质报告或其电子版报告是影像医师与转诊医师的主要沟通方式。报告的内容不仅影响患者的管理和临床结果,而且可以作为法律性文件用于医疗纠纷的评判,用于证明医疗的必要性、计费的准确性和监管的合规性。融合显像的复杂性使得完成一份高质量的PET/CT报告可能较其他影像学检查报告困难。该文讨论了一份简洁、完整的18F-脱氧葡萄糖(FDG)PET/CT肿瘤显像报告应具有的基本要素,并通过日常临床实践中的例子对这些要素进行阐述。

关键词：肿瘤学 PET/CT 报告

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织物上使用的杀菌剂

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文物保护与考古科学 1991年第1期 51-55页

作者： M.P.Nugari G.F.prior D.Mate’ F.Scala 解玉林

本文认为在艺术品的修复期间,杀菌剂可以作为一种预防措施.该八种杀菌荆的杀菌性能在其它领域早已广泛进行了试验.我们用这些杀菌剂对通常在修复上使用的三种类型的织物进行杀菌性能试验,试验时间28天.通过紫外线辐照条件下人工老化的... 详细信息

本文认为在艺术品的修复期间,杀菌剂可以作为一种预防措施.该八种杀菌荆的杀菌性能在其它领域早已广泛进行了试验.我们用这些杀菌剂对通常在修复上使用的三种类型的织物进行杀菌性能试验,试验时间28天.通过紫外线辐照条件下人工老化的前、后测得的织物反射率的变化来评价杀菌剂与织物间的相互作用,确认了可以在修复期间使用的杀菌剂,并对它们已知的毒性予以了考虑.

关键词：丝织物化合物光泽度紫外线辐照

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体重增加、胰岛素抵抗、炎症、瘦素及冠状动脉循环功能之间的相关性

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 60-61页

作者： Schindler T.H. Cardenas J. prior J.O. H.R. Schelbert 孙凯 Department of Molecular and Medical Pharmacology David Geffen School of Medicine at UCLA Box 173517 10833 Le Conte Avenue Los Angeles CA 90095-1735 United StatesDr.

OBJECTIVES:We sought to evaluate effects of obesity, insulin resistance, and inflammation on coronary circulatory function and its relationship to leptin plasma levels. BACKGROUND: It is not known whether obesity, commonly paralleled by insulin resistance, inflammation, and leptin, is independently associated with coronary circulatory dysfunction. METHODS: Myocardial blood flow(MBF) responses to cold pressor test(CPT) and pharmacologic vasodilation was measured with positron emission tomography and 13N-ammonia. Study participants were divided into three groups based on their body mass index(BMI, kg/m2): control, 20 ≤ BMI30(n=32). RESULTS: Body mass index was significantly correlated to the Homeostasis Model Assessment Index of insulin resistance and C-reactive protein levels(r=0.60 and r=0.47, p< 0.0001). Compared with control subjects, endothelium related change in MBF(Δ MBF) to CPT progressively declined in overweight and obese groups(0.32± 0.09 vs. 0.21± 0.19 and 0.07± 0.16 ml/g/min; p< 0.03 and p< 0.0001). The dipyridamole-in- duced total vasodilator capacity was significantly lower in obese than in control subjects(1.77± 0.51 vs. 2.04± 0.37 ml/g/min, p< 0.02). On multivariate analysis, BMI(p< 0.012) and age(p< 0.035) were significant independent predictors of Δ MBF. Finally, only in the obese group leptin plasma levels significantly correlated with Δ MBF(r=0.37, p< 0.036). CONCLUSIONS: Increased body weight is independently associated with abnormal coronary circulatory function that progresses from an impairment in endothelium related coronary vasomotion in overweight individuals to an impairment of the total vasodilator capacity in obese individuals. The findings that elevated leptin plasma levels in patients that are obese might exert beneficial effects on the coronary endothelium to counterbalance the adverse effects of increases in body weight on coronary circulatory function should be tested.

关键词：胰岛素抵抗指数冠状动脉循环循环功能障碍瘦素水平体重增加炎症正电子发射断层摄影冠状动脉内皮心肌血流量血管舒张

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Treatment Patterns and Healthcare Costs among U.S. Patients with Advanced Melanoma Initiating Subsequent Systemic Therapy Following Use of Ipilimumab (IPI)

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Journal of Cancer Therapy 2016年第5期7卷 335-343页

作者： Elisabetta Malangone-Monaco Tony Okoro Beata Korytowsky Amy Stanford stephen Johnston William Johnson Sigrun Hallmeyer Truven Health Analytics Bethesda USA Bristol-Myers Squibb Princeton USA Oncology Specialists SC Park Ridge USA

As the treatment landscape for advanced melanoma continues to evolve, it is critical to focus on unmet needs and understand the cost of therapy. While Ipilimumab (IPI), an immunotherapy indicated for unresectable advanced melanoma, has been a mainstay of 1st-line treatment, there was no standard of care following progression until recently. The objective of this study was to examine real-world treatment patterns and healthcare costs following IPI use in advanced melanoma patients prior to the anti-PD-1 class approval. Adult stage III or IV melanoma patients treated with IPI were selected between April 1, 2011, and September 30, 2013, from a large U.S. commercial and Medicare claims database. Patients were evaluated for therapy after IPI, with an index date set as the first systemic therapy after IPI. Per-Patient Per-Month (PPPM) healthcare costs while on active treatment were evaluated from index until treatment discontinuation, inpatient death, end of insurance enrollment, or September 30, 2013. Of 361 eligible patients, 111 (30.7%) initiated subsequent systemic therapy (mean age, 57 years;64.9% male). The most common therapies, single-agent or combination, included vemurafenib (32.4%), paclitaxel (28.8%), temozolomide (20.7%), and carboplatin (17.1%). During a median follow-up of 130 days, mean [standard deviation] PPPM all-cause total healthcare costs were $20,383 [$18,988], of which $4800 (23.6%), $5899 (28.9%), and $9684 (47.5%) were related to melanoma drug costs, medical claims with a diagnosis of melanoma, and other (non-specified) utilization, respectively. When considering total care, the costs of U.S. patients with advanced melanoma post-IPI were substantial across all commonly used agents.

关键词： Healthcare Costs Ipilimumab Melanoma Treatment Patterns

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