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Cardiorespiratory fitness,white blood cell count,and mortality in men and women

Journal of Sport and Health Science 2022年第5期11卷 605-612页

作者： stephen w.farrell David Leonard Kerem Shuval Laura F.DeFina Carolyn E.Barlow Andjelka Pavlovic william L.Haskell Research Division The Cooper InstituteDallasTX 75230USA Department of Medicine Stanford UniversityPalo AltoCA 94305USA

Background:we examined the associations of cardiorespiratory fitness(CRF) and white blood cell count(wBC) with mortality ***: A total of 52,056 apparently healthy adults completed a comprehensive health examination,including a maximal treadmill test and blood chemistry *** was categorized as high,moderate,or low by age and sex;wBC was categorized as sex-specific ***:During 17.8± 9.5 years(mean± SD) of follow-up,a total of 4088 deaths *** regressed jointly,significantly decreased allcause mortality across CRF categories was observed within each quartile of wBC in *** wBC Quartile 1,all-cause mortality hazard ratios(HRs) with a 95% confidence interval(95%CI) were 1.0(referent),1.29(95%CI:1.06-1.57),and 2.03(95%CI:1.42-2.92) for high,moderate,and low CRF categories,respectively(p for trend were observed in the remaining 3 *** the exception of cardiovascular disease(CVD) mortality within Quartile 1(p for trend=0.743),there were also similar trends across CRF categories within wBC quartiles in men for both CVD and cancer mortality(p for trend women,there were no significant trends across CRF categories for mortality outcomes within Quartiles ***,we observed significantly decreased all-cause mortality across CRF categories within wBC Quartile 4(HR=1.05(95%CI:0.76-1.44),HR=1.63(95%CI:1.20-2.21),and HR=1.87(95%CI:1.29-2.69) for high,moderate,and low CRF,respectively(p for trend=0.002)).Similar trends in women were observed for CVD and cancer mortality within wBC Quartile 4 ***:There are strong joint associations between CRF,wBC,and all-cause,CVD,and cancer mortality in men;these associations are less consistent in women.

关键词： Complete blood count Epidemiology Inflammation Physical fitness

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Association between baseline levels of muscular strength and risk of stroke in later life:The Cooper Center Longitudinal Study

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Journal of Sport and Health Science 2024年第5期13卷 642-649页

作者： stephen w.farrell David Leonard Qing Li Carolyn E.Barlow Kerem Shuval Jarett D.Berry Andjelka Pavlovic Laura F.DeFina Research Division The Cooper InstituteDallasTX 75230USA Department of Internal Medicine University of Texas at Tyler School of MedicineTylerTX 75799USA

Background:Muscular strength is an important component of physical *** evaluated the relationship between baseline muscular strength and risk of stroke among adults who were aged≥65 years during ***:we included 7627 healthy adults(mean age=43.9 years,86.0%male)underwent a baseline physical examination between 1980 and *** strength was determined by 1-repetition maximum measures for bench press and leg press and categorized into age-and sex-specific tertiles for each *** fitness(CRF)was assessed via a maximal treadmill exercise *** enrolled in fee-for-service Medicare from 1999 to 2019 were included in the *** between baseline strength and stroke outcomes were estimated using a modified Cox proportional hazards *** a secondary analysis,we examined stroke risk by categories of CRF where Quintile 1=low,Quintiles 2-3=moderate,and Quintiles 4-5=high CRF based on age and ***:After 70,072 person-years of Medicare follow-up,there were 1211 earliest indications of incident *** multivariable analyses,the hazard ratio(95%confidence interval(95%CI))for stroke across bench press categories were 1.0(referent),0.96(0.83-1.11),and 0.89(0.77-1.04),respectively(p trend=0.14).The trend across categories of leg press was also non-significant(p trend=0.79).Adjusted hazard ratio(95%CI)for stroke across ordered CRF categories were 1.0(referent),0.90(0.71-1.13),and 0.72(0.57-0.92)(p trendwhile meeting public health guidelines for muscular strengthening activities is likely to improve muscular strength as well as many health outcomes in older adults,performing such activities may not be helpful in preventing ***,meeting guidelines for aerobic activity is likely to improve CRF and lower stroke risk.

关键词： Cardiorespiratory fitness Medicare Muscular strength Stroke

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库珀中心纵向研究:有氧运动的灵魂

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体育科研 2018年第6期39卷 3-18页

作者： stephen w.farrell Laura F.DeFina 阎海朱为模库珀研究中心美国伊利偌伊大学

目的:为肯尼斯·库珀(Kenneth H. Cooper)于1970年提出的库珀中心纵向研究(CCLS)提供详细历史。方法:对库珀中心纵向研究人群和库珀诊所所检查的重要参数,以及库珀诊所患者的各种疾病发病率和死亡率进行数据描述。并对近50年来已发表的... 详细信息

目的:为肯尼斯·库珀(Kenneth H. Cooper)于1970年提出的库珀中心纵向研究(CCLS)提供详细历史。方法:对库珀中心纵向研究人群和库珀诊所所检查的重要参数,以及库珀诊所患者的各种疾病发病率和死亡率进行数据描述。并对近50年来已发表的库珀中心纵向研究的主要研究结果进行总结。结果:在库珀诊所检查期间,通过最大跑台运动测试客观地测量出的心肺功能(CRF)已成为各种疾病发病率和死亡率的强大且独立的风险因素。更具体地说,库珀中心纵向研究明确表明,中高水平的心肺功能与人体全因、心血管疾病和癌症死亡率有显著相关关系。此外,已经证明,中年人群的心肺水平是全因痴呆、Ⅱ型糖尿病、慢性肾病、癌症发病率和存活率以及一些其他慢性疾病的预测因子。因此,库珀中心纵向研究结果还表明,中年人群的心肺水平与老年时期的医疗保健成本呈显著相关。结论:除罕见情况以外,已经进行了近50年的库珀中心纵向研究的研究结果表明,相对于较低水平的心肺功能,中高水平的心肺功能可以有效预防许多疾病。

关键词：心肺健康发病率死亡率

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Acute chylous ascites mimicking acute appendicitis in a patient with pancreatitis

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world Journal of Gastroenterology 2009年第38期15卷 4849-4852页

作者： Emily K Smith Edmund Ek Daniel Croagh Lavinia A Spain stephen farrell Department of Surgery St Vincent's Hospital Melbournec/o St Vincent's Hospital Melbourne Department of Surgery St Vincent's Hospital Melbourne Department of Colorectal Surgery St Vincent's Hospital Melbourne

we report a case of acute chylous peritonitis mimicking acute appendicitis in a man with acute on chronic pancreatitis. Pancreatitis, both acute and chronic, causing the development of acute chylous ascites and peritonitis has rarely been reported in the English literature. This is the fourth published case of acute chylous ascites mimicking acute appendicitis in the literature.

关键词： Chylous ascites Pancreatitis

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Teichmller space of negatively curved metrics on complex hyperbolic manifolds is not contractible

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Science China Mathematics 2017年第4期60卷 569-580页

作者： farrell F. Thomas SORCAR Gangotryi Yau Mathematical Sciences Center and Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematics Ohio State University Columbus OH 43210 USA

we prove that for all n = 4k- 2 and k 2 there exists a closed smooth complex hyperbolic manifold M with real dimension n having non-trivial π1(T<0(M)). T<0(M) denotes the Teichm¨uller space of all negatively curved ... 详细信息

we prove that for all n = 4k- 2 and k 2 there exists a closed smooth complex hyperbolic manifold M with real dimension n having non-trivial π1(Twhich is the topological quotient of the space of all negatively curved metrics modulo the space of self-diffeomorphisms of M that are homotopic to the identity.

关键词： space of Riemannian metrics negative curvature complex hyperbolic space

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Feature mapping and state estimation for highly automated vehicles

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Journal of Control and Decision 2015年第1期2卷 1-25页

作者： Anh Vu Jay A.farrell Department of Electrical and Computer Engineering University of California-RiversideRiversideCAUSA

The past decade has witnessed an acceleration of autonomous vehicle research and development,with technological advances contributed by academia,government,and the industrial and consumer *** advancements hold the potential to improve society by enhancing transportation safety and throughput,where decreased congestion saves time and reduces vehicle *** of the key technologies to enable vehicle infrastructure interaction,advanced traffic management,and automated vehicles are automated roadway mapping and reliable vehicle state *** this paper,we present an overview and new methods for the problems automated roadway mapping plus a discussion of the extension of these methods to the problem of vehicle state *** from the application of these methods to feature mapping and state estimation are presented.

关键词： automated precise mapping vehicle state estimation Bayesian estimation vehicle infrastructure interaction advanced driver assistance systems autonomous driving

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Modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review

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Asian Journal of Andrology 2020年第1期22卷 51-59页

作者： Matthew J Ziegelmann M Ryan farrell Laurence A Levine Division of Urology Rush University Medical CenterChicagoIL 60612USA

Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual *** dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment *** a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly *** some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate ***,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without *** patients with severe penile shortening,penile length restoration techniques may also be ***,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's ***,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes.

关键词： collagenase grafting penile length penile prosthesis Peyronie's

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Diabetes, Exercise and Competitive Sports

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中国运动医学杂志 2006年第3期25卷 355-364页

作者： Peter A. farrell Department of Exercise and Sport ScienceEast Carolina University Greenville NC 27858 Ph.D.

People with diabetes mellitus—rapidly approaching one-third of the US population—either cannot produce insulin (Type 1 DM) or the insulin they produce is ineffective in stimulating the uptake of blood sugar (glucose) into the body’s cells (Type 2 DM). Accordingly, if diabetes is untreated, blood sugar rises to dangerously high levels that can eventually cause blindness, nerve damage, and other complications. Blood sugar can be controlled by the appropriate administration of insulin and other drugs and/or by the manipulation of dietary carbohydrate and exercise.During exercise, the contracting muscles produce their own insulin-like effect,causing the rapid uptake of glucose from the blood. In people without diabetes,the body naturally reduces its production of insulin to compensate; otherwise, blood glucose would fall precipitously. (A low blood glucose concentration is known as hypoglycemia.) Those with Type 1 DM (and those with Type 2 DM who use insulin to control their blood sugar) must adjust their pre-exercise insulin dosage and their carbohydrate intake before, during, and after exercise to avoid becoming hypoglycemic.

关键词：糖尿病运动保健治疗

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Single organ hepatic artery vasculitis as an unusual cause of epigastric pain:A case report

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world Journal of Clinical Cases 2022年第26期10卷 9384-9389页

作者： Rojin Kaviani Jessica farrell Natasha Dehghan Sarvee Moosavi Internal Medicine University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada Division of Radiology Providence Health CareVancouver V5T 3N4British ColumbiaCanada Division of Rheumatology Providence Health CareVancouver V5T 3N4British ColumbiaCanada Division of Gastroenterology University of British ColumbiaVancouver V6Z 2K5British ColumbiaCanada

BACKGROUND Single-organ vasculitis(SOV)is characterized by inflammation of a blood vessel,affecting one organ,such as the skin,genitourinary system,or the aorta without systemic *** SOV is rare,with hepatic artery involvement reported only in two prior published ***,we presented a case of isolated hepatic artery vasculitis presenting after Pfizer-BioNTech mRNA corona virus disease 2019(COVID-19)*** SUMMARY A 50-year-old woman with hypertension presented to our Emergency Department with recurrent diffuse abdominal pain that localized to the epigastrium and emesis without diarrhea that began eight days after the second dose of the PfizerBioNTech COVID-19 *** work revealed an elevated C-reactive protein(CRP)of 19 mg/L(normalwith hepatic artery vasculitis.A detailed review of her history and examination did not reveal infectious or systemic autoimmune causes of her *** extensive autoimmune panel was ***-19polymerase chain reaction nasopharyngeal swab,human immunodeficiency virus,viral hepatitis and Heliobacter pylori serology were *** six months,the patient’s symptoms,and blood work spontaneously *** High clinical suspicion of SOV is required for diagnosis in patients with acute abdominal pain and dyspepsia.

关键词： Single organ vasculitis Hepatic artery gastrointestinal vasculitis COVID-19 vaccine Hepatic artery vasculitis Case report

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Overview and comparison of guidelines for management of pancreatic cystic neoplasms

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world Journal of Gastroenterology 2019年第31期25卷 4405-4413页

作者： Aws Hasan Kavel Visrodia James J farrell Tamas A Gonda Division of Digestive and Liver Diseases Department of MedicineColumbia UniversityNew YorkNY 10032United States Division of Digestive Diseases Department of MedicineYale UniversityNew HavenCT 06520United States

Pancreatic cysts are identified at an increasing *** mucinous cystic neoplasms represent a pre-malignant condition,the majority of these lesions do not progress to *** the last 10 years several societies have established guidelines for the diagnosis,initial evaluation and surveillance of these *** we provide an overview of five commonly used guidelines:2015 American Gastroenterological Association,2017 International Association of Pancreatology,American College of Gastroenterology 2018,European Study Group and American College of *** describe the similarities and differences between the methods used to formulate these guidelines,the population they target and their approaches towards initial evaluation and surveillance of cystic lesions.

关键词： Pancreatic cyst surveillance Cyst malignancy Guidelines

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