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Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

Journal of Integrative Medicine 2015年第5期13卷 306-313页

作者： Deborah J.Engen samantha J.Mc Allister Mary O.Whipple stephen s.cha Liza J.Dion Ann Vincent Brent A.Bauer Dietlind L.Wahner-Roedler Department of Physical Medicine and Rehabilitation Mayo Clinic Division of General Internal Medicine Mayo Clinic Division of Biomedical statistics and Informatics Mayo Clinic

BACKGROUND： Fibromyalgia is a syndrome characterized by chronic pain, fatigue, depression, and sleep disturbances. Its primary cause is unclear. several studies have reported decreased intracellular magnesium levels in patients with fibromyalgia and have found negative correlation between magnesium levels and fibromyalgia symptoms.OBJECTIVE： To gather preliminary data on whether transdermal magnesium can improve quality of life for women who have fibromyalgia. DEsIGN, sETTING, PARTICIPANTs AND INTERVENTIONs： This is a patient questionnaires and survey in a fibremyalgia clinic at a tertiary medical center. Forty female patients with the diagnosis of fibremyalgia were enrolled. Each participant was provided a spray bottle containing a transdermal magnesium chloride solution and asked to apply 4 sprays per limb twice daily for 4 weeks. Participants were asked to complete the Revised Fibromyalgia Impact Questionnaire, sF-36v2 Health survey, and a quality-of-life analog scale at baseline, week 2, and week 4. MAIN OUTCOME MEAsURE： Questionnaire and survey scores, evaluated through intent-to-treat and per-protocol analyses. REsULTs： Twenty-four patients completed the study （mean [sD] age, 57.2 [7.6] years; white, 95%; mean body mass index, 31.3 kg/m2）. With intention-to-treat analysis, Revised Fibromyalgia Impact Questionnaire subscale and total scores were significantly improved at week 2 and week 4 （total score, P = 0.001）. Per-protocol analysis results were similar： all subscales of the Revised Fibremyalgia Impact Questionnaire were significantly improved at week 2 and week 4 （total score, P = 0.001）. CONCLUsION： This pilot study suggests that transdermal magnesium chloride applied on upper and lower limbs may be beneficial to patients with fibromyalgia.

关键词： fibromyalgia magnesium chloride Revised Fibromyalgia Impact Questionnaire clinical trial

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Less common neoplasms of the pancreas

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World Journal of Gastroenterology 2006年第20期12卷 3180-3185页

作者： Abby L Mulkeen Peter s Yoo charles.cha Department of surgery Yale University school of Medicine New HavenCT and the VACT Healthcare SystemWest HavenCT330 Cedar StreetLH 118PO Box 208062New HavenCT06520-8062United States

Recently, there has been an increased recognition of neoplasms of the pancreas other than ductal adenocarcinorna. Although not as well studied or characterized as pancreatic adenocarcinorna there are many distinct lesions which exhibit diverse biological behaviors and varying degrees of malignancy. These lesions include： endocrine neoplasms, cystic tumors, solid pseudopapillary tumors, acinar cell carcinoma, squamous cell carcinoma, primary lymphoma of the pancreas, and metastatic lesions to the pancreas. These less common neoplasms are being diagnosed more frequently as the number and sensitivity of diagnostic imaging studies increase. This review article discusses the clinical course, diagnosis, and treatment of these less common, but quite relevant, neoplasms of the pancreas.

关键词： Pancreas Neoplasms Ductal adenocarcinoma

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Gastrointestinal and hepatic manifestations of COVID-19:A comprehensive review

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World Journal of Gastroenterology 2020年第19期26卷 2323-2332页

作者： Ming Han cha Miguel Regueiro Dalbir s sandhu Department of Internal Medicine Cleveland ClinicAkron GeneralAkronOH 44307United States Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteCleveland ClinicClevelandOH 44307United States

The severe acute respiratory syndrome-coronavirus-2(sARs-CoV-2)that causes coronavirus disease-2019(COVID-19)is a global pandemic,manifested by an infectious *** patients primarily present with fever,cough and dyspnea,some patients also develop gastrointestinal(GI)and hepatic *** most common GI symptoms reported are diarrhea,nausea,vomiting,and abdominal *** chemistry abnormalities are common and include elevation of aspartate transferase,alanine transferase,and total *** have shown that sARs-CoV-2 infects the GI tract via its viral receptor angiotensin converting enzyme Ⅱ,which is expressed on enterocytes of the ileum and *** RNA has also been isolated from stool specimens of COVID-19 patients,which raised the concern for fecal-oral transmission in addition to droplet *** indirect evidence has suggested possible fecal-oral transmission of sARs-CoV-2,more effort is needed to establish the role of the fecal-oral transmission *** research will help elucidate the association between patients with underlying GI diseases,such as chronic liver disease and inflammatory bowel disease,and severity of *** this review,we summarize the data on GI involvement to date,as well as the impact of COVID-19 on underlying GI diseases.

关键词： COVID-19 sARs-CoV-2 Gastrointestinal Liver Diarrhea Inflammatory bowel disease

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Post-transcriptional regulation of vascular endothelial growth factor: Implications for tumor angiogenesis

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World Journal of Gastroenterology 2006年第31期12卷 4937-4942页

作者： Peter s Yoo Abby L Mulkeen charles H cha Gastrointestinal surgery and surgical OncologyYale school of Medicine New HavenConnecticutUnited States

Vascular endothelial growth factor （VEGF） is a potent secreted mitogen critical for physiologic and tumor angiogenesis. Regulation of VEGF occurs at several levels, including transcription, mRNA stabilization, translation, and differential cellular localization of various isoforms. Recent advances in our understanding of post-transcriptional regulation of VEGF include identification of the stabilizing mRNA binding protein, HuR, and the discovery of internal ribosomal entry sites in the 5＇UTR of the VEGF mRNA. Monoclonal anti-VEGF antibody was recently approved for use in humans, but suffers from the need for high systemic doses. RNA interference （RNAi） technology is being used in vitro and in animal models with promising results. Here, we review the literature on post-transcriptional regulation of VEGF and describe recent progress in targeting these mechanisms for therapeutic benefit.

关键词： Vascular endothelial growth factor Vascular endothelial growth hormone Post-transcriptional regulation mRNA stability HuR ELAVl Internal ribosomal entry IREs siRNA RNAi Bevacizumab

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Enhanced thermoelectric performance of spark plasma sintered p-type Ca_(3-x)Y_(x)Co_(4)O_(9+δ)systems

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Journal of Materials science & Technology 2020年第20期52卷 212-222页

作者： J.s.cha D.H.Kim H.Y.Hong K.Park Faculty of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul05006Republic of Korea

Highly textured dense Ca3-xYxCo4 O9+δ(0≤x≤0.3)samples were fabricated by combining sol-gel process with spark plasma sintering(sPs).Y^3+substitution for Ca^2+simultaneously increased the seebeck coefficient and reduced the thermal *** latter was attributed to the increase in lattice anharmonicity,structural distortion,and grain boundary area,which enhanced the phonon ***2.7Y0.3Co4 O9+δshowed the largest dimensionless figure-of-merit(ZT=0.194)at 1073 K because it had the largest seebeck coefficient and the lowest thermal *** ZT value was 55%larger than that of undoped Ca3 Co4 O9(0.125 at 1073 K).Therefore,Y^3+substitution,sol-gel powder synthesis,and sPs are highly effective for enhancing the thermoelectric prope rties of Ca_(3)Co_(4)O_(9).

关键词： Electrical conductivity Ca_(3)Co_(4)O_(9) Thermoelectric properties seebeck coefficient Thermal conductivity spark plasma sintering

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Case of cannabinoid hyperemesis syndrome with long-term follow-up

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World Journal of Clinical Cases 2014年第12期2卷 930-933页

作者： Jae Myung cha Richard A Kozarek Otto s Lin Gastroenterology Division Department of Internal Medicine Kyung Hee University Hospital at Gang Dong Kyung Hee University School of Medicine Seoul 134-727 South Korea Digestive Disease Institute Virginia Mason Medical Center Seattle WA 98101 United States

Long-term cannabis use may be associated with attacks of severe nausea and vomiting, and a characteristic learned behavior of compulsive hot bathing, termed cannabinoid hyperemesis syndrome(CHs). Long-term follow-up and prognosis of CHs have not been reported previously. A 44-year-old Caucasian man with a long history of addiction to marijuana presented with chronic abdominal pain complicated by attacks of uncontrollable vomiting for 16 years. He had a compulsion to take scalding hot showers, as many as 15 times a day, to relieve his symptoms. All previous therapies had been ineffective. However, abstinence from marijuana led to rapid and complete resolution of all symptoms and his compulsive hot showering behavior. He has been followed for nine years, and is still doing well without recurrence of symptoms. Physicians should have a high index of suspicion for this under-recognized condition, as excellent long-term prognosis of CHs can be achieved when abstinence is maintained.

关键词： Cannabinoids Hyperemesis Prognosis Abdominal pain Adverse drug effect

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Posterior propriety in nonparametric mixed efects model

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Applied Mathematics(A Journal of Chinese Universities) 2013年第3期28卷 369-378页

作者： XU An-cha TANG Yin-cai College of Mathematics and Information science Wenzhou University school of Finance and statistics East China Normal University

It is well known that spline smoothing estimator relates to the Bayesian estimate under partially informative normal prior. In this paper, we derive the conditions for the pro- priety of the posterior in the nonparametric mixed effects model under this class of partially informative normal prior for fixed effect with inverse gamma priors on the variance compo- nents and hierarchical priors for covariance matrix of random effect, then we explore the Gibbs sampling procedure.

关键词： nonparametric mixed effect model Bayesian spline smoothing Gibbs sampling.

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Proline Accumulation,Photosynthetic Abilities and Growth characters of sugarcane(saccharum officinarum L.) Plantlets in Response to Iso-Osmotic salt and Water-Deficit stress

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Agricultural sciences in China 2009年第1期8卷 51-58页

作者： suriyan cha-um chalermpol Kirdmanee National Center for Genetic Engineering and Biotechnology(BIOTEC) National Science and Technology Development Agency(NSTDA)

The aim of this study was to investigate the biochemical, physiological and morphological responses of sugarcane to iso- osmotic salt and water-deficit stress. Disease-free sugarcane plantlets derived from meristem cuttings were photo- autotrophically grown in Ms media and subsequently exposed to -0.23 （control）, -0.67 or -1.20 MPa iso-osmotic NaCl （salt stress） or mannitol （water-deficit stress）. Chlorophyll a （Chl a）, chlorophyll b （Chl b）, total carotenoids （Cx＋c）, maximum quantum yield of PsII （Fv/Fm）, photon yield of PsII （ΦPsII）, stomatal conductance （Gs） and transpiration rate （E） in the stressed plantlets were significantly reduced when compared to those of plantlets of the control group （without mannitol or NaCl）, leading to net-photosynthetic rate （Pn） and growth reduction with positive correlation. In addition, physiological changes and growth parameters of plantlets in the salt stress conditions were more sharply reduced than those in waterdeficit stress conditions. On the other hand, the proline content and non-photochemical quenching （NPQ） in the leaves of stressed plantlets increased significantly, especially in response to iso-osmotic salt stress. The chlorophyll pigments in iso-osmotic stressed leaves were significantly degraded （r^2 = 0.93）, related to low water oxidation （r^2 = 0.87）, low net- photosynthetic rate （r^2 = 0.81）, and growth reduction （r^2 = 0.97）. The multivariate biochemical, physiological and growth parameters in the present study should be further used to develop salt, or drought, tolerance indices in sugarcane breeding programs.

关键词： growth performances net-photosynthetic rate pigment degradation proline water oxidation

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Recent progress on in situ characterizations of electrochemically intercalated transition metal dichalcogenides

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Nano Research 2019年第9期12卷 2126-2139页

作者： sajad Yazdani Milad Yarali Judy J. cha Department of Mechanical Engineering and Materials science Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale University West CampusWest HavenCT 06516USA

Layered transition metal dichalcogenides(TMDCs)have been extensively studied owing to their unique physical and chemical *** van der Waals(vdW)interact!ons betwee n the stacki ng layers of TMDCs allow intercalati on of various species including mono vale nt alkali,divale nt alkaline earth and multivale nt metal ions,zero-vale nt transiti on metals,as well as orga nic molecules,all of which can drastically alter fun dame ntal properties of the *** urge to understa nd the phe nomena and the desire to exploit them for applicati ons have inspired a great deal of investigations.A large portion of the mystery has been unveiled over the past decade of intense research;however,many questions remain open and require further *** review is concerned with investigations on structural and electronic evolution of TMDCs drive n by electrochemically con trolled in tercalati ***,we aim to survey the rece nt adva nces and experime ntal platforms for mon itoring the in tercalati on processes in situ by utilizi ng nano *** additi on,several in quiries and prospects are outlined in a broader con text for future ave nues of studies.

关键词： transition metal dichalcogenides electrochemical intercalation in situ characterizations transmission electron microscopy(TEM) magnetotransport measurements

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Behavioral evidence for contextual olfactory-mediated avoidance of the ubiquitous phytopathogen Botrytis cinerea by Drosophila suzukii

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Insect science 2020年第4期27卷 771-779页

作者： Dong H.cha stephen P.Hesler Gabrielle Brind'Amour Karen s.Wentworth sara Villani Kerik D.Cox Matthew T.Boucher Anna Wallingford shinyoung K.Park Jan Nyrop Gregory M.Loeb UsDA-ARs US Pacific Basin Agricultural Research CenterHiloHawaiiUSA Department of Entomology Cornell AgriTechCornell UniversityGenevaNew YorkUSA Plant Pathology and Plant-Microbe Biology section Cornell AgriTechCornell UniversityGenevaNew YorkUSA

Herbivorous insects may benefit from avoiding the smell produced by phytopathogens infecting plant host tissue if the infected tissue reduces insect ***,in many cases the same species of phytopathogen can also infect host plant tissues that do not directly affect herbivore ***,insects may benefit from differentiating between pathogen odors emanating from food and nonfood *** is based on the hypothesis that unecessarily staying attentive to pathogen odor from nonfood tissue may incur opportunity costs associated with not responding to other important survival *** this study adults of Drosophila suzukii Matsumura,an invasive larval frugivore,showed reduced attraction to the odor of raspberry fruit,a food tissue,when infected with Botrytis cinerea Pers.,a ubiquitous phytopathogen,in favor of odors of uninfected raspberry ***,*** oviposited fewer eggs on infected raspberry fruit relative to uninfected raspberry *** survival and adult size after eclosion were significantly reduced when reared on ***-infected raspberry relative to uninfected ***,when the behavioral choice experiment was repeated using Botrytis-infected vsuninfected strawberry leaves,a nonfood tissue,in combination with fresh raspberry fruit,odor from ***-infected leaves did not reduce *** attraction to raspberries rel-ative to raspberries with uninfected *** behavioral results illustrate the important role context can play in odor-mediated interactions between insects,plants and *** discuss implications of our findings for developing a repellent that can be useful for the management of ***.

关键词： chemical ecology host finding behavior insect-microbe interactions pest management repellent semiochemicals

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