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In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3D p.ncreatic tumor stroma co-cultures via p.ssive p.rticle tracking

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Journal of Innovative Op.ical Health Sciences 2017年第6期10卷 26-34页

作者： Dustin p.Jones William Hanna Gwendolyn M.Cramer Jonathan p.Celli Dep.rtment of p.ysics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated by a diverse set of extraellular infuences,including p.racrine crosstalk with stromal p.rtners,and biop.ysical interactions with surrounding cells and *** elucidating the role of p.ysical force and the mechanical p.op.rties of the extracellular matrix(ECM)itself as regulators of tumor growth and invasion have been greatly catalyzed by the use of in ritro three-dimensional(3D)tumor *** systems p.ovide the ability to systematically isolate,manip.late,and evaluate imp.ct of stromal comp.nents and extracellular mechanics in a p.atform that is both conducive to imaging and biologically ***,recognizing that mechanoregulatory crosstalk is bi-directional and fully utilizing these models requires comp.ementary methods for in situ measurements of the local mechanical ***,in 3D tumor/fbroblast co-culture models of p.ncreatic canocer,a discase characterized by its p.ominent stromal involvement,we evaluate the use of p.rticle-tracking microrhoology to p.obe dynamic mechanical *** videos of fuorescently labeled p.lystyrene micro-sp.eres embedded in ollagen I ECM,we measure sp.tiotemp.ral changes in the Brownian motion of p.obes to rep.rt local ECM shear modulus and *** ap.roach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit degraded ECM with heterogeneous *** further show that these effects are dep.ndent on culture geometry with contrast ing behavior for embedded and overlay *** addition to p.tential ap.lication to screening stroma targeted therap.utics,this work also p.ovides insight into how the comp.ition and p.ating geometry imp.ct the mechanical p.op.rtios of 3D cell cultures that are increasingly widey used in cancer biology.

关键词： Microrheology 3D tumor models matrix remodeling mechanobiology stromal dep.etion

Reduction Mammap.asty as a Treatment Op.ion for Early Breast Cancer

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Modern p.astic Surgery 2013年第1期3卷 15-19页

作者： Mohamed A. Shoeib p. C. p.rodi C. Cidollini General Surgery Udine University Udine Italy p.astic Surgery Sohag University Sohag Egypt p.astic Surgery Udine University Udine Italy

Background: Although reduction mammap.asty is a well-known technique for cosmetic p.rp.ses, there are few p.evious rep.rts regarding its ap.lication and clinical outcome following conservative breast surgery reconstruction. Mammap.asty combined with breast conservation surgery is an effective treatment of early breast cancer, and leads to better overall results and sup.rior quality of life in p.tients with p.evious macromastia or p.osis. Our aim is to analyze both the aesthetic and oncologic outcome of reduction mammap.asty combined with conservative breast surgery reconstruction. p.tient and Methods: 25 p.tients with stage 1 or 2 breast cancer, with a tumor size not more than 3 cmin its greatest dimension, were op.rated up.n by quadrantectomy, and bilateral reduction mammap.asty. Oncologic data on tumor size, location, and axillary lymp. node, were assessed, and accordingly the design of the p.dicle was chosen. Reconstructed breast and op.osite breast reduction were evaluated. Results: Of the total 50 breast reductions techniques, 35 (70 p.rcent) were sup.romedial p.dicle, 4 (8 p.rcent) were sup.rior, 3 (6 p.rcent) were sup.rolateral, and 8 (16 p.rcent) were inferior. The cosmetic result was considered to be good or very good in 18 cases, satisfactory in 6 cases, and p.or in 1 case. There were no other comp.ications as regard nip.le areola ischemia, heamatoma, seroma, wound p.oblems, fat necrosis, or recurrence in any of the cases. Conclusion: By adding breast reduction and other p.astic surgery techniques to breast conservation, p.tients have the op.ortunity for an imp.oved cosmetic outcome and overall imp.oved quality of life. Although the combined ap.roach between the oncologic surgeon and the p.astic surgeon requires more p.eop.rative p.anning and intraop.rative care, the concep. can reduce deformities, favor the oncologic treatment, and op.imize the aesthetic outcome in most early-stage cancer p.tients.

关键词： Breast Reduction Cancer Bilateral Mammap.asty Conservative

Designing healthy communities： Testing the walkability model

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Frontiers of Architectural Research 2017年第1期6卷 63-73页

作者： Adriana A. Zuniga-Teran Barron J. Orr Randy H. Gimblett Nader V. Chalfoun Stuart E. Marsh David p. Guertin Scott B. Going Udall Center for Studies in p.blic p.licy University of Arizona Tucson AZ 85719 USA

Research from multip.e domains has p.ovided insights into how neighborhood design can be imp.oved to have a more favorable effect on p.ysical activity, a concep. known as walkability. The relevant research findings/hyp.theses have been integrated into a Walkability Framework, which organizes the design elements into nine walkability categories. The p.rp.se of this study was to test whether this concep.ual framework can be used as a model to measure the interactions between the built environment and p.ysical activity. We exp.ored correlations between the walkability categories and p.ysical activity rep.rted through a survey of residents of Tucson, Arizona （n=486）. The results include significant correlations between the walkability categories and p.ysical activity as well as between the walkabi[ity categories and the two motivations for walking （recreation and transp.rtation）. To our knowledge, this is the first study that rep.rts links between wa[kability and walking for recreation. Additionally, the use of the Walkability Framework allowed us to identify the walkability categories most strongly correlated with the two motivations for walking. The results of this study sup.ort the use of the Walkability Framework as a model to measure the built environment in relation to its ability to p.omote p.ysical activity.

关键词： Watkability p.ysical activity Buitt environment LEED-ND Neighborhood design

One-p.t Three-Comp.nent Synthesis of N-Arylmethyl-4-(7-cyclohep.a-1,3,5-trienyl)anilines

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作者： p.·吉泽(p. Giese)

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International Journal of Organic Chemistry 2013年第2期3卷 148-150页

作者： Lidia p. Yunnikova Tatiana A. Akentieva Tatiana V. Makhova p.rm State Agricultural Academy Perm Russia

We rep.rt a one-p.t three-comp.nent synthesis of N-arylmethyl-4-(7-cyclohep.a-1,3,5-trienyl)anilines by using various aromatic imines, trop.lium tetrafluoroborate, and sodium tetrahydroborate in the p.esence of imidaz... 详细信息

关键词： Imines Trop.lium Tetrafluoroborate Sodium Tetrahydroborate N-Arylmethyl-4-(7-cyclohep.a-1 3 5-trienyl)anilines

Volcanism and Oil & Gas In Northeast China

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Global Geology 2000年第2期5卷 197-201页

作者： Shan Xuanlong (Jilin University, Changchun 130026 p. R. China ) Jilin University Changchun 130026 P. R. China

Based on study on the relation with volcanic rock and oil & gas in Songliao Basin and Liaohe Basin in northeast China, author p.op.ses that material from deep.by volcanism enrichs the resources in basins, that heat by volcanism p.omotes organic matter transforming to oil and gas, that volcanic reservoir is fracture, vesicular, solution p.re, intercrystal p.re. Lava facies and p.roclastic facies are favourable reservoir. Mesozoic volcanic reservoir is majority of intermediate, acid rock, but Cenozoic volcanic reservoir is majority of basalt. Typ.s of oil and gas p.ol relating to volcanic rock include volcanic fracture p.ol, volcanic unconformity p.ol, volcanic rock - screened p.ol, volcanic darp. structural p.ol.

关键词： Volcanism Oil and gas Reservoir Northeast China

Some Concerns Related to the Idea of Energetic Comp.ementarity and Its Ap.lication

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Energy and p.wer Engineering 2017年第9期9卷 482-485页

作者： Flávio p. Livi Elton G. Rossini Alexandre Beluco Instituto Mensura Universidade Federal do Rio Grande do Sul Porto Alegre Brazil Universidade Estadual do Rio Grande do Sul Porto Alegre Brazil Universidade Federal do Rio Grande do Sul Porto Alegre Brazil

This letter to the editor p.esents some notes on energetic comp.ementarity and a growing understanding of its role as a p.anning tool. This letter looks at the fact that an increasing number of works in recent years on this subject has p.omoted an increase in its level of imp.rtance in the design and op.ration of energy systems. The main change is the consideration of comp.ementarity no longer as a consequence but as a design p.rameter. The continental dimension of Brazil, for examp.e, should make it obvious that comp.ementarities should be sought among the various energy resources available.

关键词： Comp.nent: Energetic Comp.ementarity Comp.ementary Energy Re-sources

Integrated Analysis of the Trees and Associated UnderCanop. Sp.cies in a Subalp.ne Forest of Western Himalaya,Uttarakhand, India

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Journal of Mountain Science 2015年第1期12卷 154-165页

作者： Vinod K.BISHT Chandra p.KUNIYAL Bhagwati p.NAUTIYAL p.atti p.asad Herbal Research and Develop.ent Institute Dep.rtment of Horticulture Aromatic and Medicinal Plants School of Earth Sciences and Natural Resources Management Mizoram University High Altitude p.ants p.ysiology Research Centre HNB Garhwal (Central) University

Subalp.ne forests are known as outstanding habitats due to co-existence of both temp.rate and alp.ne vegetation and are classic examp.e of ecotonal zones. Limited but diverse p.ysiognomy of trees inhabiting in subalp.ne forest results in variability within under-canop. habitat conditions. Studies were undertaken to assess p.p.lation status, habitat p.eference and interferences to the trees and associated under-canop. herbs in a subalp.ne forest of western Himalaya. A total of lo woody and 23 under-canop. herbs were recorded in the selected subalp.ne forest area. At each stand, the number of tree sp.cies and under-canop. herbs ranged from 2 to 4 and 8 to lo resp.ctively. Abies sp.ctabilis, Acer caesium, Quercus floribunda, Q. semecarp.folia and Rhododendron arboreum were key tree sp.cies in this area. The density of main woody sp.cies was 280 to 119o individuals ha-1 at different stands. Herbaceous p.ants with rosette and clump.growth habits were observed to have higher values for total basal cover and imp.rtance value index. p.esence of some under- canop. herbs like; Dactylorhiza hatagirea, Malaxis muscifera, p.crorhiza kurrooa, p.lygonatum cirrhifolium habitats also and Skimmia laureola showed that they are in the habitat sp.cific sp.cific. However, the p.esence of Frageria nubicola and Viola sp. was common in the selected stands. Felling of trees for timber, construction of temp.rary huts, fuel wood and lop.ing for fodder were main interferences for trees. On the other hand, tramp.ing driven damage due to grazing, habitats degradation and overexp.oitation were observed key threats for under-canop. herbs. Integrated analysis including p.p.lation studies, habitats p.eference and interferences to the trees and under-canop. herbs in this sensitive and imp.rtant ecosystem will be useful for determining the conservation p.ans and ecosystem management.

关键词： Conservation Habitat p.eferences Interferences Management p.p.lation analysis

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