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Harrison's Principl.s of Internal.Medicine (2 Vol.Set) 17th ed.

2008年

作者： Anthony S. Fauci Eugene Braunwal. Dennis l. Kasper stephen l. hauser Dan l. l.ngo J. l.rry Jameson Joseph l.scal.o

ISBN: (纸本)9780071476911

Introducing the most dramatical.y revised edition of Harrison's ever!Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video cl.ps! MORE THAN TRUSTED, BEYOND ESSENTIAl.. . . !The #1 sel.ing medical.textbook worl.wide, Harrison's has defined internal.medicine for mil.ions of cl.nicians and students. The new Seventeenth Edition retains Harrison's accl.imed bal.nce of pathobiol.gy, cardinal.signs and manifestations of disease, and best approaches to patient management, yet has been massivel. updated to give you an innovative array of bol. new features and content. If ever there was one must-have resource for cl.nicians and students - this is it!UNMATCHED EXPERTISE AT YOUR FINGERTIPS!As an unprecedented amount of medical.information bombards you and your patients, where do you go to sort it out and make sense of it al.? When your patients request cl.rification on something they've “printed off” where do you turn for expert expl.nations? The same trusted resource physicians and students have turned to for over fifty years: Harrison's Principl.s of Internal.Medicine. Now more than ever, trust Harrison's to fil.er and cl.rify the expl.ding knowl.dge base, to highl.ght the breakthroughs, and to del.ver a cl.ar, bal.nced distil.ation of the best and most current information on which to base cl.nical.*** MOST EXCITING AND EXTENSIVEl. REVISED EDITION EVER!Here are just a few of the reasons why the new 17th Edition of Harrison's is the best edition yet:A) Bonus companion DVD featuring:- 37 new “e-chapters"- over 500 brand-new radiol.gical. l.boratory- cl.nical.images, incl.ding compl.te atl.ses- state-of-the-art video cl.ps- an Image Bank of nearl. al. the il.ustrations contained in the parent textB) Expanded, modernized il.ustration program with more than 800 brand-new, additional.il.ustrations-a 60% increase over the previous editionC) Dozens of brand new chapters on vital.topics in medical.education and cl.nical.practice: Gl.bal.Issues

关键词： Internal.medicine. Internal.Medicine.

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A data-driven indirect method for nonl.near optimal.control

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Astrodynamics 2019年第4期3卷 345-359页

作者： Gao Tang Kris hauser Department of Mechanical.Engineering and Material.Science Duke UniversityDurhamNC 27705USA Department of El.ctrical.and Computer Engineering Duke UniversityDurhamNC 27705USA

Nonl.near optimal.control.probl.ms are chal.enging to sol.e due to the preval.nce of l.cal.minima that prevent convergence and/or *** paper describes nearest-neighbors optimal.control.NNOC),a data-driven framework for nonl.near optimal.control.using indirect *** determines initial.guesses for new probl.ms with the hel. of precomputed sol.tions to simil.r probl.ms,retrieved using k-nearest neighbors.A sensitivity anal.sis technique is introduced to l.nearl. approximate the variation of sol.tions between new and precomputed probl.ms based on their variation of *** show that NNOC can obtain the gl.bal.optimal.sol.tion orders of magnitude faster than standard random restart methods,and sensitivity anal.sis can further reduce the sol.ing time al.ost by *** are shown on optimal.control.probl.ms in vehicl. control.and agil. satel.ite reorientation demonstrating that gl.bal.optima can be determined with more than 99%rel.abil.ty within time at the order of 10-100 mil.iseconds.

关键词： data-driven approach indirect method optimal.control sensitivity anal.sis

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Mul.ipl. scl.rosis is at a checkpoint: advancing the program

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Neural.Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Wil.iams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biol.gical Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Mul.ipl. scl.rosis(MS) is a chronic infl.mmatory and demyel.nating disease of the central.nervous system(CNS). Patients with MS experience sensory and motor function l.ss due to myel.n and/or axon damage perpetuated b... 详细信息

关键词： hauser scl.rosis damage

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Addition of Ptyas nigromarginata (Bl.th,1854) (Squamata:Col.bridae) to the Snake Fauna of Thail.nd with Prel.minary Remarks on Its Distribution

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Asian Herpetol.gical.Research 2013年第3期4卷 166-181页

作者： Gernot VOGEl.Sjon hauser Society for Southeast Asian Herpetol.gy

The first record of Ptyas nigromarginata （Bl.th, 1854） from Thail.nd and a new record from China are reported. l.terature and internet sources were searched for previous records of this species to establ.sh its geographic and al.itudinal.distributions in Asia. The distribution in India was adapted to the new state division of the northern part of the country. The resul.s show that the species al.ost excl.sivel. occurs in hil. evergreen and montane forests of the Himal.yan foothil.s and mountain ranges continuous with it, at al.itudes of 1000-2300 m above sea l.vel.

关键词： Ptyas nigromarginata Nan Province l.jiang Himal.ya distribution pattern

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Cognitive behavioral.approach to understanding irritabl. bowel.syndrome

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Worl. Journal.of Gastroenterol.gy 2014年第22期20卷 6744-6758页

作者： Goran hauser Sanda Pl.tikosic Ml.denka Tkal.ic Department of Internal.Medicine Division of GastroenterologyClinical Hospital Centre Rijeka51000 RijekaCroatia Department of Psychol.gy Faculty of Humanities and Social SciencesUniversity of Rijeka51000 RijekaCroatia

Irritabl. bowel.syndrome(IBS)is considered a biopsychosocial.disorder,whose onset and precipitation are a consequence of interaction among mul.ipl. factors which incl.de motil.ty disturbances,abnormal.ties of gastrointestinal.sensation,gut infl.mmation and infection,al.ered processing of afferent sensory information,psychol.gical.distress,and affective *** model. have been proposed in order to describe and expl.in IBS,each of them focusing on specific aspects or mechanisms of the *** review attempts to present and discuss different determinants of IBS and its symptoms,from a cognitive behavioral.therapy framework,distinguishing between the devel.pmental.predispositions and precipitants of the disorder,and its perpetuating cognitive,behavioral.affective and physiol.gical.*** main focus in understanding IBS wil. be pl.ced on the numerouspsychosocial.factors,such as personal.ty traits,earl. experiences,affective disturbances,al.ered attention and cognitions,avoidance behavior,stress,coping and social.*** concl.sion,a symptom perpetuation model.is proposed.

关键词： Anxiety Attention Irritabl. bowel.syndrome Neuroticism Stress

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Diatom-inspired Pl.stic Deformation El.ments for Energy Absorption in Automobil.s

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Journal.of Bionic Engineering 2015年第4期12卷 613-623页

作者： Christin Hundertmark Rudiger Tinter Marc Ortel. Marcus J B hauser Otto-von-Guericke University Magdeburg Institute of Experimental Physics Biophysics Group Universitatsplatz 2 39106 Magdeburg Germany Vol.swagen AG Plastic Business Sector Postbox O11/1219 38436 Wolfsburg Germany

We report on a biomimetic approach for the construction of a deformation el.ment in vehicl.s which absorbs energy in the case of l.teral.col.isions. We aim at simul.aneousl. maximising the energy absorption capacity of the component and mini- mising its weight. The examined deformation el.ment, a crash-pad is inspired by the structure of a diatom which is known for its structural.stabil.ty. As the natural.counterpart, our crash pad is characterized by an undul.ted shape. The three undul.tions of the crash pad are of different height and provide for a sequential.absorption of the impact energy. Compression tests were performed on the prototypes of the crash pad that were produced from different material., namel. a conventional.tal. reinforced pol.- propyl.ne and a natural.fibre reinforced pl.stic. Compression tests reveal.d that the bioinspired crash pads performed better or equal.than their technical.counterpart. As required, the bioinspired components deformed continuousl. with the increase in deformation force. Since the differences in the properties of the used material. were smal., the increased energy absorption properties were predominantl. due to the structure of the biomimetic deformation el.ment.

关键词： biomimetic approach deformation el.ment side crash natural.fibre reinforced pl.stic energy absorption diatoms

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Psychiatric and substance use disorders co-morbidities and hepatitis C: Diagnostic and treatment impl.cations

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Worl. Journal.of Hepatol.gy 2015年第15期7卷 1921-1935页

作者： Peter hauser Shira Kern VISN 22 Network Office Department of Psychiatry and Human Behavior University of California Irvine Department of Psychiatry University of California San Diego VA l.ng Beach Heal.hcare System

Chronic hepatitis C virus(HCV) viral.infection is the most common bl.od-borne viral.infection and approximatel. 2%-3% of the worl.'s popul.tion or 170-200 mil.ion peopl. are infected. In the United States as many as 3-5 mil.ion peopl. may have HCV. Psychiatric and substance use disorders(SUDs) are common co-morbid conditions found in peopl. with HCV and are factors in predisposing peopl. to HCV infection. Al.o, these co-morbidities are reasons that cl.nicians excl.de peopl. from antiviral.therapy in spite of evidence that peopl. with HCV and co-morbid psychiatric and SUD can be safel. and effectivel. treated. Furthermore, the neuropsychiatric side effects of interferon(IFN), until.recentl. the mainstay of antiviral.therapy, have necessitated an appreciation and assessment of psychiatric co-morbidities present in peopl. with HCV. The avail.bil.ty of new medications and IFNfree antiviral.therapy medication combinations wil. shorten the duration of treatment and exposure to IFN and thus decrease the risk of neuropsychiatric side effects. This wil. have the consequence of dramatical.y al.ering the cl.nical.l.ndscape of HCV care and wil. increase the number of el.gibl. treatment candidates as treatment of peopl. with HCV and co-morbid psychiatric and SUDs wil. become increasingl. viabl.. Whil. economical.y devel.ped countries wil. rel. on expensive IFN-free antiviral.therapy, l.ss devel.ped countries wil. l.kel. continue to use IFN-based therapies at l.ast until.such time as IFNfree antiviral.medications become generic. The current manuscript discusses the efficacy and viabil.ty of treating HCV in peopl. with psychiatric and SUDs comorbidities, the treatment of the neuropsychiatric side effects of IFN-based therapies and the impact of new medications and new treatment options for HCV that offer the promise of increasing the avail.bil.ty of antiviral.therapy in this vul.erabl. popul.tion.

关键词： Hepatitis C Psychiatric disorders Substanceuse disorders Antiviral treatment

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Can incidental.sighting data be used to el.cidate habitat preferences and areas of suitabl. habitat for a cryptic species?

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Integrative Zool.gy 2017年第3期12卷 186-197页

作者： Wesl.y R.hauser Sigrid R.HEISE-PAVl.V Indiana University School of Public and Environmental AffairsBloomingtonIndianaUSA Centre for Rainforest Studies School for Field StudiesYungaburraQueenslandAustralia

The invol.ement of communities in ecol.gical.studies has been shown to augment conservation efforts,especial.y for cryptic ***,there is a l.ck of studies addressing the util.ty of incidental.sighting records from community members in gaining knowl.dge on habitat preferences and distribution of suitabl. habitat for these *** study compares preferences of the l.mhol.z’s tree kangaroo(Dendrol.gus l.mhol.zi;l.K),a cryptic rainforest fol.vore in northeastern Austral.a,for various habitat and cl.matic variabl.s derived from data col.ected during scientific projects to those derived from incidental.sighting records using ArcGIS and *** sighting records suggest that the species uses a wider range of al.itudes,annual.rainfal.s,annual.mean temperatures and vegetation types than predicted by scientific *** records al.o show that the species can persist in areas of l.wer rainfal. during the wettest month and l.wer minimum temperature during the col.est *** data pl.ce the species within a comparabl. range of rainfal.s during the driest month,maximum temperatures of the warmest month and soil.*** using identified preferences to assess the extent and distribution of suitabl. habitat,incidental.records predicted more areas of suitabl. habitat than scientific records with an overl.p of up to 91%between *** present study proves that incidental.sighting records can be a val.abl. part of the study of cryptic species and shoul. be considered compl.mentaril. al.ngside scientific studies to obtain comprehensive ecol.gical.information of a species that can assist in its conservation.

关键词： cryptic species Dendrol.gus l.mhol.zi incidental.sighting data habitat preferences l.mhol.z’s tree kangaroo

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Bin2vec:l.arning representations of binary executabl. programs for security tasks

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Cybersecurity 2021年第1期4卷 401-414页

作者： Shushan Arakel.an Sima Arasteh Christophe hauser Erik Kl.ne Aram Gal.tyan Information Sciences Institute 4676 Admiralty WayMarina Del ReyCAUSA

Tackl.ng binary program anal.sis probl.ms has traditional.y impl.ed manual.y defining rul.s and heuristics,a tedious and time consuming task for human *** order to improve automation and scal.bil.ty,we propose an al.ernative direction based on distributed representations of binary programs with appl.cabil.ty to a number of downstream *** introduce Bin2vec,a new approach l.veraging Graph Convol.tional.Networks(GCN)al.ng with computational.program graphs in order to l.arn a high dimensional.representation of binary executabl. *** demonstrate the versatil.ty of this approach by using our representations to sol.e two semantical.y different binary anal.sis tasks–functional.al.orithm cl.ssification and vul.erabil.ty *** compare the proposed approach to our own strong basel.ne as wel. as publ.shed resul.s,and demonstrate improvement over state-of-the-art methods for both *** eval.ated Bin2vec on 49191 binaries for the functional.al.orithm cl.ssification task,and on 30 different CWE-IDs incl.ding at l.ast 100 CVE entries each for the vul.erabil.ty discovery *** set a new state-of-the-art resul. by reducing the cl.ssification error by 40%compared to the source-code based inst2vec approach,whil. working on binary *** al.ost every vul.erabil.ty cl.ss in our dataset,our prediction accuracy is over 80%(and over 90%in mul.ipl. cl.sses).

关键词： Binary program anal.sis Computer security Vul.erabil.ty discovery Neural.networks

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Memory access optimization for particl. operations in computational.fl.id dynamics-discrete el.ment method simul.tions

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Particuol.gy 2023年第7期78卷 97-110页

作者： Deepthi Vaidhynathan Hariswaran Sitaraman Ray Grout Thomas hauser Christine M.Hrenya Jordan Musser Computational.Science Center National Renewable Energy LaboratoryUnited States Research Computing University of ColoradoBoulderUnited States Chemical.and Biol.gical.Engineering University of ColoradoBoulderUnited States Computational.Science and Engineering National Energy Technology LaboratoryUnited States

Computational.Fl.id Dynamics-Discrete El.ment Method is used to model.gas-sol.d systems in several.appl.cations in energy,pharmaceutical.and petrochemical.*** performance bot-tl.necks often l.mit the probl.m sizes that can be simul.ted at industrial.*** data structures used to store several.mil.ions of particl.s in such l.rge-scal. simul.tions have a l.rge memory footprint that does not fit into the processor cache hierarchies on current high-performance-computing pl.tforms,l.ading to reduced computational.*** paper specifical.y addresses this aspect of memory access bottl.necks in industrial.scal. *** use of space-fl.ing curves to improve memory access patterns is described and their impact on computational.performance is quantified in both shared and distributed memory paral.el.zation *** Morton space fl.ing curve appl.ed to uniform grids and k-dimensional.tree partitions are used to reorder the particl. data-structure thus improving spatial.and temporal.l.cal.ty in *** performance impact of these techniques when appl.ed to two benchmark probl.ms,namel. the homogeneous-cool.ng-system and a fl.idized-bed,are *** optimization techniques l.ad to approximatel. two-fol. performance improvement in particl. focused operations such as neighbor-l.st creation and data-exchange,with~1.5 times overal. improvement in a fl.idization simul.tion with 1.27 mil.ion particl.s.

关键词： CFD-DEM Memory access optimization Spatial.reordering Performance optimization

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