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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 451-453页

作者： stephen ed nsimba Phare G Mujinja Prospective College of Health & Allied Sciences(CHAS) School Of MedicineP.O.Box 395DodomaTanzania-East Africa Muhimbili University of Health and Allied Sciences School of Public Health & Social SciencesP.O.Box 65015Dar-es-Salaam Tanzania

Objective:To observe and assess the compliance to sulfadoxine-pyrimethamine(SP) one and a half years after phasing out chloroquine(CQ) in Mkuranga District,Coast region,Tanzania. Methods:A randomly controlled baseline community study was conducted in rural areas of Mkuranga district,***-structured questionnaire consisted of open-and closed -ended questions including home stocking,home use,last fever episodes and treatment of underfives with malaria using CQ or ***:The prevalence of fever or reported fever rate during the last 48 hours by their mothers or guardians was high(70%).Of all 117 blood samples,only 8 children after drug analysis were found to have CQ and 13 had SP concentrations within their blood *** of these blood drug levels were above therapeutic ranges. Conclusions:Community interventions are urgently needed in rural communities and should specifically target households nucleus on early malaria fever recognition and provision of recommended antimalarials for the sick underfive ***,sadly,there was an increase in underweight and undernourishment in the study areas,probably because of malaria in the area and poverty which are associated with poor nutrition in these youngsters.

关键词： Malaria Sulfadoxine-pyrimethamine Complaince Choroquine

Aqueous Extract of Ceiba pentandra Stimulates the Production of Fetal Hemoglobin in Sickle Cell Patients

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Journal of Biosciences and Medicines 2024年第8期12卷 295-306页

作者： Marie Miezi nsimba Magain Barihuta Mihatano Blaise Maya Mbamu Aline Diza Lubongo Thoms Nzaji Kolombo Josué Matadi Mukengeshaie José Nzunzu Lami Laboratoire de Recherche Bio-Organique Dpartement de Chimie Mdicinale et Pharmacognosie Facult des Sciences Pharmaceutiques Universit de Kinshasa Kinshasa Democratic Republic of the Congo Laboratoire dAnalyse Biologique Hpital Biamba Marie Mutombo Kinshasa Democratic Republic of the Congo Centre de Phytothrapie Moderne NIECA Commune de Ngaba Kinshasa Democratic Republic of the Congo Traumatology Service Department of Surgery Kinshasa University Hospital University of Kinshasa Kinshasa Democratic Republic of the Congo

Subsequent studies have demonstrated the reversed activity of the aqueous extract of Ceiba pentandra on the deformity of sickled red blood cells in hypoxia conditions. The observation which related to an in vitro study had given rise to hopes as to the management of sickle cell disease (SCD) by the use of this plant species. In this paper, the authors aimed to investigate the effect of the aqueous extract of C. pentandra on the production of fetal hemoglobin in SCD patients. The work carried out hemoglobin electrophoresis, for a period of six months, on blood samples from SCD patients who voluntarily undergone routine treatment, based on the medicinal recipe prepared from the bark of the trunk and branches of C. pentandra, in a hospital center of herbal medicines located in Kinshasa. The medicinal recipe called BEAT-SS is a patented product of the hospital center named Centre de Phytothérapie Moderne NIECA. Blood samples from patients under treatment were taken to evaluate the behavior of different forms of hemoglobin (hemoglobin S, hemoglobin F and hemoglobin A2). Agarose gel electrophoresis with integrated reading was used for the separation of the different forms of hemoglobin, as well as their dosage on each sample of sickle blood. A reduction in the proportion of hemoglobin S and an increase in the proportion of fetal hemoglobin were found in all sickle cell patients during the treatment period. This observation could affirm that the management of sickle cell patients using the recipe prepared from the aqueous extract of C. pentandra could increase the level of fetal hemoglobin in these patients.

关键词： Sickle Cell Disease Hemoglobin S Fetal Hemoglobin Ceiba pentandra

Need for improving quality of operating structures and processes for better ARV adherence for patients with HIV/AIDS in Tanzania and other African countries:an experience from Tanzania

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Asian Pacific Journal of Tropical Medicine 2009年第4期2卷 67-74页

作者： Irunde H nsimba Sed Comoro CJ Tanzania Food and Drug Authority(TFDA) P.O.Box 77150Dares SalaamTanzania Muhimbili University of Health & Allied Sciences(MUHAS) Department of Clinical PharmacologyP.O.Box 65010Dares-SalaamTanzania Department of Sociology & Social Sciences University of Dares-SalaamP.O Box 35091Dares-Salaam Tanzania

Objective:The study was carried out in order to determine the following objectives:(1) To determine the proportion of patients who state achieving or not achieving optimal adherence to antiretroviral therapy(ART) in selected Care and Treatment Sites in Arusha and Dares Salaam regions in Tanzania.(2) To identify factors such as structural,cultural or disease related contributing to sub-optimal adherence to antiretroviral(ARVs). (3) To assess quality of operating structures and processes for provision of antiretroviral(ARVs) in the selected healthcare facilities.(4) To document suggestions and proposals for improving ART adherence among ARV ***:Data from 7 studied facilities(3 public and 4 private/or faith based) includes 207 interviews from ARV users,28 staff interview staff,26 observations during consultations,8 focus group discussions,10 key informant interviews,and stock checks in 6 *** study design was a cross-sectional using both qualitative and quantitative data collection *** data were collected by using an adherence tool check list,while qualitative data were obtained using a consultation observation checklist,semi-structured interviews,focus group discussions(FGDs) and key informant ***:There were slight variations in the quality of operating structures and processes in the two studied *** results indicate that ARV adherence in Arusha region was comparatively similar to that of Dares *** composite adherence for one month in seven facilities was 90%and only 21%of ARV users achieved optimal adherence. Conclusion:The overall mean composite adherence rate of 90%in the two areas surveyed is encouraging. More efforts to improve the quality and processes of operating structures in our study facilities and others in Tanzania are heeded to ensure optimal adherence among the larger group(79%) of ARV users who are currently taking less than the critical 95%of their medications.

关键词： Antiretrovirals(ARVs) HIV/AIDS Antiretroviral therapy(ART) Adherence Tanzania

Effect of Cooking Condiments on the Mass Loss of Artisanal Aluminum Cooking Utensils: The Case of Congo—Brazzaville

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Journal of Minerals and Materials Characterization and Engineering 2022年第2期10卷 139-152页

作者： Thierry Arcady Vila Noemie Grace Mazel Ifo Jean-Claude Bibila Mafouba Vivien Igor Banzouzi Samba Mpissi Zita Flora Diamouangana Nursie Rarahu Oba Mboho Christ Dorvy Privillège Tsaty nsimba Joseph-Marie Moutou Laboratoire de Chimie Minérale et Appliquée Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Republic of the Congo Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Republic of the Congo Ecole Normale Supérieure Université Marien Ngouabii Brazzaville Republic of the Congo

Corrosion of cookware is a growing concern for the durability of materials. A rapidly emerging theme that is one of the major current societal challenges at the interface of environmental and health issues. In this present work, the corrosion of aluminum in food environments (salt water and fresh tomatoes) was studied. The three aluminum utensils were purchased in the various workshops in Brazzaville (Republic of the Congo). The weight loss method followed the effect of cooking media on cookware, X-ray diffraction (XRD) and fluorescence (XRF) are two methods used to characterize alloys. XRF analysis indicates that the samples consist of aluminum as a basic element. XRD reveals that the essential building blocks of cookware samples are aluminum, silicon, iron, copper, magnesium and zinc. Finally, gravimetric measurements are carried out to assess the mass losses of samples of artisanal kitchen utensils when cooking food. Aluminum is found to be sensitive in TF and OS media.

关键词： Kitchen Utensils Corrosion Loss of Mass Intermetallic Compounds Aluminum Salt Water XRD

Distortions and Deformations of Metaled Meso-Substituted and Unsubstituted Porphyrins and Derivatives in Crystal Structures

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Crystal Structure Theory and Applications 2016年第1期5卷 1-15页

作者： Philippe V. Tsalu Tharcisse O. Monama Hilaire V. Mambo Dorothée D. Tshilanda Pius T. Mpiana Bodrique M. nsimba Virima Mudogo Pitchou N. Bokolombe Damien S. T. Tshibangu Zephyrin G. Yav Department of Chemistry Faculty of Science University of Kinshasa Kinshasa Democratic Republic of the Congo Departement de Géochimie Appliquée Centre de Recherches Géologiques et Minières Kinshasa Democratic Republic of the Congo

Experimental crystallographic structural parameters of a range of metaled meso-substituted and unsubstituted porphyrins were reviewed to show how far the meso-substitution by any functional group and the insertion of metal in the porphyrins core macrocycle may affect the geometry. The analysis of twists and angles has shown two kinds of distortions: external [T(Cβ-Cα-Cmeso-Xn) and T(Cβ-Cα-Cmeso-Cα)] and internal [T(Nm-Cα-Cmeso-Xn) and T(Nn-Cα-Cmeso-Cα)] with averages of [+6°and –6°] and [–5°and +5°], respectively. In the meso-substituted case, the external and internal twists Cβ-Cα-Cmeso-X and N-Cα-Cmeso-X, respectively are oppositely orientated. Similar effect is observed in meso-unsubstituted of Cβ-Cα- Cmeso-H and N-Cα-Cmeso-H. However, the external distortions are more significant than internal. Considering the same order, the limit of distortions is [97°and 132°(–48°)] for external and [91°(–89°) and 52°] for internal. In the two cases, the substituents have opposite directions of distortions. The meso-substituted porphyrins have a high limit of twisting than usubstituted one, depending of the weight of substituents. The average of the bond angular deformations is 168°, almost planar. However, the limit of angular deformation is 94°.

关键词： Metaled Meso-Substituted and Unsubstituted Porphyrins and Derivates Crystals Structures Distortions and Bonds Angular Deformations