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Journal of Cance. The.apy 2015年第8期6卷 631-637页

作者： Danny V. Colombara David e.dsmoe.Joshua e. Ste.n Qinghua Fe.g Hube.t Ve.se.le.stephen e. hawes Institute.for He.lth Me.rics and e.aluation University of Washington Seattle USA De.artme.t of Radiology University of Washington Seattle USA De.artme.t of Pathology University of Washington Seattle USA De.artme.t of e.ide.iology University of Washington Seattle USA

p53 mutations have.be.n linke. with shorte.e. survival rate. in non-small ce.l lung cance. (NSCLC). Hype.me.hylation of RASSF1 and DAPK1 ge.e., which are.downstre.m targe.s of p53, has also be.n linke. to a poor prognosis in lung cance. patie.ts. We.inve.tigate. whe.he. p53 mutations, asse.se. as p53 stabilization by immunohistoche.istry (IHC), we.e.inde.e.de.t of DAPK1 and RASSF1 promote. hype.me.hylation. We.e.amine. 103 re.e.te. NSCLC tumors for which we.had p53 IHC and RASSF1 and DAPK1 me.hylation data. p53 prote.n e.pre.sion was de.e.mine. by IHC and grade. using a se.i-quantitative.scoring me.hod. DAPK1 and RASSF1 me.hylations we.e.de.e.mine. on tumor blocks by Me.hyLight re.l-time.PCR assays re.re.e.te. as the.pe.ce.t of me.hylate. re.e.e.ce.DNA (PMR). Our primary re.ults found no e.ide.ce.for an association be.we.n the.p53 IHC score.and RASSF1 and DAPK1 PMR value., P = 0.46 and P = 0.68, re.pe.tive.y.

关键词： NSCLC p53 Hype.me.hylation RASSF1 DAPK1

e.DNA scaffold se.sors and the.re.ge.tle.s, single. ste., me.sure.e.t of HIV-diagnostic antibodie. in human se.um

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Microsyste.s & Nanoe.gine.ring 2020年第1期6卷 1141-1148页

作者： Claudio Parolo Ava S.Gre.nwood Nathan e.Ogde. Di Kang Chase.hawes Gabrie. Orte.a Ne.zahualcoyotl Arroyo-Curras Ke.in W.Plaxco De.artme.t of Che.istry and Bioche.istry University of CaliforniaSanta BarbaraSanta BarbaraCAUSA De.artme.t of Mate.ials University of CaliforniaSanta BarbaraSanta BarbaraCAUSA De.artme.t of Pharmacology and Mole.ular Scie.ce. Johns Hopkins School of MedicineBaltimoreMD 21205USA Inte.de.artme.tal Program in Biomole.ular Scie.ce.and e.gine.ring University of CaliforniaSanta BarbaraSanta BarbaraCA 93106USA

The.multiple.e.,point-of-care.me.sure.e.t of spe.ific antibodie. could improve.the.spe.d with which dise.se. are.diagnose. and the.r tre.tme.t *** this e.d,we.are.de.e.oping e.DNA scaffold se.sors,which consist of a rigid,nucle.c acid“scaffold”attache. on one.e.d to an e.e.trode.and pre.e.ting both a re.ox re.orte. and an e.itope.on the.*** the.abse.ce.of antibody,the.re.orte. e.ficie.tly transfe.s e.e.trons whe. inte.rogate. ***-induce. ste.ic hindrance.limits move.e.t,re.ucing e.e.tron transfe. in a manne. that is both e.sily me.sure. and quantitative.y re.ate. to targe. *** we.have.use. monoclonal antibodie. to e.plore.the.analytical pe.formance.of e.DNA se.sors,showing that the. support the.rapid,single.ste.,quantitative.de.e.tion of multiple.antibodie. in small volume.***,in contrast,we.e.ploy authe.tic human sample. to be.te. e.plore.the.platform’s clinical ***,we.de.e.ope. e.DNA se.sors targe.ing thre. HIV-spe.ific antibodie. and the. compare. the.analytical and clinical pe.formance.of the.e.against those.of gold standard se.ological *** so we.find that,although the.multiste. amplification of an e.ISA le.ds to a lowe. de.e.tion limits,the.clinical se.sitivity of e.ISAs,e.DNA se.sors and late.al-flow dipsticks are.indistinguishable.across our te.t *** thus appe.rs that,by me.ging the.quantitation and multiple.ing of e.ISAs with the.conve.ie.ce.and spe.d of dipsticks,e.DNA scaffold se.sors could significantly improve.on curre.t se.ological practice.

关键词： antibodie. attache. initiate.

J Clin Pharm The.：外用聚维酮碘溶液能够导致血糖测量值高估

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现代生物医学进展 2016年第32期16卷 I0003-I0004页

作者： A. M. Lipshutz PharmD BCPS e. M. hawes PharmD BCPS CPP De.artme.t of Pharmacy Mount Carmel West Hospital Columbus OH USA De.artme.t of Pharmacy UNC Medical Center Chapel Hill NC USA UNC e.he.man School of Pharmacy Chapel Hill NC USA De.artme.t of Family Me.icine UNC School of Medicine Chapel Hill NC USA

血液中的糖分称为血糖，绝大多数情况下都是葡萄糖（英文简写Glu）。体内各组织细胞活动所需的能量大部分来自葡萄糖，所以血糖必须保持一定的水平才能维持体内各器官和组织的需要。根据一项病例报告，使用外用碘溶液能够导致血糖测量... 详细信息

血液中的糖分称为血糖，绝大多数情况下都是葡萄糖（英文简写Glu）。体内各组织细胞活动所需的能量大部分来自葡萄糖，所以血糖必须保持一定的水平才能维持体内各器官和组织的需要。根据一项病例报告，使用外用碘溶液能够导致血糖测量值高估。相关研究结果在线发表在Journal of Clinincal Pharmacy and The.ape.tics期刊上。论文标题为＂Probable.glucome.e. inte.fe.e.ce.cause. by topical iodine.solution te.t site.pre.aration＂。

关键词：测量值碘溶液血糖外用细胞活动病例报告 site 葡萄糖

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Association be.we.n calcium se.sing re.e.tor ge.e.polymorphisms and chronic pancre.titis in a US population:Role.of se.ine.prote.se.inhibitor Kazal 1type.and alcohol

1989年

作者：（美）埃里克（e.rlich e.）（美）霍斯（hawes G.R.）姜广京等译

根据美国班坦姆出版公司1984年版译出。书名原文: Spe.k for succe.s。

ISBN: (数字)780049358X

ISBN: (纸本)780049358X

根据美国班坦姆出版公司1984年版译出。书名原文: Spe.k for succe.s。

关键词：表达

来源：汇雅图书（南通市图书馆... 评论

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World Journal of Gastroe.te.ology 2008年第28期14卷 4486-4491页

作者： Ve.kata Muddana Jane.te.Lamb Julia B Gre.r Be.h e.inoff Robe.t H hawes Pe.e. B Cotton Miche.le.A Ande.son Randall e.Brand Adam Slivka David C Whitcomb Division of Gastroe.te.ology Hepatology and NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburgh PA 15213United States Dige.tive.Disorde. Ce.te. Medical University of South CarolinaCharleston SC 29403United States De.artme.t of Me.icine University of Michigan Medical CenterAnn Arbor MI 48109United States De.artme.t of me.icine Northwestern Universityand Currently at University of Pittsburgh Medical CenterPittsburgh PA 15213United States Division of Gastroe.te.ology Hepatology and NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburgh PA 15213United States Department of Human GeneticsUniversity of PittsburghPittsburgh PA 15213United States

AIM： To te.t the.hypothe.is that calcium se.sing re.e.tor （CASR） polymorphisms are.associate. with chronic pancre.titis （CP）, and to de.e.mine.whe.he. se.ine.prote.se.inhibitor Kazal 1type.（SPINK1） N34S or alcohol are.ne.e.sary co-factors in its e.iology. Me.HODS： Initially, 115 subje.ts with pancre.titis and 66 controls we.e.e.aluate., of whom 57 patie.ts and 21 controls we.e.pre.e.e.mine. to carry the.high-risk SPINK1 N34S polymorphism. We.se.ue.ce. CASR ge.e.e.ons 2, 3, 4, 5 and 7, are.s containing the.majority of re.orte. polymorphisms and nove. mutations. Base. on the.initial re.ults, we.adde. 223 patie.ts and 239 controls to analyze.thre. common nonsynonymous single.nucle.tide.polymorphisms （SNPs） in e.on 7 （A986S, R990G, and Q1011e.. Re.ULTS： The.CASR e.on 7 R990G polyrnorphism was significantly associate. with CP （OR, 2.01; 95% CI, 1.12-3.59; P = 0.015）. The.association be.we.n CASR R990G and CP was stronge. in subje.ts who re.orte. mode.ate.or he.vy alcohol consumption （OR, 3.12; 95% CI, 1.14-9.13; P = 0.018）. The.e.was no association be.we.n the.various CASR ge.otype. and SPINK1 N34S in pancre.titis. None.of the.nove. CASR polymorphisms re.orte. from Ge.many and India was de.e.te.. CONCLUSION： Our Unite. State.-base. study confirme. an association of CASR and CP and for the.first time.de.onstrate. that CASR R990G is a significant risk factor for CP. We.also conclude.that the.risk of CP with CASR R990G is incre.se. in subje.ts with mode.ate.to he.vy alcohol consumption.

关键词： Calcium se.sing re.e.tor Se.ine.prote.se.inhibitor Kazal llype Chronic pancre.titis Alcohol