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Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples

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Journal of Pharmaceutical Analysis 2024年第5期14卷 733-743页

作者： Alongkorn Kurilung Suphitcha Limjiasahapong Khwanta Kaewnarin Pattipong Wisanpitayakorn Narumol Jariyasopit Kwanjeera Wanichthanarak Sitanan Sartyoungkul stephen choong chee wong Nuankanya Sathirapongsasuti Chagriya Kitiyakara Yongyut Sirivatanauksorn Sakda Khoomrung Siriraj Center of Research Excellent in Metabolomics and Systems Biology(SiCORE-MSB) Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Siriraj Metabolomics and Phenomics Center Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Department of Biomedical Informatics University of Arkansas for Medical SciencesLittle RockAR72205USA SingHealth Duke-NUS Institute of Biodiversity Medicine National Cancer Centre Singapore168583Singapore Waters Pacific Pte. Ltd.Singapore117528Singapore Program in Translational Medicine Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi HospitalMahidol UniversitySamut Prakan10540Thailand Department of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Department of Biochemistry Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Center of Excellence for Innovation in Chemistry(PERCH-CIC) Faculty of ScienceMahidol UniversityBangkok10400Thailand

The collision cross-sections(CCS)measurement using ion mobility spectrometry(IMS)in combination with mass spectrometry(MS)offers a great opportunity to increase confidence in metabolite ***,owing to the lack of sensitivity and resolution,IMS has an analytical challenge in studying the CCS values of very low-molecular-weight metabolites(VLMs250 Da).Here,we describe an analytical method using ultrahigh-performance liquid chromatography(UPLC)coupled to a traveling wave ion mobility-quadrupole-time-of-flight mass spectrometer optimized for the measurement of VLMs in human urine *** experimental CCS values,along with mass spectral properties,were reported for the 174 *** experimental data included the mass-to-charge ratio(m/z),retention time(RT),tandem MS(MS/MS)spectra,and CCS *** the studied metabolites,263 traveling wave ion mobility spectrometry(TWIMS)-derived CCS values(TWCCSN2)were reported for the first time,and more than 70%of these were CCS values of *** TWCCSN2 values were highly repeatable,with inter-day variations of<1%relative standard deviation(RSD).The developed method revealed excellent TWCCSN2 accuracy with a CCS difference(DCCS)within±2%of the reported drift tube IMS(DTIMS)and TWIMS CCS *** complexity of the urine matrix did not affect the precision of the method,as evidenced by DCCS within±1.92%.According to the Metabolomics Standards Initiative,55 urinary metabolites were identified with a confidence level of *** these 55 metabolites,53(96%)were *** larger number of confirmed compounds found in this study was a result of the addition of TWCCSN2 values,which clearly increased metabolite identification confidence.

关键词： Very low-molecular-weight metabolites Traveling wave ion mobility Collision cross-section Human urine

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Low phase noise K-band signal generation using polarization diverse single-soliton integrated microcombs

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Photonics Research 2024年第6期12卷 1175-1185页

作者： ALWALEED ALDHAFEERI HSIAO-HSUAN CHIN TRISTAN MELTON DONG IL LEE ALLEN CHU WENTING WANG MINGBIN YU PATRICK GUO-QIANG LO DIM-LEE Kwong chee WEI wong Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwave and millimeter-wave repetition rates provide a compact solution for coherent communication and information *** implementation of these microcombs using a CMOS-compatible platform further paves the way for large-scale photonic integration and ***,we demonstrate free-running soliton microcombs with K-band repetition rates with very low phase noise over a 4 GHz pump detuning range reaching−117(−123)dBc/Hz at 10 kHz offset for a 19.7(10)GHz carrier without active pump stabilization,exceeding commercial electronic microwave oscillators at frequency offsets above 40 *** minimum laser noise to soliton microwave signal transduction factor observed is−*** noise performance is achieved using a hybridized dual-mode for soliton generation to achieve passive thermal stabilization and minimal soliton spectrum shift from prior Raman scattering and dispersive wave *** further examine the locking of the repetition rate to an external ultrastable photonic oscillator to illustrate the feasibility of phase noise suppression below the thermorefractive noise limits of microresonator frequency combs.

关键词： pump polarization millimeter

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IgG4 Coronary Arteritis Presenting as a Cardiac Pseudo-Tumour

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Case Reports in Clinical Medicine 2024年第9期13卷 345-352页

作者： Elaine Mo-chee Chau Catherine Yuet-Hung wong Raymond Hin-Suen Liang Cardiology Centre Hong Kong Sanatorium & Hospital Hong Kong SAR China Nuclear Medicine Department Hong Kong Sanatorium & Hospital Hong Kong SAR China Comprehensive Oncology Centre Hong Kong Sanatorium & Hospital Hong Kong SAR China

We report on an unusual case presenting with a cardiac pseudo-tumour on echocardiogram, which corresponded to a large soft tissue mural thickening around the mid-right coronary artery. There were similar but not as thick mural lesions around other parts of the coronary arteries. The so-called “pigs-in-a-blanket” sign on computed tomography (CT) scan was pathognomonic of IgG4 coronary arteritis. The IgG4 level was grossly elevated at more than 10 times the upper limit of normal. Positron emission tomography (PET)-CT scans with 18F-fluoro-deoxy-glucose (FDG) and 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) were performed to assess the extent of organ involvement of the IgG4-related disease. The patient was treated with 8 injections of rituximab with good serological response. However, the coronary arteritis findings on CT scan remained unchanged.

关键词： IgG4-Related Disease Coronary Arteritis Cardiac Pseudo-Tumour “Pigs-in-a-Blanket” Sign

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Current advances of stem cell-based therapy for kidney diseases

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World Journal of Stem Cells 2021年第7期13卷 914-933页

作者： chee-Yin wong Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanKajang 43000SelangorMalaysia Research Department CytopeuticsCyberjaya 63000SelangorMalaysia

Kidney diseases are a prevalent health problem around the *** therapy used in the current routine treatment for kidney diseases can only delay disease *** of these drugs or treatments can reverse the progression to an end-stage of the ***,it is crucial to explore novel therapeutics to improve patients’quality of life and possibly cure,reverse,or alleviate the kidney *** cells have promising potentials as a form of regenerative medicine for kidney diseases due to their unlimited replication and their ability to differentiate into kidney cells in *** evidences from the administration of stem cells in an experimental kidney disease model suggested that stem cell-based therapy has therapeutic or renoprotective effects to attenuate kidney damage while improving the function and structure of both glomerular and tubular *** review summarises the current stem cell-based therapeutic approaches to treat kidney diseases,including the various cell sources,animal models or in vitro *** challenges of progressing from proof-of-principle in the laboratory to widespread clinical application and the human clinical trial outcomes reported to date are also *** success of cell-based therapy could widen the scope of regenerative medicine in the future.

关键词： Stem cells Kidney regeneration Kidney disease Mesenchymal stem cells Embryonic stem cells Induced pluripotent stem cells

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An integrated approach for machine-learning-based system identification of dynamical systems under control:application towards the model predictive control of a highly nonlinear reactor system

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Frontiers of Chemical Science and Engineering 2022年第2期16卷 237-250页

作者： Ewan chee Wee Chin wong Xiaonan Wang Department of Chemical&Biomolecular Engineering Faculty of EngineeringNational University of SingaporeSingapore 117585Singapore Chemical Engineering&Food Technology Cluster Singapore Institute of TechnologySingapore 138683Singapore

Advanced model-based control strategies,e.g.,model predictive control,can offer superior control of key process variables for multiple-input multiple-output *** quality of the system model is critical to controller performance and should adequately describe the process dynamics across its operating range while remaining amenable to fast *** work articulates an integrated system identification procedure for deriving black-box nonlinear continuous-time multiple-input multiple-output system models for nonlinear model predictive *** showcase this approach,five candidate models for polynomial and interaction features of both output and manipulated variables were trained on simulated data and integrated into a nonlinear model predictive controller for a highly nonlinear continuous stirred tank reactor *** procedure successfully identified system models that enabled effective control in both servo and regulator problems across wider operating *** controllers also had reasonable per-iteration times of ca.0.1 *** demonstration of how such system models could be identified for nonlinear model predictive control without prior knowledge of system dynamics opens further possibilities for direct data-driven methodologies for model-based control which,in the face of process uncertainties or modelling limitations,allow rapid and stable control over wider operating ranges.

关键词： nonlinear model predictive control black-box modeling continuous-time system identification machine learning industrial applications of process control

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Hydrodynamical self-interference of a scattered polariton quanta

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Light(Science & Applications) 2020年第1期9卷 541-542页

作者： Jiahui Huang Wei Liu chee Wei wong Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA

Researchers have observed the free-propagation of a single microcavity polariton directly and its self-interference when scattering upon a *** experimental observations of quantum hydrodynamics in the single polariton limit test the wave-particle duality and aid in the development of polariton-based photonic circuits in quantum information processing.

关键词： defect polar quantum

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Science Letters:Human-centered modeling for style-based adaptive games

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第4期10卷 530-534页

作者： chee-onn wong Jongin KIM Eunjung HAN Keechul JUNG Human-Centered Interfaces Lab Department of Digital Media Soongsil UniversitySeoul 156743 Korea

This letter proposes a categorization matrix to analyze the playing style of a computer game player for a shooting game genre. Our aim is to use human-centered modeling as a strategy for adaptive games based on entertainment measure to evaluate the playing experience. We utilized a self-organizing map (SOM) to cluster the player's style with the data obtained while playing the game. We further argued that style-based adaptation contributes to higher enjoyment, and this is reflected in our experiment using a supervised multilayered perceptron (MLP) network.

关键词： Player modeling Categorization matrix Adaptive games Human-centered modeling Data clustering

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Optomechanically-induced-transparency cooling of massive mechanical resonators to the quantum ground state

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Science China(Physics,Mechanics & Astronomy) 2015年第5期58卷 46-51页

作者： LIU Yong-Chun XIAO Yun-Feng LUAN Xing-Sheng wong chee Wei State Key Laboratory for Mesoscopic Physics and School of Physics Peking University Collaborative Innovation Center of Quantum Matter Optical Nanostructures Laboratory Columbia University

Ground state cooling of massive mechanical objects remains a difficult task restricted by the unresolved mechanical sidebands. We propose an optomechanically-induced-transparency cooling scheme to achieve ground state cooling of mechanical motion without the resolved sideband condition in a pure optomechanical system with two mechanical modes coupled to the same optical cavity mode. We show that ground state cooling is achievable for sideband resolution ωm/k as low as - 0.003. This provides a new route for quantum manipulation of massive macroscopic devices and high-precision measurements.

关键词： ground state cooling resolved sideband limit optomechanics

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Optimal location query based on k nearest neighbours

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Frontiers of Computer Science 2021年第2期15卷 105-117页

作者： Yubao LIU Zitong CHEN Ada Wai-chee FU Raymond Chi-Wing wong Genan DAI School of Data and Computer Science Sun Yat-Sen UniversityGuangzhou510006China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou510006China Department of Computer Science and Engineering Chinese University of Hong KongHong Kong999077China Department of Computer Science and Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Optimal location query in road networks is a basic operation in the location intelligence *** a set of clients and servers on a road network,the purpose of optimal location query is to obtain a location for a new server,so that a certain objective function calculated based on the locations of clients and servers is *** works assume no labels for servers and that a client only visits the nearest *** assumptions are not realistic and it renders the existing work not useful in many *** this paper,we relax these assumptions and consider the k nearest neighbours(KNN)of *** introduce the problem of KNN-based optimal location query(KOLQ)which considers the k nearest servers of clients and labeled *** also introduce a variant problem called relocation KOLQ(RKOLQ)which aims at relocating an existing server to an optimal *** main analysis algorithms are proposed for these *** experiments on the real road networks illustrate the efficiency of our proposed solutions.

关键词： optimal location query k nearest neighbours road network

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Efficient page layout analysis on small devices

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 800-804页

作者： Eun-jung HAN chee-onn wong Kee-chul JUNG Kyung-ho LEE Eun-yi KIM Department of Naval Architecture and Ocean Engineering Inha University Human-Centered Interfaces Lab Department of Digital MediaSoongsil University Internet and Media Engineering Konkuk University

Previously we have designed and implemented new image browsing facilities to support effective offiine image contents on mobile devices with limited capabilities： low bandwidth, small display, and slow processing. In this letter, we fulfill the automatic production of cartoon contents fitting small-screen display, and introduce a clustering method useful for various types of cartoon images as a prerequisite stage for preserving semantic meaning. The usage of neural networks is to properly cut the various forms of pages. Texture information that is useful for grayscale image segmentation gives us a good clue for page layout analysis using the multilayer perceptron （MLP） based x-y recursive algorithm. We also automatically frame the segment MLP using agglomerative segmentation. Our experimental results show that the combined approaches yield good results of segmentation for several cartoons.

关键词： Efficient page layout analysis MLP-based segmentation Mobile devices Image segmentation Neural network

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