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Significance Analysis of Flexural Behaviour of Hybrid Sandwich Panels

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Open Journal of Civil Engineering 2013年第3期3卷 1-7页

作者： Jauhar Fajrin Yan Zhuge Frank bullen Hao Wang Centre of Excellence in Engineering Composite (CEEFC) University of Southern Queensland Toowoomba Toowoomba Australia

This paper presents the significance analysis of a new type of hybrid composite sandwich wall panel which can be manufactured as modular panelised system. Two different types of natural fibers reinforced plastics (NFRP) laminate were incorporated into the new sandwich panel as an intermediate layer. The significance analysis in this research has been carried out using analysis of variance (ANOVA). As the aim of the analysis is to select the most appropriate natural fiber composites for the intermediate layer, the experiments were arranged as a single factor experiment in which 3 levels of a factor have been examined. The factor refers to the type of intermediate layer used in the sandwich panel. The result of this study shows that the incorporation of intermediate layer has significantly enhanced the load carrying capacity of the sandwich panels.

关键词： Hybrid Structure Sandwich Panels Significance Analysis Natural Fiber Composites Building Construction

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

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Journal of Innovative Optical Health Sciences 2015年第4期8卷 97-104页

作者： Joseph T.Acquaviva III Cody F.Bahavar Feifan Zhou Xiaosong Li Eric W.Howard Liz C.bullen Ricardo P.Silvy Wei R.Chen Biophotonics Research Laboratory Center for Interdisciplinary Biomedical Education and Research University of Central Oklahoma EdmondOklahoma 73034USA South West Nano Technologies NormanOklahoma 73071USA Department of Oncology The First Affiliated Hospital of Chinese PLA General Hospital Fucheng Road 51 BeijingP.R.China University of Oklahoma Health Sciences Center 940 Stanton.L.Young Blvd. BMSB Rm.513 Oklahoma City Oklahoma 73104USA

The ideal treatment modality for metastatic cancer would be a local treatment that can destroy primary tumors while inducing an effective systemic anti-tumor *** this end,we de-veloped laser immunotherapy,combining photothermal laser application with an immunoadju-vant for the treatment of metastatic ***,to enhance the selective photothermal effect,we integrated light-absorbing nanomaterials into this innovative ***,we developed an immunologically modified carbon nanotube combining single-walled carbon nanotubes(SWNTs)with the immunoadjuvant glycated chitosan(GC).To determine the ef-fectiveness of laser iradiation,a series of experiments were performed using two different irra-diation durations-5 and 10 *** were inoculated with DMBA-4 cancer cells,a metastatic cancer cell *** treatment group of rats receiving laser irradiation for 10 min had a 50%long-term survival rate without residual primary or metastatic *** treatment group of rats receiving laser irradiation for 5 min had no long-term survivors;all rats died with multiple metastases at several distant ***,Laser+SWNT-GC treatment with 10 min of laser irradiation proved to be efective at reducing tumor size and inducing long-term anti-tumor immunity.

关键词： Anti-tumor immune response laser immunotherapy single-walled carbon nanotubes glycated chitosan laser irradiation

Evaluation of Biotinylated PAMAM Dendrimer Toxicity in Models of the Blood Brain Barrier: A Biophysical and Cellular Approach

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Journal of Biomaterials and Nanobiotechnology 2011年第5期2卷 485-493页

作者： Heather A. bullen Ruth Hemmer Anthony Haskamp Chevelle Cason stephen Wall Robert Spaulding Brett Rossow Michael Hester Megan Caroway Kristi L. Haik 不详

The interaction of biotinylated G4 poly(amidoamine) (PAMAM) dendrimer conjugates and G4 PAMAM dendrimers with in vitro models of the blood brain barrier (BBB) was evaluated using Langmuir Blodgett monolayer techniques, atomic force microscopy (AFM) and lactate dehydrogenase measures of cell membrane toxicity. Results indicate that both G4 and G4 biotinylated PAMAM dendrimers disrupt the composition of the liquid condensed (LC) and liquid expanded (LE) phases of the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid monolayer. The disruption is concentration dependent and more marked for G4 biotinylated PAMAMs. Lactate dehydrogenase (LDH) assays using endothelial cell culture models of the BBB indicate that biotinylation results in higher levels of toxicity than non-biotinylation. This approach provides valuable information to assess nanoparticle toxicity for drug delivery to the brain.

关键词： Dendrimers Drug Delivery Blood Brain Barrier Toxicity

Optimizing Aircraft Utilization for Herbicide Application by Evaluation of Herbicide Spray Drift in West Bank Berbice Guyana South America

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Agricultural Sciences 2019年第6期10卷 727-752页

作者： Ramphal Chablall Ravindra Persaud Raghunath Chandranauth Simon Chibi Gavindra Ramnarain Suresh Amichand Courtney bullen Guyana Sugar Corporation Georgetown Guyana National Agricultural Research and Extension Institute Georgetown Guyana Cuso International National Agricultural Research and Extension Institute Georgetown Guyana Pesticides and Toxic Chemicals Control Board Georgetown Guyana Faculty of Agriculture and Forestry University of Guyana Georgetown Guyana

Aerial herbicide drift caused mainly by weather and climatic conditions may be the most challenging problem facing farmers. Spray drift reaching off-target areas can destroy sensitive crops;pollute air and water resources thus causing serious health problems to humans and animals. Nonetheless, buffer zones of 500 meters are indicated to limit these negative impacts of spray drift. The Guyana Sugar Corporation controls weeds and ripens canes by aerial herbicide application. The corporation, in the 1990s, instituted 750-metre buffer zones, which greatly affected the optimization of aircraft use in herbicide application and ripening of cane. This study tested the utility of the 750-meters buffer zone on Rose Hall, Albion and Blairmont Sugar estates. The actual drift distances were determined within 06:00 hours and 09:00 hours for 9 herbicide applications. Drift patterns associated with the three 1- hour time periods were correlated with prevailing weather conditions to determine optimal flying periods for the locations. The droplets concentration per sensitive paper was collected for each period. It was noted that the drift is less with the distance from the field up to 510 m;thereafter the number of droplets was 2 or less per sensitive paper. The wind speed increases as time goes up, thus increasing the drift. The windward side is where 510 m were recorded to have droplets of 2 and nil at 510 m from the opposite side.

关键词： Herbicide Aircraft Drift Buffer Zones Sensitive Paper

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显微成像技术在药物发现中的应用

国际药学研究杂志 2008年第4期35卷 295-298,301页

作者： bullen A 徐培培王林不详军事医学科学院放射与辐射研究所北京100850

显微成像技术通过帮助描述疾病过程及在此过程中可能进行干预的潜在治疗方法,可进一步加快药物发现过程。最近的一些新技术和对已有技术的改进集中解决了过去显微成像技术应用的技术难点,即增加了显微成像技术的空间分辨率,提高了组织... 详细信息

显微成像技术通过帮助描述疾病过程及在此过程中可能进行干预的潜在治疗方法,可进一步加快药物发现过程。最近的一些新技术和对已有技术的改进集中解决了过去显微成像技术应用的技术难点,即增加了显微成像技术的空间分辨率,提高了组织穿透率、跨越机体组织障碍的能力,增加了实验通量。本文集中介绍最近显微成像技术一些值得注意的发展趋势,包括超显微技术的发展,多光子技术引入,纤维光学显微技术和自动成像技术以及应用于高内涵筛选的图像分析技术。总之,这些技术进步不仅仅加速了早期药物发现中已有的实验测定和疾病模型,还催生了许多新的测定方法和疾病模型。

关键词：显微成像超高分辨率显微技术活体显微技术纤维光学技术高通量显微技术