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A systematic review of randomized controlled trials examining the effectiveness of saffron(Crocus sativus L.) on psychological and behavioral outcomes

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Journal of Integrative Medicine 2015年第4期13卷 231-240页

作者： Heather Ann Hausenblas Kacey Heekin Heather Lee Mutchie stephen anton Department of Kinesiology Jacksonville University Department of Aging & Geriatric Research University of Florida

BACKGROUND：Throughout the past three decades,increased scientifi c attention has been given to examining saffron’s（Crocus sativus L.）use as a potential therapeutic or preventive agent for a number of health conditions,including cancer,cardiovascular disease,and ***：The purpose of this systematic review is to examine and categorize the current state of scientifi c evidence from randomized controlled trials（RCTs）regarding the effi cacy of saffron on psychological/behavioral *** STRATEGY：Electronic and non-electronic systematic searches were conducted to identify all relevant human clinical research on *** search strategy was extensive and was designed according to the＂Preferred Reporting Items for Systematic Reviews and Meta-Analyses（PRISMA）.＂Reference lists of articles that met the inclusion criteria were *** English language studies were *** CRITERIA：Saffron trials in combination with other substances and saffron safety studies were considered,in accordance with the PRISMA *** studies must have a control *** studies must measure a physiological and/or a behavioral *** EXTRACTION AND ANALYSIS：The methodological quality of all included studies was independently evaluated by two reviewers using the Jadad *** scores and P-values of measures were compared both inter-and intra-study for each parameter（i.e.,depression）.RESULTS：Twelve studies met our inclusion *** studies examined the effects of saffron on psychological/behavioral outcomes of：major depressive disorder（n=6）,premenstrual syndrome（n=1）,sexual dysfunction and infertility（n=4）,and weight loss/snacking behaviors（n=1）.The data from these studies support the effi cacy of saffron as compared to placebo in improving the following conditions：depressive symptoms（compared to anti-depressants and placebo）,premenstrual symptoms,and sexual *** addition,saffron use was also effective in reducing exce

关键词： Crocus health-rela ted outcomes systematic review

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Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health

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Journal of Integrative Medicine 2013年第1期11卷 2-10页

作者： stephen D. anton Kacey Heekin Carrah Simkins Andres Acosta Department of Aging and Geriatric Research University of FloridaGainesville Florida 32611 USA Department of Medicine University of FloridaGainesville Florida 32611 USA

According to the classic ＂diet-heart＂ hypothesis, high dietary intake of saturated fats and cholesterol combined with low intake of polyunsaturated fats can increase levels of serum cholesterol and lead to the development of atherogenic plaques and ultimately cardio- vascular diseases. Recently, the beneficial health effects of omega-6 polyunsaturated fatty acids, particularly linoleic acid （LA）, on cardiovascular health have been called into question with some scientists suggesting that consumption of LA should be reduced in Western countries. The focus of this critical review is on the controversy surrounding the effects of dietary intake of LA on cardiovascular health. Specifically, we critically examined the effects of both unadulterated and adulterated forms of LA on cardiovascular health outcomes based on findings from epidemiological studies and randomized controlled trials. Additionally, we address common concems surrounding dietary intake of LA regarding its relationship with arachidonic acid, the ratio of omega-6 to omega-3 fatty acids, and its relationship with inflammation. Our critical review indicates that unadulterated forms of LA are cardioprotective and should be consumed as part of a healthy diet. In contrast, abundant evidence now indicates that adulterated forms of LA, predominantly hydrogenated vegetable oils, are atherogenic and should not be considered part of a healthy diet. The ability to adulterate the natural omega-6 fatty acid, LA, has contributed to mixed findings regarding the effects of this fatty acid on cardiovascular health. Thus, it is critical that the source of LA be taken into account when drawing conclusions about the physiological effects of this fatty acid. The findings of the present review are in line with current dietary recommendations of the American Heart Association.

关键词： diet fatty acids linoleic acids cardiovascular diseases review

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Saffron (Crocus sativus L.) and major depressive disorder:a meta-analysis of randomized clinical trials

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Journal of Integrative Medicine 2013年第6期11卷 377-383页

作者： Heather Ann Hausenblas Debbie Saha Pamela Jean Dubyak stephen Douglas anton Department of Sport and Exercise Sciences Jacksonville University Department of Aging and Geriatric Research University of Florida

Due to safety concerns and side effects of many antidepressant medications, herbal psychopharmacology research has increased, and herbal remedies are becoming increasingly popular as alternatives to prescribed medications for the treatment of major depressive disorder （MDD）. Of these, accumulating trials reveal positive effects of the spice saffron （Crocus sativus L.） for the treatment of depression. A comprehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted. OBJECTIVE： The purpose of this study was to conduct a meta-analysis of published randomized controlled trials examining the effects of saffron supplementation on symptoms of depression among participants with MDD. SEARCH STRATEGY： We conducted electronic and non-electronic searches to identify all relevant randomized, double-blind controlled trials. Reference lists of all retrieved articles were searched for relevant studies. INCLUSION CRITERIA： The criteria for study selection included the following：（1） adults （aged 18 and older） with symptoms of depression, （2） randomized controlled trial, （3） effects of saffron supplementation on depressive symptoms examined, and （4） study had either a placebo control or antidepressant comparison group. DATA EXTRACTION AND ANALYSIS： Using random effects modeling procedures, we calculated weighted mean effect sizes separately for the saffron supplementation vs placebo control groups, and for the saffron supplementation vs antidepressant groups. The methodological quality of all studies was assessed using the Jadad score. The computer software Comprehensive Meta- analysis 2 was used to analyze the data. RESULTS： Based on our pre-specified criteria, five randomized controlled trials （n = 2 placebo controlled trials, n = 3 antidepressant controlled trials） were included in our review. A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms （M ES = 1.62, P 〈

关键词： Crocus depressive disorder dietary supplements mood disorders quality of life medicine, herbal meta-analysis

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Effect of a novel dietary supplement on pH levels of healthy volunteers:a pilot study

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Journal of Integrative Medicine 2013年第6期11卷 384-388页

作者： stephen Douglas anton Xiaomin Lu Ginny Bank Kacey Heekin Debbie Saha Pamela J.Dubyak Heather Ann Hausenblas Department of Aging and Geriatric Research University of Florida Department of Clinical and Health Psychology University of Florida Department of Biostatistics University of Florida RFI Ingredients Department of Sport and Exercise Sciences University of Florida Department of Sport and Exercise Sciences Jacksonville University

OBJECTIVE： To examine the effects of a greens alkalizing dietary supplement on urinary pH levels in individuals with lower-than-average pH levels. METHODS： The present study investigated the effects of an alkalizing formula （Reserveage Wholeganic GreensTM） on four individuals who had average urinary pH levels below 6.0 for three consecutive days. Following the three-day, baseline period, participants received Reserveage Wholeganic GreensTM for four consecutive days and were instructed to continue to measure their urine pH levels. Paired samples t-tests were used to examine pH levels before and after a four-day treatment period with Reserveage Wholeganic GreensTM. RESULTS： Compared to baseline, mean urine pH levels in all volunteers were significantly higher following the supplementation with Reserveage Wholeganic GreensTM （5.89 ±0.20 vs 5.56 ± 0.23; P〈0.01）. Participants＇ pH levels were also significantly higher than baseline on days 5, 6, and 7 of the treatment period （P 〈 0.05）. Noteworthy, on day 7, participants＇ mean pH levels were significantly higher than at the beginning of the treatment period （6.03 ± 0.15 at day 7 vs 5.65 ± 0.24 at day 4; P 〈 0.01）. CONCLUSION： The findings of this study suggest that supplementation with Reserveage Wholeganic GreensTM has an alkalizing effect on the body and can increase the urine pH levels in individuals with lower-than-average pH levels.

关键词： dietary supplements urinalysis acidosis pilot study

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“双盲、安慰剂对照交叉设计研究植物药对于进食量、饱腹感、体重减轻及氧化应激的影响”的研究方案(英文)

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中西医结合学报 2011年第11期9卷 1190-1198页

作者： stephen D.anton Jonathan Shuster Christiaan Leeuwenburgh Department of Aging and Geriatric Research University of FloridaGainesvilleFlorida 32611USA Department of Health Outcomes and Policy University of FloridaGainesvilleFlorida 32611USA

背景:植物性治疗药物作为一种重要且尚未被完全开发的药用资源,可能有助于热量控制从而产生长期的减重功效。从藤黄果(Garcinia combogia Desr.)中提取的羟基柠檬酸可能通过影响与饱腹有关的神经通路而减少摄食量和减轻体重。方法与设计... 详细信息

背景:植物性治疗药物作为一种重要且尚未被完全开发的药用资源,可能有助于热量控制从而产生长期的减重功效。从藤黄果(Garcinia combogia Desr.)中提取的羟基柠檬酸可能通过影响与饱腹有关的神经通路而减少摄食量和减轻体重。方法与设计:本研究为双盲、安慰剂对照、交叉设计试验,共计划纳入48名超重或肥胖的健康受试者(体重指数25.0～39.9 kg/m^2,年龄50～70岁),研究两种剂量藤黄果来源的羟基柠檬酸对摄食量、饱腹感、体重减轻及氧化应激水平的影响。摄食量作为主要结局指标,根据受试者在测量日的早餐、午餐和晚餐的摄食量计算。与平行设计的研究相比,本研究所使用的受试者数量将大大减少。讨论:本研究选择藤黄果来源的羟基柠檬酸为研究对象是因为该药物能够安全地减少摄食量、减轻体重和降低氧化应激水平。我们将会在研究过程中探讨其可能的作用机制和安全指标。

关键词：藤黄果植物提取物羟基柠檬酸减肥药营养保健品交叉研究临床方案

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Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang stephen Temitayo Bello Department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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Engineering for problem solving in future: Eco-social market economy and eco-social tech

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Journal of Environmental Sciences 2001年第3期13卷 257-264页

作者： Moser, anton Institute of Biotechnology Group Eco-Tech A-8010 Graz Petersgasse 12 Austria. E-mail:

The paper differentiates approaches in technology (end-of-pipe, cleaner production, industrial ecology, zero emission and eco-social tech) and compares them in respect to the problem solving capacity on the ecological as well as social dimension by showing the eco-impact reduction and job creation. Eco-social-tech represents the approach with highest problem solution as it is based on "eco-social market economy", which will the replace free market economy. The deep background of these innovations is "ecosophy", the wisdom of nature, which serves as guideline for eco-restructuring the world.

关键词： Eco-social market economy and eco-social tech Engineering for problem solving in future In

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The Minimax Equality; Sufficient and Necessary Conditions

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Acta Mathematica Sinica,English Series 2007年第4期23卷 677-684页

作者： anton STEFANESCU University of Bucharest Faculty of Mathematics14 Academiei St010014 BucharestRomania

The paper produces new versions of the minimax theorem based on original conditions. Moreover, we investigate not only the sufficiency, but also the necessity of such conditions. The proofs are very simple and preclud... 详细信息

关键词： Minimax equality Convexlike functions Affine-connectedness

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Lefschetz Formulae for p-Adic Groups

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Chinese Annals of Mathematics,Series B 2007年第4期28卷 463-474页

作者： anton DEITMAR Mathematisches Institut Auf der Morgenstelle 10 72076 TübingenGermany.

In this paper, Lefschetz formulae for torus actions on p-adic groups are proven. These are similar to comparable formulae for real Lie groups. Applications lie in the realm of dynamical zeta functions.

关键词： Arithmetic groups Trace formula Lefschetz formula

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