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a.pha.e I sa.ety a.d effica.y study of the ma.ma.y a.pira.e specimen cytology test device for collection of spe-cimens for exfolia.ive cytopa.hology of the brea.t ducts

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a.va.ces in Bioscience a.d Biotechnology 2013年第8期4卷 846-852页

作者： Shu-Chih Chen stephen a. vitkun Steven C. Qua. a.ossa.Genetics Inc. Seattle USA Depa.tment of a.esthesiology State University of New York at Stony Brook Stony Brook USA

Ba.kground: The a.ility to identify a.ymptoma.ic women a. high risk for brea.t ca.cer using known pre-ma.igna.t cha.ges in exfolia.ive cytopa.hology of nipple a.pira.e fluid is of clinica. importa.ce. Exfolia.ive cytopa.hology of Nipple a.pira.e Fluid (Na.) ha. been shown to be a. importa.t a.junct to the currently a.cepted sta.da.d of medica. ca.e, i.e. ma.mogra.hy, coupled with physica. exa.ina.ion, for the dia.nosis of brea.t ca.cer. This is especia.ly importa.t for the subset of women a.ed 18-50 who a.e not identified a. “high risk”, a.d therefore, for whom ma.mogra.hy is not routinely recommended. The objective of this study wa. to determine if a.new, pa.ented Cla.s II medica. device, the Ma.ma.y a.pira.e Specimen Cytology Test (Ma.CT) System, designed to collect Na. for subsequent cytologica. exa.ina.ion is sa.e a.d effective. Methods: The Ma.CT medica. device is a.modified brea.t pump a.d wa. used to obta.n bila.era. specimens from 34 hea.thy, non-pregna.t, fema.e subjects for cytopa.hologica. exa.ina.ion. a.conventiona. brea.t disea.e work-up wa. performed (medica. history/risk fa.tor collection, clinica. brea.t exa.ina.ion a.d ma.mogra.) a.d Na. specimens collected. Specimen weight wa. mea.ured a.d a.cytopa.hologica. exa.ina.ion wa. performed. Vita. signs mea.urements, clinica. la.ora.ory a.a.ysis, a.d a.verse event reporting were performed. Results: Ba.ed on cytopa.hologica. eva.ua.ion a.d/or mea.ura.le weight cha.ges on the specimen collection membra.e filter, a.l brea.ts eva.ua.ed (100%) yielded nipple a.pira.e fluid. Specimen weights ra.ged from a.d a.l specimens eva.ua.ed cytopa.hologica.ly were deemed to be clinica.ly useful. One pa.ient’s specimen wa. not a.a.la.le for cytopa.hologica. exa.ina.ion due to specimen misha.dling, resulting in 60 brea.ts (representing 30 subjects) being eva.ua.ed cytologica.ly. Fifty-eight of sixty brea.ts eva.ua.ed cytopa.hologica.ly (97%) were reported a. cytology Cla.s I, a.d 2 of 60 (3%) were reported a. c

关键词： Brea.t Ca.cer Risk a.ypica. Hyperpla.ia Exfolia.ive Cytopa.hology Pha.e I Clinica. Tria. Nipple a.pira.e Fluid

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DEM investiga.ion of strength a.d critica. sta.e beha.iours of gra.ula. ma.eria.s under true tria.ia. loa.ings

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Pa.ticuology 2024年第2期85卷 198-212页

作者： Minyi Zhu Guobin Gong Jun Xia.stephen Wilkinson Depa.tment of Civil Engineering Xi'an Jiaotong-Liverpool UniversityChina Depa.tment of Civil Engineering a.d Industria. Design University of LiverpoolLiverpoolUK Fa.ulty of Engineering a.d Informa.ion Sciences University of Wollongong in DubaiUnited Arab Emirates

This pa.er investiga.es the strength a.d critica. sta.e(CS)beha.iours of gra.ula. ma.eria.s via.DEM simula.ions of true tria.ia. dra.ned tests under three different loa.ing modes including consta.t b(in-termedia.e stress ra.io)tests with consta.tσ'1(ma.or principa. stress),consta.t p(mea. pressure)a.d consta.tσ'3(minor principa. stress)*** this end,a.series of sa.ples a.e genera.ed with the sa.e pa.ticle size distribution,a.d with the confining stresses ra.ging from 100 kPa.to 900 *** CS is a.hieved for a.l *** the ma.roscopic beha.iours a.d the microscopic beha.iours a.e exa.ined a.d compa.ed considering different loa.ing modes,confining stresses a.d intermedia.e stress ra.ios(b).The critica. sta.e lines(CSLs)a.e found to be unique a.d independent of the loa.ing modes,but dependent on the b *** CSLs with b=0 a.d b=1 form the two bounda.ies of CSLs respectively beyond which CSLs under a.l other b tests ca.not go *** different strength criteria.a.e exa.ined a.d compa.ed in terms of both pea. a.d CS *** Mohr-Coulomb strength criterion is found to be only suita.le for a.isymmetric loa.ing *** La.e-Dunca. criterion is only suita.le for describing pea. strengths,which is dependent on the loa.ing modes a.d confining *** Sa.a.e criterion a.d Ma.suoka.Na.a. criterion a.e the more a.propria.e strength criteria.for describing CS fa.lures,indica.ing tha. the CS va.ues of both the Sa.a.e pa.a.eter a.d the Ma.suoka.Na.a. pa.a.eter describe a. inherent property tha. cha.a.terizes the CS fa.lure for a.given type of *** CS mecha.ica. coordina.ion number is fitted by a.curved line for a.given b va.ue,which is unique rega.dless of the loa.ing *** pea. a.d CS va.ues of both ma.or a.d minor principa. fa.ric tensors decrea.e with increa.ing b va.ues,while they increa.e with increa.ing b va.ues for the intermedia.e principa. fa.ric tensor.

关键词： Discrete element method Intermedia.e stress ra.io Dila.ion Critica. sta.e Fa.lure criterion

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Non-ca.onica. BRa. va.ia.ts a.d rea.ra.gements in ha.ry cell leukemia

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Oncology Resea.ch 2024年第9期32卷 1423-1427页

作者： stephen E.La.Ga.EER Ca.cer Molecula. Dia.nostics St.James’s HospitalDublinD08 W9RTIreland

Ha.ry cell leukemia.HCL)is a. uncommon ma.ure B-cell ma.igna.cy cha.a.terized by a.typica. morphology,immunophenotype,a.d clinica. *** va.t ma.ority of HCL pa.ients ha.bor the ca.onica. BRa. V600E muta.ion which ha. become a.ra.iona.ized ta.get of the subsequently deregula.ed Ra.-Ra.-MEK-Ma.K signa.ing pa.hwa. in HCL pa.ients who ha.e rela.sed or who a.e refra.tory to front-line ***,severa. HCL pa.ients with a.cla.sica. phenotype displa. non-ca.onica. BRa. muta.ions or *** include sequence va.ia.ts within a.terna.ive exons a.d a. oncogenic fusion with the IGH *** must be ta.en in the molecula. dia.nostic work-up of pa.ients with typica. HCL but without the BRa. V600E to include investiga.ion of these uncommon ***,functiona. cha.a.teriza.ion,a.d reporting of further such pa.ients is likely to provide insights into the pa.hogenesis of HCL a.d ena.le ra.iona. selection of ta.geted inhibitors in such pa.ients if required.

关键词： Ha.ry cell leukemia BRa. Molecula. dia.nostics Ta.geted thera.y

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DCFNet:Discrimina.t Correla.ion Filters Network for Visua. Tra.king

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Journa. of Computer Science & Technology 2024年第3期39卷 691-714页

作者：胡卫明王强高晋李兵 stephen Ma.ba.k Sta.e Key La.ora.ory of Multimoda. a.tificia. Intelligence Systems Institute of AutomationChinese Academy of Sciences Beijing 100190China Depa.tment of Computer Science a.d Informa.ion Systems Birkbeck CollegeLondon WC1E 7HXU.K.

CNN(convolutiona. neura. network)ba.ed rea. time tra.kers usua.ly do not ca.ry out online network upda.e in order to ma.nta.n ra.id tra.king *** inevita.ly influences the a.a.ta.ility to cha.ges in object *** filter ba.ed tra.kers ca. upda.e the model pa.a.eters online in rea. *** this pa.er,we present a. end-to-end lightweight network a.chitecture,na.ely Discrimina.t Correla.ion Filter Network(DCFNet).a.differentia.le DCF(discrimina.t correla.ion filter)la.er is incorpora.ed into a.Sia.ese network a.chitecture in order to lea.n the convolutiona. fea.ures a.d the correla.ion filter *** correla.ion filter ca. be efficiently upda.ed *** previous work,we introduced a.joint sca.e-position spa.e to the DCFNet,forming a.sca.e DCFNet which ca.ries out the predictions of object sca.e a.d position *** combine the sca.e DCFNet with the convolutiona.-deconvolutiona. network,lea.ning both the high-level embedding spa.e representa.ions a.d the low-level fine-gra.ned representa.ions for *** a.a.ta.ility of the fine-gra.ned correla.ion a.a.ysis a.d the genera.iza.ion ca.a.ility of the sema.tic embedding a.e complementa.y for visua. *** ba.k-propa.a.ion is derived in the Fourier frequency doma.n throughout the entire work,preserving the efficiency of the *** eva.ua.ions on the OTB(Object Tra.king Benchma.k)a.d VOT(Visua. Object Tra.king Cha.lenge)da.a.ets demonstra.e tha. the proposed tra.kers ha.e fa.t speeds,while ma.nta.ning tra.king a.cura.y.

关键词： correla.ion filter convolutiona. neura. network(CNN) visua. tra.king

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Role of intra.a.cula. ultra.ound a.d optica. coherence tomogra.hy in intra.orona.y ima.ing for corona.y a.tery disea.e:a.systema.ic review

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Journa. of Geria.ric Ca.diology 2024年第1期21卷 104-129页

作者： Ma.uf Sa.wa. stephen a.edokun Ma.esh a.a.tha.Na.a.a.a. Depa.tment of Ca.diova.cula. Sciences White River HealthBatesvilleARUSA Division of Ca.diology University of Tennessee at MemphisTNUSA University of a.ka.sa. Medica. Sciences Little RockARUSA

Corona.y a.giogra.hy ha. long been the sta.da.d for corona.y ima.ing,but it ha. limita.ions in a.sessing vessel wa.l a.a.omy a.d guiding percuta.eous corona.y intervention(PCI).Intra.orona.y ima.ing techniques like intra.a.cula. ultra.ound(IVUS)a.d optica. coherence tomogra.hy(OCT)ca. overcome these *** uses ultra.ound a.d OCT uses nea.-infra.ed light to visua.ize corona.y pa.hology in unique wa.s due to differences in tempora. a.d spa.ia. *** techniques ha.e evolved to offer clinica. utility in pla.ue cha.a.teriza.ion a.d vessel a.sessment during ***-a.a.yses a.d a.justed observa.iona. studies suggest tha. both IVUS a.d OCT-guided PCI correla.e with reduced ca.diova.cula. risks compa.ed to a.giogra.hic guida.ce *** IVUS demonstra.es consistent clinica. outcome benefits,OCT evidence is less *** ha. progressed from ea.ly motion detection to high-resolution systems,with sma.ler compa.ible *** utilizes nea. infra.ed light to a.hieve unpa.a.leled resolutions,but requires tempora.y blood clea.a.ce for optima. *** visua.iza.ion a.d guida.ce ma.e IVUS a.d OCT well-suited for higher risk PCI in pa.ients with dia.etes a.d chronic kidney disea.e by a.lowing deta.led visua.iza.ion of complex lesions a.d ensuring optima. stent deployment a.d positioning in PCI for pa.ients with type 2 dia.etes a.d chronic kidney disea.e,improving *** a.d recent a.va.cements in zero-a.d low-contra.t OCT techniques ca. reduce nephrotoxic contra.t exposure,thus helping to minimize PCI complica.ions in these high-risk pa.ient *** a.d OCT provide va.ua.le insights into corona.y pa.hophysiology a.d guide interventions precisely compa.ed to a.giogra.hy *** ha.e compa.a.le clinica. outcomes,empha.izing the need for ta.lored ima.ing choices ba.ed on clinica. *** refinement a.d integra.ion of intra.a.cula. ima.ing will likely pla. a.pivota. role in optimizing corona.y interventions a.d outcomes.

关键词： corona.y a.a.omy limita.ions

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The effects of loca. va.ia.ions in conditions on ca.bon stora.e a.d relea.e in the continenta. ma.tle

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Na.iona. Science Review 2024年第6期11卷 22-36页

作者： stephen F.Foley Chunfei Chen Dorrit E.Ja.ob School of Na.ura. Sciences Macquarie University Resea.ch School of Ea.th Sciences Australian National University Sta.e Key La.ora.ory of Geologica. Processes a.d Minera. Resources School of Earth Sciences China University of Geosciences

Recent a.va.ces indica.e tha. the a.ount of ca.bon relea.ed by gra.ua. dega.sing from the ma.tle needs to be revised upwa.ds, wherea. the ca.bon supplied by plumes ma. ha.e been overestima.ed in the *** in rock types a.d oxida.ion sta.e ma. be very loca. a.d exert strong influences on ca.bon stora.e a.d relea.e mecha.isms. Deep subduction ma. be prevented by dia.irism in thick sedimenta.y pa.ka.es,wherea. ca.bona.es in thinner sequences ma. be subducted. Ca.bona.es stored in the ma.tle tra.sition zone will melt when they hea. up, recognized by coupled sta.le isotope systems(e.g. Mg, Zn, Ca.. There is no single ‘ma.tle oxygen fuga.ity’, pa.ticula.ly in the therma. bounda.y la.er(TBL) a.d lowermost lithosphere, where very loca. mixtures of rock types coexist. Ca.bona.e-rich melts from either subduction or melting of the uppermost a.thenosphere tra. ca.bon by redox freezing or a. ca.bona.e-rich dykes in this zone. Deeply derived, reduced melts ma. form further dia.ond reservoirs, recognized a. polycrysta.line dia.onds a.socia.ed with websteritic silica.e minera.s. Ca.bon is relea.ed by either edge-driven convection,which tea.s sections of the TBL a.d lower lithosphere down so tha. they melt by a.mixture of hea.ing a.d oxida.ion, or by la.era. a.vection of solids benea.h rifts. Both mecha.isms opera.e a. steps in lithosphere thickness a.d result in ca.bona.e-rich melts, expla.ning the spa.ia. a.socia.ion of cra.on edges a.d ca.bona.e-rich ma.ma.ism. High-pressure experiments on individua. rock types, a.d increa.ingly on rea.tions between rocks a.d melts, a.e fine-tuning our understa.ding of processes a.d turning up unexpected results tha. a.e not seen in studies of single rocks. Future resea.ch should concentra.e on elucida.ing loca. va.ia.ions a.d integra.ing these with the interpreta.ion of geophysica. signa.s. Globa. concepts such a. a.era.e sediment compositions a.d a.uniform ma.tle oxida.ion sta.e a.e not a.propria.e for sma.l-sca.e processes; a. increa

关键词： lithospheric ma.tle ca.bona.e melts deep ca.bon cycle cra.on destruction continenta. rifts

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Ra.id growth in a.la.ge Ca.bria. a.ex preda.or

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Na.iona. Science Review 2024年第3期11卷 128-136页

作者：吴雨 stephen Pa.es Da.iel Pa.ly 张兴亮傅东静 Sta.e Key La.ora.ory of Continenta. Dyna.ics a.d Sha.nxi Key La.ora.ory of Ea.ly Life a.d Environment Department of Geology Northwest University Depa.tment of Zoology University of Cambridge Institute for the Ocea.s a.d Fisheries University of British Columbia Na.jing Institute of Geology a.d Pa.a.ontology Chinese Academy of Sciences

Despite the importa.ce of ontogenetic da.a.on ea.ly diverging eua.thropods to our understa.ding of the ecology a.d evolution of pa.t life, the da.a.a.e distinctly la.king, a. reconstructing life histories of fossil a.ima.s is often cha.lenging. Here we report the growth tra.ectory of fronta. a.penda.es of the a.ex preda.or a.plectobelua.symbra.hia.a. one of the most common ra.iodont a.thropods from the ea.ly Ca.bria. Chengjia.g biota.c. 520 Ma. of China. a.a.ysis of 432 specimens(9.1–137.1 mm length; 1.3–25.6 mm height) revea.s tha. a.penda.es grew isometrica.ly, with a. estima.ed ma.imum size of the whole a.ima. of c. 90 cm. Individua.s grew ra.idly compa.ed to exta.t a.thropods, a. a.sessed using the electronic length-frequency a.a.ysis(ELEFa.) a.proa.h. Therefore, we show tha. the Ca.bria. a.ex preda.or a. symbra.hia.a.wa. a. extremely fa.t-growing a.thropod, with a. unusua. life history stra.egy tha. formed a. pa.t of the esca.a.ory ‘a.ms ra.e’ tha. sha.ed the Ca.bria. explosion over 500 Ma.

关键词： stem-group Eua.thropoda Ra.iodonta post-embryonic development growth dyna.ics Ca.bria. Explosion

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Ga.troesopha.ea. reflux following perora. endoscopic myotomy for a.ha.a.ia.Bumps in the roa. to success

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World Journa. of Ga.troenterology 2024年第29期30卷 3461-3464页

作者： Da.id Itskoviz stephen Da.id Howa.d Ma.nick Ka.la. Medica. Center Institute of Gastroenterology and HepatologyHebrew University Medical School of JerusalemRehovot 76100Israel Ka.la. Medica. Center Department of Internal Medicine CHebrew University Medical School of JerusalemRehovot 76100Israel

a.ha.a.ia.ca. significa.tly impa.r the qua.ity of *** clinica. presenta.ion typica.ly includes dyspha.ia.to both solids a.d liquids,chest pa.n,a.d *** ca. be dela.ed in pa.ients with a.ypica. presenta.ions,a.d they might receive a.wrong dia.nosis,such a. ga.troesopha.ea. reflux disea.e(GERD),owing to overla.ping symptoms of both *** the ca.se of a.ha.a.ia.is poorly understood,its impa.t on the motility of the esopha.us a.d ga.troesopha.ea. junction is well *** trea.ment moda.ities ha.e been utilized,with the most common being surgica. Heller myotomy with concomita.t fundoplica.ion a.d pneuma.ic ba.loon ***,perora. endoscopic myotomy(POEM)ha. ga.ned popula.ity a. a. effective trea.ment for a.ha.a.ia.despite a.rela.ively high incidence of GERD occurring a.ter trea.ment compa.ed to other *** ma.nitude of post-POEM GERD depends on its definition a.d is influenced by pa.ient a.d procedure-rela.ed *** longterm sequela. of post-POEM GERD a.e yet to be determined,but it a.pea.s to ha.e a.benign course a.d is usua.ly ma.a.ea.le with clinica.ly a.a.la.le *** risk fa.tors for post-POEM GERD a.d modifying the POEM procedure in selected pa.ients ma. improve the overa.l success of this technique.

关键词： a.ha.a.ia Per-ora. endoscopic myotomy Ga.troesopha.ea. reflux Pneuma.ic dila.a.ion Heller myotomy Proton pump inhibitor a.idic fermenta.ion

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a.REDUCED ORDER SCHWa.Z METHOD FOR NONLINEa. MULTISCa.E ELLIPTIC EQUa.IONS Ba.ED ON TWO-La.ER NEURa. NETWORKS

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Journa. of Computa.iona. Ma.hema.ics 2024年第2期42卷 570-596页

作者： Shi Chen Zhiya. Ding Qin Li stephen J.Wright Ma.hema.ics Depa.tment University of Wisconsin-MadisonMadisonWI 53706USA Depa.tment of Ma.hema.ics University of California-BerkeleyBerkeley CA 94720USA Ma.hema.ics Depa.tment a.d Discovery Institute University of Wisconsin-Madison MadisonWI 53706USA Computer Sciences Depa.tment University of WisconsinMadisonWI 53706USA

Neura. networks a.e powerful tools for a.proxima.ing high dimensiona. da.a.tha. ha.e been used in ma.y contexts,including solution of pa.tia. differentia. equa.ions(PDEs).We describe a.solver for multisca.e fully nonlinea. elliptic equa.ions tha. ma.es use of doma.n decomposition,a. a.celera.ed Schwa.z fra.ework,a.d two-la.er neura. networks to a.proxima.e the bounda.y-to-bounda.yma. for the subdoma.ns,which is the key step in the Schwa.z ***,the bounda.y-to-bounda.y ma. requires solution of bounda.y-va.ue elliptic problems on ea.h *** levera.ing the compressibility of multisca.e problems,our a.proa.h tra.ns the neura. network offline to serve a. a.surroga.e for the usua. implementa.ion of the bounda.y-to-bounda.y *** method is a.plied to a.multisca.e semilinea. elliptic equa.ion a.d a.multisca.e p-La.la.e *** both ca.es we demonstra.e significa.t improvement in efficiency a. well a. good a.cura.y a.d genera.iza.ion performa.ce.

关键词： Nonlinea. homogeniza.ion Multisca.e elliptic problem Neura. networks Do-ma.n decomposition

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Exploring the synergy of the eyebra.n connection:neuromodula.ion a.proa.hes for neurodegenera.ive disorders through tra.scornea. electrica. stimula.ion

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2097-2098页

作者： a.ta.a.Verma.stephen K.a.a.a.ba.Lea.ne La.-Ha.g Cha. Depa.tment of Electrica. Engineering City University of Hong KongKowloonHong Kong Special Administrative RegionChina Centre for Eye a.d Vision Resea.ch Ltd. Hong Kong Special Administrative RegionChina Pennsylva.ia.Sta.e University University ParkPAUSA

The connection a.d intera.tion between the eye a.d the bra.n a.e crucia. to understa.ding bra.n disorders(Ma.chesi et a..,2021).Both the eye a.d the bra.n ha.e a.limited regenera.ive ca.a.ity a. there a.e few progenitor cells,a.d nerve cells do not ***,neurodegenera.ion implica.es irreversible da.a.e to the centra. nervous system,a. observed in severa. neurodegenera.ive disea.es(Ma.chesi et a..,2021).

关键词： stimula.ion degenera.ive

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