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Munc18/SNARE proteins’ regulation of exocytosis in guinea pig duodenal Brunner’s gland acini

World Journal of Gastroenterology 2008年第15期14卷 2314-2322页

作者： Laura I Cosen-Binker Gerry P Morris stephen vanner Herbert Y Gaisano Department of Medicine University of Toronto Toronto Ontario M5S 1A8 Canada Gastrointestinal Diseases Research Unit Queen's University Kingston Ontario KL7 5G2 Canada

AIM: To examine the molecular mechanism of exocytosis in the Brunner’s gland acinar cell. METHODS: We used a submucosal preparation of guinea pig duodenal Brunner’s gland acini to visualize the dilation of the ductal lumen in response to cholinergic stimulus. We correlated this to electron microscopy to determine the extent of exocytosis of the mucin-filled vesicles. We then examined the behavior of SNARE and interacting Munc18 proteins by confocal microscopy. RESULTS: One and 6 μmol/L carbachol evoked a dose- dependent dilation of Brunner’s gland acini lumen, which correlated to the massive exocytosis of mucin. Munc18c and its cognate SNARE proteins Syntaxin-4 and SNAP-23 were localized to the apical plasma membrane, and upon cholinergic stimulation, Munc18c was displaced into the cytosol leaving Syntaxin-4 and SNAP-23 intact. CONCLUSION: Physiologic cholinergic stimulation induces Munc18c displacement from the Brunner’s gland acinar apical plasma membrane, which enables apical membrane Syntaxin-4 and SNAP-23 to form a SNARE complex with mucin-filled vesicle SNARE proteins to affect exocytosis.

关键词： Apical exocytosis Brunner's gland acini Munc18c Syntaxin-4 Carbachol

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Coherent suppression of backscattering in optical microresonators

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Light(Science & Applications) 2020年第1期9卷 16-23页

作者： Andreas O.Svela Jonathan M.Silver Leonardo Del Bino Shuangyou Zhang Michael T.M.Woodley Michael R.vanner Pascal Del’Haye National Physical Laboratory Teddington TW110LWUK Blackett Laboratory Imperial College LondonLondon SW72AZUK Clarendon Laboratory University of OxfordOxford OX13PUUK City University of London London EC1V 0HBUK Max Planck Institute for the Science of Light StaudtstaBe 291058 ErlangenGermany Heriot-Watt University Edinburgh EH144ASUK Friedrich Alexander University Erlangen-Nuremberg 91058 ErlangenGermany

As light propagates along a waveguide,a fraction of the field can be reflected by Rayleigh *** high-qualityfactor whispering-gallery-mode microresonators,this intrinsic backscattering is primarily caused by either surface or bulk material *** several types of microresonator-based experiments and applications,minimal backscattering in the cavity is of critical importance,and thus,the ability to suppress backscattering is *** demonstrate that the introduction of an additional scatterer into the near field of a high-quality-factor microresonator can coherently suppress the amount of backscattering in the microresonator by more than 30 *** method relies on controlling the scatterer position such that the intrinsic and scatterer-induced backpropagating fields destructively *** technique is useful in microresonator applications where backscattering is currently limiting the performance of devices,such as ring-laser gyroscopes and dual frequency combs,which both suffer from injection ***,these findings are of interest for integrated photonic circuits in which back reflections could negatively impact the stability of laser sources or other components.

关键词： resonator waveguide scatter

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基础型式和土壤条件季节性变化对线路杆塔基础上拔抵抗力的影响

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电力建设 1984年第10期 56-65页

作者： M. J. vanner 洪晋宝

1.绪言历史上早期建造的送电线基础,基本原理简单。可是,当送电线杆塔尺寸增大后就需要相应的基础来支持。较大尺寸的基础意味着需要变更方法来解决基础设计和施工中所发现的问题,现在。送电线路的路径常常

关键词：直柱基础基础型式未扰动土原状土抵抗力土壤条件

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