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全球生态系统服务与自然资本的价值估算

生态学杂志 1999年第2期18卷 70-78页

作者： Robert Costanza Ralph d'Arge Rudolf de Groot stephen farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) 美国马里兰大学美国怀俄明大学荷兰瓦格宁根农业大学美国匹次堡大学美国伊利诺大学美国米尔布卢克生态系统研究所美国明尼苏达大学美国橡树岭国家实验室环境科学部阿根廷布依诺斯艾利斯大学美国加里福尼亚喷气推进实验室美国加州大学美国生态经济研究和应用公司不详

编者按：地球上的生态系统是一种复杂的生命支持系统，生态系统对人类的贡献，在生态学研究中经常用“社会效益和经济效益”来表述，是可以用经济价值来估算的。然而，由于其复杂性和不确定性，对这两个效益如何进行估价，一直是困扰生... 详细信息

编者按：地球上的生态系统是一种复杂的生命支持系统，生态系统对人类的贡献，在生态学研究中经常用“社会效益和经济效益”来表述，是可以用经济价值来估算的。然而，由于其复杂性和不确定性，对这两个效益如何进行估价，一直是困扰生态学家和经济学家的重要问题。Ｃｏｓ...

关键词：全球生态系统自然资本价值估算

Contemporary Approaches for Identifying Rare Bone Disease Causing Genes

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Bone Research 2013年第4期1卷 301-310页

作者： Charles R.farber Thomas L.Clemens Center for Public Health Genomics University of Virginia Departments of Public Health Sciences and Biochemistry and Molecular Genetics University of Virginia Department of Orthopaedic Surgery Johns Hopkins School of Medicine Baltimore Veterans Administration Medical Center

Recent improvements in the speed and accuracy of DNA sequencing, together with increasingly sophisti- cated mathematical approaches for annotating gene networks, have revolutionized the field of human genetics and made these once time consuming approaches assessable to most investigators. In the field of bone research, a particularly active area of gene discovery has occurred in patients with rare bone disorders such as osteogenesis imperfecta （OI） that are caused by mutations in single genes. In this perspective, we highlight some of these technological advances and describe how they have been used to identify the genetic determinants underlying two previously unexplained cases of OI. The widespread availability of advanced methods for DNA sequencing and bioinformatics analysis can be expected to greatly facilitate identification of novel gene networks that normally function to control bone formation and maintenance.

关键词： exome sequencing genome sequencing bioinformatics osteogenesis imperfect pigment epithelium-derived factor (PEDF) bone restricted ifitm-like protein (Bril)

The SDIMS-case study of integrate management for modern mining enterprise

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Journal of Coal Science & Engineering(China) 2004年第2期10卷 122-124页

作者：宋华岭王金力 David Michael farber School of International Exchanges Shandong Institute of Business and Technology Yantai 264005 China Shenfu Dongsheng Coal Company Ltd Shenmu 719315 China

Shenfu Dongsheng Coal Co. Ltd. of the Shenhua Group is a modern mining enterprise. To construct this first class world enterprise, Shendong Company placed em- phasis on construction and production, and complied the internal administration with the international standards spontaneously. In order to strengthen the administration of the en- terprise, enhance the running efficiency of the systems, achieve the best administrative performances and goals, the Shendong Company began to engineer the integrated man- aging system(SDIMS) in early 2002. This article, as a case study, introduces the planning and construction processes of the SDIMS’s, and sums up the empirical experiences for modern and international mining enterprise.

关键词： SDIMS planning the three systems

Evaluation and management of acquired ptosis

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Plastic and Aesthetic Research 2020年第4期7卷 40-62页

作者： Stephanie E.farber Mark A.Codner Department of Plastic Surgery University of PittsburghPA 15261USA Division of Plastic Surgery Emory UniversityAtlantaGA 30322USA

Periorbital rejuvenation is a common aesthetic goal sought by patients presenting to the plastic or oculoplastic *** this reason,it is critical that the surgeon understand the functional considerations,such as preexisting blepharoptosis,which will contribute to the ultimate aesthetic *** article will review the anatomy of the normal and ptotic lid and will discuss the approach to diagnosing and characterizing the type and degree of lid ***-yield surgical techniques for ptosis correction will then be described,including the indications for and steps of each ***,the diagnosis and management of common complications that follow ptosis surgery will be *** main objective is to arm the surgeon with the preoperative and operative planning tools to successfully manage comorbid ptosis and thereby improve blepharoplasty outcomes.

关键词： Functional eyelid surgery eyelid ptosis acquired ptosis blepharoplasty blepharoptosis periorbital rejuvenation

OSKM-mediated reversible reprogramming of cardiomyocytes regenerates injured myocardium

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Cell Regeneration 2022年第1期11卷 55-57页

作者： Gregory farber Jiandong Liu Li Qian Department of Pathology and Laboratory Medicine McAllister Heart InstituteUniversity of North CarolinaChapel HillNC 27599USA

Cellular reprogramming has rapidly become a promising methodology to generate new cardiomyocytes from non-cardiomyocyte cell *** the transient expression of OSKM factors,Chen et *** a unique reprogramming strategy involving the modulation of the resident adult cardiomyocyte identity to an immature proliferative state(Science 373:1537–40,2021).This OSKM-mediated reversion results in the adoption by adult murine cardiomyocytes of a transcriptional profile similar to cardiomyocytes found in developing hearts,as well as increased proliferative capacity of these reprogrammed cardiomyocytes compared to mature ***,this novel approach enhances the regeneration of adult murine hearts post-myocardial *** concerns and questions remain,the encouraging results of this study advance the field of cardiac regeneration by providing a new technique to generate cardiomyocytes as well as insights into cardiomyocyte dedifferentiation and its relation to proliferation.

关键词： cardiomyocytes programming myocardium

Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-b2

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Cellular & Molecular Immunology 2010年第6期7卷 428-439页

作者： Aiko-Konno Shirakawa Fang Liao Hongwei H Zhang Michael N Hedrick Satya P Singh Dianqing Wu Joshua M farber Inflammation Biology Section Laboratory of Molecular ImmunologyNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA Department of Pharmacology Yale University School of MedicineNew HavenCTUSA

Lymphocyte activation leads to changes in chemokine receptor *** are limited data,however,on how lymphocyte activators can alter chemokine signaling by affecting downstream *** hypothesized that B cell-activating agents might alter chemokine responses by affecting downstream signal transducers,and that such effects might differ depending on the *** found that activating mouse B cells using either anti-IgM or lipopolysaccharide(LPS)increased the surface expression of CCR6 and CCR7 with large increases in chemotaxis to their cognate *** contrast,while anti-IgM also led to enhanced calcium responses,LPS-treated cells showed only small changes in calcium signaling as compared with cells that were freshly *** particular interest,we found that LPS caused a reduction in the level of B-cell phospholipase C(PLC)-b2 mRNA and *** obtained using PLC-b22/2 mice showed that the b2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells,and we found that calcium signals in the LPS-treated cells were boosted by increasing the level of PLC-b2 using transfection,consistent with a functional effect of downregulating ***,our results show activator-specific effects on responses through B-cell chemokine receptors that are mediated by quantitative changes in a downstream signal-transducing protein,revealing an activity for LPS as a downregulator of PLC-b2,and a novel mechanism for controlling chemokine-induced signals in lymphocytes.

关键词： B cells calcium chemokine chemotaxis GPCR

Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection

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World Journal of Stem Cells 2021年第9期13卷 1248-1277页

作者： Quang Le Vedavathi Madhu Joseph M Hart Charles R farber Eli R Zunder Abhijit S Dighe Quanjun Cui Department of Orthopaedic Surgery University of Virginia School of MedicineCharlottesvilleVA 22908United States Orthopaedic Surgery Research Thomas Jefferson UniversityPhiladelphiaPA 19107United States Center for Public Health Genomics University of VirginiaCharlottesvilleVA 22908United States Departments of Public Health Sciences and Biochemistry and Molecular Genetics University of VirginiaCharlottesvilleVA 22908United States Department of Biomedical Engineering University of VirginiaCharlottesvilleVA 22908United States

Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the *** isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cell

关键词： Mesenchymal stem cells Adipose-derived stem cells Endogenous stem cells Skeletal stem cells Bone regeneration

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摄影技巧

1988年

作者： Paul R.farber原王茂才编译

来源：汇雅图书（南通市图书馆... 评论

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基础统计学第2版