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Asian Journal of Andrology 2014年第2期16卷 248-255,I0009页

作者： Lori A Cooper stephanie t page Departments of Medicine Division of Endocrinology and Metabolism University of Washington Seattle University of Washington and Harborview Medical Center Seattle Washington USA.

A growing body of literature has established the anabolic benefits of testosterone （t） therapy in hypogonadal men. However, there remains a paucity of data regarding the risks of exogenous androgen use in older men and the potential for adverse effects on the prostate gland. Whether t therapy in older, hypogonadal men might worsen lower urinary tract symptoms or exacerbate, unmask, or even incite prostate cancer development has tempered enthusiasm for t therapy, while known prostatic disease has served as a relative contraindication to t therapy. Androgens are necessary for the development and maintenance of the prostate gland. However, epidemiologic studies do not consistently find a positive relationship between endogenous serum androgen concentrations and the risk of prostate disease. Recent data demonstrate that 5α-reductase inhibitors decrease the risk of low-grade prostate cancer, suggesting that modifying androgen metabolism may have beneficial effects on prostate health, yet similar reductions in high-grade disease have not been observed, thereby questioning the true clinical benefits of these agents for chemoprevention. Knowing how to best investigate the relationship between androgens and the development of prostate disease given the lack of large, randomized trials is difficult. Accumulating data challenges the assumption that alterations in serum androgens have parallel effects within the prostate hormonal environment or change androgen-regulated processes within the gland. Long-term intervention studies are needed to truly ascertain the effects of androgen manipulation on prostate tissue and disease risk. However, available data do not support the notion that restoring serum androgens to normal physiologic ranges drives prostate disease.

关键词： androgens male hypogonadism prostate testosterone

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A role for dihydrotestosterone treatment in older men？

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Asian Journal of Andrology 2011年第2期13卷 199-200页

作者： Mara Y Roth stephanie t page University of Washington Medical Center 1959 NEPacific St Box 357138 Seattle WA 98195 USA

Androgens play a vital role in the main- tenance of health in normal *** supports bone development and strength, provides anabolic effects for maintenance of lean muscle mass, and contributes to normal sexual function... 详细信息

关键词： Androgens Men Health testosterone Experimentation Growth Aging Uses Associations Prostate

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Androgens exert sexually dimorphic effects on angiogenesis： novel insight into the relationship between androgens and cardiovascular disease

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Asian Journal of Andrology 2011年第4期13卷 626-627页

作者： Katya B Rubinow John K Amory stephanie t page Division of Metabolism Endocrinology and Nutrition University of Washington Seattle WA 98195 USA General internal Med c ne Un versity of Washington Seattle WA 98195 USA

the effects of androgen exposure on cardiovascular disease （CVD） risk in men remain poorly understood. Given the earlier incidence of CVD among men relative to women, androgens historically have been assumed to pote... 详细信息

关键词： Androgens sexually

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Androgen receptor deficiency in monocytes/ macrophages does not alter adiposity or glucose homeostasis in male mice

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Asian Journal of Andrology 2018年第3期20卷 276-283页

作者： Katya B Rubinow Barbara Houston Shari Wang Leela Goodspeed Kayoko Ogimoto Gregory J Morton Christopher McCarty Robert E Braun stephanie t page Division of Metabolism Endocrinology and Nutrition Department of Medicine University of Washington School of Medicine Seattle WA 98195 USA Jackson Laboratory Bar Harbor ME 04609 USA

Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor （AR） is expressed in monocytes/macrophages, which are resident in key metabolic tissues and influence energy metabolism in surrounding cells. Male mice bearing a cell-specific knockout of the AR in monocytes/macrophages （M-ARKO） were generated to determine whether selective loss of androgen signaling in these cells would lead to altered body composition. Wild-type （Wt） and M-ARKO mice （12-22 weeks of age, n = 12 per group） were maintained on a regular chow diet for 8 weeks and then switched to a high-fat diet for 8 additional weeks. At baseline and on both the regular chow and high-fat diets, no differences in lean mass or fat mass were observed between groups. Consistent with the absence of differential body weight or adiposity, no differences in food intake （3.0 ± 0.5 g per day for Wt mice vs 2.8 ± 0.4 g per day for M-ARKO mice） or total energy expenditure （0.6 ± 0.1 Kcal h-1 for Wt mice vs 0.5 ± 0.1 Kcal h-1 for M-ARKO mice） were evident between groups during high-fat feeding. Liver weight was greater in M-ARKO than that in Wt mice （1.5 ± 0.1 g vs 1.3 ± 0.0 g, respectively, P = 0.02）. Finally, M-ARKO mice did not exhibit impairments in glucose tolerance or insulin sensitivity relative to Wt mice at any study time point. In aggregate, these findings suggest that AR signaling specifically in monocytes/macrophages does not contribute to the regulation of systemic energy balance, adiposity, or insulin sensitivity in male mice.

关键词： androgen receptor knockout mice macrophages male hypogonadism metabolic syndrome

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Higher testosterone levels are associated with increased highdensity lipoprotein cholesterol in men with cardiovascular disease： results from the Massachusetts Male Aging Study

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Asian Journal of Andrology 2008年第2期10卷 193-200页

作者： stephanie t. page Beth A. Mohr Carol L. Link Amy B. O＇Oonnell William J. Bremner John B. McKinlay Department of Medicine University of Washington Seattle 98195 USA New England Research Institutes Watertown 02472 USA

Aim： to study the relationship between circulating androgens （total testosterone [tt], free testosterone [It] and dihydrotestosterone [DHt]） and high-density lipoprotein cholesterol （HDL-C） in men with and without cardiovascular disease （CVD）. Methods： Cross-sectional analyses included 1 661 baseline samples from the Massachusetts Male Aging Study （MMAS）, a population-based cohort of men ages 40-70 years. Serum hormones were measured by radioimmunoassay and HDL-C was determined following precipitation of the lower density lipoproteins. CVD was determined by self-report. Analyses were performed using multiple linear regression. Results： tt and HDL-C were positively correlated in the entire sample （r = 0.11, P = 0.0001）. After adjusting for confounders, we found this relationship was mostly limited to the 209 men with CVD. Among men with CVD, tt （P = 0.0004）, it （P = 0.0172） and DHt （P = 0.0128） were all positively correlated with HDL-C, whereas in men without CVD only tt correlated with HDL-C （P = 0.0099）. Conclusion： Our results suggest that if androgens contribute to CVD in middle-aged men, the effect is not related to a suppressive effect of endogenous t on HDL-C. （Asian JAndrol 2008 Mar; 10： 193-200）

关键词： testosterone high-density lipoprotein cholesterol androgens epidemiology

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testicular fine-needle aspiration for the assessmen＇ of intratesticular hormone concentrations

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Asian Journal of Andrology 2016年第1期18卷 21-24页

作者： Ada P Lee Mara Y Roth Jean-Jacques Nya-Ngatchou Kat Lin thomas J Walsh stephanie t page Alvin M Matsumoto William J Bremner John K Amory Bradley D Anawalt Department of Medicine University of California San Francisco San Francisco CA USA Department of Medicine and Center for Research in Reproduction and Contraception University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Washington Seattle WA USA Department of Urology University of Washington Seattle WA USA Department of Medicine Geriatric Research Education and Clinical Center VA Puget Sound Health Care System Seattle WA USA.

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration （FNA） completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. two serious adverse events （0.5%） required surgical intervention. the risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

关键词： male contraception physiology reproductive and urinary testis

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Potential effects of climate change on a marine invasion： the importance of current context

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Current Zoology 2012年第1期58卷 1-8页

作者： Côté, Isabelle M. Green, stephanie J. Department of Biological Sciences Simon Fraser University 8888 University Drive Burnaby BC Canada V5A 1S6

Species invasions threaten marine biodiversity globally. there is a concern that climate change is exacerbating this problem. Here, we examined some of the potential effects of warming water temperatures on the invasion of Western Atlantic habitats by a marine predator, the Indo-Pacific lionfish （Pterois volitans and P. miles）. We focussed on two temperature-dependent aspects of lionfish life-history and behaviour： pelagic larval duration, because of its link to dispersal potential, and prey consump- tion rate, because it is an important determinant of the impacts of lionfish on native prey. Using models derived from fundamental metabolic theory, we predict that the length of time spent by lionfish in the plankton in early life should decrease with warming temperatures, with a concomitant reduction in potential dispersal distance. Although the uncertainty around change in dispersal distances is large, predicted reductions are, on average, more than an order of magnitude smaller than the current rate of range expansion of lionfisli in the Caribbean. Nevertheless, because shorter pelagic larval duration has the potential to increase local re- tention of larvae, local lionfish management will become increasingly important under projected climate change. Increasing tem- perature is also expected to worsen the current imbalance between rates of prey consumption by lionfish and biomass production by their prey, leading to a heightened decline in native reef fish biomass. However, the magnitude of climate-induced decline is predicted to be minor compared to the effect of current rates of lionfish population increases （and hence overall prey consumption rates） on invaded reefs. Placing the predicted effects of climate change in the current context thus reveals that, at least for the lionfish invasion, the threat is clear and present, rather than future [Current Zoology 58 （1）： 1-8, 2012].

关键词： Non-indigenous species Coral reefs Dispersal Ecological impacts of invasion

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Proton Emission–Recent Results and Future Prospects

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原子核物理评论 2016年第2期33卷 180-183页

作者： R.D.page D.t.Joss Department of Physics Oliver Lodge LaboratoryUniversity of Liverpool

Considerable progress has been made in the study of proton-emitting nuclei since the first observation of direct proton emission nearly half a century ago. this has led to improvements in our understanding of this rare decay process and provided invaluable nuclear structure data far from the valley of beta stability. this paper reviews the implications of some recent results for exotic iridium, rhenium and tantalum isotopes and considers prospects for future experimental studies of proton-emitting nuclei located at and above the N = 82 neutron shell closure.

关键词： proton emission alpha decay reduced proton-decay width

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What Does She Look Like？

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空中英语教室（初级版．大家说英语） 2014年第3期 33-35,54,55页

作者： Ellen Lie stephanie Chang(page design )

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A ROAD tRIP

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空中英语教室（初级版．大家说英语） 2014年第3期 20-22,51页

作者： Ruth Devlin stephanie Chang(page design )

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