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Bioactive materials 2021年第12期6卷 4342-4359页

作者： Sophia Hauck Paula Zager Norbert Halfter Elke Wandel marta Torregrossa Ainur Kakpenova Sandra Rother michelle Ordieres Susann Räthel Albrecht Berg stephanie möller matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz Department of Dermatology Venerology und AllergologyLeipzig University04103LeipzigGermany Institute of materials Science Max Bergmann Center for BiomaterialsTechnische Universitǎt Dresden01069DresdenGermany Biomaterials Department INNOVENT e.V.JenaGermany

Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic *** of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic *** we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound *** sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in *** further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo *** a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the *** is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation *** in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one *** immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound *** sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.

关键词： 4-6):sulfated hyaluronan macrophages Immunomodulation Chronic wounds Hydrogel Skin inflammation

Adolescents’ perspectives on a school-based physical activity intervention:A mixed method study

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Journal of Sport and Health Science 2020年第1期9卷 28-40,F0003页

作者： stephanie T.Jong Caroline H.D.Croxson Cornelia Guell Emma R.Lawlor Campbell Foubister Helen E.Brown Emma K.Wells Paul Wilkinson Anna Vignoles Esther m.F.van Sluijs Kirsten Corder mRC Epidemiology Unit and UKCRC Centre for Diet and Activity Research(CEDAR) University of Cambridge School of Clinical MedicineCambridgeCB2 OQQUK Nuffield Department of Primary Care Health Sciences University of OxfordOxfordOX26GGU European Centre for Environment and Human Health University of Exeter Medical SchoolKnowledge SpaRoyal Cornwall HospitalTruroTRI 3HDUK Department of Psychiatry University of Cambridge and Cambridgeshire and Peterborough NHS Foundation TrustCambridgeCB215EFUK Faculty of Education University of CambridgeCambridgeCB28PQUK

Purpose'. To examine adolescent experiences and perspectives of the GoActive intervention (ISRCTN31583496) using mixed methods processevaluation to determine satisfaction with intervention components and interpret a*dolescents experiences of the intervention process in order toprovide insights for future intervention ***'. Participants (n = 1542;13.2 土 0.4 years, mean 土 SD) provided questionnaire data at baseline (shyness, activity level) and post-intervention(intervention acceptability, satisfaction with components). Between-group differences (boys vs. girls and shy/inactive vs. others) weretested with linear regression models, accounting for school clustering. Data from 16 individual interviews (shy/inactive) and 11 focus groupswith 48 participants (mean = 4;range 2—7) were thematically coded. Qualitative and quantitative data were merged in an integrative mixedmethods convergence matrix, which denoted convergence and dissonance across ***'. Effect sizes for quantitative results were small and may not represent substantial between-group differences. Boys (vs. girls) preferredclass-based sessions (0 = 0.2, 95% confidence interval (CI): 0.1—0.3);qualitative data suggested that this was because boys preferred competition,which was supported quantitatively (0 = 0.2, 95%CI: 0.1-0.3). Shy/inactive students did not enjoy the competition (0 = -0.3, 95%CI:—0.5 to —0.1). Boys enjoyed trying new activities more (0 = 0.1, 95%CI: 0.1 -0.2);qualitative data indicated a desire to try new activities acrossall subgroups but identified barriers to choosing unfamiliar activities with self-imposed choice restriction leading to boredom. Qualitative datahighlighted critique of mentorship;adolescents liked the idea, but older mentors did not meet ***. We interpreted adolescent perspectives of intervention components and implementation to provide insights into future complexinterventions aimed at increasing young people's physical activity in s

关键词： Adolescent Intervention mixed methods Physical activity Process evaluation

Fused-core particle technology in high-performance liquid chromatography: An overview

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Journal of Pharmaceutical Analysis 2013年第5期3卷 303-312页

作者： Joseph J.Kirkland stephanie A.Schuster William L.Johnson Barry E.Boyes Advanced materials Technology Inc. Complex Carbohydrate Research Center

The advent of superficially porous particles （SPPs） for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations. The very high efficiency of such columns, combined with convenient operating conditions, modest back pressures and the ability to use conventional HPLC instruments has resulted in intense basic studies of SPP technology, and widespread applications in many sciences. This report contains an overview of the SPP technology first developed in 2006 by Advanced materials Technology, Inc., for sub-3-11m particles, then expanded into a family of SPP products with different particle sizes, pore sizes and other physical parameters. This approach was designed so that each particle of the family could be optimized for separating a particular group of compounds, usually based on solute size.

关键词： Superfcially porous particles Fused-core particles Core–shell particles Peptides Proteins Drug separations

Ophthalmology in the time of COVID-19: experience from Hong Kong Eye Hospital

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 851-859页

作者： stephanie S.L.Cheung Cherie Y.K.Wong Jason C.K.Chan Carmen K.m.Chan N.m.Lam Hunter K.L.Yuen Victoria W.Y.Wong Chi Wai Tsang Clement C.Y.Tham Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SARChina Hong Kong Eye Hospital Hong Kong SARChina

AIm:To review international guidelines and to share our infection control experience during the coronavirus disease 2019(COVID-19)pandemic at a tertiary eye centre in Hong ***:Infection control guidelines and recommendations from international ophthalmological bodies are reviewed and *** measures at our hospital were drawn up as per international and local health authorities’guidelines and implemented with the collaboration of doctors,nurses and administrative ***:The aims of our infection control measures are to 1)minimize cross-infection within the hospital;2)protect and support hospital staff;3)ensure environmental *** minimize the risk of cross-infection,outpatient attendance and elective surgery have been reduced by 40%,and general anesthesia procedures were reduced by 90%.Patients entering the hospital are screened for fever,travel history,contact and cluster history,and COVID-19 related *** protect and support hospital staff,we ensure provision of adequate personal protective equipment(PPE)and provide clear guidelines on the level of PPE needed,depending on the clinical *** protective measures include provision of work uniforms,easy access to alcohol-based hand rub,opening new lunch areas,implementation of self-monitoring and self-reporting systems,and communication via online education and ***,environmental control is achieved by ensuring regular disinfection of the hospital premise,enhancing ventilation,and usage of disposable ophthalmic ***:Our multi-pronged approach to infection control is,so far,successful in minimizing infection risks,while allowing the maintenance of essential ophthalmic services.

关键词： COVID-19 coronavirus SARS-CoV-2 ophthalmology infection control Hong Kong

High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

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World Journal of Gastroenterology 2021年第24期27卷 3630-3642页

作者： Ulrike Bauer Sabine Gerum Falk Roeder Stefan münch stephanie E Combs Alexander B Philipp Enrico N De Toni martha m Kirstein Arndt Vogel Carolin mogler Bernhard Haller Jens Neumann Rickmer F Braren marcus R makowski Philipp Paprottka markus Guba Fabian Geisler Roland m Schmid Andreas Umgelter Ursula Ehmer Internal medicine Ⅱ Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Radiotherapy and Radiation Oncology University of SalzburgSalzburg 5020Austria Department of Radiation Oncology University Hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Department of Radiation Oncology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of medicine II Liver CentreUniversity HospitalLMU MunichMunich 81377Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Institute of Pathology Technical University of MunichMunich 81675Germany Institute of medical Informatics Statistics and EpidemiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Faculty of MedicineUniversity Hospital of MunichMunich 81377Germany Institute of Diagnostic and Interventional Radiology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Diagnostic and Interventional Radiology Section for Interventional RadiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of General- Visceral-Vascular-and Transplant-SurgeryUniversity hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Emergency Department Vivantes hospital groupHumboldt hospitalBerlin 13509Germany

BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation *** to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor *** chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in ***,it remains unclear if one of those treatment options is *** analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by *** To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT *** In this multicenter retrospective study,27 patients who received liver transplantation for HCC were *** received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver *** explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging *** analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and mann-Whitney-U *** Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and *** were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor ***,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests th

关键词： Hepatocellular carcinoma Transarterial chemoembolization Stereotactic body radiation therapy Bridging therapy Liver transplantation

Biologic Augmented microdrilling Surgery for multiple and Large Full-Thickness Cartilage Lesions in the Knee: Early Clinical and Radiological Results

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Surgical Science 2017年第2期8卷 102-117页

作者： Joseph E. Broyles m. Adaire O’Brien stephanie T. Broyles m. Patrick Stagg Bone and Joint Clinic of Baton Rouge Baton Rouge Louisiana USA Pennington Biomedical Research Center Baton Rouge Louisiana USA medical Oncology OLOL Physician Group Baton Rouge Louisiana USA

Background: Various biologic treatments are available for articular cartilage lesions in the knee, but no one exists that is applicable to the full range of chondral disease and that is compliant with United States Food and Drug Administration regulations. The aim of this study was to evaluate outcomes following microdrilling surgery augmented with postoperative injections of bone marrow aspirate concentrate (BmAC), platelet rich plasma (PRP) and hyaluronic acid (HA). methods: Eighteen patients with at least one symptomatic, full-thickness chondral lesion underwent arthroscopic microdrilling surgery. Immediately following surgery, patients received an intra-articular injection of fresh BmAC, PRP, and HA. This injection was repeated once per week for 5 consecutive weeks. At 4 and 12 months postoperatively, patients received 3 additional weekly injections for a total of 12 injections. Outcome measures: IKDC (International Knee Documentation Committee) scores, KS (Knee Society) scores and plain radiographs. Results: The mean treated area was 6.2 ± 4.5 (range, 0.6 - 14.7) cm2. The mean preoperative IKDC and KS scores (±SE) were 43.0 ± 3.2 and 68.3 ± 3.6 respectively. At 24 months postoperatively, IKDC and KS scores improved to 85.3 ± 4.2 and 94.7 ± 4.4, respectively;both changes from baseline were significant (p p = 0.05). This change was greater in patients with preoperative JS p for the difference between groups = 0.1). Conclusions: microdrilling of cartilage lesions augmented with BmAC, PRP, and HA may be a viable treatment for a range of chondral disease with good early clinical and radiological results.

关键词： Cartilage microdrilling Stem Cells Joint Space

Dose Adjustment for Normal Eating: Longer Term Perspectives of Adults with Type 1 Diabetes

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Journal of Diabetes mellitus 2014年第3期4卷 179-188页

作者： Pat Rapley stephanie Axon Gwen Babel Krystina Creighton Joey m. Kaye Suzanne Brown Centre for Nursing Research Sir Charles Gairdner Hospital Perth Australia Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital Perth Australia

Aim:?To explore the longer term blood glucose self-monitoring outcomes and frequency of monitoring for outpatients with diabetes type 1 after completion of the Dose Adjustment for Normal Eating (DAFNE) course. The hypothesis was that DAFNE outcomes would differ according to frequency of glucose ***:?A?sequential data-triangulation design using existing?baseline (T0) and 12-months (T12)?DAFNE course data and interview data from 12 randomly selected participants who had completed the course two years ago.?Results: Age range was 23 to 70 years with HbA1c 6.1% to 12.6% at T0?and 6.1% to 11.4% at T12. Comparisons of HbA1c, PAID, HAD subscales?anxiety?and?depression,?and covariate data between T0?and T12indicatedsignificant reductions in the mean depression and PAID scores (both?P?mes or three or more times per day, changes were not significantly different. For both groups, the trend between T0?and T12?was downwards for change in mean blood glucose level and all survey scales. The proportion of all participants with T12?HbA1c at or below their T0?value was greater than 50% (Proportion = 69%, 95% CI: 56% - 79%) but only the highest HbA1c tertile group showed a significant difference (P?= 0.003). There was an average decrease in the incidence of hypoglycaemic events of 0.6 overall: The greatest change was for the high HbA1c tertile with a mean decrease of 0.8. The interview data suggested that DAFNE graduates experimented more with food, exercise, and insulin;gained knowledge;learnt personal body needs;increased awareness of blood glucose level;gained confidence and improved their quality of life. Conclusions: There was insufficient evidence to conclude that frequency of blood glucose monitoring influenced metabolic control. However, people with type 1 diabetes who undertake the less restricted DAFNE approach to diabetes self-management can improve their qualit

关键词： DAFNE Adults Type 1 Diabetes Long Term

Co-contaminants of microplastics in two seabird species from the Canadian Arctic

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Environmental Science and Ecotechnology 2022年第4期12卷 87-96页

作者： Roxana Sühring Julia E.Baak Robert J.Letcher Birgit m.Braune Amila de Silva Cody Dey Kim Fernie Zhe Lu mark L.mallory stephanie Avery-Gomm Jennifer F.Provencher Department of Chemistry and Biology Toronto Metropolitan University(formerly known as Ryerson University)350 Victoria StTorontoONM5B 2K3Canada Department of Natural Resource Science McGill UniversitySainte Anne de BellevueQuebecH9X 3V9Canada Environment and Climate Change Canada National Wildlife Research CentreCarleton UniversityRaven RoadOttawaOntarioK1A 0H3Canada Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Ecotoxicology&Wildlife Health Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Institut des Sciences de la mer de Rimouski Université du Québec à RimouskiRimouskiQuébecG5L 3A1Canada Department of Biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Through ingestion and subsequent egestion,Arctic seabirds can bioaccumulate microplastics at and around their colony breeding *** microplastics in Arctic seabirds have been well documented,it is not yet understood to what extent these particles can act as transport vehicles for plastic-associated contaminants,including legacy persistent organic pollutants(POPs),trace metals,and organic *** investigated the occurrence and pattern of organic and inorganic co-contaminants of microplastics in two seabird species from the Canadian Arctic-northern fulmar(Fulmarus glacialis)and black-legged kittiwake(Rissa tridactyla).We found that fulmars had higher levels of plastic contamination and emerging organic compounds(known to be plastic additives)than kittiwakes,whereas higher concentrations of legacy POPs were found in kittiwakes than the ***,fulmars,the species with the much larger foraging range(~200 km),had higher plastic pollution and overall contaminant burdens,indicating that birds may be acting as long-range transport vectors for plasticassociated *** results suggest a potential connection between plastic additive contamination and plastic pollution burdens in the bird stomachs,highlighting the importance of treating plastic particles and plastic-associated organic additives as co-contaminants rather than separate pollution issues.

关键词： Plastic contaminants Contaminants of emerging arctic concern Arctic Seabirds PFAS OPEs PBDEs Trace metals