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Establishing research priorities in prevention and control of vector-borne diseases in urban areas:a collaborative process

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Infectious Diseases of Poverty 2018年第1期7卷 860-869页

作者： Christian Dagenais stephanie Degroote Mariam Otmani Del Barrio Clara Bermudez-Tamay. Valery.Ridde Department of Psy.hology University of MontrealPavillon Marie-VictorinBureau C-355C.P.6128succursale Centre-ville.MontrealQC H3C 3J7Canada University.of Montreal Public Health Research Institute MontrealQCCanada Vector Environment and Society UnitSpecial Programme for Research and Training in Tropical Diseases(TDR)World Health OrganizationGenevaSwitzerland Andalusian School of Public Health GranadaSpain CIBER of Epidemiology.and Public Health(CIBERESP) MadridSpain IRD(French Institute for Research on Sustainable Development) CEPED(IRD-Universite Paris Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance.

Background:In 2015,following a call for proposals from the Special Programme for Research and Training in Tropical Diseases(TDR),six scoping reviews on the prevention and control of vector-borne diseases in urban areas were *** reviews provided a clear picture of the available knowledge and highlighted knowledge gaps,as well as needs and opportunities for future *** on the research findings of the scoping reviews,a concept mapping exercise was undertaken to produce a list of priority.research needs to be ***:Members of the six research teams responsible for the“VEctor boRne DiseAses Scoping reviews”(VERDAS)consortium’s scoping reviews met for 2 day. with decision-makers from Colombia,Brazil,Peru,Pan-American Health Organization,and World Health Organization.A total of 11 researchers and seven decision-makers(from ministries of health,city.and regional vector control departments,and vector control programs)completed the concept mapping,answering the question:“In view of the knowledge sy.thesis and y.ur own expertise,what do we still need to know about vector-borne diseases and other infectious diseases of poverty.in urban areas?”Participants rated each statement on two scales from 1 to 5,one relative to‘priority.and the other to‘policy.relevance’,and grouped statements into clusters based on their own individual criteria and ***:The final map consisted of 12 *** considered those entitled“Equity.,“Technology.,and“Surveillance”to have the highest *** cluster considered the most important concerns equity.issues,confirming that these issues are rarely.addressed in research on vector-borne *** the other hand,the“Population mobility.and“Collaboration”clusters were considered to be the lowest priority.but remained identified by.participants as research *** average policy.relevance scores for each of the 12 clusters were roughly.the same as the priority.scores for all ***

关键词： Concept mapping Research priorities Vector-borne diseases Urban areas

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微创技术治疗肝细胞癌的进展

中华消化外科杂志 2009年第2期8卷 81-84页

作者：刘允怡赖俊雄刘晓欣香港中文大学医学院、沙田威尔斯亲王医院

肝细胞癌（hepatocellular carcinoma，HCC）是全球第5位常见恶性肿瘤，50％以上发生在我国。HCC的高危人群以35～65岁为主，尤其以男性患者较多，是女性患者的2～4倍。HCC早期症状不明显，导致大多数患者就诊较晚，整体预后很差。80％... 详细信息

肝细胞癌（hepatocellular carcinoma，HCC）是全球第5位常见恶性肿瘤，50％以上发生在我国。HCC的高危人群以35～65岁为主，尤其以男性患者较多，是女性患者的2～4倍。HCC早期症状不明显，导致大多数患者就诊较晚，整体预后很差。80％～90％的患者在确诊时，由于受肿瘤的大小、部位以及肝脏的基本病变、肝功能和全身状况的影响，不能耐受手术切除。此时，微创技术就成为治疗HCC的重要手段。

关键词：肝肿瘤腹腔镜检查肝切除术导管消融术经肝动脉治疗

Ki-67标记指数作为眼表新生物的一个恶性标记

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 49-49页

作者： ohara M. Sotozono C. Tsuchihashi y. Kinoshita S. 肖颖 Department of Ophthalmology Kyoto Prefectoral Univ. of Medicine 465 Kajii-cho Kamigyo-ku Kyoto 602- 8566 Japan

Purpose: To evaluate the relationships among histopathological ty.e, clinical malignant grade, and Ki-67 labeling index (LI) in sebaceous gland carcinoma (SGC), conjunctival squamous cell carcinoma (SCC), and conjunctival intraepithelial neoplasia (CIN), with ptery.ium and normal conjunctiva as controls. Methods: This retrospective study.was conducted at the Department of Ophthalmology. Ky.to Prefectural University.of Medicine, Ky.to, Japan. We used tissue specimens obtained from 20 patients (four SGC, four SCC, four CIN, four ptery.ium, and four normal conjunctiva). Ki-67 immunohistochemical analy.is was performed in all 20 cases. Results: The Ki-67 labeling index (LI) was 46.1± 3.0% (average± SD) in SGC, 28.4± 4.5% in SCC, 20.0± 7.2% in CIN, 9.0± 2.2% in ptery.ium, and 6.8± 2.3% in normal conjunctiva. Ki-67 LI was significantly.(Mann-Whitney.U test, P y. in SCC than in CIN. Ki-67 LI was significantly.(P y.ium. Conclusions: These results suggest that Ki-67 LI may.be a sensitive marker for ocular malignant tumor grading.

关键词：标记指数新生物结膜鳞状细胞癌翼状胬肉睑板腺癌眼部肿瘤结膜组织恶性程度结膜上皮病理学分型

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自身免疫性胰腺炎与胰腺癌的鉴别诊断

中华消化外科杂志 2013年第2期12卷 96-99页

作者：刘允怡刘晓欣李丽赖俊雄香港中文大学医学院佛山市第一人民医院肝胆外科 528000

自身免疫性胰腺炎（AIP）是全身炎症一纤维化的胰腺表现，亦是免疫球蛋白G4相关的硬化性疾病。AIP具有独特的临床症状、影像学、血清学、病理组织学及胰腺外症状特点。AIP的临床特征与胰腺癌有相似之处，但也有区别。特别要强调的是仅... 详细信息

自身免疫性胰腺炎（AIP）是全身炎症一纤维化的胰腺表现，亦是免疫球蛋白G4相关的硬化性疾病。AIP具有独特的临床症状、影像学、血清学、病理组织学及胰腺外症状特点。AIP的临床特征与胰腺癌有相似之处，但也有区别。特别要强调的是仅以临床表现不能明确鉴别两者。对于AIP的诊断目前有两个不同的诊断标准：美国May.中心的临床HISORt诊断标准，以及日本胰腺学会和韩国医学中心提出的亚洲诊断标准。AIP确诊后，主要治疗手段为类固醇类药物治疗，治疗效果较好；但在患者良好反应后类固醇类药物是否作为维持治疗尚有争议。

关键词：自身免疫性胰腺炎胰腺肿瘤诊断

Exposure to Fine Particles by.Mine Tailing and Lung Function Effects in a Panel of Schoolchildren,Chanaral,Chile

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Journal of Environmental Protection 2015年第2期6卷 118-128页

作者： Karla y.hannessen Vasquez Sergio Alvarado Orellana stephanie Mesias Monsalve Jose Klarian Vergara Claudio Silva Zamora Daniella Vidal Munoz Dante D.Caceres Lillo Programa de Salud Ambiental Escuela de Salud PublicaFacultad de MedicinaUniversidad de ChileSantiago de ChileChile Grups de Recerca d’America i AfricaLlatines Unitat de BioestadisticaFacultat de MedicinaUniversitat Autonoma de BarcelonaBarcelonaEspana Facultad de Ciencias de la Salud Universidad de TarapacaAricaChile Departamento de Prevencion de Riesgos y.Medio Ambiente Universidad Tecnologica MetropolitanaSantiagoChile

There is much literature on the effects of fine particulate matter (PM2.5) on respiratory.and cardiovascular health. However, few studies have evaluated the impact of PM2.5 on a population living in the vicinity.of a massive deposit of mine tailings. A longitudinal panel study.was performed to evaluate the association between exposure to PM2.5 and acute effects on lung function in schoolchildren from November 2012 to May.2013. Ambient levels of PM2.5 and its metal composition were measured. Lung function was evaluated using spirometric testing. Associations were quantified using GEE multilevel analy.is controlling for confounders by.using different lag time periods. The chemical characterization of PM2.5 had high levels of S > Na > Cl > Ca > Si > Fe > Al > Mg > K > Cu > Ti > and Zn, which would be associated with metals present in tailings. We found a negative association between the temporal variation of PM2.5 and changes in lung function specifically.on forced vital capacity. Our results suggest that schoolchildren exposed to fine particulate matter from tailings deposited in the bay.of Chanaral have their forced vital capacity.decreased, which would affect their present and future lung development, increasing the risk of developing chronic respiratory.diseases.

关键词： Mine Tailings Fine Particulate Matter Heavy.Metals Lung Function Schoolchildren

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y.人带来崭新工作态度

疯狂英语（初中天地） 2006年第3期 46-46页

作者： stephanie Armour 何如佑

你是y.人吗?你觉得自己是个我行我素又独立自主的人吗?本文向你介绍了y.人的一些特点。 Check it out!

关键词：工作态度

Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genoty.e 1b infection

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World Journal of Gastroenterology 2018年第12期24卷 1361-1372页

作者： Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey.A y.kovlev Wen Xie Eduard Burnevich Jun-Qi Niu y.ng Jin Jung Xiang-Jun Jiang Min Xu Xin-y.e Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou y.sh Gandhi Wen-Hua Hu Fiona McPhee stephanie Noviello Michelle Treitel Ling Mo Jun Deng Peking University.People’s Hospital and Peking University.Hepatology.Institute Beijing 100044China Qingdao Municipal Hospital Qingdao 266011Shandong ProvinceChina Guangzhou No.8 People’s Hospital Guangzhou 510060Guangdong ProvinceChina Beijing y.uan Hospital Capital Medical UniversityBeijing 100069China Shanghai Ruijin Hospital Jiaotong University School of MedicineShenyang 200025Liaoning ProvinceChina TheFirst Affiliated Hospital with Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Hepatology.Unit Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina China Medical University Shengjing HospitalShenyang 110004Liaoning ProvinceChina Bristol-My.rs Squibb PrincetonNJ 08540United States Bristol-My.rs Squibb WallingfordCT 06492United States 302 Military.Hospital of China Beijing 100039China Bristol-My.rs Squibb Shanghai 200040China the Sixth People’s Hospital of Sheny.ng Shenyang 110006Liaoning ProvinceChina Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Saint-Petersburg State Healthcare Institution'Clinical Infectious Hospital n.a.S.P.Botkin’ Saint-Petersburg 191167Russia Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China I.M.Sechenov First Moscow State Medical University Moscow 119991Russia The First Hospital of Jilin University Jilin 1300021Jilin ProvinceChina SMG-SNU Boramae Medical Center Seoul 07061South Korea

AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genoty.e 1 b infection. METHODS Patients were randomly.assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily.and asunaprevir 100 mg twice daily. beginning on day.1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary.endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study.were blinded. Safety.was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms *** In total, 207 patients were randomly.assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged y.ars(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genoty.es and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by.92%(95% confidence interval: 87.2-96.0), which was significantly.higher than the historical comparator rate(70%). SVR12 was largely.unaffected by.cirrhosis(89%), age ≥ 65 y.ars(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genoty.es(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated poly.orphisms(at L31 or y.3 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy.combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory.tract infection; emergent

关键词： Asunaprevir Daclatasvir Direct-acting antiviral Chronic hepatitis C Liver disease NS3 NS5A Genoty.e 1b

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道天地法将成功企业必备的五大谋略

2006年

作者：（美）叶祖尧（Ray.ond T. y.h）（美）叶馨梅（stephanie y.h）周伯生廖彬山译

本书作者把孙子兵法中的五大谋略放在西方最好的企业经营案例中加以验证，论述了企业管理的最高境界、管理的实务流程以及演进过程的自然步骤。

ISBN: (数字)7802075181

ISBN: (纸本)7802075181

本书作者把孙子兵法中的五大谋略放在西方最好的企业经营案例中加以验证，论述了企业管理的最高境界、管理的实务流程以及演进过程的自然步骤。

关键词：企业管理研究

来源：汇雅图书（南通市图书馆... 评论

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肝实质离断技术的选择与评价

中华消化外科杂志 2010年第2期9卷 87-89页

作者：赖俊雄刘晓欣刘允怡香港中文大学医学院、沙田威尔斯亲王医院

在肝脏外科的发展过程中，肝实质离断技术经历过许多演变。传统的技术有指折法和钳夹法。近年来新的肝实质离断技术和器械不断涌现。这些技术都基于同一个目的：快速肝实质离断、将失血量降至最少及封闭胆管以避免术后发生胆汁漏。不同... 详细信息

在肝脏外科的发展过程中，肝实质离断技术经历过许多演变。传统的技术有指折法和钳夹法。近年来新的肝实质离断技术和器械不断涌现。这些技术都基于同一个目的：快速肝实质离断、将失血量降至最少及封闭胆管以避免术后发生胆汁漏。不同的肝实质离断技术各有其优缺点。这些技术的具体使用则取决于患者的一般情况、术者的经验以及单位的条件。本文旨在讨论及比较各种肝实质的离断技术。

关键词：肝切除术肝肿瘤出血