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Childhood opportunity and appropriate use of child safety restraints in motor vehicle collisions

World Journal of Pediatric Surgery 2024年第2期7卷 142-149页

作者： stephanie y chen Iris Garcia Shadassa Ourshalimian Chantel Lowery Pradip P Chaudhari Ryan G Spurrier Pediatric Surgery Children's Hospital Los AngelesLos AngelesCaliforniaUSA Injury Prevention Program Children's Hospital Los AngelesLos AngelesCaliforniaUSA Emergency and Transport Medicine Children's Hospital Los AngelesLos AngelesCaliforniaUSA Pediatrics University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA Surgery University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA

Objectives Safety restraints reduce injuries from motor vehicle collisions(MVCs)but are often improperly applied or not *** Childhood Opportunity Index(COI)reflects social determinants of health and its study in pediatric trauma is *** hypothesized that MVC patients from low-opportunity neighborhoods are less likely to be appropriately *** A retrospective cross-sectional study was performed on children/adolescents≤18 years old in MVCs between January 1,2011 and December 31,*** were identified from the Children's Hospital Los Angeles trauma *** outcome was safety restraint use(appropriately restrained,not appropriately restrained).COI levels by home zip codes were stratified as very low,low,moderate,high,and very *** regression controlling for age identified factors associated with safety restraint *** Of 337 patients,73.9%were appropriately restrained and 26.1%were not appropriately *** with appropriately restrained patients,more not appropriately restrained patients were from low-COI(26.1%vs 20.9%),high-COI(14.8%vs 10.8%)and very high-COI(10.2%vs 3.6%)*** analysis demonstrated no significant associations in appropriate restraint use and *** was a non-significant trend that children/adolescents from moderate-COI neighborhoods were more likely than those from very low-COI neighborhoods to be appropriately restrained(OR=1.82,95%CI 0.78,4.28).Conclusion Injury prevention initiatives focused on safety restraints should target families of children from all neighborhood types.

关键词： MVC restrained neighborhood

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PCR-based methodologies for detection and characterization of Listeria monocytogenes and Listeria ivanovii in foods and environmental sources

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Food Science and Human Wellness 2017年第2期6卷 39-59页

作者： Jin-Qiang chen stephanie Healey Patrick Regan Pongpan Laksanalamai Zonglin Hu Winchester Engineering&Analytical Center(WEAC) HFR-NE460Office of Regulatory AffairsUS Food and Drug Administration109 Holton StreetWinchesterMA 01890USA MD DHMH Laboratories Administration Division of MicrobiologyRoom 5281770 Ashland Ave.BaltimoreMD 21205USA

Listeria monocytogenes is an important foodborne pathogen responsible for listeriosis,a fatal *** is widely distributed in various foods and environmental *** this review,we focused on addressing PCR-based technologies,including conventional PCR,qPCR and droplet digital PCR(ddPCR).Specifically,we described(a)conventional PCR and mono-,duplex-and multiplex-qPCR methodologies;(b)development and applications of gene HlyA-,Iap-,PrfA–and SsrA-based conventional and qPCR assays as well as PCR assays targeting newly identified gene targets for specific detection of ***;differentiation of viable from dead *** by qPCR in conjugation with propidium monoazide pretreatment;PCR-based serotype identification of *** isolates;PCR-based detection of ***,infecting ruminants,differentiation of *** from other Listeria species;and sigB-gene based PCR identification of Listeria spp;(c)applications of ddPCR in detection of ***;and(d)application of qPCR assays in detection and subtyping of *** in milk and dairy products;meats,meat products and meat-processing environment;and seafood,seafood products and processing *** goal was to provide a relatively comprehensive overview of PCR-based methodologies available in detection,characterization and subtyping of various strains of *** in foods and environmental sources.

关键词： Foodborne pathogens Listeria monocytogenes Listeria ivanovii qPCR

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Synchrotron microtomography reveals insights into the degradation kinetics of bio-degradable coronary magnesium scaffolds

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Bioactive Materials 2024年第2期32卷 1-11页

作者： Roman Menze Bernhard Hesse Maciej Kusmierczuk Duote chen Timm Weitkamp stephanie Bettink Bruno Scheller MeKo Manufacturing e.K. Im Kirchenfelde 12-1431157SarstedtGermany Xploraytion GmbH Bismarckstr.10-1210625BerlinGermany Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190Saint-AubinFrance InnoRa GmbH Robert-Koch-Platz 410115BerlinGermany Universität des Saarlandes Campus Homburg66421HomburgGermany

Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis,especially for young *** to the degradation of these scaffolds(<1 year),long-term device-related clinical events c... 详细信息

Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis,especially for young *** to the degradation of these scaffolds(year),long-term device-related clinical events could be reduced compared to treatments with conventional drug eluting *** clinical trials indicate a return of vasomotion after one year,which may be associated with improved long-term clinical ***,even after decades of development,the degradation process,ideal degradation time and biological response in vivo are still not fully *** present study investigates the in vivo degradation of magnesium scaffolds in the coronary arteries of pigs influenced by different strut thicknesses and the presence of antiproliferative *** to high 3D image contrast of synchrotron-based micro-CT with phase contrast(SR-μCT),a qualitative and quantitative evaluation of the degradation morphology of magnesium scaffolds was *** the segmentation of theμCT images a convolutional network architecture(U-net)was exploited,demonstrating the huge potential of merging high resolution SR-μCT with deep learning(DL)supported data *** total,30 scaffolds,made of the rare earth alloy Resoloy^(®),with different strut designs were implanted into the coronary arteries of 10 domestic pigs for 28 days using drug-coated or uncoated angioplasty balloons for *** degradation morphology was analyzed using scanning electron microscopy,energy dispersive x-ray spectroscopy and SR-μ*** data from these methods were then related to data from angiography,optical coherence tomography and histology.A thinner strut size(95 vs.130μm)and the presence of paclitaxel indicated a slower degradation rate at 28 d in vivo,which positively influences the late lumen loss(0.5 and 0.6 mm vs.1.0 and 1.1 mm)and recoil values(0 and 1.7%vs.6.1 and 22%).

关键词： Resoloy Magnesium scaffold DCB Paclitaxel Degradation Inflammation Artificial intelligence

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Contactless probing of the intrinsic carrier transport single-walled carbon nanotubes

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Nano Research 2014年第11期7卷 1623-1630页

作者： yize stephanie Li Jun Ge Jinhua Cai Jie Zhang Wei Lu Jia Liu Liwei chen Suzhou Institute of Nano-Tech and Nono-Bionics Chinese Academy of Sciences Suzhou Jiongsu 215123 Chino Present address: Department of Materials Science and Engineering University of Wisconsin-Madison Madison W153 706 USA Present address: Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA

Intrinsic carrier transport properties of single-walled carbon nanotubes have been probed by two parallel methods on the same individual tubes： The contactless dielectric force microscopy （DFM） technique and the conventional field-effect transistor （FET） method. The dielectric responses of SWNTs are strongly correlated with electronic transport of the corresponding FETs. The DC bias voltage in DFM plays a role analogous to the gate voltage in FET. A microscopic model based on the general continuity equation and numerical simulation is built to reveal the link between intrinsic properties such as carrier concentration and mobility and the macroscopic observable, i.e. dielectric responses, in DFM experiments. Local transport barriers in nanotubes, which influence the device transport behaviors, are also detected with nanometer scale resolution.

关键词： single-walled carbon nanotubes electronic transport dielectric force microscopy field-effect transistor carrier density carrier mobility

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Trends of carbon and nutrient accumulation through time in the Andong salt marsh,Hangzhou Bay,China

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Journal of Oceanology and Limnology 2023年第6期41卷 2134-2145页

作者： Pei Sun LOH Aimin JIN Zhanghua LOU Xuegang chen Shuangyan HE chen-Tung Arthur chen stephanie PARKER Jianxiong HU Hongwei yUAN Longxiu chenG Department of Marine Sciences Ocean CollegeZhejiang UniversityZhoushan 316021China Department of Oceanography National Sun Yat-sen UniversityKaohsiung 804China

Salt marshes are important carbon and nutrient sinks that are threatened by climate changes and human *** this study,the accumulation rates of sedimentary total organic carbon(TOC),total nitrogen(TN),and total phosphorus(TP)from two cores in the Andong salt marsh,Hangzhou Bay,were investigated to determine whether TOC,TN,and TP show increasing or decreasing trends toward the *** TOC accumulation rates at the relatively lower marsh were lower during 1990-1996(1.63-2.37 g/(cm^(2)·a))than 1997-2014(1.15-4.30 g/(cm^(2)·a)).The TN accumulation rates increased from 1990(0.14 g/(cm^(2)·a))toward 2012(0.40 g/(cm^(2)·a)),then decreased toward 2014(0.16 g/(cm^(2)·a)).The TP accumulation rates were lower during 1990-1999(0.10-0.21 mg/(cm^(2)·a)),and decreased from 2000(0.32 mg/(cm^(2)·a))toward 2014(0.15 mg/(cm^(2)·a)).The TOC accumulation rates along the relatively upper marsh during 1982-1992(1.18-3.25 g/(cm^(2)·a))were lower than during 1998-2010(2.30-4.20 g/(cm^(2)·a)),and then decreased toward 2015(2.15 g/(cm^(2)·a)).TN increased from 1982(0.18 g/(cm^(2)·a))to 2005(0.41 g/(cm^(2)·a)),then decreased toward 2015(0.22 g/(cm^(2)·a)).TP accumulation rates fluctuated within a narrow range during 1982-1997(0.21-0.41 mg/(cm^(2)·a)),increased from 1998(0.50 mg/(cm^(2)·a))to 2004(0.87 mg/(cm^(2)·a)),then decreased to 2015(0.38 mg/(cm^(2)·a)).Thus,increases in accumulation rates of TOC,TN,and TP from the 1980s to 1990s indicates that the marsh likely served as carbon and nutrient sinks,then the rates decreased during 2000-2015 due probably to the reduced sediment inputs from rivers and intensified sea level rise.

关键词： wetland climate change anthropogenic activity marsh degradation

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Aluminum and Glyphosate Can Synergistically Induce Pineal Gland Pathology: Connection to Gut Dysbiosis and Neurological Disease

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Agricultural Sciences 2015年第1期6卷 42-70页

作者： stephanie Seneff Nancy Swanson chen Li Computer Science and Artificial Intelligence Laboratory MIT Cambridge MA USA Independent Researcher Abacus Enterprises Lummi Island WA USA

Many neurological diseases, including autism, depression, dementia, anxiety disorder and Parkinson’s disease, are associated with abnormal sleep patterns, which are directly linked to pineal gland dysfunction. The pineal gland is highly susceptible to environmental toxicants. Two pervasive substances in modern industrialized nations are aluminum and glyphosate, the active ingredient in the herbicide, Roundup?. In this paper, we show how these two toxicants work synergistically to induce neurological damage. Glyphosate disrupts gut bacteria, leading to an overgrowth of Clostridium difficile. Its toxic product, p-cresol, is linked to autism in both human and mouse models. p-Cresol enhances uptake of aluminum via transferrin. Anemia, a result of both aluminum disruption of heme and impaired heme synthesis by glyphosate, leads to hypoxia, which induces increased pineal gland transferrin synthesis. Premature birth is associated with hypoxic stress and with substantial increased risk to the subsequent development of autism, linking hypoxia to autism. Glyphosate chelates aluminum, allowing ingested aluminum to bypass the gut barrier. This leads to anemia-induced hypoxia, promoting neurotoxicity and damaging the pineal gland. Both glyphosate and aluminum disrupt cytochrome P450 enzymes, which are involved in melatonin metabolism. Furthermore, melatonin is derived from tryptophan, whose synthesis in plants and microbes is blocked by glyphosate. We also demonstrate a plausible role for vitamin D3 dysbiosis in impaired gut function and impaired serotonin synthesis. This paper proposes that impaired sulfate supply to the brain mediates the damage induced by the synergistic action of aluminum and glyphosate on the pineal gland and related midbrain nuclei.

关键词： Pineal Gland Aluminum Glyphosate Genetically Engineered Crops Autism Sulfate

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Digital earth:yesterday,today,and tomorrow

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International Journal of Digital Earth 2023年第1期16卷 1022-1072页

作者： Alessandro Annoni Stefano Nativi ArzuÇöltekin Cheryl Desha Eugene Eremchenko Caroline M.Gevaert Gregory Giuliani Min chen Luis Perez-Mora Joseph Strobl stephanie Tumampos International Society for Digital Earth BeijingPeople’s Republic of China National Research Council RomeItaly University of Applied Sciences and Arts Northwestern Switzerland FHNW School of EngineeringInstitute of Interactive Technologies IITBrugg-WindischSwitzerland Nathan Campus Griffith UniversityCities Research InstituteBrisbaneAustralia Lomonosov Moscow State University MoscowRussia Department of Earth Observation Science University of TwenteTwenteThe Netherland Institute for Environmental Sciences/enviroSPACE University of GenevaGenevaSwitzerland Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjingPeople’s Republic of China Cities Research Institute Nathan CampusGriffith UniversityBrisbaneAustralia Department of Geoinformatics University of SalzburgSalzburgAustria Chair of Remote Sensing Technology Technical University of MunichMunichGermany Big Geospatial Data Management Technical University of MunichMunichGermany

The concept of Digital Earth(DE)was formalized by Al Gore in *** that time the technologies needed for its implementation were in an embryonic stage and the concept was quite *** then digital technologies have progressed significantly and their speed and pervasiveness have generated and are still causing the digital transformation of our *** creates new opportunities and challenges for the realization of DE.‘What is DE today?’,‘What could DE be in the future?’,and‘What is needed to make DE a reality?’.To answer these questions it is necessary to examine DE considering all the technological,scientific,social,and economic aspects,but also bearing in mind the principles that inspired its *** understanding the lessons learned from the past,it becomes possible to identify the remaining scientific and technological challenges,and the actions needed to achieve the ultimate goal of a‘Digital Earth for all’.This article reviews the evolution of the DE vision and its multiple definitions,illustrates what has been achieved so far,explains the impact of digital transformation,illustrates the new vision,and concludes with possible future scenarios and recommended actions to facilitate full DE implementation.

关键词： Digital Earth digital transformation sustainable development data governance and ethic citizen empowerment and industry engagement

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Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?

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Asian Journal of Urology 2019年第3期6卷 264-269页

作者： Dominique Thomas Kevin C.Zorn Nadir Zaidi stephanie Ashley chen yiye Zhang Alexis Te Bilal Chughtai Department of Urology Weill Cornell Medical College/New York PresbyterianNew YorkNYUSA Section of Urology Department of SurgeryUniversity of Montreal Hospital CenterMontrealQCCanada Department of Healthcare Policy and Research Weill Cornell Medical College/New York PresbyterianNYUSA

Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were *** patients underwent *** retention was noted by the preoperative necessity for an indwelling or intermittent *** collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative *** parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of *** baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary *** baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not *** was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not *** UDS parameter predicted who would void postoperatively or improvements in ***:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS *** men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months.

关键词： Benign prostatic enlargement Detrusor underactivity Follow-up Photovaporization of the prostate Urodynamic study

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Death as a Drug Side Effect in FAERS: Is Glyphosate Contamination a Factor?

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Agricultural Sciences 2015年第12期6卷 1472-1501页

作者： stephanie Seneff Nancy Swanson chen Li Gerald Koenig Computer Science and Artificial Intelligence Laboratory MIT Cambridge MA USA Abacus Enterprises Lummi Island WA USA Health-e-Iron LLC Austin TX USA

An analysis of selected datasets from the FDA’s drug Adverse Event Reporting System (FAERS) leads us to hypothesize that glyphosate contamination in both food and drugs is a major contributor to chronic and acute kidney failure respectively. In chronic kidney failure, glyphosate-induced pancreatitis results in the release of trypsin, causing a leaky vasculature. The albumin-bound glyphosate escapes into the tissues, protecting the circulatory system and kidneys but resulting in multiple symptoms related to skin, gut, brain, bones, lungs, etc. The rare and poorly understood acute kidney failure response reported for protamine sulfate and Trasylol? is strikingly similar to that associated with glyphosate poisoning. Both drugs are derived from biological tissues that are plausibly contaminated with glyphosate. These drugs protect from haemorrhage, which leads to retention of glyphosate in the vasculature, are followed by circulatory collapse and a high likelihood of death as an outcome. We support our argument by comparing symptom profiles of selected subsets of FAERS with those related to glyphosate poisoning, anomalous reactions to protamine sulfate, and conditions showing strong statistical time-trend correlations with glyphosate.

关键词： Drug Side Effects Drug Contamination Renal Failure Glyphosate Pancreatitis Osteonecrosis Protamine Sulfate Aprotinin Oedema

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Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography(PET)

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1204-1215页

作者： yu Lan Ping Bai Zude chen Ramesh Neelamegam Michael SPlaczek Hao Wang stephanie AFiedler Jing yang Gengyang yuan Xiying Qu Hayden RSchmidt Jinchun Song Marc DNormandin Chongzhao Ran Changning Wang Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Gordon Center for Medical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02129USA Department of Pharmacy Renmin Hospital of Wuhan UniversityWuhan 430060China

The sigma-1 receptor(σ1R)is a unique intracellular protein.σ1R plays a major role in various pathological conditions in the central nervous system(CNS),implicated in several neuropsychiatric *** ofσ1R in the brain using positron emission tomography(PET)could serve as a noninvasively tool for enhancing the understanding of the disease’s ***,σ1R PET tracers can be used for target validation and quantification in ***,we describe the radiosynthesis,in vivo PET/CT imaging of novelσ1R11C-labeled radioligands based on 6-hydroxypyridazinone,[11C]HCC0923 and[11C]*** radioligands have high affinities toσ1R,with good *** mice PET/CT imaging,both radioligands showed appropriate kinetics and ***,the specific interactions of two radioligands were reduced by compounds 13 and 15(self-blocking).Ofthe two,[11C]HCC0929 was further investigated in positive ligands blocking studies,using classicσ1R agonist SA 4503 andσ1R antagonist PD ***σ1R ligands could extensively decreased the uptake of[11C]HCC0929 in mice ***,the biodistribution of major brain regions and organs of mice were determined in *** studies demonstrated that two radioligands,especially[11C]HCC0929,possessed ideal imaging properties and might be valuable tools for non-invasive quantification ofσ1R in brain.

关键词： σ1R PET Brain imaging 6-Hydroxypyridazinone 11C-labeled radioligand

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