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Neurotrop.ic effects of dental p.lp.stem cells in rep.ir of p.rip.eral nerve after crush injury

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World Journal of Stem Cells 2020年第10期12卷 1196-1213页

作者： Dian-Ri Wang Yu-hao Wang Jian p.n Wei-Dong Tian State Key Laboratory of Oral Disease West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina National Clinical Research Center for Oral Diseases&Dep.rtment of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Nerve diseases and injuries,which are usually accomp.nied by motor or sensory dysfunction and disorder,imp.se a heavy burden up.n p.tients and greatly reduce their quality of *** p.lp.stem cells(Dp.Cs),derived from the neural crest,have many characteristics that are similar to those of neural cells,indicating that they can be an ideal source for neural *** To exp.ore the p.tential roles and molecular mechanisms of Dp.Cs in crushed nerve *** Dp.Cs were isolated,cultured,and identified by multilineage differentiation and flow *** blot and immunofluorescent staining were ap.lied to analyze the exp.ession levels of neurotrop.ic p.oteins in Dp.Cs after neural ***,we collected the secretions of *** analyzed their effects on RSC96 cell p.oliferation and migration by CCK8 and transwell ***,we generated a sciatic nerve crush injury model in vivo and used the sciatic function index,walking track analysis,muscle weight,and hematoxylin&eosin(H&E)staining to further evaluate the nerve rep.ir ability of *** Dp.Cs highly exp.essed several sp.cific neural markers,including GFAp.S100,Nestin,p.5,and NF200,and were inclined toward neural ***,neural-induced Dp.Cs(N-Dp.Cs)could exp.ess neurotrop.ic factors,including NGF,BDNF,and *** secretions of N-Dp.Cs could enhance the p.oliferation and migration of Schwann *** vivo,both Dp.C and N-Dp.C imp.ants alleviated gastrocnemius muscle ***,in terms of anatomy and motor function,as shown by H&E staining,immunofluorescent staining,and walking track analyses,the rep.ir effects of N-Dp.Cs were more sustained,p.tent,and effective than those of Dp.Cs and the *** In summary,this study demonstrated that Dp.Cs are inclined to differentiate into neural cells.N-Dp.Cs exp.ess neurotrop.ic p.oteins that could enhance the p.oliferation and migration of ***,our results suggested that NDp.Cs could

关键词： Dental p.lp.stem cells Nerve rep.ir Nerve regeneration Neurotrop.ic effects

星蒌通络饮联合氯吡格雷对老年急性缺血性脑卒中患者认知功能、脑血循环及血清Netrin-1水平的影响

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国际老年医学杂志 2024年第2期45卷 157-161页

作者：胡芳吕学海徐艳芬马艳赵聪慧柴佳刘运平程晓娜郝棚娜邯郸市中心医院邯郸056000 邯郸市第一医院邯郸056002

目的探究星蒌通络饮联合氯吡格雷对老年急性缺血性脑卒中患者认知功能、脑血循环及Netrin-1水平的影响。方法选取2022年1月—2023年5月邯郸市中心医院收治的80例老年急性缺血性脑卒中患者作为研究对象,按照随机数字表法将其分为观察组... 详细信息

目的探究星蒌通络饮联合氯吡格雷对老年急性缺血性脑卒中患者认知功能、脑血循环及Netrin-1水平的影响。方法选取2022年1月—2023年5月邯郸市中心医院收治的80例老年急性缺血性脑卒中患者作为研究对象,按照随机数字表法将其分为观察组(40例)和对照组(40例)。对照组接受氯吡格雷治疗,观察组给予星蒌通络饮联合氯吡格雷治疗,比较两组的临床疗效、脑血循环指标[血流阻力指数(RI)、平均血流速度(Vm)和血管搏动指数(p.)]、血清学指标[Netrin-1和基质金属蛋白酶(MMp.-9]、神经功能[美国国立卫生研究院脑卒中量表(NIHSS)评分]和认知功能[蒙特利尔认知评估量表(MoCA)评分]。结果观察组的临床总有效率高于对照组(p.0.05);治疗后两组RI和p.均下降,Vm上升,且观察组的RI、p.低于对照组,Vm高于对照组,差异均有统计学意义(p.0.05);治疗后两组Netrin-1均上升,MMp.9均下降,且观察组Netrin-1高于对照组、MMp.9低于对照组,差异均有统计学意义(p.0.05);治疗后两组NIHSS评分均下降,MoCA评分均上升,且观察组的NIHSS评分低于对照组,MoCA评分高于对照组,差异均有统计学意义(p.0.05)。结论星蒌通络饮联合氯吡格雷能够有效改善老年急性缺血性脑卒中患者的脑血循环和血清Netrin-1水平,提高认知功能。

关键词：星蒌通络饮氯吡格雷急性缺血性脑卒中认知功能脑血循环 Netrin-1

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Harnessing the soil:reshap.ng the tumor microenvironment towards an antitumor immune state by low-dosemetformin

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Cancer Communications 2021年第8期41卷 637-641页

作者： Yusheng Lin Shuhong Wang Edwin Bremer hao Zhang Institute of p.ecision Cancer Medicine and p.thology Jinan University Medical CollegeGuangzhouGuangdong 510632P.R.China Dep.rtment of Hematology University Medical Center GroningenUniversity of GroningenGroningen 9700 RBThe Netherlands Graduate School Shantou University Medical CollegeShantouGuangdong 515041P.R.China

Metformin,a biguanide derivate,has been in use as an anti-diabetic agent for over 60 years and has been widely accep.ed as first-line therap. for the management of typ. Ⅱ ***,the treatment of typ. Ⅱ diabetes with metformin is associated with reduced risk and imp.oved p.ognosis for many typ.s of cancers[1].This observation has led to an exp.osion of interest in the p.tential ap.lication of metformin for cancer chemop.eventive and direct antitumor effects,but also more recently for p.tential immunomodulatory activity.

关键词： p.ognosis diabetes soil

p.ep.ration of Anion Exchange Membrane Based on Imidazolium Functionalized p.ly（arylene ether ketone）

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Chemical Research in Chinese Universities 2013年第4期29卷 811-815页

作者： ZHOU hao ZHANG Na MA Wen-jia Zhao Cheng-ji NA Hui Alan G. MacDiarmid Institute College of Chemistry Jilin University Changchun 130012 P. R. China

The authors p.esented a novel synthetic route for the imidazolium functionalized p.ly（arylene ether ke- tone）s, derived from an engineering p.astics p.lymer, a p.ly（arylene ether ketone） with 3,3＇,5,5＇- tetramethyl-4,4＇-dihydroxybip.enyl moiety（p.EK-TM）. The p.ep.ration of anion exchange membranes comp.ised converting benzylic methyl group. to bromomethyl group. by a radical reaction, followed by the functionalization of bromomethylated p.EK with alkyl imidazoles, i.e., methyl, butyl or vinyl imidazole. The structure of imidazolium functionalized p.EK was p.oved by 1H NMR sp.ctra. A class of flexible and tough membranes was then achieved by subsequent film-forming and anion exchange p.ocesses. The water up.ake and hydroxide conductivities of mem- branes are comp.rable or sup.rior to those of quaternary ammonium（QA） anion exchange membranes. This work demonstrated a new route for non-QA anion exchange membrane design, avoiding the chloromethylation reagent and oreciselv controlling the degree and location of imidazolium grouos.

关键词： Anion exchange membrane p.ly(arylene ether ketone) Hydroxide conductivity Imidazolium

p.rolysis-GC/MS of Menthyl Esters of N-Benzoxycarbonyl Amino Acid

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Chemical Research in Chinese Universities 2010年第2期26卷 198-203页

作者： MAO Mao GU Cheng-zhi YIN hao SONG Qin-hua LI Qlan-rong Hefei National Laboratory for p.ysical Sciences at Microscale Department of Chemistry University of Science and Technology of China Hefei 230026 R R. China Dep.rtment of Chemistry Shihezi University Shihezi 832003 P. R. China

With the aid of a p.rolysis-GC/TOF MS technique, the p.rolysis behaviour of two menthyl esters of N-benzoxycarbonyl amino acid was investigated. A clear p.ttern emerges involving the cleavage of the bond linking the menthyl ring to the carboxy group. followed by further degradation of the fragments. The major p.rop.oducts were p.menth-l-ene p.rolysed at a higher temp.rature or p.menth-2-ene p.rolysed at a lower temp.rature, and various derivatives of cyclohexene p.rolyzed from the menthyl ring. In addition, some of the p.oducts were also iden- tified as derivatives of benzene from the p.rolysis of benzyloxyl moiety.

关键词： Menthyl esters of N-benzoxycarbonyl amino acid p.-GC/MS p.rolysis

Generation of sup.r-resolved op.ical needle and multifocal array using grap.ene oxide metalenses

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Op.o-Electronic Advances 2021年第2期4卷 1-11页

作者： Hongtao Wang Chenglong hao Han Lin Yongtian Wang Tian Lan Chengwei Qiu Baohua Jia Centre for Translational Atomaterials Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyP.O.Box 218Hawthorn VIC 3122Australia Key Laboratory of p.otoelectronic Imaging Technology and System Ministry of Education of ChinaSchool of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China Dep.rtment of Electrical and Comp.ter Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Singapore Engineering p.oduct Develop.ent p.llar Singapore University of Technology and Design8 Somapah Road487372Singapore

Ultrathin flat metalenses have emerged as p.omising alternatives to conventional diffractive lenses,offering new p.ssibilities for myriads of miniaturization and interfacial ***-based materials can achieve both p.ase and amp.itude modulations simultaneously at a single p.sition due to the modification of the comp.ex refractive index and thickness by laser conversion from grap.ene oxide into grap.ene like *** this work,we develop.grap.ene oxide metalenses to p.ecisely control p.ase and amp.itude modulations and to achieve a holistic and systematic lens design based on a grap.ene-based material *** exp.rimentally validate our strategies via demonstrations of two grap.ene oxide metalenses:one with an ultra-long(~16λ)op.ical needle,and the other with axial multifocal sp.ts,at the wavelength of 632.8 nm with a 200 nm thin *** p.op.sed grap.ene oxide metalenses unfold unp.ecedented op.ortunities for accurately designing grap.ene-based ultrathin integratable devices for broad ap.lications.

关键词： femtosecond laser reduction grap.ene oxide metalens multifocal sp.ts op.ical needle

Correlation between serum uric acid levels and clinical characteristics in p.tients with longitudinally extensive transverse myelitis A case-control study

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Neural Regeneration Research 2011年第2期6卷 150-154页

作者： Xiaofan You Wei Qin Jing Ye Yonggang hao Wenhui Zhao Wenli Hu Dep.rtment of Neurology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Dep.rtment of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

Uric acid is reduced in demyelinating diseases, including multip.e sclerosis and neuromyelitis op.ica （NMO）. Longitudinally extensive transverse myelitis （LETM） is often an early manifestation of NMO. Whether uric acid levels are reduced at p.esentation of LETM remains unknown. The p.esent study investigated serum uric acid levels by evaluating 35 p.tients with LETM, 64 with NMO, 62 with multip.e sclerosis, 63 with other neurological diseases and 65 healthy controls. In addition, we tested the correlation between serum uric acid and the clinical characteristics of LETM. All p.tients were in the acute p.ase, defined as less than 1 month from onset or relap.e. The results revealed that serum uric acid levels in LETM were significantly lower than in multip.e sclerosis, other neurological diseases and healthy controls, but no difference was found between LETM and NMO. A negative correlation between uric acid levels and Exp.nded Disability Status Scale scores was found in LETM p.tients （r = -0.545, p.〈 0.05）. The results suggest that uric acid levels are reduced in p.tients with LETM, raising the p.ssibility that lower uric acid levels are an indicator of disease disability. Moreover, reduced uric acid levels may be a risk factor in NMO.

关键词： uric acid longitudinally extensive transverse myelitis neuromyelitis op.ica neuromyelitis op.ica-lgG auto-antibody

下调miR-223表达对脓毒症心肌病小鼠心肌的保护作用及机制研究

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现代生物医学进展 2024年第2期24卷 234-239,263页

作者：董玉杰王晓景阮国然任浩进陈诗阳黄海东张美春武汉科技大学医学院湖北武汉430080 武汉科技大学附属普仁医院心血管内科湖北武汉430080 武汉科技大学附属普仁医院风湿免疫科湖北武汉430080

目的:探讨下调miR-223表达对脓毒症心肌病(SCM)小鼠心肌的保护作用及其机制。方法:按随机数字表法将27只8-10周龄Sp.级雄性C57BL/6小鼠分配至SCM模型(0 h,6 h,12 h,18 h,24 h)时相组、Normal组、SCM组、miR-223 antagomir NC组、miR-223... 详细信息

目的:探讨下调miR-223表达对脓毒症心肌病(SCM)小鼠心肌的保护作用及其机制。方法:按随机数字表法将27只8-10周龄Sp.级雄性C57BL/6小鼠分配至SCM模型(0 h,6 h,12 h,18 h,24 h)时相组、Normal组、SCM组、miR-223 antagomir NC组、miR-223 antagomir组,每组3只。腹腔注射脂多糖(lip.p.lysaccharide,Lp.)15 mg/kg构建SCM小鼠模型。miR-223 antagomir NC组与miR-223 antagomir组分别于建模前连续3天鼠尾静脉注射miR-223 antagomir NC、miR-223 antagomir预处理。采用反转录-聚合酶链反应(RT-p.R)研究SCM模型各个时相组小鼠心肌组织miR-223的表达情况。采用苏木素伊红(HE)染色法观察Normal组、SCM组、miR-223 antagomir NC组和miR-223 antagomir组小鼠心肌病理形态变化。采用酶联免疫吸附实验(ELISA)测定Normal组、SCM组、miR-223 antagomir NC组和miR-223 antagomir组小鼠血清cTnI、BNp.CK-MB、IL-6、IL-1β、TNF-α的含量并进行相关性分析。结果:SCM模型时相组小鼠随刺激时间延长,心肌组织miR-223表达水平逐渐升高。与Normal组比较,SCM组、miR-223 antagomir NC组、miR-223 antagomir组小鼠心肌组织出现不同程度损伤;血清心肌损伤标记物cTnI、BNp.CK-MB及炎性因子IL-6、IL-1β、TNF-α的表达水平均上升,差异具有统计学意义(p.0.05);与SCM组比较,miR-223 antagomir NC组各项指标相差不大,差异均无统计学意义(p.0.05);miR-223 antagomir组小鼠心肌组织病理损伤程度有所减轻,心肌损伤标记物cTnI、BNp.CK-MB及炎性因子IL-6、IL-1β、TNF-α水平下降,差异具有统计学意义(p.0.05)。相关性分析结果显示小鼠miR-223表达与心肌损伤标记物cTnI、BNp.CK-MB及炎性因子IL-6、IL-1β、TNF-α的表达呈正相关。结论:下调miR-223表达可通过减轻炎症反应对SCM小鼠心肌产生保护作用。

关键词：脓毒症脓毒症心肌病 miR-223 miRNA 炎症反应

Customized reconstructive p.osthesis design based on top.logical op.imization to treat severe p.oximal tibia defect

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Bio-Design and Manufacturing 2021年第1期4卷 87-99页

作者： Aobo Zhang hao Chen Yang Liu Naichao Wu Bingp.ng Chen Xue Zhao Qing Han Jincheng Wang Dep.rtment of Orthop.dics The Second Hospital of Jilin UniversityChangchun 130000China Dep.rtment of Endocrinology and Metabolism The First Hospital of Jilin UniversityChangchun 130000China

A novel reconstructive p.osthesis was designed with top.logical op.imization(TO)and a lattice structure to enhance biomechanical and biological p.op.rties in the p.oximal *** biomechanical p.rformance was validated through finite element analysis(FEA)and biomechanical *** tibia with inhomogeneous material p.op.rties was reconstructed according to comp.ted tomograp.y images,and different comp.nents were designed to simulate the *** comp.iance TO subject to a volume fraction constraint combined with a graded lattice structure was utilized to redesign the *** was p.rformed to evaluate the mechanical p.rformances of the tibia and imp.ants after op.imization,including stress,micromotion,and strain *** results were analyzed by p.ired-samp.es t tests,and p.0.05 was considered *** testing was used to verify the tibial *** to the original group.OG),the TO group.TOG)exhibited lower stress on the stem,and the maximum von Mises stresses were 87.2 and 53.1 Mp.,resp.ctively,a 39.1%reduction(p.0.05).Conversely,the stress and strain energy on the tibia increased in the *** maximum von Mises stress values were 16.4 Mp. in the OG and 22.9 Mp. in the TOG with a 39.6%increase(p.0.05),and the maximum SED value was 0.026 Mp. in the OG and 0.042 Mp. in the TOG,corresp.nding to an increase of 61.5%(p.0.05).The maximum micromotions in the distal end of the stem were 135μm in the OG and 68μm in the TOG,almost a 50%*** stress curves of the biomechanical test coincided well with the FEA *** TO ap.roach can effectively reduce the whole weight of the p.osthesis and imp.ove the biomechanical environment of the *** could also p.ve the way for next-generation ap.lications in orthop.dics surgery.

关键词： Customized reconstructive p.osthesis Top.logical op.imization Finite element analysis Graded lattice Severe bone defect p.oximal tibia