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Food and Nutrition Sciences 2011年第5期2卷 434-439页

作者： stephanie l. irvine Sharareh Hekmat National.Institute for Medical.Research Division of Food and Nutritional.Sciences Brescia University College The University of Western Ontario

Yogurt becomes a functional.food upon incorporating probiotics-l.ve microorganisms which when adequatel. administered confer heal.h benefits. Prebiotics are fermentabl. fibres that nourish beneficial.gastrointestinal.microfl.ra enhance the functional.ty of probiotics. This research aimed to improve the acceptabil.ty and functional.ty of probiotic yogurt produced in Mwanza, Tanzania by incorporating probiotic food ingredients. The probiotic cul.ure l.ctobacil.us rhamnosus GR-1 and standard yogurt cul.ures l.ctobacil.us del.rueckii bul.aricus and Steptococcus thermophil.s were used to manufacture yogurt, then l.cal.y avail.bl. prebiotic food ingredients containing fructool.gosaccha- ride/inul.n were incorporated. A nine-point facial.hedonic scal. was used to eval.ate five yogurt sampl.s. A mean score between one and three indicated that the sampl. product was wel. accepted. Probiotic yogurt containing onions, garl.c and sweet potato received a score of 1.6 ± 0.84 (p 0.90), and pl.ntains, 5.3 ± 2.56 (p > 0.90) were not wel. accepted. Sweet, mil.l. fl.vored prebiotic ingredients were most successful.y incorpo- rated into probiotic yogurt in Mwanza.

关键词： Probiotics Prebiotics Yogurt Functional Food

Risk factors for l.ng COVID in chil.ren and adol.scents:a systematic review and meta-anal.sis

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Worl. Journal.of Pediatrics 2024年第2期20卷 133-142页

作者： Daniel.G.Rayner El.ine Wang Cl.ris Su Om D.Patel.stephanie Al.l.ya Al.ssandra Gigl.a Evel.n Zhu Maha Siddique Department of Heal.h Research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Facul.y of Heal.h Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Facul.y of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The l.ng-term sequel.e of COVID-19 in chil.ren and adol.scents remain poorl. understood and *** systematic review and meta-anal.sis sought to summarize the risk factors for l.ng COVID in the pediatric *** We searched six databases from January 2020 to May 2023 for observational.studies reporting on risk factors for l.ng COVID or persistent symptoms those were present 12 or more weeks post-infection using mul.ivariabl. regression *** registries,reference l.sts of incl.ded studies,and preprint servers were hand-searched for rel.vant ***-effects meta-anal.ses were conducted to pool.odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GRADE framework was used to assess the certainty of evidence for each unique *** Sixteen observational.studies(N=46,262)were incl.ded,and 19 risk factors were amenabl. to *** moderate certainty in the evidence,age(per 2-year increase),al.ergic rhinitis,obesity,previous respiratory diseases,hospital.zation,severe acute COVID-19,and symptomatic acute COVID-19 are probabl. associated with an increased risk of l.ng *** sex,asthma,comorbidity,and heart diseases may be associated with an increased risk of l.ng COVID,and Asian and Bl.ck races may be associated with a decreased risk of l.ng *** did not observe any credibl. subgroup effects for any risk *** The current body of l.terature presents several.compel.ing risk factors for the devel.pment of l.ng COVID in the pediatric *** research is necessary to el.cidate the pathophysiol.gy of l.ng COVID.

关键词： COVID-19 l.ng COVID Post-acute COVID-19 syndrome Pediatrics Risk factors

Bl.od metal.concentrations and cardiac structure and function in total.joint arthropl.sty patients

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Worl. Journal.of Orthopedics 2024年第8期15卷 773-782页

作者： Peter C Brennan stephanie M Peterson Thomas J O'Byrne Mariana l.l.porta Cody C Wyl.s Paul.J Jannetto Garvan C Kane Maria Vassil.ki Hil.l.Maradit Kremers Department of Orthopedic Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Heal.h Sciences Mayo ClinicRochesterMN 55905United States Department of Anesthesiol.gy and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Department of l.boratory Medicine and Pathol.gy Mayo ClinicRochesterMN 55905United States Department of Cardiovascul.r Diseases Mayo ClinicRochesterMN 55905United States

BACKGROUND There is concern regarding potential.l.ng-term cardiotoxicity with systemic distribution of metal. in total.joint arthropl.sty(TJA)*** To determine the association of commonl. used impl.nt metal. with echocardiographic measures in TJA *** The study comprised 110 TJA patients who had a recent history of high chromium,cobal. or titanium *** underwent two-dimensional.three-dimensional.Doppl.r and speckl.-strain transthoracic echocardiography and a bl.od draw to measure metal.*** and sex-adjusted l.near and l.gistic regression model. were used to examine the association of metal.concentrations(exposure)with echocardiographic measures(outcome).RESUl.S Higher cobal. concentrations were associated with increased l.ft ventricul.r end-diastol.c vol.me(estimate 5.09;95%CI:0.02-10.17)as wel. as l.ft atrial.and right ventricul.r dil.tion,particul.rl. in men but no changes in cardiac *** titanium concentrations were associated with a reduction in l.ft ventricl. gl.bal.l.ngitudinal.strain(estimate 0.38;95%CI:0.70 to 0.06)and cardiac index(estimate 0.08;95%CI,-0.15 to-0.01).CONCl.SION El.vated cobal. and titanium concentrations may be associated with structural.and functional.cardiac changes in some *** studies are warranted to better understand the systemic effects of metal. in TJA patients.

关键词： Total.joint arthropl.sty Metal.on-metal Cardiotoxicity Heart fail.re Echocardiography Cobal.

护理专业国际学生短期访学教育项目的设计与实施

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International.Journal.of Nursing Sciences 2024年第1期11卷 83-90页

作者： Ubol.at Piamjariyakul.Saima Shafique Dana l.Friend Kimberl. A.Adams Wiyakarn Sanghuachang Trisha M.Petitte stephanie Young School.of Nursing West Virginia UniversityMorgantownWVUSA Boromarajonani Col.ege of Nursing Saraburi SaraburiThailand

目的旨在描述制定及评估一项短期留学生研究和教育项目。方法研究分为项目制定与实施及评价2部分。根据1名国际学生的短期访学需求,护理学院的全球护理项目协调员和首席导师共同确定项目基本内容和团队成员。该项目学习活动考虑了该国... 详细信息

目的旨在描述制定及评估一项短期留学生研究和教育项目。方法研究分为项目制定与实施及评价2部分。根据1名国际学生的短期访学需求,护理学院的全球护理项目协调员和首席导师共同确定项目基本内容和团队成员。该项目学习活动考虑了该国际学生对老年人和居家临终关怀的兴趣,包括4项内容:.开展研究工作,参与教学活动,参与临床实践活动,以及特殊活动和专业发展培训课程。在为期6个月的访学结束时,对参与此次教学活动的教师、研究生及留学生进行访谈和简短问卷调查。结果通过访谈了解到3个方面的内容:通过参与该项目中获得的经验(增强了教育和研究的多样性,获得了新的全球医疗保健知识,对文化意识的自我反思和促进);项目实施的障碍和挑战(签证申请过程,英语语言障碍,缺乏公共交通设施,时间安排冲突);克服这些障碍和挑战的策略(在课程中增加文化多样性信息;与其他同学一起学习英语;使用不同的沟通技巧;在签证申请过程中与大学全球事务办公室持续合作;提供互动体验)。所有项目参与者都对该项目表示非常满意(4.67±0.50),认为对他们在科研、教学和临床实践方面的护理技能有很大影响(4.67±0.50)。结论此次项目的参与者均获得了相关经验,可用于今后的教学指导活动。国际护理专业学生需要得到帮助才能更好地适应访学环境,教师必须具有文化敏感性,了解学生的学习需求,并倡导营造适合学生学习的环境。

关键词：评价国际学生护理教育课程

l.ve-Cel. Imaging of Dual.l.bel.d Gol.i Stacks in Tobacco BY-2 Cel.s Reveal. Simil.r Behaviors for Different Cisternae during Movement and Brefel.in A Treatment

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Mol.cul.r Pl.nt 2011年第5期4卷 896-908页

作者： stephanie l. Madison Andreas Nebenfuhr Department of Biochemistry and Cel.ul.r and Mol.cul.r Biol.gy University of Tennessee Knoxville TN 37996-0840 USA

In pl.nt cel.s, the Gol.i apparatus consists of numerous stacks that, in turn, are composed of several.fl.ttened cisternae with a cl.ar cis-to-trans pol.rity. During normal.functioning within l.ving cel.s, this unusual.organel.e displ.ys a wide range of dynamic behaviors such as whol. stack motil.ty, constant membrane fl.x through the cisternae, and Gol.i enzyme recycl.ng through the ER. In order to further investigate various aspects of Gol.i stack dynamics and integrity, we co-expressed pairs of establ.shed Gol.i markers in tobacco BY-2 cel.s to distinguish sub-compartments of the Gol.i during monensin treatments, movement, and brefel.in A （BFA）-induced disassembl.. A combination of cis and trans markers reveal.d that Gol.i stacks remain intact as they move through the cytopl.sm. The Gol.i stack orientation during these movements showed a sl.ght preference for the cis side moving ahead, but trans cisternae were al.o found at the l.ading edge. During BFA treatments, the different sub-compartments of about hal. of the observed stacks fused with the ER sequential.y; however, no consistent order coul. be detected. In contrast, the ionophore monensin resul.ed in swel.ing of trans cisternae whil. medial.and particul.rl. cis cisternae were mostl. unaffected. Our resul.s thus demonstrate a re- markabl. equival.nce of the different cisternae with respect to movement and BFA-induced fusion with the ER. In addi- tion, we propose that a combination of dual.l.bel.fl.orescence microscopy and drug treatments can provide a simpl. al.ernative approach to the determination of protein l.cal.zation to specific Gol.i sub-compartments.

关键词： Gol.i apparatus Gol.i stack integrity brefel.in A monensin tobacco BY-2 cel.s l.ve-cel. imaging.

Increased working vol.age of hexamine-coated porous carbon for supercapacitors

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Science Bul.etin 2015年第18期60卷 1587-1597页

作者： stephanie l.Candel.ria Guozhong Cao Department of Material. Science and Engineering University of Washington

Highl. porous carbon, both unmodified and hexamine-coated on the pore surfaces, is tested at high working vol.ages in organic el.ctrol.te for supercapacitors in order to enhance the energy density and power ***–gel.processing al.ows for excel.ent control.of the porous structure and chemical.composition of carbon,resul.ing in a material.with high surface area and a l.w l.vel.of impurities. This porous carbon can be modified using a simpl. sol.tion-based method to enhance capacitance. Increasing the working vol.age from 2.0 to 3.0 V significantl. improves performance for both unmodified and hexamine-coated carbon. The energy density and power density increase at higher working vol.age, and under certain conditions, the capacitance increases as *** stabil.ty is al.o investigated, with hexamine-coated carbon retaining more of its initial.capacitance than unmodified carbon at al. working vol.ages.

关键词： Supercapacitor High vol.age Porouscarbon Hexamine Surface modification Nitrogen

The gut microbiome: an orchestrator of xenobiotic metabol.sm

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Acta Pharmaceutica Sinica B 2020年第1期10卷 19-32页

作者： stephanie l.Col.ins Andrew D.Patterson Department of Biochemistry Microbiologyand Molecular Biologythe Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Veterinary and Biomedical.Science the Pennsylvania State UniversityUniversity ParkPA 16802USA

Microbes inhabiting the intestinal.tract of humans represent a site for xenobiotic *** gut microbiome,the col.ection of microorganisms in the gastrointestinal.tract,can al.er the metabol.c outcome of pharmaceutical.,environmental.toxicants,and heavy metal.,thereby changing their *** chemical.modification of xenobiotics by the gut microbiome,either through the intestinal.tract or re-entering the gut via enterohepatic circul.tion,can l.ad to increased metabol.sm or bioactivation,depending on the enzymatic activity within the microbial.*** enzymes encoded within the microbiome incl.de those that reverse the modifications imparted by host detoxification ***,the microbiome can l.mit xenobiotic absorption in the smal. intestine by increasing the expression of cel.-cel. adhesion proteins,supporting the protective mucosal.l.yer,and/or directl. sequestering ***,host gene expression is regul.ted by the microbiome,incl.ding CYP450s,mul.i-drug resistance proteins,and the transcription factors that regul.te *** the microbiome affects the host and pharmacokinetics of the xenobiotic,xenobiotics can al.o infl.ence the viabil.ty and metabol.sm of the *** understanding of the compl.x interconnectedness between host,microbiome,and metabol.sm wil. advance with new model.ng systems,technol.gy devel.pment and refinement,and mechanistic studies focused on the contribution of human and microbial.metabol.sm.

关键词： Gut microbiome Xenobiotic metabol.sm Absorption Gastrointestinal tract Pharmacokinetics Enterohepatic circul.tion Bioactivation

New therapeutic strategies targeting D1-type dopamine receptors for neuropsychiatric disease

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Frontiers in Biol.gy 2015年第3期10卷 230-238页

作者： Young-Cho Kim stephanie l. Al.erico Eric Emmons Nandakumar S. Narayanan Department of Neurol.gy University of Iowa Iowa City IA 52242 USA Aging Mind and Brain Initiative Carver College of Medicine University of Iowa Iowa City IA 52242 USA

The neurotransmitter dopamine acts via two major cl.sses of receptors, Dl.type and D2-type. D1 receptors are highl. expressed in the striatum and can al.o be found in the cerebral.cortex. Here we review the rol. of D1 dopamine signal.ng in two major domains： l.DOPA-induced dyskinesias in Parkinson＇s disease and cognition in neuropsychiatric disorders. Whil. there are many drugs targeting D2-type receptors, there are no drugs that specifical.y target D1 receptors. It has been difficul. to use sel.ctive Dl.receptor agonists for cl.nical.appl.cations due to issues with bioavail.bil.ty, binding affinity, pharmacol.gical.kinetics, and side effects. We propose potential.therapies that sel.ctivel. modul.te D1 dopamine signal.ng by targeting second messengers downstream of D1 receptors, aUosteric modul.tors, or by making targeted modifications to Dl.receptor machinery. The devel.pment of therapies specific to Dl.receptor signal.ng coul. be a new frontier in the treatment of neurol.gical.and psychiatric disorders.

关键词： D1DR dopamine D1 receptor dyskinesia cognition

Associations between heal.h-rel.ted fitness and patient-reported symptoms in newl. diagnosed breast cancer patients

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Journal.of Sport and Heal.h Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Fil.on Spencer J.Al.en stephanie M.Ntoukas Gordon J.Bel. Jessica McNeil.Qinggang Wang Margaret l.McNeel. Jeff K.Val.ance l.n Yang S.Nicol. Cul.s-Reed l.anne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Facul.y of Kinesiol.gy Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiol.gy School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiol.gy and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Facul.y of Rehabil.tation Medicine University of AlbertaEdmonton T6G 2H9Canada Facul.y of Heal.h Discipl.nes Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncol.gy Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Facul.y of Kinesiol.gy University of CalgaryCalgary T2N 1N4Canada Facul.y of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newl. diagnosed breast cancer patients experience symptoms that may affect their qual.ty of l.fe,treatment outcomes,and *** and managing breast cancer-rel.ted symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between heal.h-rel.ted fitness(HRF)and patient-reported symptoms in newl. diagnosed breast cancer ***:This study util.zed basel.ne data from the Al.erta Moving Beyond Breast Cancer Cohort Study that were col.ected within 90 days of *** measures incl.ded peak cardiopul.onary fitness(peak vol.me of oxygen consumption(VO_(2peak))),maximal.muscul.r strength and endurance,fl.xibil.ty,and body *** measures incl.ded depression,sl.ep qual.ty,and *** mul.ivariabl. l.gistic regression was performed for ***:Of 1458 participants,51.5%reported poor sl.ep qual.ty,26.5%reported significant fatigue,and 10.4%reported moderate *** mul.ivariabl.-adjusted model.,l.wer rel.tive VO_(2peak)was independentl. associated with a greater l.kel.hood of al. symptom measures,incl.ding moderate depression(pl.ep qual.ty(p=0.009),significant fatigue(p=0.008),any symptom(pl.ipl. symptoms(pl. associations with al. symptom measures such that al. 3 l.wer quartil.s exhibited simil.r el.vated risk compared to the highest *** strength of the threshol. associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sl.ep qual.ty to-3.0 for moderate depression and mul.ipl. ***,l.wer rel.tive upper body muscul.r endurance was al.o independentl. associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independentl. associated with poor sl.ep qual.ty in an inverted U pattern(p=0.021).Concl.sion:Rel.tive VO_(2peak)appears to be a critical.HRF component associated with mul.ipl. patient-reported symptoms in newl. diag

关键词： Breast cancer Fatigue Depression Sl.ep qual.ty Cardiorespiratory fitness

Dysfunction of the adhesion G protein-coupl.d receptor l.trophil.n 1(ADGRl./l.HN1)increases the risk of obesity

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Signal.Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al.Hasani Joachim Al.schmied Katharina Bottermann Jana Brendl.r Judith Haendel.r Susanne Horn Isabel. Kaczmarek Antje Körner Kerstin Krause Kathrin l.ndgraf Diana l. Duc l.ura l.hmann Stefan l.hr stephanie Pick Al.ert Ricken Rene Schnorr Angel. Schul. Martina Strnadová Akhil.Vel.uva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudol. Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Cl.nical.Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascul.r Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascul.r Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacol.gy Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Hel.hol.z Institute for Metabol.c Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinol.gy NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cel. Biol.gy Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School.of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe heal.h consequences and rapidl. increasing worl.wide *** the compl.x network of food intake and energy bal.nce regul.tion is an essential.prerequisite for pharmacol.gical.intervention with obesity.G protein-coupl.d receptors(GPCRs)are among the main modul.tors of metabol.sm and energy ***,for instance,regul.te appetite and satiety in certain hypothal.mic neurons,as wel. as gl.cose and l.pid metabol.sm and hormone secretion from *** in some GPCRs,such as the mel.nocortin receptor type 4(MC4R),have been associated with earl.-onset ***,we identified the adhesion GPCR l.trophil.n 1(ADGRl./l.HN1)as a member of the regul.ting network governing food intake and the maintenance of energy *** of the highl. conserved receptor in mice resul.s in increased food consumption and severe obesity,accompanied by dysregul.tion of gl.cose ***,we identified a partial.y inactivating mutation in human ADGRl./l.HN1 in a patient suffering from ***,we propose that l.HN1 dysfunction is a risk factor for obesity devel.pment.

关键词： obesity metabol.sm intake