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Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases

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genes & Diseases 2022年第5期9卷 1194-1207页

作者： XiaoYi He stephanie Tan Zhong Shao Xiao Wang Department of Neurology Affiliated Zhongshan Hospital of Dalian UniversityDalianLiaoning 116001PR China The Third Hospital of Fushun FushunLiaoning 113004PR China Stanley Manne Children’s Research Institute Ann&Robert H.Lurie Children’s Hospital of ChicagoChicagoIL 60611USA Department of Pediatrics Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA

Macrophages are dominant innate immune *** demonstrate remarkable het-erogeneity and plasticity that are essential for homeostasis and host *** heterogeneity of tissue macrophages is shaped by the ontogeny,tissue factors,and environmental signals,a pattern in a tissue-associated latitudinal *** the same time,macrophages have long been considered as mainly plastic *** cells respond to stimulation quickly and in a stimulus-specific way by utilizing a longitudinal cascaded activation,including coordination of signal trans-ducer,epigenetic elements,and transcription factors,conclusively determine the macrophage phenotypes and *** the development of cutting-edge technologies,such as fate-mapping,single-cell transcriptomics,ipsc platform,nanotherapeutic materials,etc.,our under-standing of macrophage biology and the roles in the pathogenesis of diseases is much *** review summarizes recent progress on the latitudinal and longitudinal regulation of tissue macrophages in inflammatory *** latitudinal regulation covers the tissue macrophage or-igins,tissue factors,and environmental signals,reflecting the macrophage *** lon-gitudinal regulation focuses on how multiple factors shape the phenotypes and functions of macrophage subsets to gain plasticity in inflammatory diseases(i.e.,inflammatory bowel disease).In addition,how to target macrophages as a potential therapeutic approach and cutting edge-technologies for tissue macrophage study are also discussed in this review.

关键词： Epigenetic regulation Inflammatory disease microRNA Macrophage origin Macrophage polarization Single-cell RNA-sequencing Tissue macrophage

Inverse-designed spinodoid metamaterials

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npj Computational Materials 2020年第1期6卷 1029-1038页

作者： Siddhant Kumar stephanie Tan Li Zheng Dennis M.Kochmann Mechanics&Materials Lab Department of Mechanical and Process EngineeringETH Zürich8092 ZürichSwitzerland Faculty of Electrical Engineering Mathematics and Computer ScienceDelft University of Technology2628 CD DelftNetherlands graduate Aerospace Laboratories California Institute of TechnologyPasadenaCA 91125USA

After a decade of periodic truss-,plate-,and shell-based architectures having dominated the design of metamaterials,we introduce the non-periodic class of spinodoid *** by natural self-assembly processes,spinodoid metamaterials are a close approximation of microstructures observed during spinodal phase *** theoretical parametrization is so intriguingly simple that one can bypass costly phase-field simulations and obtain a rich and seamlessly tunable property ***,breaking with the periodicity of classical metamaterials is the enabling factor to the large property space and the ability to introduce seamless functional *** introduce an efficient and robust machine learning technique for the inverse design of(meta-)materials which,when applied to spinodoid topologies,enables us to generate uniform and functionally graded cellular mechanical metamaterials with tailored direction-dependent(anisotropic)stiffness and *** specifically present biomimetic artificial bone architectures that not only reproduce the properties of trabecular bone accurately but also even geometrically resemble natural bone.

关键词： density property periodic

Androgens exert sexually dimorphic effects on angiogenesis： novel insight into the relationship between androgens and cardiovascular disease

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Asian Journal of Andrology 2011年第4期13卷 626-627页

作者： Katya B Rubinow John K Amory stephanie T Page Division of Metabolism Endocrinology and Nutrition University of Washington Seattle WA 98195 USA general internal Med c ne Un versity of Washington Seattle WA 98195 USA

The effects of androgen exposure on cardiovascular disease （CVD） risk in men remain poorly understood. given the earlier incidence of CVD among men relative to women, androgens historically have been assumed to pote... 详细信息

关键词： Androgens sexually

Leaf size versus leaf numbertradeoffs in dioecious angiosperms

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Journal of Plant Ecology 2013年第1期6卷 29-35页

作者： stephanie L.Scott Lonnie W.Aarssen Department of Biology Queen’s UniversityKingstonOntarioCanada K7L 3N6

Aims We explore the possible role of leaf size/number trade-offs for the interpretation of leaf size dimorphism in dioecious plant *** Total above-ground biomass(both male and female)for three herbaceous dioecious species and individual shoots(from both male and female plants)for three woody dioecious species were sampled to record individual leaf dry mass,number of leaves,dry mass of residual above-ground tissue(all remaining non-leaf biomass),number of flowers/inflorescences(for herbaceous species)and number of *** Findings For two out of three woody species and two out of three herbaceous species examined,male plants produced smaller leaves but with higher leafing intensity—*** leaves per unit of supporting(residual)shoot tissue or plant body mass—compared with *** and female plants,however,did not differ in shoot or plant body mass or branching *** interpret these results as possible evidence for a dimorphic leaf deployment strategy that promotes both male and female function,*** male plants,capacity as a pollen donor may be favored by selection for a broadly spaced floral display,hence favoring relatively high leafing intensity because this provides more numerous axillary meristems that can be deployed for flowering,thus requiring a relatively small leaf as a *** one herbaceous species,higher leafing intensity in males was associated with greater flower production than in *** contrast,in female plants,selection favors a relatively large leaf,we propose,because this promotes greater capacity for localized photosynthate production,thus supporting the locally high energetic cost of axillary fruit and seed development,which in turn requires a relatively low leafing intensity as a trade-off.

关键词： bud bank leaf dimorphism leafing intensity dioecy

Applications of 3D printed chimeric DNA biomaterials

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Engineered Regeneration 2022年第1期3卷 13-23页

作者： stephanie Dobres giridhar Mula Jonathan Sauer Donghui Zhu Department of Biomedical Engineering Stony Brook University100 Nicolls RdStony BrookNY 11794USA

The influence of genetic engineering on daily life is prominent,from genetically modified food to transgenic,antibiotic resistant *** direct manipulation of an organism’s genotype has opened the door to a myriad of applications in an effort to treat chronic *** paper proposes the unification of chimeric DNA technology and three-dimensional bioprinting to spark the development of new *** studies of chimeric DNA,*** DNA,have been conducted since 1970,bioprinting is a budding method for tissue engineering and regenerative *** technologies are further described in the background section of this paper,and followed by a detailed analysis into current research,benefits,and limitations of 3D printed chimeric *** benefits include low-cost and effective treatments for cancer,bio-morphological nanostructures for targeted drug delivery,personalized medicine with the use of stem cells,and a significantly reduced rate of addi-tional surgeries and transplant rejection after ***,there are several shortcomings with current chimeric DNA applications,***-T cell therapies,and ethical dilemmas regarding the creation and regulation of human-animal *** review then presents future directions,in which inks made from chimeric DNA and live cells can be printed into bioactive engineered tissue,or biodegradable vehicles for targeted delivery of hiPSCs or CAR ***,this review concludes with a reaffirmation of its main points and the authors’thoughts on the potential of 3D printed chimeric biomaterials.

关键词： Chimeric DNA biomaterials Chimeric biomaterials Recombinant DNA 3D printing Bioprinting Tissue engineering Regenerative medicine CAR T-cell therapy

Secretory IgA in complex with Lactobacillus rhamnosus potentiates mucosal dendritic cell-mediated Treg cell differentiation via TLR regulatory proteins, RALDH2 and secretion of IL-IO and TgF-β

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Cellular & Molecular Immunology 2017年第6期14卷 546-556页

作者： Josip Mikulic stephanie Longet Laurent Favre Jalil Benyacoub Blaise Corthesy R&D Laboratory Division of Immunology and Allergy CHUV Centre des Laboratoires d'Epalinges 1066 Epalinges Switzerl Nutrition and Health Nestle Research Center 1000 Lausanne 26 Switzerland

The importance of secretory IgA in controlling the microbiota is well known, yet how the antibody affects the perception of the commensals by the local immune system is still poorly defined. We have previously shown that the transport of secretory IgA in complex with bacteria across intestinal micmfold cells results in an association with dendritic cells in Peyer＇s patches. However, the consequences of such an interaction on dendritic cell conditioning have not been elucidated. In this study, we analyzed the impact of the commensal Lactobacillus rhamnosus, alone or associated with secretory IgA, on the responsiveness of dendritic cells freshly recovered from mouse Peyer＇s patches, mesenteric lymph nodes, and spleen. Lactobacillus rhamnosus-conditioned mucosal dendritic cells are characterized by increased expression of Toll-like receptor regulatory proteins lincluding single immunoglobulin interleukin-1 receptor-related molecule, suppressor of cytokine signaling 1, and Toll-interacting moleculel and retinaldehyde dehydrogenase 2, low surface expression of co-stimulatory markers, high anti- versus pro-inflammatory cytokine production ratios, and induction of T regulatory cells with suppressive function. Association with secretory IgA enhanced the anti-inflammatory/regulatory Lactobacillus rhamnosus-induced conditioning of mucosal dendritic cells, particularly in Peyer＇s patches. At the systemic level, activation of splenic dendritic cells exposed to Lactobacillus rhamnosus was partially dampened upon association with secretory IgA. These data suggest that secretory IgA, through coating of commensal bacteria, contributes to the conditioning of mucosal dendritic cells toward tolerogenic profiles essential for the maintenance of intestinal homeostasis.

关键词： commensal bacteria dendritic cells secretory IgA TLR regulatory proteins T regulatory cells

Beyond Brexit Negotiations: The Impact of Brexit on UK-China Relations from A Higher Education Perspective

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Beyond Brexit Negotiations: The Impact of Brexit on UK-China...

作者： stephanie Sam 上海交通大学

学位级别：硕士

This thesis explores the changes of UK-China bilateral relations from 2013-2019,using the2016 Brexit referendum as a crucial turning *** explores the UK's approach and policy towards China,particularly focusing on the higher education sector in developing what was coined the ‘golden Era' by British politicians,which gradually emerged as official rhetoric during the Cameron era before intensifying at the peak of bilateral relations in 2015 with the first official state visit from China to the UK in a *** motivations behind the deep political divisions of Brexit are examined based on the destabilising conception of how national identity trumps a united Pan-European dialogue,as well as the perceptions of the EU as a normative *** thesis looks at the influence and the use of the higher education sector to bridge relations for the future while arguing that Brexit is change of normative force that contributes to a new understanding of UK domestic and foreign policy and where Britain sees its alignments in the ***,the research looks to the future of UK relations with China after leaving the *** thesis concludes that despite the eager attempts of promoting this narrative,Britain's declining power on the global stage has already increased reliance and dependency on China as a partner,not only in the traditional trade and investments but also has a huge potential impact on the education *** research provides qualitative analysis of Britain's past and future in the education sector,taking a closer look at an often overlooked but influential sector.

关键词： UK-China Relations Brexit Higher Education Constructivism Normative Power

Biogreen Synthesis of Carbon Dots for Biotechnology and Nanomedicine Applications

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Nano-Micro Letters 2018年第4期10卷 268-313页

作者： Kok Ken Chan stephanie Hui Kit Yap Ken-Tye Yong School of Electrical and Electronic Engineering Nanyang Technological University

Over the past decade, carbon dots have ignited a burst of interest in many different fields, including nanomedicine, solar energy, optoelectronics, energy storage,and sensing applications, owing to their excellent photoluminescence properties and the easiness to modify their optical properties through doping and functionalization. In this review, the synthesis, structural and optical properties,as well as photoluminescence mechanisms of carbon dots are first reviewed and summarized. Then, we describe a series of designs for carbon dot-based sensors and the different sensing mechanisms associated with ***, we elaborate on recent research advances on carbon dot-based sensors for the selective and sensitive detection of a wide range of analytes, including heavy metals, cations, anions, biomolecules, biomarkers,nitroaromatic explosives, pollutants, vitamins, and ***, we provide a concluding perspective on the overall status, challenges, and future directions for the use of carbon dots in real-life sensing.

关键词： Carbon dots Heavy metal sensing Photoluminescence mechanism Sensing mechanism Sensor design

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萨塔玛活动中心芬兰科特卡

世界建筑导报 2024年第2期39卷 77-81页

作者： Juho grönholm Antti Nousjoki Samuli Woolston Sampo Honkala Chris Morris Ricardo Cruz Recalde Mirja Sillanpää Niklas Mahlberg Thomas Miyauchi stephanie Polochowitz Tuomas Uusheimo(摄影) ALA建筑师事务所不详

新开业的萨塔玛活动中心位于科特卡市最古老的港口坎塔萨塔玛,距离著名的维拉莫海事中心(已在港口区立足15年)只有几步之遥。该活动中心与目前正在建设的芬兰东南应用科技大学新校区大楼和未来酒店位于同一地块。这三座新建筑将有助于... 详细信息

新开业的萨塔玛活动中心位于科特卡市最古老的港口坎塔萨塔玛,距离著名的维拉莫海事中心(已在港口区立足15年)只有几步之遥。该活动中心与目前正在建设的芬兰东南应用科技大学新校区大楼和未来酒店位于同一地块。这三座新建筑将有助于加强港口与城市中心之间的视觉和功能联系。该活动中心是举办各种文化、体育和商务活动的理想场所。ALA建筑师事务所的设计工作侧重于将极具吸引力的建筑与功能性和环境目标相结合。其建筑特征来源于环境和项目目标。

关键词：活动中心建筑师事务所大学新校区港口区科特萨塔功能性芬兰