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Applications of 3D printed chimeric DNA biomaterials

Engineered Regeneration 2022年第1期3卷 13-23页

作者： stephanie dobres Giridhar Mula Jonathan Sauer Donghui Zhu Department of Biomedical Engineering Stony Brook University100 Nicolls RdStony BrookNY 11794USA

The influence of genetic engineering on daily life is prominent,from genetically modified food to transgenic,antibiotic resistant *** direct manipulation of an organism’s genotype has opened the door to a myriad of applications in an effort to treat chronic *** paper proposes the unification of chimeric DNA technology and three-dimensional bioprinting to spark the development of new *** studies of chimeric DNA,*** DNA,have been conducted since 1970,bioprinting is a budding method for tissue engineering and regenerative *** technologies are further described in the background section of this paper,and followed by a detailed analysis into current research,benefits,and limitations of 3D printed chimeric *** benefits include low-cost and effective treatments for cancer,bio-morphological nanostructures for targeted drug delivery,personalized medicine with the use of stem cells,and a significantly reduced rate of addi-tional surgeries and transplant rejection after ***,there are several shortcomings with current chimeric DNA applications,***-T cell therapies,and ethical dilemmas regarding the creation and regulation of human-animal *** review then presents future directions,in which inks made from chimeric DNA and live cells can be printed into bioactive engineered tissue,or biodegradable vehicles for targeted delivery of hiPSCs or CAR ***,this review concludes with a reaffirmation of its main points and the authors’thoughts on the potential of 3D printed chimeric biomaterials.

关键词： Chimeric DNA biomaterials Chimeric biomaterials Recombinant DNA 3D printing Bioprinting Tissue engineering Regenerative medicine CAR T-cell therapy

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Supplemental mineral ions for bone regeneration and osteoporosis treatment

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Engineered Regeneration 2023年第2期4卷 170-182页

作者： Yingchao Su Matthew Cappock stephanie dobres Allan J.Kucine Wayne C.Waltzer Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Oral and Maxillofacial Surgery Stony Brook UniversityStony BrookNY 11794USA Department of Urology Stony Brook UniversityStony BrookNY 11794USA

Mineral ions play a crucial role in various biological processes in the human body,particularly in bone repair and *** with mineral ions offers several advantages over other therapies or treatments for bone repair and regeneration,such as higher biosafety,universal applicability,and compatibility with the immune ***,supplementation with mineral ions may avoid the need for invasive surgical *** aim of this review is to provide a comprehensive overview of the functions of potentially beneficial mineral ions and their effects on bone regeneration and osteoporosis *** examining previous studies,including in vitro cellular experiments,in vivo animal models,and clinical trials,this review compares the benefits and potential adverse effects of these mineral ***,the review provides guidelines for suggested daily supplementation of these mineral ions to assist future preclinical and clinical studies in bone regeneration and osteoporosis treatment.

关键词： Mineral elements Metallic ions Dietary supplementation Bone repair Bone regeneration Osteoporosis

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