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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1007-1019页

作者： stephanie lee Stovall Jennifer A Kaplan Joanna K Law David R Flum Vlad V Simianu Department of Surgery Virginia Mason Franciscan HealthSeattleWA 98101United States Department of Gastroenterology Virginia Mason Franciscan HealthSeattleWA 98101United States Department of Surgery University of Washington MedicalSeattleWA 98195United States

The disease burden of diverticulitis is high across inpatient and outpatient settings,and the prevalence of diverticulitis has ***,patients with acute diverticulitis were admitted routinely for intravenous antibiotics and many had urgent surgery with colostomy or elective surgery after only a few *** recent studies have challenged the standards of how acute and recurrent diverticulitis are managed,and many clinical practice guidelines(CPGs)have pivoted to recommend outpatient management and individualized decisions about *** the rates of diverticulitis hospitalizations and operations are increasing in the United States,suggesting there is a disconnect from or delay in adoption of CPGs across the spectrum of diverticular *** this review,we propose approaching diverticulitis care from a population level to understand the gaps between contemporary studies and real-world practice and suggest strategies to implement and improve future care.

关键词： Diverticulitis Hospitalization Elective Emergent surgery Clinical guidelines Diverticular disease

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刺猬家的大事件

小哥白尼（野生动物） 2008年第7期 8-10页

作者：尹飒 stephanie lee

曼尼是一只宠物刺猬,在主人的精心照料下,生活一向安逸自在。可如今,它竟然也开始烦恼了。因为,它们刺猬家族出大事儿了!宝贝疙瘩要消失虽然心里有一万个不乐意,刺猬还是在2007年被"拉"进了英国濒危动物排行榜。这个"重磅炸弹"让很多人... 详细信息

曼尼是一只宠物刺猬,在主人的精心照料下,生活一向安逸自在。可如今,它竟然也开始烦恼了。因为,它们刺猬家族出大事儿了!宝贝疙瘩要消失虽然心里有一万个不乐意,刺猬还是在2007年被"拉"进了英国濒危动物排行榜。这个"重磅炸弹"让很多人的下巴颌儿都快惊掉了。要知道,刺猬可一直都是当地的保护动物。曼尼做梦都想去英国旅游一趟,感受一下"万般宠爱"是啥滋味。喏,现在没戏了。

关键词：小刺冬眠刺猬事件英国人弗罗斯特食物体温过低动物医院美食

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早期口腔运动干预对早产儿预后的影响

中华危重病急救医学 2019年第2期31卷 150-154页

作者：杨春燕刘凤敏周丽英申青华贾焕荣许平李延辉 stephanie lee 聊城市人民医院儿科山东聊城252200 Department of Neonatology National Children's HospitalColumbus 43202America

目的探讨早期口腔运动干预改善早产儿预后的临床意义。方法选择2015年1月至2017年1月入住聊城市人民医院新生儿重症加强治疗病房(NICU)治疗的早产儿为研究对象。按随机数字表法并经过法定监护人同意将患儿分为干预组和对照组,所有患儿... 详细信息

目的探讨早期口腔运动干预改善早产儿预后的临床意义。方法选择2015年1月至2017年1月入住聊城市人民医院新生儿重症加强治疗病房(NICU)治疗的早产儿为研究对象。按随机数字表法并经过法定监护人同意将患儿分为干预组和对照组,所有患儿生命体征稳定后均给予常规治疗,干预组在此基础上进行吸吮运动、吞咽功能刺激以及SandraFucile口腔按摩,每日1次,连续14 d;两组均随访6个月。通过进奶5 min时摄入奶量占医嘱奶量百分比(PRO)、喂养效率、喂养进程、非营养性吸吮系统评分(NNS)评价早产儿经口喂养能力;矫正胎龄(PMA)40周时,采用行为神经测定(NBNA)评估新生儿脑发育;生后3月龄、6月龄时,采用婴儿神经系统国际测验量表(Infanib)进行早期运动发育评估。结果最终纳入151例早产儿,其中干预组78例,对照组73例。干预组达完全经口喂养时间明显短于对照组(d:18.1±3.7比23.4±5.8,P0.05)。患儿3月龄时Infanib评估结果显示,干预组早期运动发育正常的比例明显高于对照组〔67.95%(53/78)比49.31%(36/73),P<0.05〕;6月龄时,干预组早期运动发育正常的比例也明显高于对照组〔84.62%(66/78)比58.90%(43/73),P<0.01〕。结论早期口腔运动干预能够缩短NICU早产儿从管饲喂养到完全经口喂养的过渡时间,改善患儿喂养时的表现。

关键词：口腔运动干预婴儿,早产预后

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Achieving competence in colonoscopy: Milestones and the need for a new endoscopic curriculum in gastroenterology training

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World Journal of Gastrointestinal Endoscopy 2015年第18期7卷 1279-1286页

作者： Sara B Stanford stephanie lee Candace Masaquel Robert H lee Division of Gastroenterology University of California Irvine and Long Beach Veterans’ Affairs Hospital

Colonoscopy is considered to be the most effective tool for reducing colorectal cancer(CRC) morbidity and mortality. As a result, certifying trainee competence in the performance of colonoscopy is critical to maximizing CRC screening and prevention efforts. Guidelines on training and accreditation around the world have been revised to emphasize the attainment of milestones in the technical and cognitive skills necessary to perform the procedure. To meet this challenge, new evaluation systems have been developed to measure trainee competence through all aspects of colonoscopy training. These changes stem from increased recognition that procedural numbers alone do not necessarily guarantee trainees' proficiency in the performance of colonoscopy. Variability in endoscopic practice and in CRC screening outcomes also point to deficiencies in the current approach towards colonoscopy instruction. However, technological innovations hold great promise in training endoscopists to perform high quality colonoscopy. Furthermore, potential advances in the use of feedback as a training tool provide new avenues for research. This review summarizes the latest evidence on the effort to define, evaluate and promote the achievement of competence in colonoscopy among trainees.

关键词： Competence Colonoscopy Colorectal cancer Core curr

Epidemiology and Clonal Spread Evidence of Carbapenem-Resistant Organisms in the Center of Care and Protection of Orphaned Children, Vietnam

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Open Journal of Medical Microbiology 2024年第3期14卷 165-189页

作者： Van Kim Nguyen Pirom Noisumdaeng Pol. Maj. Katiya Ivanovitch Stephen Baker Eugene Athan stephanie Jones Le Thi Lan Larry Croft Yin Peng lee Tara Cassidy Van Hung Tran Thi Hang Phan Huu Tinh Ho Faculty of Public Health Thammasat University Bangkok Thailand Department of Prevention and Infection Control Hung Vuong Hospital HCM City Vietnam Microbiology of Faculty of Public Health Thammasat University Bangkok Thailand Thammasat University Research Unit in Modern Microbiology and Public Health Genomics Thammasat University Bangkok Thailand National Heart & Lung Institute (NHLI) University of Cambridge Cambridge UK Barwon South West Public Health Unit Geelong Australia Center for Innovation in Infectious Disease and Immunology Research (CIIDIR) Geelong Australia School of Medicine Deakin University Burwood Australia Monash Health Berwick Australia Center of Care and Protection of Orphaned Children HCM City Vietnam Charles River Laboratories Microbial Solutions Melbourne Australia Personnel Department of Nhan Dan Gia Dinh Hospital HCM City Vietnam Hung Vuong Hospital HCM City Vietnam Department of Epidemiology Institute of Public Health HCM City Vietnam

Objective: To determine the prevalence of colonization and transmission of carbapenem-resistant Gram-negative organisms in order to develop of an effective infection prevention program. Design: Cross-sectional study with carbapenem-resistant organisms (CRO) colonization detection from the fecal specimens of 20 Health Care Workers (HCWs) and 67 residents and 175 random environment specimens from September 2022 to September 2023. Setting: A Care and Protection Centre of Orphaned Children in South of HCM City. Participants: It included 20 HCWs, 67 residents, and 175 randomly collected environmental specimens. Method: Rectal and environmental swabs were collected from 20 HCWs, 67 residents (most of them were children), and 175 environmental specimens. MELAB Chromogenic CARBA agar plates, Card NID, and NMIC-500 CPO of the BD Phoenix TM Automated Microbiology System and whole genome sequencing (WGS) were the tests to screen, confirm CROs, respectively and determine CRO colonization and transmission between HCWs, residents, and the environment. Result: We detected 36 CRO isolates, including 6, 11 and 19 CROs found in 6 HCWs, 10 residents and 19 environments. The prevalence of detectable CRO was 30% (6/20) in HCWs, 14.92% (10/67) in residents, and 10.86% (19/175) in environmental swabs in our study. WGS demonstrated CRO colonization and transmission with the clonal spread of E. coli and A. nosocomialis, among HCWs and residents (children). Conclusion: Significant CRO colonization and transmission was evident in HCWs, residents, and the center environment. Cleaning and disinfection of the environment and performing regular hand hygiene are priorities to reduce the risk of CRO colonization and transmission.

关键词： Carbapenem-Resistant Organisms Contamination Hand Hygiene Whole Genome Sequencing Infection Prevention

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上海油罐艺术中心

建筑实践 2020年第2期 132-141页

作者：叶青罗韧 Victor Quiros 周亭婷陈修远李振涛赵耀卢笛贾瀚张译文史程昱周小晨黄中汉陈逸岚崔雨柔杨骐戈灿高琪 stephanie lee 金波安张浩王莽原闫迪华张畅 Tomas Kowalsky 蒋思敏 OPEN建筑事务所

时代变迁及城市发展,给一组废弃的航空油罐带来了新生的契机,这是一个工业遗存经由艺术获得重生的有趣故事。项目基地位于上海市徐汇滨江西岸,原龙华机场旧址。经过6年的设计改造与施工,昔日的油罐变身为艺术与生活的载体,以其丰富的功... 详细信息

时代变迁及城市发展,给一组废弃的航空油罐带来了新生的契机,这是一个工业遗存经由艺术获得重生的有趣故事。项目基地位于上海市徐汇滨江西岸,原龙华机场旧址。经过6年的设计改造与施工,昔日的油罐变身为艺术与生活的载体,以其丰富的功能及开放的公园,吸引公众亲近自然、感受艺术。新建建筑低调地消隐于地景和公园之中,在尊重工业遗存的同时,重新建立起艺术、自然与

关键词：工业遗存

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油罐艺术公园

城市环境设计 2018年第5期115卷 104-121页

作者：李虎黄文菁叶青罗韧 Victor Quiros 李振涛周亭婷赵耀陈修远张译文史程昱卢笛周小晨黄中汉陈逸岚崔雨柔杨骐戈灿高琪 stephanie lee 贾翰金波安张浩王莽原闫迪华张畅 Tomas Kowalsky 蒋思敏吴清山

上海,2013-2019时代变迁及城市发展为一组废弃的航油油罐带来了新生的契机,这是一个工业遗存经由艺术获得重生的有趣故事。项目基地位于上海市徐汇滨江原龙华机场旧址。废弃储油罐、消防水池及一些配套设施是保留下来的历史的见证。OPE... 详细信息

上海,2013-2019时代变迁及城市发展为一组废弃的航油油罐带来了新生的契机,这是一个工业遗存经由艺术获得重生的有趣故事。项目基地位于上海市徐汇滨江原龙华机场旧址。废弃储油罐、消防水池及一些配套设施是保留下来的历史的见证。OPEN的设计主要包含五个油罐罐体及将其连通的超级表面(Super-Surface)、都市森林、城市广场、草坪广场以及项目空间。

关键词：城市广场

Large Vessel Vasculitis in a Patient with Systemic Lupus Erythematosus Presenting as Takayasu’s Pulseless Arteritis

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International Journal of Clinical Medicine 2021年第10期12卷 415-423页

作者： Cathy-lee Jagdeo stephanie Battersby Azad Esack Department of Neurology The Eric Williams Medical Sciences Complex Mt. Hope Trinidad and Tobago

Systemic lupus erythematosus (SLE) with an associated aortoarteritis presenting as an ischemic stroke is a rarity in the medical literature. We report the case of an 11-year-old male presenting with an acute ischemic stroke meeting the criteria for the diagnosis of SLE and findings consistent with an aortitis on imaging but mimicking the diagnosis of Takayasu’s pulseless arteritis. Blood and imaging investigations revealed the finding of SLE aortitis following an acute stroke presentation. Thus, it is imperative to note that even though it is infrequent, SLE can be associated with a large vessel vasculitis.

关键词： Systemic Lupus Erythematosus Aortoarteritis Takayasu’s Pulseless Arteritis

Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2020年第9期26卷 904-917页

作者： Ezekiel Maloney Yak-Nam Wang Ravneet Vohra Helena Son Stella Whang Tatiana Khokhlova Joshua Park Kayla Gravelle stephanie Totten Joo Ha Hwang Donghoon lee Department of Radiology University of WashingtonSeattleWA 98195United States Applied Physics Laboratory University of WashingtonSeattleWA 98195United States Division of Gastroenterology University of WashingtonSeattle 98195WAUnited States Division of Gastroenterology&Hepatology Stanford University School of MedicineRedwood CityCA 94063United States

BACKGROUND The robust fibroinflammatory stroma characteristic of pancreatic ductal adenocarcinoma(PDA)impedes effective drug *** focused ultrasound(pFUS)can disrupt this stroma and has improved survival in an early clinical ***-invasive methods to characterize pFUS treatment effects are desirable for advancement of this promising treatment modality in larger clinical *** To identify promising,non-invasive pre-clinical imaging methods to characterize acute pFUS treatment effects for in vivo models of *** We utilized quantitative magnetic resonance imaging methods at 14 tesla in three mouse models of PDA(subcutaneous,orthotopic and transgenic-KrasLSLG12D/+,Trp53LSL-R172H/+,Cre or“KPC”)to assess immediate tumor response to pFUS treatment(VIFU 2000 Alpinion Medical Systems;475 W peak electric power,1 ms pulse duration,1 Hz,duty cycle 0.1%)vs sham therapy,and correlated our results with histochemical *** pFUS treatment parameters were previously shown to enhance tumor permeability to chemotherapeutics.T1 and T2 relaxation maps,high(126,180,234,340,549)vs low(7,47,81)b-value apparent diffusion coefficient(ADC)maps,magnetization transfer ratio(MTR)maps,and chemical exchange saturation transfer(CEST)maps for the amide proton spectrum(3.5 parts per million or“ppm”)and the glycosaminoglycan spectrum(0.5-1.5 ppm)were generated and analyzed pre-treatment,and immediately post-treatment,using *** were sacrificed immediately following post-treatment *** whole-tumor was selected as the region of interest for data analysis and subsequent statistical analysis.T-tests and Pearson correlation were used for statistical *** Mean high-b value ADC measurements increased significantly with pFUS treatment for all *** glycosaminoglycan CEST and T2 measurements decreased significantly post-treatment for the KPC *** MTR and amide CEST values increased significantly for the KPC *** acid focal int

关键词： Pancreatic adenocarcinoma Multiparametric magnetic resonance imaging Focused ultrasound

Testicular fine-needle aspiration for the assessmen＇ of intratesticular hormone concentrations

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Asian Journal of Andrology 2016年第1期18卷 21-24页

作者： Ada P lee Mara Y Roth Jean-Jacques Nya-Ngatchou Kat Lin Thomas J Walsh stephanie T Page Alvin M Matsumoto William J Bremner John K Amory Bradley D Anawalt Department of Medicine University of California San Francisco San Francisco CA USA Department of Medicine and Center for Research in Reproduction and Contraception University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Washington Seattle WA USA Department of Urology University of Washington Seattle WA USA Department of Medicine Geriatric Research Education and Clinical Center VA Puget Sound Health Care System Seattle WA USA.

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration （FNA） completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. Two serious adverse events （0.5%） required surgical intervention. The risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. Testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. Testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

关键词： male contraception physiology reproductive and urinary testis