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Journal of Otology 2019年第4期14卷 155-157页

作者： stephane Gargula Guillaume Poillon Mary Daval Marc Williams Mathieu Veyrat Homa Adle-Biassette Denis Ayache Department of Otolaryngogy Head and Neck SurgeryFoundation Adolphe de Rothschild HospitalParisFrance Department of Neuroradiology Foundation Adolphe de Rothschild HospitalParisFrance Department of Pathology Lariboisiere HospitalParis DiderotParis-Cite-Sorbonne UniversityParisFrance

We present a very rare case of tophaceous gout of the middle ear causing conductive hearing loss,with special emphasis on Computed Tomography presentation.

关键词： Gout Middle ear Hearing loss Conductive hearing loss Computed tomography

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欧美家禽沙门菌的控制及食品安全对策

中国家禽 2009年第11期31卷 34-35页

作者： stephane Lemiere 梅里亚全球兽医总监

1欧盟对沙门菌的控制1．1法规2003年11月17日（欧共体）欧洲议会和委员会的第2160／2003号法规，关于沙门菌及其他特定的经食品传染的动物源性病原体的控制方法，目的是减少其流行以及对公共安全的危害。

关键词：沙门菌安全对策控制食品家禽欧美欧洲议会公共安全

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家禽腺胃炎和肌胃糜烂的研究动态

中国家禽 2010年第15期32卷 42-44页

作者： stephane Lemiere 梅里亚动物保健有限公司

1肌胃和腺胃的功能腺胃呈橄榄型，体积差异大，其主体细胞分泌胃酸，降低胃内容物的pH值，使胃蛋白酶分解蛋白质。黏膜细胞分泌黏液保护胃表面的上皮细胞不会被胃酸所侵蚀，防止食物磨擦。

关键词：肌胃糜烂腺胃炎家禽细胞分泌胃内容物上皮细胞蛋白质 pH值

The Deep Thioredoxome in Chlamydomonas reinhardtii： New Insights into Redox Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esther Perez-Perez Adeline Mauries Alexandre Maes Nicolas J. Tourasse Marion Hamon stephane D. Lemaire Christophe H. Marchand Institut de Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathio- nylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii, while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have comprehensively investigated the Chlamydomonas thioredoxome and 1188 targets have been identified. They participate in a wide range of metabolic pathways and cellular pro- cesses. This study broadens not only the redox regulation to new enzymes involved in well-known thiore- doxin-regulated metabolic pathways but also sheds light on cellular processes for which data supporting redox regulation are scarce （aromatic amino acid biosynthesis, nuclear transport, etc）. Moreover, we char- acterized 1052 thioredoxin-dependent regulatory sites and showed that these data constitute a valuable resource for future functional studies in Chlamydomonas. By comparing this thioredoxome with proteomic data for glutathionylation and nitrosylation at the protein and cysteine levels, this work confirms the existence of a complex redox regulation network in Chlamydomonas and provides evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.

关键词： Chlamydomonas reinhardtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation thioredoxin targets

Prompt and Easy Activation by Specific Thioredoxins of Calvin Cycle Enzymes of Arabidopsis thaliana Associated in the GAPDH/CP12/PRK Supramolecular Complex

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Molecular Plant 2009年第2期2卷 259-269页

作者： Lucia Marri Mirko Zaffagnini Valerie Collin Emmanuelle Issakidis-Bourguet stephane D. Lemaire Paolo Pupillo Francesca Sparla Myroslawa Miginiac-Maslow Paolo Trost Laboratory of Molecular Plant Physiology Department of Experimental Evolutionary Biology University of Bologna Via Irnerio 42 1-40126 Bologna Italy Institut de Biotechnologie des Plantes UMR 8618 CNRS/Univ. Paris-Sud 1 1 91405 Orsay Cedex France

The Calvin cycle enzymes glyceraldehyde-3-phosphate dehydrogenase （GAPDH） and phosphoribulokinase （PRK） can form under oxidizing conditions a supramolecular complex with the regulatory protein CP12. Both GAPDH and PRK activities are inhibited within the complex, but they can be fully restored by reduced thioredoxins （TRXs）. We have investigated the interactions of eight different chloroplast thioredoxin isoforms （TRX f1, m1, m2, m3, m4, y1, y2, x） with GAPDH （A4, B4, and B8 isoforms）, PRK and CP12 （isoform 2）, all from Arabidopsis thaliana. In the complex, both A4-GAPDH and PRK were promptly activated by TRX f1, or more slowly by TRXs ml and m2, but all other TRXs were ineffective. Free PRK was regulated by TRX f1, m1, or m2, while B4- and Bs-GAPDH were absolutely specific for TRX fl. Interestingly, reductive activation of PRK caged in the complex was much faster than reductive activation of free oxidized PRK, and activation of A4-GAPDH in the complex was much faster （and less demanding in terms of reducing potential） than activation of free oxidized B4- or BB-GAPDH. It is proposed that CP12-assembled supramolecular complex may represent a reservoir of inhibited enzymes ready to be released in fully active conformation following reduction and dissociation of the complex by TRXs upon the shift from dark to low light. On the contrary, autonomous redox-modulation of GAPDH （B- containing isoforms） would be more suited to conditions of very active photosynthesis.

关键词： carbon metabolism enzymology light regulation metabolic regulation photosynthesis Arabidopsis.

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家禽的免疫抑制及其解决方案

中国家禽 2007年第13期29卷 43-44页

作者： stephane Lemiere 何士军梅里亚动物保健有限公司

　　1免疫抑制的发生　　疾病从病鸡传染给健康鸡可以通过多种途径进行,如:鼻、眼的分泌物,羽毛囊细胞,粪便,精液等.并且传染通常在病鸡出现症状之前就已经发生了.而通过疫苗的免疫接种,可以保护家禽的免疫系统、呼吸系统、消化系统和... 详细信息

　　1免疫抑制的发生　　疾病从病鸡传染给健康鸡可以通过多种途径进行,如:鼻、眼的分泌物,羽毛囊细胞,粪便,精液等.并且传染通常在病鸡出现症状之前就已经发生了.而通过疫苗的免疫接种,可以保护家禽的免疫系统、呼吸系统、消化系统和生殖系统免受感染,甚至可以通过蛋内接种或者1日龄免疫接种对强毒的早期感染进行及早预防.但是免疫抑制对疫苗的免疫接种效果有很大的破坏作用,使疫苗的保效果降低,甚至造成免疫失败.……

关键词：法氏囊病毒鸡群母源抗体大肠杆菌大肠埃希氏菌埃希氏杆菌属免疫抑制马立克氏病家禽禽类

Assessing a Model-Driven Web-Application Engineering Approach

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Journal of Software Engineering and Applications 2014年第5期7卷 360-370页

作者： Ali Fatolahi stephane S. Some School of Electrical Engineering and Computer Science University of Ottawa Ottawa Canada

Model-Driven Engineering (MDE) by reframing software development as the transformation of high-level models, promises lots of gains to Software Engineering in terms of productivity, quality and reusability. Although a number of empirical studies have established the reality of these gains, there are still lots of reluctances toward the adoption of MDE in practice. This resistance can be explained by several technological and social factors among which a natural scepticism toward novel approaches. In this paper we attempt to provide arguments to help alleviate this scepticism by conducting an assessment of a MDE approach. Our goal is to show that although this MDE is novel, it retains similarities with the conventional Software Engineering approach while automating aspects of it.

关键词： Model-Driven Engineering (MDE) Software Process Assessment Web-Engineering

Incorporation of Essential Oils from Cymbopogon Citratus and Ceasalpinia Decapitala Leaves, Citrus Lemon and Citrus Sinensis Peels into HPC （HydroxyPropyl Cellulose） Films and Assessment of Their Antibacterial Activity

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Journal of Chemistry and Chemical Engineering 2013年第5期7卷 420-430页

作者： Theoneste Muhizi stephane Grelier Veronique Coma Department of Chemistry National University of Rwanda Butare 117 Rwanda Laboratory of Chemistry and Organic Polymers (LCPO) University of Bordeaux 1 Pessac F-33600 France CNRS LCPO Pessac F-33600 France

In this study, essential oils from Cymbopogon citratus and Ceasalpinia decapitala leaves, Citrus lemon and Citrus sinens＆ peels, were extracted, chemically characterized and evaluated on both Gram positive and Gram negative bacteria, Salmonella Typhimurium, Escherichia coli, Listeria innocua, Staphylococcus aureus, Klebsiella pneumonia and Streptococcus pyogenes. Essential oil of C. citratus was found to be rich in geranial （33.0%） and neral （49.7%）, that from C. decapitala in 13-pinene （8.4%）, ct-pinene （25.5%）, 13-ocymene （31.6%）, 15-phellandrene （8.4%）, caryophyllene （7.5%） and geranial （5.9%）. The essential oil from C. lemon and C. sinensis where mainly composed by limonene with percentages of 77.5% and 83.3% respectively, and 13-phellandrene with percentages of 8.1% and 10.8% for the essential oil of C. lemon and C. sinensis, respectively. The antibacterial activity assessment realized on different microorganisms contaminating food showed that essential oil from C. citratus was shah more effective against all tested bacteria while that from C. sinensis was the less active essential oil. The incorporation of essential oils in HPC （hydroxy-propyl cellulose） films showed that those essential oils, especially essential oils from C. citratus, maintained their antibacterial activities against targeted microorganisms and therefore can be applied in food packing.

关键词： Essential oils Cymbopogon citratus Ceasalpinia decapitala Citrus lemon Citrus sinensis Essential oils-HPC films antibacterial activity.

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家禽生产中免疫的成本-效益分析

中国家禽 2013年第22期35卷 61-62页

作者： stephane Lemiere 何士军梅里亚动物保健有限公司

家禽生产中，免疫接种是预防家禽主要疾病的关键方法。制定免疫程序的目标是防控家禽的主要疾病，尤其是影响较大的新城疫和高致病性禽流感，从而提高鸡群的成活率。免疫程序也可防控某些亚急性型疾病，这类疾病往往导致经济效益下降，... 详细信息

家禽生产中，免疫接种是预防家禽主要疾病的关键方法。制定免疫程序的目标是防控家禽的主要疾病，尤其是影响较大的新城疫和高致病性禽流感，从而提高鸡群的成活率。免疫程序也可防控某些亚急性型疾病，这类疾病往往导致经济效益下降，如肉鸡屠宰场废弃率升高、抗生素和药物治疗成本升高、生产成绩变差、出肉率降低等。

关键词：成本-效益分析家禽生产免疫接种高致病性禽流感免疫程序经济效益药物治疗疾病