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Relaxation Schemes for the M1 Model with Space-Dependent Flux:Application to Radiotherapy Dose Calculation

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Communications in Computational Physics 2016年第1期19卷 168-191页

作者： Teddy Pichard Denise Aregba-Driollet stephane Brull Bruno Dubroca Martin Frank Centre Lasers Intenses et Applications Universite de Bordeaux351 cours de la liberationTalence33400France Mathematics division Center for Computational Engineering ScienceRheinisch-Westf¨alische Technische HochschuleSchinkelstrasse 2Aachen52062Germany Institut de Mathematiques de Bordeaux Universite de Bordeaux351 cours de la liberationTalence33400France

Because of stability constraints,most numerical schemes applied to hyperbolic systems of equations turn out to be costly when the flux term is multiplied by some very large *** problem emerges with the M_(1)system of equations in the field of radiotherapy when considering heterogeneous media with very disparate ***,the flux term of the M_(1)system is non-linear,and in order for the model to be well-posed the numerical solution needs to fulfill conditions called *** this paper,we propose a numerical method that overcomes the stability constraint and preserves the realizability *** this purpose,we relax the M_(1)system to obtain a linear flux *** we extend the stencil of the difference quotient to obtain *** scheme is applied to a radiotherapy dose calculation example.

关键词： Radiotherapy Moments models relaxation models method of characteristics

Aerosol Optical Properties and Its Radiative Forcing over Yulin, China in 2001 and 2002

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Advances in Atmospheric Sciences 2009年第3期26卷 564-576页

作者：车慧正张小曳 stephane ALFRARO Bernadette CHATENET Laurent GOMES 赵剑琦 Key Laboratory of Atmospheric Chemistry Centre for Atmosphere Watch and ServicesChinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081 Laboratoire Inter-Universitaire des Systmes Atmosphriques Universit Paris Ⅶ/Paris Ⅻ94010 Crteil Cedex France Centre National de la Recherche Scientifique Meto-France/CNRM/GMEI/MNPCA31057ToulouseFrance State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029

The aerosol optical properties and direct radiative forcing over the Mu Us desert of northern China, acquired through a CE318 sunphotometer of the ground-based Aerosol Robotic Network （AERONET）, are analyzed. The seasonal variations in the aerosol optical properties are examined. The effect of meteorological elements （pressure, temperature, water vapor pressure, relative humidity and wind speed） on the aerosol optical properties is also studied. Then, the sources and optical properties under two different cases, a dust event and a pollution event, are compared. The results show that the high aerosol optical depth （AOD） found in Yulin was mostly attributed to the occurrence of dust events in spring from the Mu Us desert and deserts of West China and Mongolia, as well as the impacts of anthropogenic pollutant particles from the middle part of China in the other seasons. The seasonal variation and the probability distribution of the radiative forcing and the radiative forcing efficiency at the surface and the top of the atmosphere are analyzed and regressed using the linear and Gaussian regression methods.

关键词： aerosol optical properties aerosol radiative forcing Mu Us desert China

Methods for Analysis of Protein Glutathionylation and their Application to Photosynthetic Organisms

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Molecular Plant 2009年第2期2卷 218-235页

作者： Xing-Huang Gao Mariette Bedhomme Daniel Veyel Mirko Zaffagnini stephane D. Lemaire Institut de Biotechnologie des Plantes UMR 8618 CNRS/Universite Paris-Sud 11 Batiment 630 Orsay 91405 Cedex France

Protein S-glutathionylation, the reversible formation of a mixed-disulfide between glutathione and protein thiols, is involved in protection of protein cysteines from irreversible oxidation, but also in protein redox regulation. Recent studies have implicated S-glutathionylation as a cellular response to oxidative/nitrosative stress, likely playing an important role in signaling. Considering the potential importance of glutathionylation, a number of methods have been developed for identifying proteins undergoing glutathionylation. These methods, ranging from analysis of purified proteins in vitro to large-scale proteomic analyses in vivo, allowed identification of nearly 200 targets in mammals. By contrast, the number of known glutathionylated proteins is more limited in photosynthetic organisms, although they are severely exposed to oxidative stress. The aim of this review is to detail the methods available for identification and analysis of glutathionylated proteins in vivo and in vitro. The advantages and drawbacks of each technique will be discussed as well as their application to photosynthetic organisms. Furthermore, an overview of known glutathionylated proteins in photosynthetic organisms is provided and the physiological importance of this post-translational modification is discussed.

关键词： environmental signals oxidative and photo-oxidative stress proteomics signal transduction Glutathionylation Methods Glutaredoxin Glutathione.

Proteomic composition of the acrostyle＂ Novel approaches to identify cuticular proteins involved in virus-insect interactions

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Insect Science 2017年第6期24卷 990-1002页

作者： Craig Graham Webster Maelle Thillier Elodie Pirolles Bastien Cayrol stephane Blanc Marilyne Uzest INRA UMR 0385 BGPI CIRAD-INRA-Montpellier SupAgro Campus International de Baillarguet Montpellier Cedex France

The acrostyle is a distinct anatomical region present on the cuticle at the inner face of the common food/salivary canal at the tip of aphid maxillary stylets. This conserved structure is of particular interest as it harbors the protein receptors of at least l plant virus, Cauliflower mosaic virus＇, and presumably has other roles in plant-insect interactions. Previously we reported immunolabeling of a highly conserved motif of cuticular proteins from the CPR family （named for the presence of a Rebers and Riddiford consensus） within the acrostyle. Here we report the development of novel tools to further study the proteomic composition of this region and to identify proteins involved in insect- virus interactions. Using a series of antibodies against cuticular proteins from the RR-2 subfamily, we identified additional peptides present within the acrostyle. Our results demonstrated that the acrostyle is a complex structure containing multiple domains of cuticular proteins accessible for interaction. In addition, an array of overlapping peptides,which covers the diversity of the majority of the RR-2 subfamily, was ~tevelopect as a generic tool to characterize cuticular protein/pathogen interactions. Upon probing this array with Cucumber mosaic virus particles, consensus peptide sequences from hybridizing peptides were identified. Use of these novel tools has extended our knowledge of the proteomic composition of insect maxillary stylets and identified sequences that could be involved in virus binding, thus contributing to further elucidation of the various properties and functions of the acrostyle.

关键词： acrostyle aphid cuticular protein immunolabeling peptide array stylet

Assessment of left-ventricular diastolic function in pediatric intensive-care patients:a review of parameters and indications compared with those for adults

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World Journal of Pediatrics 2021年第1期17卷 21-30页

作者： Morgan Recher Astrid Botte Jerome Soquet Jean-Benoit Baudelet François Godart stephane Leteurtre ULR 2694-METRICS:évaluation des Technologies de santéet des Pratiques Médicales Univ.LilleCHU Lille59000 LilleFrance Réanimation et Surveillance Continue Pédiatriques Hopital Jeanne de FlandreCHU de Lille59037 Lille CedexFrance Pediatric and Neonatal Intensive Care Unit CHU Bordeaux33076 BordeauxFrance Cardiac Surgery Unit CHU Lille59000 LilleFrance Congenital and Pediatric Cardiology Unit CHU Lille59000 LilleFrance

Background The incidence of diastolic heart failure has increased over *** evaluation of left-ventricular diastolic func-tion is complex,ongoing,and remains poorly performed in pediatric intensive-care *** study aimed to review the literature and to provide an update on the evaluation of left-ventricular diastolic function in adults and children in intensive *** sources We searched data from PubMed/***-two studies were *** pragmatic questions were identified:(1)What is the physiopathology of diastolic dysfunction?(2)Which tools are required to evaluate diastolic func-tion?(3)What are the echocardiographic criteria needed to evaluate diastolic function?(4)When should diastolic function be evaluated in pediatric intensive care?Results Early diastole allows characterization of relaxation,whereas compliance assessments and filling pressures are evalu-ated during late *** evolution of diastolic function differs between adults and *** in adults,decreased compliance occurs at the same time as delayed relaxation in *** function can be evaluated by Doppler *** echocardiographic criteria for ventricular relaxation include the E wave,E/A wave ratio,and isovolumic relaxation *** compliance can be assessed by the E/e'wave ratio,atrial volume,and Ap wave duration during pulmonary vein *** adult intensive-care patients,the E/e'ratio can be used as an index of tolerance for volume expan-sion in septic patients and to adjust the inotropic *** Clinical studies would allow some of these parameters to be validated for use in children in intensive care.

关键词： diastole Echocardiography Heart failure Intensive-care unit Pediatric

Anionic Polymerization of Butadiene Using Lithium/Potassium Multi-metallic Systems:Influence on Polymerization Control and Polybutadiene Microstructure

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Chinese Journal of Polymer Science 2020年第4期38卷 357-362,I0006页

作者： Antoine Forens Kevin Roos Charlotte dire Benoit Gadenne stephane Carlotti Univ.Bordeaux CNRSBordeaux INPLCPOUMR 5629F-33600PessacFrance MFP Michelin Centre de Technologie/Ladoux23 Place des Carmes Dechaux63040 Clermont-Ferrand cedex 9France

Thermal,mechanical,and viscoelastic properties of polybutadiene-based rubber materials are highly dependent on polybutadiene *** use of polar modifier in association with alkyllithium is a well-known method to obtain polybutadiene with a high vinyl con *** approach is to use bimetallic initiating species such as alkyllithium combined to heavier alkali metal alkoxide(RONa,ROK...).The polymerization control is n evertheless not achieved and several parameters were found to influe nee *** bimetallic in itiating systems based on alkyllithium and a potassium alkoxide,alkyllithium structure,initiator preformation time,and initiator composition were identified as parameters influencing the anionic polymerization process of butadiene and/or polybutadiene *** addition,the use of trimetallic systems based on alkyllithium,potassium alkoxide,and alkylaluminum was investigated in order to prevent side reactions regardless of the[K]/[Li]ratio and of the initiator preformation time.

关键词： Polybutadiene Anionic polymerization Microstructure (Multi)metallic systems Lithium/potassium-based systems

Investigation of dynamics of discrete framed structures by a numerical wave-based method and an analytical homogenization approach

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Chinese Journal of Aeronautics 2017年第1期30卷 66-74页

作者： Zhou Changwei Sun Xiangkun Mohamed Ichchou Abdel-Malek Zine Jean-Pierre Lainé stephane Hans Claude Boutin Laboratory of Tribology and Systems Dynamics Ecole Centrale de Lyon Ecully 69134 France Institut Camille Jordan Ecole Centrale de Lyon Ecully 69134 France Laboratory of Tribology and Systems Dynamics Ecole Nationale des Travaux Publics de l'Etat Vaulx-en-Velinx 69518 France

In this article, the analytical homogenization method of periodic discrete media（HPDM）and the numerical condensed wave finite element method（CWFEM） are employed to study the longitudinal and transverse vibrations of framed structures. The valid frequency range of the HPDM is re-evaluated using the wave propagation feature identified by the CWFEM. The relative error of the wavenumber by the HPDM compared to that by the CWFEM is illustrated in functions of frequency and scale ratio. A parametric study on the thickness of the structure is carried out where the dispersion relation and the relative error are given for three different thicknesses. The dynamics of a finite structure such as natural frequency and forced response are also investigated using the HPDM and the CWFEM.

关键词： Framed structures Homogenization method Periodic structures Wave finite element method Wave propagation

Effect of Recycling Cycles on the Mechanical and Damping Properties of Short Alfa Fibre Reinforced Polypropylene Composite

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Journal of Renewable Materials 2019年第3期7卷 253-267页

作者： Fatima Ezzahra El Abbassi Mustapha Assarar Rezak Ayad Hamid Sabhi stephane Buet Nouzha Lamdouar Department of Civil Engineering University of Cadi AyyadMorocco Laboratory of Engineering and Material Sciences University of Reims Champagne-ArdenneFrance Laboratory of Simulation Instrumentation and MeasurementUniversity of Mohammed VMorocco

This paper aims at studying the effect of recycling on the static and dynamic properties of short alfa fibre reinforced *** this purpose,alfa fibres reinforced composites were elaborated by an injection moulding process and were subjected to different mechanical recycling ***,non-recycled and recycled materials were subjected to static tests and Dynamic Mechanical Analysis(DMA)to evaluate the effect of recycling on their ***,the effects of alkali and salt water treatments on the static and dynamic properties of the alfa composite were also *** obtained results show that tensile and flexural properties of alfa fibres reinforced composites decrease during recycling ***,the recycling induces a drop in the storage modulus and enhances the loss factor of these *** composites with alfa fibre especially the alkali treated composite show the same resistance to recycling as composites with hemp ***,SEM observations indicate a decrease in the fibres dimension with the recycling cycles,especially for alfa fibres,which can explain the decrease in the properties of the alfa composite during recycling operations.

关键词： Alfa fibre hemp fibre eco-composites recycling mechanical properties dynamic properties

Noise Pollution Reduction through a Novel Optimization Procedure in Passive Control Methods

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 1-18页

作者： Haojie Lian Leilei Chen Xiao Lin Wenchang Zhao stephane P.A.Bordas Mingdong Zhou Key Laboratory of In-Situ Property-Improving Mining of Ministry of Education Taiyuan University of TechnologyTaiyuan030024China Henan International Joint Laboratory of Structural Mechanics and Computational Simulation Huanghuai UniversityZhumadian463000China College of Architecture and Civil Engineering Xinyang Normal UniversityXinyang464000China The York Management School University of YorkYorkYO105DDUK CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of ChinaHefei230027China Institute for Computational Engineering Faculty of ScienceTechnology and CommunicationUniversity of LuxembourgLuxembourgSA28PPUK School of Engineering Cardiff UniversityCardiffCF243AAUK Shanghai Key Laboratory of digital Manufacture for Thin-Walled Structures School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

This paper proposes a novel optimization framework in passive control techniques to reduce noise *** geometries of the structures are represented by Catmull-Clark subdivision surfaces,which are able to build gap-free Computer-Aided Design models and meanwhile tackle the extraordinary points that are commonly encountered in *** acoustic fields are simulated using the isogeometric boundary elementmethod,and a density-based topology optimization is conducted to optimize distribution of sound-absorbing materials adhered to structural *** approach enables one to perform acoustic optimization from Computer-Aided Design models directly without needingmeshing and volume parameterization,thereby avoiding the geometric errors and time-consuming preprocessing steps in conventional simulation and optimization *** effectiveness of the present method is demonstrated by three dimensional numerical examples.

关键词： Noise control topology optimization Catmull-Clark subdivision surfaces isogeometric analysis boundary element methods