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Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

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World Journal of Gastroenterology 2014年第47期20卷 17851-17862页

作者： Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas dorothy Loo Brian Gabrielli Michelle M hill Matthew J Sweet Andrew d Clouston Elizabeth E Powell Centre for Liver disease Research School of MedicineThe University of QueenslandTranslational Research InstituteBrisbane 4102Australia Institute for Molecular Bio-science The University of QueenslandBrisbane 4067Australia The University of Queensland diamantina Institute The University of Queensland Translational Research InstituteBrisbane 4102Australia department of Gastroenterology and Hepatology Princess Alexandra HospitalBrisbane 4102Australia

AIM: To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype (SASP).

关键词： Cell aging Chemokines Hepatocytes Inflammation Liver diseases Macrophages

Increased connectivity of hiPSC-derived neural networks in multiphase granular hydrogel scaffolds

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Bioactive Materials 2022年第3期7卷 358-372页

作者： Chia-Chen Hsu Julian H.George Sharlayne waller Cyril Besnard david A Nagel Eric J hill Michael d.Coleman Alexander M.Korsunsky Zhanfeng Cui Hua Ye Institute of Biomedical Engineering Department of Engineering ScienceUniversity of OxfordOX37DQUK MBLEM Department of Engineering ScienceUniversity of OxfordParks RoadOxfordOX13PJUK School of Biosciences College of Health and Life SciencesAston UniversityBirminghamB47ETUK Translational Medicine Research Group Aston Medical SchoolCollege of Health and Life SciencesAston UniversityBirminghamB47ETUK

To reflect human development,it is critical to create a substrate that can support long-term cell survival,differentiation,and *** are promising materials for 3d ***,a bulk structure consisting of dense polymer networks often leads to suboptimal microenvironments that impedes nutrient exchange and cell-to-cell ***,granular hydrogel-based scaffolds were used to support 3d human induced pluripotent stem cell(hiPSC)-derived neural networks.A custom designed 3d printed toolset was developed to extrude hyaluronic acid hydrogel through a porous nylon fabric to generate hydrogel *** and hydrogel granules were combined using a weaker secondary gelation step,forming self-supporting cell laden *** three and seven days,granular scaffolds supported higher cell viability compared to bulk hydrogels,whereas granular scaffolds supported more neurite bearing cells and longer neurite extensions(65.52±11.59μm)after seven days compared to bulk hydrogels(22.90±4.70μm).Long-term(three-month)cultures of clinically relevant hiPSC-derived neural cells in granular hydrogels supported well established neuronal and astrocytic colonies and a high level of neurite extension both inside and beyond the *** approach is significant as it provides a simple,rapid and efficient way to achieve a tissue-relevant granular structure within hydrogel cultures.

关键词： Microgel Hydrogel Hyaluronan iPSC Neural tissue engineering 3d printing

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格老秀斯其人其书

华东政法学院学报 2004年第2期 79-88页

作者： d.J.hill 何勤华竹青不详华东政法学院

格老秀斯的伟大著作(de. Jure Belliac Pacis),并非凭借着经典作品通常所体现出的写作风格而被列入通用经典学术丛书系列.该书修辞欠佳,推理繁琐,表达晦涩,因此,人们难以将其视为一部雅作.

关键词：格老秀斯《战争与和平法》国际关系法生平事迹法学家

All-optical tuning of a diamond micro-disk resonator on silicon

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Photonics Research 2020年第3期8卷 318-324页

作者： PAUL hill CHARALAMBOS KLITIS BENOIT GUILHABERT MARC SOREL ERdAN GU MARTIN d.dAWSON MICHAEL J.STRAIN Institute of Photonics Department of PhysicsTechnology and Innovation CentreUniversity of StrathclydeGlasgow G11RDUK diamond Science and Technology Centre for Doctoral TrainingUniversity of WarwickCoventry CV47ALUK School of Engineering University of GlasgowGlasgow G128LTUK

High-quality integrated diamond photonic devices have previously been demonstrated in applications from nonlinear photonics to on-chip quantum ***,the small sample sizes of single crystal material available,and the difficulty in tuning its optical properties,are barriers to the scaling of these *** of these issues can be addressed by integrating micrometer-scale diamond devices onto host photonic integrated circuits using a highly accurate micro-assembly *** this work a diamond micro-disk resonator is integrated with a standard single-mode silicon-on-insulator waveguide,exhibiting an average loaded Q-factor of 3.1×10^4 across a range of spatial modes,with a maximum loaded Q-factor of 1.05×10^*** micrometer-scale device size and high thermal impedance of the silica interface layer allow for significant thermal loading and continuous resonant wavelength tuning across a 450 pm range using a milliwatt-level optical *** diamond-on-demand integration technique paves the way for tunable devices coupled across large-scale photonic circuits.

关键词： tuning resonator waveguide

The Properties and Applications of MoS_2/Ti Composite Coatings in dry Cutting and Forming

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材料热处理学报 2004年第5B期25卷 894-898页

作者： XiaolingZhang HailinSun d.Becker S.wagner d.G.Teer TeerCoatingsLtd. WestStineHouseBerryHillIndustrialEstateDroitwichWorcestershireUK InstituteforMetalFormingTechnology stuttgartUniversityStuttgartGermany

MoSi/Ti composite coatings (MoST?), have been deposited by a closed-field unbalanced magnetron sputter ion-plating system. The high ion-current densities at low substrate bias voltage of the system ensures that the MoST? coatings are characteristic of dense coherent structures, with high adhesion (critical scratch load above 120 N), high load bearing capacity up to 5 GPa., low friction (0.02-0.1), high wear resistance (less than 4xlO"17 m3/N m) even at a relative humidity of 40%, and high temperature resistance up to 350 °C. The successful applications of MoST? coatings in large- scale productions for dry cutting and forming, with increasing lifetime and productivity are presented.

关键词： MoS2/Ti复合涂层干切割低摩擦力磁控管溅射

Using Pharmacokinetic Modeling and Electronic Health Record data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

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Congenital Heart disease 2023年第3期18卷 295-313页

作者： Henry P.Foote Huali Wu Stephen J.Balevic Elizabeth J.Thompson Kevin d.hill Eric M.Graham Christoph P.Hornik Karan R.Kumar department of Pediatrics Duke UniversityDurhamUSA duke Clinical Research Institute DurhamUSA department of Pediatrics Medical University of South CarolinaCharlestonUSA

Background:Infants undergoing cardiac surgery with cardiopulmonary bypass(CPB)frequently receive intraoperative methylprednisolone(MP)to suppress CPB-related inflammation;however,the optimal dosing strategy and efficacy of MP remain ***:We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our *** combined real-world dosing data from the electronic health record(EHR)and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration(Cmax)and area under the concentration-time curve for 24 h(AUC24)for MP and the inflammatory cytokines interleukin-6(IL-6)and interleukin-10(IL-10).We evaluated the relationships between post-operative,safety,and other clinical outcomes obtained from the EHR with each predicted exposure using non-parametric ***:A total of 142 infants with median post-natal age 8(interquartile range[IQR]:5,37)days received a total dose of 30(19,49)mg/kg of ***(8%)died,37(26%)met the composite post-operative outcome,114(80%)met the composite safety outcome,and 23(16%)had a major *** median Cmax and AUC24 IL-6 exposure was significantly higher for infants meeting the composite post-operative outcome and those with major *** median Cmax and AUC24 MP exposure was significantly higher for infants requiring *** exposure was associated with death or other safety ***:Pro-inflammatory IL-6,but not MP exposure,was associated with post-operative organ dysfunction,suggesting current MP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical *** study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants.

关键词： Neonates cardiopulmonary bypass methylprednisolone exposure

Evolutionary Relationship of Protein Sequences of SARS-CoV-2 and Other Viruses through Chaos Game Representation

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Computational Molecular Bioscience 2022年第3期12卷 123-143页

作者： Matthew d. hill Kevin E. Simmons dipendra C. Sengupta department of Mathematics Computer Science and Engineering Technology Elizabeth City State University Elizabeth City NC USA

Comparison between different biological sequences is a key step in bioinformatics when analyzing similarities of sequences and phylogenetic relationships. A method of graphically representing biological sequences known as Chaos Game Representation (CGR) has achieved many applications in the studies of bioinformatics. The key issue in the application of CGR is to extract as many useful features as possible from CGR. Initially, CGR was applied to dNA sequences, but in this paper, a CGR-based approach is used to extract suitable features for comparing protein sequences of SARS-CoV-2 and other viruses. For this aim, several viral protein sequences from 12 groups are considered and CGR centroid, amino acid frequency, compounded frequency, Shannon entropy, and Kullback-Lieber discrimination Information are applied to find the inter-relationship among the sequences. The experimental results demonstrate the potential strengths of CGR-based method for examining the evolutionary relationship of protein sequences. Our method is powerful for extracting effective features from protein sequences, and therefore important in classifying proteins and inferring the phylogeny of viruses.

关键词： Chaos Game Representation (CGR) Protein Multi-dimensional Scaling (MdS)

用单克隆抗体免疫化学技术鉴定不育妇女子宫内膜中白细胞成分

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中国免疫学杂志 1990年第5期6卷 301-303页

作者：徐崇 hill J. A Anderson d. J. 四川省计划生育科学研究所世界卫生组织人类生殖研究合作中心成都610041 美国哈佛大学医学院妇产和生殖生物学系

用白细胞亚类特异性单克隆抗体研究了不育妇女子宫内膜中白细胞成分。发现NKH—1阳性细胞为其主要成分,占50～75%,巨噬细胞次之。整个月经周期中T协助细胞始终多于T抑制细胞,其比例有波动。B淋巴细胞和粒细胞罕见。讨论了不育妇女子宫... 详细信息

用白细胞亚类特异性单克隆抗体研究了不育妇女子宫内膜中白细胞成分。发现NKH—1阳性细胞为其主要成分,占50～75%,巨噬细胞次之。整个月经周期中T协助细胞始终多于T抑制细胞,其比例有波动。B淋巴细胞和粒细胞罕见。讨论了不育妇女子宫内膜中NKH—1阳性细胞和巨噬细胞的存在以及T_H/T_s比例在月经周期中波动的可能意义。

关键词：子宫内膜白细胞不育免疫化学