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A 3d In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

International Journal of Oral Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Boussahel Rafael O.Moreno-Tortolero Mark R.Shannon Nicola West darryl hill Adam Perriman School of Cellular and Molecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife Research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Bristol Centre for Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom Periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3d in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hMSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3d dentine-bone interface models.

关键词： interface den surface

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Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.d.James J.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

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The 2024 Compendium of Physical Activities and its expansion

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Journal of Sport and Health Science 2024年第1期13卷 1-2,F0003页

作者： Stephen d.Herrmann Erik A.Willis Barbara E.Ainsworth Kansas Center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Exercise and Health Shanghai University of SportShanghai 200438China

First developed 30 years ago,the Compendium of Physical Activities(Compendium)was created to provide a standardized way of measuring and classifying specific physical activities(PAs),allowing researchers and health professionals to assess the energy expenditure and health benefits associated with different PA.1Since its inception,the Compendium has been widely utilized and recognized as a fundamental PA and health resource.

关键词： has utilized classify

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Equations of Propagation of Uncertainty on the ITS-90 in the Sub-ranges from 13.8033 K to 933.473 K

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Chinese Physics Letters 2005年第3期22卷 558-560页

作者：康志茹傅广生 K.d.hill CollegeofPhysicsTechnology HebeiUniversityBaoding071002//HebeiProvincialInstituteofMetrologyShijiazhuang050051 CollegeofPhysicsTechnology HebeiUniversityBaoding071002 NationalResearchCouncilofCanada OttawaCanada

Based on implicit differentiation, we present the total differential of linear interpolation and the equation of propagation of uncertainty on the ITS-90 in any of the sub-ranges from 13.8033K to 933.473K. It is proven that the sensitivity coefficients of the linear interpolation are still linear combinations of the basis functions comprising the interpolation equation, only with different constants that can be presented in the determinant form. This solves the question to express the equation of propagation of uncertainty of a complex interpolation comprised of many different basic functions.

关键词： TS-90 Sub-ranges 13.8033K 933.473K

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Probing Electrocatalytic CO_(2) Reduction at Individual Cu Nanostructures via Optically Targeted Electrochemical Cell Microscopy

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Journal of Analysis and Testing 2019年第2期3卷 140-149页

作者： Joshua d.walmsley Joshua W.hill Partha Saha Caleb M.hill department of Chemistry University of WyomingLaramieWY 82071USA

Optically targeted electrochemical cell microscopy(OTECCM)was applied to measure electrocatalytic rates at individual Cu nanoparticles(NPs)under electrolyte conditions relevant to CO_(2) *** electrocatalytic responses from individual NPs were found to exhibit a wide variation in behavior,with significant NP-to-NP variations in the magnitude of electrocata-lytic currents and necessary overpotentials being *** of these quantities with metrics of NP size suggest no significant variations in the inherent electrocatalytic activity of the NPs with *** element simulations of diffusion in this system demonstrate the observed diffusion-limited currents are significantly smaller than expected,attributable to the presence of a significant amount of residual ligand on the surface of the Cu NPs,which were prepared via an organic phase *** results presented here further demonstrate the promise of techniques which employ correlated optical and electrochemical measurements,such as OTECCM,for studying electrocatalysis at individual NPs.

关键词： Electrochemistry Electrochemical microscopy Nanoparticles CO_(2)reduction

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So much for the city:Urban–rural song variation in a widespread Asiatic songbird

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Integrative Zoology 2018年第2期13卷 194-205页

作者： Samuel d.hill Achyut ARYAL Matthew d.M.PAWLEY Weihong JI Human-Wildlife Interactions Research Group Institute of Natural and Mathematical SciencesMassey UniversityAucklandNew Zealand School of Life and Environmental Sciences Faculty of ScienceUniversity of SydneySydneyAustralia department of Forestry and Resource Management Toi Ohomai Institute of TechnologyRotoruaNew Zealand Institute of Natural and Mathematical Sciences Massey UniversityAucklandNew Zealand

Song plays a fundamental role in intraspecific communication in *** temporal and structural components of songs can vary in different *** include urban habitats where anthropogenic sounds and alteration of habitat structure can significantly affect songbird vocal ***-rural variations in song complexity,song length and syllable rate are not fully *** this study,using the oriental magpie-robin(Copsychus saularis)as a model,we investigated urban-rural variation in song complexity,song length,syllable rate,syllable length and inter-syllable *** urban and rural songs from 7 countries across its natural Asiatic range(Bangladesh,India,Malaysia,Nepal,Singapore,Sri Lanka and Thailand),we found no significant differences in oriental magpie-robin song ***,we found significant differences in temporal song variables between urban and rural *** songs and inter-syllable intervals in addition to slower syllable rates within urban sites contributed the most to this *** indicates that the urban environment may have driven production of longer and slower songs to maximize efficient transmission of important song information in urban habitats.

关键词： communication complexity length oriental magpie-robin song syllable

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deformable microlaser force sensing

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Light(Science & Applications) 2024年第6期13卷 1196-1209页

作者： Eleni dalaka Joseph Shill Jonathan H.H.Booth Anna Popczyk Stefan R.Pulver Malte C.Gather Marcel Schubert Centre of Biophotonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK Humboldt Centre for Nano-and Biophotonics Department of ChemistryUniversity of CologneKölnGermany School of Psychology and Neuroscience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of Catalonia BarcelonaSpain

Mechanical forces are key regulators of cellular behavior and function,affecting many fundamental biological processes such as cell migration,embryogenesis,immunological responses,and pathological *** force sensors and imaging techniques have been developed to quantify these otherwise invisible forces in single cells and in ***,current techniques rely heavily on high-resolution microscopy and do not allow interrogation of optically dense tissue,reducing their application to 2d cell cultures and highly transparent biological ***,we introduce dEFORM,deformable microlaser force sensing,a spectroscopic technique that detects sub-nanonewton forces with unprecedented spatio-temporal *** is based on the spectral analysis of laser emission from dye-doped oil microdroplets and uses the force-induced lifting of laser mode degeneracy in these droplets to detect nanometer *** validation by atomic force microscopy and development of a model that links changes in laser spectrum to applied force,dEFORM is used to measure forces in 3d and at depths of hundreds of microns within tumor spheroids and late-stage drosophila *** furthermore show continuous force sensing with single-cell spatial and millisecond temporal resolution,thus paving the way for non-invasive studies of biomechanical forces in advanced stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion otherwise hundreds

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Investigating the raveling test for full-depth reclamation

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Frontiers of Structural and Civil Engineering 2018年第2期12卷 222-226页

作者： Robert hill Andrew BRAHAM department of Civil Engineering University of Arkansas Fayetteville AR 72701 USA

Full-depth Reclamation （FdR） is a sustainable method of building pavement structure compared to more traditional rehabilitation methods. Traffic is generally returned to an FdR project before a surface course is applied, as water in the FdR needs time to evaporate from the structure. This should not be done too quickly or raveling occurs. Currently, there is no test to quantify the timing of return to traffic. In this study, the ＂Raveling test of cold mixed bituminous emulsion samples＂（ASTM d7196） was used to compare asphalt emulsion and asphalt foam FdR. Asphalt emulsion samples were cured at ambient and 40℃ temperatures, while asphalt foam samples were cured at ambient temperatures. Raveling test data was collected from 0 to 48 hours of curing, however, samples were often not able to withstand fifteen minutes of testing. Therefore, the ＂time lasted＂（the time the raveling head loses contact with the surface of the sample） was recorded. In general, the asphalt emulsion samples that were cured in the oven at 40℃ had a longer time lasted and showed higher potential for determination of return to traffic. In addition, the asphalt emulsion samples had a longer time lasted than the asphalt foam samples at ambient temperatures.

关键词： raveling full depth reclamation

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2024 Wheelchair Compendium of Physical Activities:An update of activity codes and energy expenditure values

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Journal of Sport and Health Science 2024年第1期13卷 18-23页

作者： Scott A.Conger Stephen d.Herrmann Erik A.Willis Tom E.Nightingale Joseph R.Sherman Barbara E.Ainsworth department of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an update of the 2011 Wheelchair Compendium of Physical Activities designed for wheelchair users and is referred to as the 2024 Wheelchair *** Wheelchair Compendium aims to curate existing knowledge of the energy expenditure for wheelchair physical activities(PAs).Methods:A systematic review of the published energy expenditure of PA for wheelchair users was completed between 2011 and May *** added these data to the 2011 Wheelchair Compendium data that was compiled previously in a systematic review through ***:A total of 47 studies were included,and 124 different wheelchair PA reported energy expenditure values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nordic sit skiing).Conclusion:In introducing the updated 2024 Wheelchair Compendium,we hope to bridge the resource gap and challenge the prevailing narratives that inadvertently exclude wheelchair users from physical fitness and health PAs.

关键词： disability Exercise MET Mobility

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Framework for atomic-level characterisation of quantum computer arrays by machine learning

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npj Computational Materials 2020年第1期6卷 1513-1520页

作者： Muhammad Usman Yi Zheng Wong Charles d.hill Lloyd C.L.Hollenberg Center for Quantum Computation and Communication Technology University of MelbourneParkvilleVIC 3010Australia School of Physics University of MelbourneParkvilleVIC 3010Australia School of Computing and Information Systems Melbourne School of EngineeringUniversity of MelbourneParkvilleVIC 3010Australia School of Mathematics and Statistics University of MelbourneParkvilleVIC 3010Australia

Atomic-level qubits in silicon are attractive candidates for large-scale quantum computing;however,their quantum properties and controllability are sensitive to details such as the number of donor atoms comprising a qubit and their precise *** work combines machine learning techniques with million-atom simulations of scanning tunnelling microscopic(STM)images of dopants to formulate a theoretical framework capable of determining the number of dopants at a particular qubit location and their positions with exact lattice site precision.A convolutional neural network(CNN)was trained on 100,000 simulated STM images,acquiring a characterisation fidelity(number and absolute donor positions)of>98% over a set of 17,600 test images including planar and blurring noise commensurate with experimental *** formalism is based on a systematic symmetry analysis and feature-detection processing of the STM images to optimise the computational *** technique is demonstrated for qubits formed by single and pairs of closely spaced donor atoms,with the potential to generalise it for larger donor *** method established here will enable a high-precision post-fabrication characterisation of dopant qubits in silicon,with high-throughput potentially alleviating the requirements on the level of resources required for quantum-based characterisation,which will otherwise be a challenge in the context of large qubit arrays for universal quantum computing.

关键词： quantum character donor

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