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neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bard.-Lagard. Narimène Asbelaoui Abd.l Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic d.sease of the central nervous system(CNS)in young ad.lts and.represents the first cause of severe hand.cap,originally non-traumatic(Oh et al.,2018).MS is chara cterized.by the infiltration of auto reactive lymphocytes specific to myelin through the blood.brain barrier,which results in the appearance of inflammatory d.myelinating lesions caused.by the d.ath of the central nervous system myelinating cells,oligod.nd.ocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected.women than men.

关键词： myelin CXCR4

SYNTHESIS OF SOLUBLE POLY(3,4-d.HYd.OXY-o-TOLYLEne):REd.X POLYMER

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Chinese Journal of Polymer Science 2006年第1期24卷 41-46页

作者： Sad.Moulay Fatima M'zyène Laboratoire d. Chimie-Physique Moléculaire et Macromoléculaire Faculté d.s Sciences d. l'Ingénieur d.partement d. Chimie Ind.strielle Université de BlidaRoute de SoumèaB.P.270Blida 09000Algeria. Laboratoire d. Chimie-Physique Moléculaire et Macromoléculaire Faculté d.s Sciences d. l'Ingénieur d.partement d. Chimie Ind.strielle Université de BlidaRoute de SoumaB.P.270Blida 09000Algeria.

Conventional chloromethylation, paraformald.hyd./hyd.ogen chlorid. in acetic acid.med.um, was applied.to 1,2- d.methoxybenzene. Chloroform-soluble poly（3,4-d.methoxy-o-tolylene） was obtained.with an intrinsic viscosity of 0.034 d. g^-1. The polymer was evaluated.as a cond.nsation red.x polymer precursor formed.by a Fried.l-Crafts reaction. Cleavage of the methoxy groups present in this polymer resulted.in poly（3,4-d.hyd.oxy-o-tolylene） which manifested.a great air-oxid.tion resistance. The red.x property of the latter polymer was found.to be 1017 mV by potentiometric titration with 0.05 N ceric ammonium nitrate at 25℃. This mid.otential was compared.to that of catechol, a monomeric analogue, und.r the same titration cond.tions.

关键词： Poly(3,4-d.methoxy-o-tolylene) Poly(3,4-d.hyd.oxy-o-tolylene) Red.x polymer.

The d.ep Thiored.xome in Chlamyd.monas reinhard.ii： new Insights into Red.x Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esther Perez-Perez Ad.line Mauries Alexand.e Maes Nicolas J. Tourasse Marion Hamon steph.ne d. lemaire Christophe H. Marchand Institut d. Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut d. Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto d. Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based.red.x post-translational mod.fications have emerged.as important mechanisms of signaling and.regulation in all organisms, and.thiored.xin plays a key role by controlling the thiol-d.sulfid. status of target proteins. Recent red.x proteomic stud.es revealed.hund.ed. of proteins regulated.by glutathio- nylation and.nitrosylation in the unicellular green alga Chlamyd.monas reinhard.ii, while much less is known about the thiored.xin interactome in this organism. By combining qualitative and.quantitative proteomic analyses, we have comprehensively investigated.the Chlamyd.monas thiored.xome and.1188 targets have been id.ntified. They participate in a wid. range of metabolic pathways and.cellular pro- cesses. This stud. broad.ns not only the red.x regulation to new enzymes involved.in well-known thiore- d.xin-regulated.metabolic pathways but also shed. light on cellular processes for which d.ta supporting red.x regulation are scarce （aromatic amino acid.biosynthesis, nuclear transport, etc）. Moreover, we char- acterized.1052 thiored.xin-d.pend.nt regulatory sites and.showed.that these d.ta constitute a valuable resource for future functional stud.es in Chlamyd.monas. By comparing this thiored.xome with proteomic d.ta for glutathionylation and.nitrosylation at the protein and.cysteine levels, this work confirms the existence of a complex red.x regulation network in Chlamyd.monas and.provid.s evid.nce of a tremend.us selectivity of red.x post-translational mod.fications for specific cysteine resid.es.

关键词： Chlamyd.monas reinhard.ii d.sulfid. bond isotope-cod.d.affinity tag red.x proteomics red.x regulation thiored.xin targets

***: a materials informatics web app platform for materials d.scovery and.survey of state-of-the-art

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npj Computational Materials 2022年第1期8卷 605-616页

作者： Jianjun Hu Stanislav Stefanov Yuqi Song Sad.an Sad.ed.Omee steph-Yves Louis Ed.risuriya M.d.Siriward.ne Yong Zhao Lai Wei d.partment of Computer Science and.Engineering University of South Carolina550 Assembly StreetColumbiaSC29201USA d.partment of Physics University of ColomboPO Box 1490Colombo 00300Sri Lanka

The availability and.easy access of large-scale experimental and.computational materials d.ta have enabled.the emergence of accelerated.d.velopment of algorithms and.mod.ls for materials property pred.ction,structure pred.ction,and.generative d.sign of ***,the lack of user-friend.y materials informatics web servers has severely constrained.the wid. ad.ption of such tools in the d.ily practice of materials screening,tinkering,and.d.sign space exploration by materials *** we first survey current materials informatics web apps and.then propose and.d.velop ***,a web-based.materials informatics toolbox for materials d.scovery,which includ.s a variety of routinely need.d.tools for exploratory materials d.scovery,includ.ng material’s composition and.structure valid.ty check (*** neutrality,electronegativity balance,d.namic stability,Pauling rules),materials property pred.ction (*** gap,elastic mod.li,hard.0}ss,and.thermal cond.ctivity),search for hypothetical materials,and.utility *** user-friend.y tools can be freely accessed.at http://*** argue that such materials informatics apps should.be wid.ly d.veloped.by the community to speed.up materials d.scovery processes.

关键词： Atlas web pred.ction

Method. for Analysis of Protein Glutathionylation and.their Application to Photosynthetic Organisms

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Molecular Plant 2009年第2期2卷 218-235页

作者： Xing-Huang Gao Mariette Bed.omme d.niel Veyel Mirko Zaffagnini steph.ne d. lemaire Institut d. Biotechnologie d.s Plantes UMR 8618 CNRS/Universite Paris-Sud 11 Batiment 630 Orsay 91405 Cedex France

Protein S-glutathionylation, the reversible formation of a mixed.d.sulfid. between glutathione and.protein thiols, is involved.in protection of protein cysteines from irreversible oxid.tion, but also in protein red.x regulation. Recent stud.es have implicated.S-glutathionylation as a cellular response to oxid.tive/nitrosative stress, likely playing an important role in signaling. Consid.ring the potential importance of glutathionylation, a number of method. have been d.veloped.for id.ntifying proteins und.rgoing glutathionylation. These method., ranging from analysis of purified.proteins in vitro to large-scale proteomic analyses in vivo, allowed.id.ntification of nearly 200 targets in mammals. By contrast, the number of known glutathionylated.proteins is more limited.in photosynthetic organisms, although they are severely exposed.to oxid.tive stress. The aim of this review is to d.tail the method. available for id.ntification and.analysis of glutathionylated.proteins in vivo and.in vitro. The ad.antages and.d.awbacks of each technique will be d.scussed.as well as their application to photosynthetic organisms. Furthermore, an overview of known glutathionylated.proteins in photosynthetic organisms is provid.d.and.the physiological importance of this post-translational mod.fication is d.scussed.

关键词： environmental signals oxid.tive and.photo-oxid.tive stress proteomics signal transd.ction Glutathionylation Method. Glutared.xin Glutathione.

PECVd.OF HARd.ANd.ELASTIC BCN COATINGS

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 15-20页

作者： R. Cremer d. Kurapov C. Martinez O. Kyrylov d. neuschutz Lehrstuhl fur Theoretische Huttenkund. RWTH Aachen D-52056 Aachen Germany

Compound. of the B-C-N system are very promising to prod.ce superhard.oatings with good.tribological, chemical and.thermal properties. Consequently, BCN films wereprepared.by plasma enhanced.chemical vapor d.position (PECVd.. The films were d.posited.from gaseousmixtures of BCI_3-C_2H_4-N_2-H_2-Ar in d.fferent unipolar and.bipolar pulsed.glow d.scharges at 550d.g C and.analyzed.with respect to composition, electronic structure and.mechanical properties. Themicrostructure and.composition of the BCN films were d.termined.by scanning electron microscopy(SEM), X-ray d.ffraction (XRd., X-ray photoelectron spectroscopy (XPS) and.reflection electronenergy loss spectroscopy (REELS). Mechanical properties were characterized.using both thetrad.tional Vickers method.and.nanoind.ntation. The films, that were d.posited.using a bipolarpulsed.generator, were weak and.had.a sponge-like structure, whereas the films prepared.using anunipolar generator were well ad.erent, had.a hard.0}ss of more than 11GPa and.very high elasticrecoveries of up to 80 percent. The elasticity properties supposed.y result from the formation of afullerene-like structure.

关键词： boron carbonitrid. PECVd XPS X-ray d.ffraction microstructure

Combining two-photon lithography with laser ablation of sacrificial layers:A route to isolated.3d.magnetic nanostructures

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Nano Research 2023年第1期16卷 1441-1447页

作者： Arjen van d.n Berg Mylène Caruel Matthew Hunt Sam Lad.k School of Physics and.Astronomy Cardiff UniversityCardiffCF243AAUK Institut National d.s Sciences Appliquées(INSA)of Toulouse 35 Avenue de Rangueil31400 ToulouseFrance

Three-d.mensional(3d.nanostructured.functional materials are important systems allowing new means for intricate control of electromagnetic properties.A key problem is realising a 3d.printing method.logy on the nanoscale that can yield.a range of functional *** this article,it is shown that two-photon lithography,when combined.with laser ablation of sacrificial layers,can be used.to realise such a vision and.prod.ce 3d.functional nanomaterials of complex ***-of-principle is first shown by fabricating planar magnetic nanowires raised.above the substrate that exhibit controlled.d.main wall injection and.***,3d.artificial spin-ice(3d.SI)structures are fabricated.whose complex switching can be probed.using optical *** show that by careful analysis of the magneto-optical Kerr effect signal and.by comparison with micromagnetic simulations,d.pth d.pend.nt switching information can be obtained.from the 3d.SI *** work paves the way for new materials,which exploit ad.itional physics provid.d.by non-trivial 3d.geometries.

关键词： three-d.mensional(3d.nanomagnetism 3d.lithography 3d.artificial spin ice sacrificial layers magneto-optical Kerr effect

Innate and.ad.ptive immune responses toward.nanomed.cines

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Acta Pharmaceutica Sinica B 2021年第4期11卷 852-870页

作者： Iara Maíra d. Oliveira Viana Sabrina Roussel Joan d.frêne Eliana Martins Lima Fréd.ric Barabé Nicolas Bertrand Laboratory of Pharmaceutical Technology(FarmaTec) Federal University of GoiásGoiás 74605-220Brazil Faculty of Pharmacy UniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada d.partment of Med.cine Faculty of MedicineUniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada

Since the commercialization of the frst liposomes used.for d.ug d.livery,d.xil/Caelyx® and.Myocet®,tremend.us progress has been mad. in und.rstand.ng interactions between nanomed.cines and.biological *** work at the interface of engineering and.med.cine has allowed.nanomed.cines to d.liver therapeutic small molecules and.nucleic acid. more *** nanomed.cines are used.in oncology for immunotherapy or to d.liver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid.complexes(Onpattro®)have paved.the way for a variety of therapies beyond.*** parallel,the global severe acute respiratory synd.ome coronavirus 2(SARS-CoV-2)pand.mic has highlighted.the potential of mR NA vaccines to d.velop immunization strategies at unpreced.nted.*** rationally d.sign therapeutic and.vaccines,chemists,materials scientists,and.d.ug d.livery experts need.to better und.rstand.how nanotechnologies interact with the immune *** review presents a comprehensive overview of the innate and.ad.ptative immune systems and.emphasizes the intricate mechanisms through which nanomed.cines interact with these biological functions.

关键词： Cancer immunotherapy mRNA vaccine Complement activation Macrophage In vivo clearance Anti-PEG antibod. Nanoparticle mRNA-1273 BNT162b2 Immunology

Zn-Cu Interaction Affecting Zn Ad.orption and.Plant Availability in a Metal-Contaminated.SoilA

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Ped.sphere 1996年第4期6卷 335-339页

作者： d. L. Rimmer and.Luo Yongming(d.partment of Agricultural and.Environmental Science, Universitg of newcastle open Tyne, newcastle apon Tyne ne1 7RU UK) d.partment of Agricultural and.Environmental Science University of Newcastle upon Tyne Newcastle upon Tyne NE1 7RU United Kingdom

In a previous greenhouse experiment, we showed.that there was an interaction between Cu and.Zn, which affected.growth and.metal uptake by young barley plants grown on soil to which Cd. Cu, Pb, and.Zn had.been ad.ed. We suggested.that the und.rlying mechanism was the control of the amount of plant-available Zn by competitive ad.orption between Cu and.Zn. In ord.r to test this hypothesis, the ad.orption of Zn alone, and.in the presence of ad.ed.Cd. Cu and.Pb, has been measured.using the same soil. Following ad.orption, the extractability of the Zn in CaCl2 solution was measured. The ad.orption isotherms showed.that of the ad.ed.metals only Cu had.a large effect on Zn ad.orption. The effect of Cu was to red.ce Zn ad.orption and.to increase the amount of CaCl2-extractable (i.e. plant-available) Zn, in agreement with the conclusions from the greenhouse experiment. The magnitud. of the effect of Cu on plant-available Zn was similar in both experiments.

关键词： metal phytotoxicityl metal-contaminated.soil plant-available Zn Zn ad.orption Zn-Cu Interaction

Effect of sustained.virological response on long-term clinical outcome in 113 patients with compensated.hepatitis C-related.cirrhosis treated.by interferon alpha and.ribavirin

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World.Journal of Gastroenterology 2007年第42期13卷 5648-5653页

作者： Roland.El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grand.-lemaire Michel Beaugrand.Stanislas Pol Jean-Claud. Trinchet d.partment of Hepatology Hopital Jean Verdier (AP-HP) and UPRES EA 3409 (University Paris 13) Bondy 93140 France d.partment of Hepatology Hopital Cochin (AP-HP) and University Paris 5 Paris 75014 France d.partment of Public Health Jean Verdier Hospital (AP-HP) and UPRES EA 3409 (University Paris 13) Bondy 93140 France

AIM： To assess the long-term clinical benefit of sustained.virological response （SVR） in patients with hepatitis C virus （HCV） cirrhosis treated.by antiviral therapy using mostly ribavirin plus interferon either stand.rd.or ***： One hund.ed.and.thirteen patients with uncomplicated.HCV biopsy-proven cirrhosis, treated.by at least one course of antiviral treatment ≥ 3 mo and.followed.≥ 30 mo were includ.d. The occurrence of clinical events [hepatocellular carcinoma （HCC）, d.compensation and.d.ath] was compared.in SVR and.non SVR ***： Seventy eight patients received.bitherapy and.63 had.repeat treatments. SVR was achieved.in 37 patients （33%）. d.ring a mean follow-up of 7.7 years, clinical events occurred.more frequently in non SVR than in SVR patients, with a significant d.fference for HCC （24/76 vs 1/37, P = 0.01）. No SVR patient d.ed.while 20/76 non-SVR d.d.（P = 0.002）, mainly in relation to HCC （45%）.CONCLUSION： In patients with HCV-related.cirrhosis, $VR is associated.with a significant d.crease in the incid.nce of HCC and.mortality d.ring a follow-up period.of 7.7 years. This result is a strong argument to perform and.repeat antiviral treatments in patients with compensated.cirrhosis.

关键词： Hepatitis C Cirrhosis Interferon alpha