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Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients

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World Journal of Clinical Oncology 2017年第4期8卷 343-350页

作者： Tatjana Gruber-Rouh marcel Langenbach Nagy nn Naguib Nour-Eldin m Nour-Eldin Thomas J Vogl step.an Zangos martin Beeres Institute for Diagnostic and Interventional Radiology University Hospital Frankfurt

AIm To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).mETHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(mRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors *** TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up mRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC.

关键词： Colorectal neoplasms Breast neoplasms Neoplasm metastasis Neoplasms Drug therapy

Re-EValuaTion after 15 Years of 4-Lid Laser-Blepharoplasty

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Re-EValuaTion after 15 Years of 4-Lid Laser-Blepharoplasty

中华医学会整形外科学分会第十一次全国会议、中国人民解放军整形外科学专业委员会学术交流会、中国中西医结合学会医学美容专业委员会全国会议

作者： Constance m.Neuha nn-Lorenz Diakonie-Clinic munich

OBJECTIVES: Since 1994 4-lid blepharoplasty with CO2-Laser has been described extensively with consistent results. Nevertheless this technique has not evolved as a standard blepharoplasty,also due to the fact,that conventional techniques have shown good patient satisfaction especially in upper eyelid correction. After 15 years of using the ultrapulsed Co2 Laser for 4-lid blepharoplasties in 5150 lids,and nearly 2000 patientsabout 95%of all my blepharoplasties the results were evaluated retrospectively.

关键词： Re-EValuaTion after 15 Years of 4-Lid Laser-Blepharoplasty

来源： cnki会议评论

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三维断裂问题中的位移不连续方法

湘潭大学学报（自然科学版） 2020年第4期42卷 69-93页

作者： Zvyaguin AV Smirnov nn Luzhin AA Shamina AA 国立莫斯科罗蒙诺索夫大学俄罗斯莫斯科119992 俄罗斯科学院联邦科学中心系统分析科学研究所俄罗斯莫斯科117218

该研究将位移不连续方法引入三维空间中对边界元数值方法进行改进,旨在有效地减少计算过程中三维空间单元数.该方法通过对裂缝表面进行基础单元划分来表征弹性介质的非连续特征,并有效地降低了计算规模.此外,该文还给出了一个基于双层... 详细信息

该研究将位移不连续方法引入三维空间中对边界元数值方法进行改进,旨在有效地减少计算过程中三维空间单元数.该方法通过对裂缝表面进行基础单元划分来表征弹性介质的非连续特征,并有效地降低了计算规模.此外,该文还给出了一个基于双层位势的新基本解.与此同时,可认为该方法能有效地模拟水力裂缝扩展及其与天然断层之间的相互作用效应.

关键词：三维空间弹性介质裂缝边界单元法位移不连续方法

Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

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matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert P.Hesselbach m.Schorner V.Bagnoud R.Belikov P.Drechsel B.Heuser O.SHumphries P.Katrik B.Lindqvist C.Qu R.Redmer D.Riley G.Schaumann S.Schumacher A.Tauschwitz D.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.major P.Neumayer D.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

Effects of the phase variation and high-order momentum transfer components of nn amplitude on p-~4He elastic scattering

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Nuclear Science and Techniques 2018年第1期29卷 65-76页

作者： I.m.A.Tag-Eldin m.m.Taha S.S.A.Hassan Nuclear Experimental Physics Department Nuclear Research Center Atomic Energy Authority mathematics and Theoretical Physics Department Nuclear Research Center Atomic Energy Authority

Elastic scattering differential cross sections for a p- ~4He system are calculated within the framework of optical limit approximation of the Glauber multiple scattering model. Three different ranges for proton energy(E_(lab)), 19〈E_(lab)〈50 me V, 100≤E_(lab)≤1730 me V, and 45 ≤E_(lab)≤393 Ge V are considered. It is shown that the Pauli blocking fails to describe the data up to the proton energy, E_(lab)〈100 me V. For higher proton energies, a qualitative agreement is obtained. The observed elastic scattering differential cross section is nicely reproduced in the whole range of scattering angles in the center of mass system up to Θ_(c.m.)〈200° for 19〈E_(lab) ≤100 me V when the effect of both the nucleon–nucleon(nn) phase variation parameter γnn and higher-order momentum transfer components(λ_n; n = 1 and 2) of(nn) elastic scattering amplitude is included. In the range of 200 E_(lab) 1730 me V, introducing λ_n plays a significant role in describing the data up to the momentum transfer, q^2≤1:2(Ge V/c)~***, it is found that considering only the effect of phase variation parameter, cnn, improved the agreement in the region of minima for elastic scattering differential cross section for 45≤E_(lab)≤393 Ge V. The values of cnnand kn as a function of incident proton energies are presented.

关键词： Elastic scattering Optical limit approximation Glauber multiple scattering model

Contribution of Coherent and Incoherent π-Photoproduction Channels to the Spin Asymmetry and the GDH Sum Rule for the Deuteron

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Chinese Physics Letters 2015年第12期32卷 35-39页

作者： Darwish Eed m. Physics Department Faculty of ScienceTaibah University Physics Department Faculty of ScienceSohag University

An explicit evaluation of the deuteron spin asymmetry and the associated Gerasimov-Drell Hearn （GDH） integral for coherent and incoherent π-photoproduction channels with inclusion of rescattering effects is presented. The helicity-dependent total inclusive photoabsorption cross section on the deuteron and the helicity-dependent semiexclusive channels γd→π± nn and γd→π0X （X = pn or d） are explicitly evaluated up to 1.5 GeV. Our model calculations indicate that convergence of the GDH integral is reached for π-production, while it is not completely reached for π-production. For the sum of 7d → πnn and γd→ π0d contributions to the finite GDH integral by explicit integration up to 1.5 GeV, a value of 249.73μb is obtained. The extracted results are compared with available experimental data from mAmI and ELSA. We find that our predictions fairly well reproduce the data in the μ±nn case, while fail to predict the measured shape of the μ0X channel.

关键词： GDH Contribution of Coherent and Incoherent

Influence of the Choice of nn Potential model on γd→τ~0d Observables near η-Threshold

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Chinese Physics Letters 2016年第4期33卷 14-18页

作者： E.m.Darwish Physics Department Faculty of ScienceTaibah University Physics Department Faculty of ScienceSohag University

Influence of the choice of the nn potential model governing the deuteron wave function on the observables for coherent π0-photoproduction on the deuteron near η-threshom is investigated by using a three-body model for the intermediate ηN N system with separable two-body interactions. Results for unpolarized differential cross section and polarization observables are predicted. It is revealed that the choice of the nn potential model has a visible effect on the differential cross section and most of the polarization observables, especially in the photon energy range of 600-800 meV and extreme backward pion angles. We find that the deviation among results obtained by using different deuteron wave functions is quite large. The use of the CD-Bonn nn potential for deuteron wave function doubles the differential cross section in this kinematic region. Compared with the experimental data from CLAS collaboration for differential cross section, sizeable discrepancies are found.

关键词： of in Observables near Threshold nn that for on CLAS

Study of K^(*)(892)^(0)andФ(1020)meson production in proton–proton and Pb–Pb collisions at√S_(nn)=2.76 TeV

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Communications in Theoretical Physics 2021年第2期73卷 89-95页

作者： Y Ali m Ahmed A Arif Q Ali U Tabassam U Rubab m Suleymanov Department of Physics COMSATS UniversityPark RoadIslamabad44000Pakistan Institute for Physical Problems Baku Suate UniversityBakuAZ 1000Azrbajan

In this paper,we describe a study of charged particle yield as a function of pT for K^(*)(892)0 and phgr(1020)mesons in proton–proton(pp)and Pb–Pb collisions at√S_(nn)=2.76 TeV in the central rapidity region of|y|mportant ratio,the nuclear modification factor,to study the effects of the medium in the most central region,i.e.0%–5%*** data simulation,we used the EPOS-LHC and EPOS-1.99 *** check the validity of these models'simulations,we compared the data obtained from these monte Carlo simulation programs with ALICE experimental data for√S_(nn)=2.76 *** was concluded that the models'predictions for the phgr-meson in pp and for the most central Pb-Pb collisions disagreed with the ALICE data,and that the difference increased with *** may be connected with the essential role of collective parton behaviors which could not have been taken into account by the *** K^(*)0 mesons,both programs gave almost the same predictions,and with pT in the interval pT>3 GeV c^(−1),the predictions were very close to the experimental *** models gave higher predictions for the soft pT interval and lower predictions for the hard *** values of the RAA distributions were lower than unity and both models were very close to the ALICE *** is very interesting that the models were not able to describe the pT distributions,but they gave good predictions for their *** may possibly be due to parton collective *** observed some additional suppression of K^(*)0 at low values of pT with respect to phgr-mesons,which may be related to the role of the masses of the particles in soft *** rising trend for R_(AA)in the region from pT=10 GeV c^(−1)to 20 GeV c^(−1) observed by the ALICE experiment was absent for theФ-mesons.

关键词： Quark Gluon Plasma EPOS-LHC nuclear modification factor

machine Learning Techniques for Detecting Phishing URL Attacks

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Computers, materials & Continua 2023年第4期75卷 1271-1290页

作者： Diana T.mosa mahmoud Y.Shams Amr AAbohany El-Sayed m.El-kenawy m.Thabet Department of Cyber Security College of Engineering and Information TechnologyBuraydah Private CollegesBuraydah51418Kingdom of Saudi Arabia Faculty of Computers and Information Kafrelsheikh UniversityKafrelsheikh33516Egypt Faculty of Artificial Intelligence Kafrelsheikh UniversityKafrelsheikh33516Egypt Delta Higher Institute of Engineering and Technology Mansoura35111Egypt Faculty of Computers and Information Fayoum UniversityFayoumEgypt

Cyber Attacks are critical and destructive to all industry *** affect social engineering by allowing unapproved access to a Personal Computer(PC)that breaks the corrupted system and threatens *** defense of security requires understanding the nature of Cyber Attacks,so prevention becomes easy and accurate by acquiring sufficient knowledge about various features of Cyber ***-Security proposes appropriate actions that can handle and block attacks.A phishing attack is one of the cybercrimes in which users follow a link to illegal websites that will persuade them to divulge their private *** of the online security challenges is the enormous number of daily transactions done via phishing *** Cyber-Security have a priority for all organizations,Cyber-Security risks are considered part of an organization’s risk management *** paper presents a survey of different modern machine-learning approaches that handle phishing problems and detect with high-quality accuracy different phishing attacks.A dataset consisting of more than 11000 websites from the Kaggle dataset was utilized and studying the effect of 30 website features and the resulting class label indicating whether or not it is a phishing website(1 or−1).Furthermore,we determined the confusion matrices of machine Learning models:Neural Networks(nn),Na飗e Bayes,and Adaboost,and the results indicated that the accuracies achieved were 90.23%,92.97%,and 95.43%,respectively.

关键词： Cyber security phishing attack URL phishing online social networks machine learning