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中南财经政法大学学报 2008年第4期 142-144页

作者： .4 .J .1

Community Structure and Seasonal Variation of Soil Arthropods in the Forest-steppe Ecotone of the Mountainous Region in Northern Hebei,China

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Journal of Mountain Science 2010年第2期7卷 187-196页

作者： ZHU Xinyu GAO Baojia YUAN Shengliang HU Yunchuan Institute of Mountain Hazards and Environment CAS Chengdu 610041 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China Hebei North University Zhangjiakou 075000 China Agricultural University ofHebei Baoding 071000 China

Soil fauna have been receiving more and more attention because they play an important role in nutrient ***,there is a lack of information on soil arthropods in the forest-steppe ecotone in the mountainous region of northern Hebei,which makes it difficult to meet the need of protecting biodiversity in this *** arthropod communities were investigated in the forest-steppe ecotone in northern Hebei province to provide basic information on changes in mountain soil fertility,which could promote the development of soil arthropod communities in mountain *** the preliminary identification,a total of 7994 individual soil arthropods were collected,which belonged to 25 groups,6 classes and 24 ***,Hymenoptera and Collembola were the dominant groups in the *** number of Acarina was higher than Collembola,and this phenomenon was obviously different from other areas in the same climate *** increased abundance of rare groups in the Forest zone with the richer vegetation,higher arthropod abundance and more substantial litter depth,could be interpreted as a reaction to the suitable soil environment and food *** these rare groups were sensitive to environmental changes,which could be regarded as biotic indicators for evaluating soil *** analysis of community diversity showed that the abundance index (d),the Shannon-Wiener index (H'),the evenness index (J) and the density-group index (DG) were significantly higher in the forest zone,lower in the forest-steppe zone,and lowest in the meadow-steppe *** variations in community composition correlated with changes in average air temperature and precipitation in this *** and individuals of soil arthropod communities in the three zones were present in greater numbers in the middle of the rainy season than in the early or late periods of the rainy season as a *** the same time,seasonal changes in soil arthropod communities from different plots were also

关键词： Soil arthropods Diversity Composition Ecotone Seasonal change

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Association between Physical Activity and Telomere Length in a North Chinese Population： A China Suboptimal Health Cohort Study

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Biomedical and Environmental Sciences 2018年第5期31卷 394-398页

作者： DING Li Xiang ZHANG Yah Hong2 XU Xi Zhu3 ZHANG Jie4 SUN Ming4 LIU Di4 ZHAO Zhong Yao4 ZHOU Yong5 ZHANG Qun6 WANG You Xin4 Department of Orthopedics Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Internal Medicine Weifang Material and Child Health HospitalWeifang 261011ShandongChina School of Public Health Taishan Medical UniversityTaian 271016ShandongChina Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeiing 100069China Beijing Institute of Heart Lung and Blood Vessel DiseasesBeijing Anzhen HospitalCapital Medical UniversityBeiing 100029China Chinese Center for Disease Control and Prevention Beiing 102206China

Several studies have demonstrated an association between physical activity and telomere length; however, the association remains inconsistent. A cross-sectional study consisting of 588 participants （375 females, median age of 33.8 years） was carried out to investigate the association between telomere length and physical activity in a general population from North China. The results show that relative telomere length is not significantly different in participants in the northern Chinese population with different levels of physical activity, either in the model only adjusted for age （F = 2.127, P = 0.120） or in the model adjusted for demographics and lifestyle （F = 1.227, P = 0.294）. The gender-stratified analysis also produced insignificant results. Our study confirmed a non-significant association between physical activity and telomere length in the northern Chinese population, which adds to the inconsistent association between physical activity and telomere length across different ethnic populations.

关键词： Physical activity Telomere length Relative telomere length Chinese

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国家发展改革委国家数据局财政部自然资源部关于深化智慧城市发展推进城市全域数字化转型的指导意见

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中国产经 2024年第10期 12-17页

作者： 1.国家发展改革委 2.国家数据局 3.财政部 4.自然资源部国家发展改革委国家数据局财政部自然资源部

各省列、市、自新治疆区、生直产辖建市设及兵计团发划展单改革委、数据管理部门、财政厅（局）、自然资源主管部门：城市是推进数字中国建设的综合载体，推进城市数字化转型、智慧化发展，是面向未来构筑城市竞争新优势的关键之举，也...

各省列、市、自新治疆区、生直产辖建市设及兵计团发划展单改革委、数据管理部门、财政厅（局）、自然资源主管部门：城市是推进数字中国建设的综合载体，推进城市数字化转型、智慧化发展，是面向未来构筑城市竞争新优势的关键之举，也是推动城市治理体系和治理能力现代化的必然要求。为深入贯彻落实党中央、国务院关于数字中国建设的决策部署，以数据融通、开发利用贯穿城市全域数字化转型建设始终，更好服务城市高质量发展、高效能治理、高品质生活，支撑发展新质生产力，推进中国式现代化城市建设，特制定本意见。

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Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide

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Acta Pharmacologica Sinica 2007年第12期28卷 1914-1918页

作者： Yan TAN~(2,3,5),Qiang TANG~4,Ben-rong HU~4,Ji-zhou XIANG~4~2 Institute of Urology,Renmin Hospital,Yunyang Medical College,Shiyan 442000 China,~3 Department of Pharmacology,Yunyang MedicalCollege,Shiyan 442000,China,~4 Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Teehnology,Wuhan 430030,China Institute of Urology Renmin Hospital Yunyang Medical College Shiyan China Department of Pharmacology Yunyang Medical College Shiyan China Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To investigate the antioxidant properties of berberine (Ber) on corpuscavenosum smooth muscle cells (CCSMC) in penile erectile ***:We examined the effects of Ber on cultured rabbit CCSMC damaged by hydrogenperoxide (H2O2) through examining cell viability by methyl thiazolyl tetrazoliumassay and assessing the level of malondialdehyde (MDA),superoxide dismutase,(SOD) activity,nitric oxide (NO) products,and lactate dehydrogenase (LDH) re-lease in cells after stimulation with ***:Treatment with 1 mmol/L H2O2significantly decreased the cell viability,NO products,and SOD activity of CCSMCfrom 100% to 48.57%±4.1% (P49.5±1.8 to 30.1±2.6 U/mL (P497.6±69.5 to 1100.5±56.3 U/L (P4±2.9nmol/mg protein (P<0.01),***,treatment with different con-centrations of Ber (10-1000 μmol/L) inhibited the damaging effects of H2O2,withincreased cell viability (P<0.05 or P<0.01),NO production (P<0.01),and SODactivity (P<0.01) and decreased LDH release and MDA content (both P<0.01).Conclusion:Bet could produce its antioxidant action on oxidative stress-inducedcultured *** effects may be of benefit in the prevention of penileerectile dysfunction.

关键词： berberine antioxidant action corpus cavernosum erectile dysfunction

The Kinematic Theory of Solar Dynamo

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Chinese Journal of Astronomy and Astrophysics 2003年第1期3卷 12-32,i001页

作者： Ke-Ke Zhang and Xin-Hao LiaoSchool of Mathematical Sciences, University of Exeter, EX4 4QE, UK kzhang@ex.ac.ukShanghai Astronomical Observatory, Shanghai 200030 xhliao@*** School of Mathematical Sciences University of Exeter EX4 4QE UK Shanghai Astronomical Observatory Shanghai 200030 China

Generation of the Sun's magnetic fields by self-inductive processes in the solar electrically conducting interior, the solar dynamo theory, is a fundamentally important subject in astrophysics. The kinematic dynamo theory concerns how the magnetic fields are produced by kinematically possible flows without being constrained by the dynamic equation. We review a number of basic aspects of the kinematic dynamo theory, including the magnetohydrodynamic approximation for the dynamo equation, the impossibility of dynamo action with the solar differential rotation, the Cowling's anti-dynamo theorem in the solar context, the turbulent alpha effect and recently constructed three-dimensional interface dynamos controlled by the solar tachocline at the base of the convection zone.

关键词： Solar magnetic fields - kinematic dynamos - magnetohydrody- namics

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Mycophenolic acid inhibits SLE-associated cytokine expression and promotes apoptosis of peripheral blood mononuclear cells from patients with systemic lupus erythematosus

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Acta Pharmacologica Sinica 2006年第8期27卷 1051-1057页

作者： Ding-lei SU~(2,3) Hui-juan WANG~2 Xiao-hui JI~(2,5) Yuan-yuan LI~4 Heng-bao XUAN~4 Chun HENG~4 Yu-feng LI~4 ~2Department of Immunology,Nanjing Medical University,Nanjing 210029,China:~3Department of Hematology,Nanjing First Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China ~4Department of Hematology,Affiliated Huai'an First Hospital of Nanjing Medical University,Huai'an 223300.China Department of Immunology Nanjing Medical University Nanjing China Department of Hematology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing China Department of Hematology Affiliated Huai'an First Hospital of Nanjing Medical University Huai'an China

Aim:To investigate the effect of the novel immunosuppressant mycophenolicacid（MPA）on cytokine production and apoptosis of the peripheral blood mono-nuclear cells（PBMC）of patients with systemic lupus erythematosus（SLE）.Methods:The levels of IL-10,IL-12,IFN-γ,sFas and sFasL in the supernatants ofcultured PBMC from 41 SLE patients was determined by the ABC-ELISA *** percentage of IFN-γIL- 10-,IFN-γ-IL-10+,and IFN-γ+IL-10+subsets in CD4+ceils were detected by three-color flow *** percentage of apoptoticTh cells was detected by AV-FITC/PI flow *** from 22 sex-andage-comparable healthy people were used as normal ***:The lev-els of IL-10,IL-12,and IFN-γwere all significantly elevated in the supernatants ofcultured PBMC from SLE samples,compared with normal *** enhancedproductions of IL-10,IL-12,and IFN-γ by PBMC from SLE both spontaneouslyand stimulated by phytohaemagglutinin（PHA）were significantly reduced by *** percentages of CD4+IFN-γIL-10+and CD4+IFN-γ+IL-10+cell subsets in cul-tured PBMC from SLE were significantly increased,but decreased when MPA wasadded into the *** being cultured in vitro for 48h,the PBMC of SLEpatients showed a higher secretion of sFasL as well as a higher percentage *** significantly increased the apoptotic percentage of SLE PBMC,but reduced the secretion of sFasL and ***:MPA reduces theabnormal production of SLE-associated cytokines,such as IL-10,IL-12,and IFN-γ,inhibits the increase of CD4+IFN-γ+IL-10,CD4+IFN-γIL-10+and CD4+IFN-γ+IL-10+subset;and promotes the apoptosis of PBMC in SLE patients,which may beassociated with the therapeutic mechanism of MPA for SLE.

关键词： systemic lupus erythematosus mycophenolic acid cytokine apoptosis therapeutic mechanism

Clinical implication of VEGF serum levels in cirrhotic patients with or without portal hypertension

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World Journal of Gastroenterology 1999年第4期5卷 24-28页

作者： Nimer Assy 1,4 , M Paizi 3,4 , D Gaitini 2, Y Baruch 1,4 and G Spira 3,4,5

AIM To determine whether serum vascular endothelial growth factor (VEGF) levels correlates with the severity of liver cirrhosis and whether portal hypertension impacts on the expression of serum VEGF protein. METHODS Fifty three patients (mean age 56±2 years) with HCV ( n =26), HBV ( n =13), and cryptogenic liver cirrhosis ( n =14) (Child Pughs class A: 24, B: 19 and C: 12) and normal renal function constitute the patient population, who were all diagnosed by clinical, histological and radiological findings. Six healthy people and six patients with acute hepatitis served as controls. Severity of liver disease was evaluated by the CP score. Serum levels of IGF 1 and VEGF were measured by radioimmunoassay and ELISA, respectively. Portal hypertension was assessed using pulsed Doppler ultrasound. RESULTS The mean serum VEGF levels in all cirrhotic patients (73±58) were significantly lower than those of healthy controls (360±217, P 49 4ng/L , range, 21ng/L - 260ng/L , Class B: median 59 9ng/L ; range 21-92, and Class C: median 69; range 20ng/L - 247ng/L ). A significant correlation was noted between serum VEGF and two accurate parameters of portal hypertension: portal blood flow velocity ( r =0 6) and spleen size ( r =0 55). No correlation was found between VEGF serum levels and serum albumin, IGF 1, platelets count and aminotrasnferases ( r =0 2, r =0 1, r =0 2 and r =0 2, respectively). CONCLUSION Circulating VEGF level in patients with liver cirrhosis could not serve as an indicator of the progression of chronic liver disease but rather, they may reflect increased portal hypertension or decreased hepatic regenerative activity or the combination of both.

关键词： VEGF growth factors liver cirrhosis liver regeneration hypertension portal duplex sonography angiogenesis

Blockade of L-type calcium channel in myocardium and calcium-induced contractions of vascular smooth muscle by CPU 86017

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Acta Pharmacologica Sinica 2004年第4期 18-25页

作者： De-zai DAI2, Hui-juan HU3, JingZHAO, Xue-mei HAO4, Dong-mei YANG4, Pei-ai ZHOU4,Cai-hong WU4 Research Division of Pharmacology, China Pharmaceutical University, Nanjing, 210009 4National Laboratoryof Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China

AIM: To assess the blockade by CPU 86017 on the L-type calcium channels in the myocardium and on the Ca2+- related contractions of vascular smooth muscle. METHODS: The whole-cell patch-clamp was applied to investi- gate the blocking effect of CPU 86017 on the L-type calcium current in isolated guinea pig myocytes and contrac- tions by KCl or phenylephrine (Phe) of the isolated rat tail arteries were measured. RESULTS: Suppression of the L-type current of the isolated myocytes by CPU 86017 was moderate, in time- and concentration-dependent man- ner and with no influence on the activation and inactivation curves. The IC50was 11.5 μmol/L. Suppressive effect of CPU 86017 on vaso-contractions induced by KCl 100 mmol/L, phenylephrine 1 μmol/Lin KH solution (phase 1), Ca2+ free KH solution ( phase 2) , and by addition of CaCl2 into Ca2+-free KH solution (phase 3) were observed. The IC50 to suppress vaso-contractions by calcium entry via the receptor operated channel (ROC) and voltage-depen- dent channel (VDC) was 0.324 μmol/L and 16.3 μmol/L, respectively. The relative potency of CPU 86017 to suppress vascular tone by Ca2+ entry through ROC and VDC is 1/187 of prazosin and 1/37 of verapamil, respectively. CONCLUSION: The blocking effects of CPU 86017 on the L-type calcium channel of myocardium and vessel are moderate and non-selective. CPU 86017 is approximately 50 times more potent in inhibiting ROC than VDC.

关键词： chlorobenzyltetrahydroberine myocardium vascular smooth muscle patch-clamp techniques berberine calcium