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Intensive blood pressure control on arterial stiffness among older patients with hypertension

Chinese Medical Journal 2024年第9期137卷 1078-1087页

作者： Shuyuan Zhang Yixuan Zhong Shouling Wu Hailei Wu Jun Cai Weili Zhang On behalf of the step Study Group National Clinical Research Center of Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Central China Subcenter of National Center for Cardiovascular Diseases Henan Cardiovascular Disease CenterFuwai Central-China Cardiovascular HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 450046China 不详

Background:Arterial stiffening increases with age and blood pressure and is associated with cardiovascular disease(CVD),but the relationship between blood pressure lowering and arterial stiffening is still uncertain,especially in older *** study aimed to evaluate the effect of intensive blood pressure treatment on the progression of arterial stiffness and risk of CVD in older patients with ***:The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients(step)trial was a multicenter,randomized,controlled trial performed at 42 clinical centers throughout China,and 8511 patients aged 60-80 years with essential hypertension were enrolled and randomly assigned to systolic blood pressure(SBP)target of 110 mmHg to49.8-73.2 cm/s)in the intensive treatment group and 98.4 cm/s(95%CI:86.7-110.1 cm/s)in the standard treatment group(P<0.001).Intensive treatment significantly delayed the progression of arterial stiffness,with an annual change of 23.1 cm·s^(-1)·year-1 vs.36.7 cm·s^(-1)·year^(-1)of baPWV in the intensive and standard treatment groups,*** a median follow-up period of 3.36 years,primary CVD outcomes occurred in 77(2.9%)patients in the intensive treatment group compared with 93(3.5%)in the standard treatment *** tre

关键词： Hypertension Arterial stiffness Cardiovascular disease Older people Blood pressure Pulse wave velocity

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梦想无线电电子工作室(8)——工具·扳手篇(上)

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无线电 2024年第9期 9-13页

作者：杨法(BD4AAF) 不详

本期分享的手动工具是手动扳手(见图1)。五金手动工具中的扳手用于紧固和拆卸螺纹件,如螺母和螺栓的主力工具,也是无线电和电子爱好者拆装电子产品经常会用到的专业工具。虽然扳手在电子工作室的出镜率远不如螺丝刀,但仍是重要的工具。... 详细信息

本期分享的手动工具是手动扳手(见图1)。五金手动工具中的扳手用于紧固和拆卸螺纹件,如螺母和螺栓的主力工具,也是无线电和电子爱好者拆装电子产品经常会用到的专业工具。虽然扳手在电子工作室的出镜率远不如螺丝刀,但仍是重要的工具。平时我们随手使用得看似平平无奇的扳手,从种类、规格、材质、工艺方面都蕴含着诸多专业知识。

关键词：手动工具电子产品工作室扳手电子爱好者螺丝刀出镜率专业知识

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SSABA:Search step Adjustment Based Algorithm

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Computers, Materials & Continua 2022年第6期71卷 4237-4256页

作者： Fatemeh Ahmadi Zeidabadi Ali Dehghani Mohammad Dehghani Zeinab Montazeri stepán Hubálovsky Pavel Trojovsky Gaurav Dhiman Department of Mathematics and Computer Sciences Sirjan University of TechnologySirjanIran Department of Civil Engineering Islamic Azad UniversityEstahban BranchEstahbanIran Department of Mathematics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Electrical and Electronics Engineering Shiraz University of TechnologyShirazIran Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Computer Science Government Bikram College of CommercePatialaPunjabIndia

Finding the suitable solution to optimization problems is a fundamental challenge in various *** algorithms are one of the effective stochastic methods in solving optimization *** this paper,a new stochastic optimization algorithm called Search stepAdjustment Based Algorithm(SSABA)is presented to provide quasi-optimal solutions to various optimization *** the initial iterations of the algorithm,the step index is set to the highest value for a comprehensive search of the search ***,with increasing repetitions in order to focus the search of the algorithm in achieving the optimal solution closer to the global optimal,the step index is reduced to reach the minimum value at the end of the algorithm *** is mathematically modeled and its performance in optimization is evaluated on twenty-three different standard objective functions of unimodal and multimodal *** results of optimization of unimodal functions show that the proposed algorithm SSABA has high exploitation power and the results of optimization of multimodal functions show the appropriate exploration power of the proposed *** addition,the performance of the proposed SSABA is compared with the performance of eight well-known algorithms,including Particle Swarm Optimization(PSO),Genetic Algorithm(GA),Teaching-Learning Based Optimization(TLBO),Gravitational Search Algorithm(GSA),Grey Wolf Optimization(GWO),Whale Optimization Algorithm(WOA),Marine Predators Algorithm(MPA),and Tunicate Swarm Algorithm(TSA).The simulation results show that the proposed SSABA is better and more competitive than the eight compared algorithms with better performance.

关键词： Optimization population-based optimization problem search step optimization algorithm minimization maximization

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小丑虾的恶趣味信息素“骗局”与生存游戏

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环球人文地理 2024年第15期 70-77页

作者： Sara stockpix4u serg＿dibrova diveivanov Alex Traveler suwatsir DaiMar Vitalii6447 beelaa MARYGRACE piboon

用信息素迫使异性百依百顺，夫妻同生共死，喜欢“活体盛宴”……只有5厘米大的虾，是如何在海底“为非作歹”，让生物避之不及？动物世界中，为了在求偶游戏中获胜，大家各显神通。作为为数不多的终身一夫一妻制的生物，小丑虾会在海...

用信息素迫使异性百依百顺，夫妻同生共死，喜欢“活体盛宴”……只有5厘米大的虾，是如何在海底“为非作歹”，让生物避之不及？动物世界中，为了在求偶游戏中获胜，大家各显神通。作为为数不多的终身一夫一妻制的生物，小丑虾会在海底深处的珊瑚礁里施展“魅惑之术”，让伴侣对自己死心塌地。小丑虾不丑海底世界的迷你油画小丑虾一般是指夏威夷海星虾，它还有别的名字，如油彩蜡膜虾、海星虾、贵宾虾等等，通常生活在印度洋至太平洋沿岸，以及夏威夷潮间带之下的珊瑚礁岩附近。

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Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-κB

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Acta Pharmacologica Sinica 2005年第7期26卷 887-892页

作者： Jin-nan YANG~(2,3) Jin-mao CHEN~4 Lin LUO~4 Shao-chun LIN~4 Dai LI~4 Shi-xing HU~(4,5,6) 2 School of Pharmacy,Xinxiang Medical College,Xinxiang 453003,China 4 Zhongshan Ophthalmic Centre,Sun Yat-sen University,Guangzhou 510060,China 5 Eye Hospital of China,Academy of Traditional Chinese Medicine,Beijing 100040,China School of Pharmacy Xinxiang Medical College Xinxiang China Zhongshan Ophthalmic Centre Sun Yat-sen University Guangzhou China Eye Hospital of China Academy of Traditional Chinese Medicine Beijing China

Aim:To evaluate the effect of tetramethylpyrazine(TMP)injection on retinaldamage induced by N-methyl-N-nitrosourea(MNU)in rats and on nuclear factor-kappa B(NF-κB)family ***:Female Sprague-Dawley(SD)ratswere randomly divided into groups:(i),control group;(ii),model group;and(iii),TMP-injection groups,in which the rats were subdivided into 40 mg/kg,80 mg/kgand 160 mg/kg *** were injected ip into 47-day-old SD rats once a *** 50 days of age,all rats in the model group and drug groups also received asingle ip injection of 60 mg/kg *** in group 1 received ip injection ofphysiological *** rats were killed at different times after MNU or physi-ological saline *** apoptotic index of photoreceptor cells was calcu-lated by TUNEL labeling;retinal damage was evaluated based on retinal thicknessand the expression of NF-κB family members was detected by Western ***:TMP injections,in a dose-dependent manner,suppressed photorecep-tor cell apoptosis and decreased its loss in the peripheral *** comparedwith the MNU-treated group,TMP injection at a dose of 160 mg/kg also time-dependently upregulated the NF-κB/p65 protein level in the nucleus anddownregulated the IκBα protein level in the ***,no protectiveeffect of TMP injection on MNU-induced central retinal damage was ***:TMP injection partially protects against MNU-induced retinal dam-age by upregulating the nuclear translocation of p65 to inhibit photoreceptor cellsapoptosis.

关键词： tetramethylpyrazine photoreceptors methylnitrosourea apoptosis NF-kappa B retinitis pigmentosa

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Turbulent combustion modeling using a flamelet generated manifold approach——a validation study in Open FOAM

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Applied Mathematics and Mechanics(English Edition) 2019年第8期40卷 1197-1210页

作者： Tao LI Fanfu KONG4 Baopeng XU Xiaohan WANG Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640China Key Laboratory of Renewable Energy Chinese Academy of Sciences Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of TechnologyDalian 116024Liaoning ProvinceChina

An OpenFOAM based turbulence combustion solver with flamelet generated manifolds (FGMs) is presented in this paper. A series of flamelets, representative for turbulent flames, are calculated first by a one-dimensional (1D) detailed chemistry solver with the consideration of both transport and stretch/curvature contributions. The flame structure is then parameterized as a function of multiple reaction control variables. A manifold, which collects the 1D flame properties, is built from the 1D flame solutions. The control variables of the mixture fraction and the progress variable are solved from the corresponding transport equations. During the calculation, the scalar variables, e.g., temperature and species concentration, are retrieved from the manifolds by interpolation. A transport equation for NO is solved to improve its prediction accuracy. To verify the ability to deal with the enthalpy loss effect, the temperature retrieved directly from the manifolds is compared with the temperature solved from a transport equation of absolute enthalpy. The resulting FGM-computational fluid dynamics (CFD) coupled code has three significant features, i.e., accurate NO prediction, the ability to treat the heat loss effect and the adoption at the turbulence level, and high quality prediction within practical industrial configurations. The proposed method is validated against the Sandia flame D, and good agreement with the experimental data is obtained.

关键词： flamelet generated manifold turbulent combustion NO prediction

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Tetramethylpyrazine suppresses HIF-1α,TNF-α,and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats

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Acta Pharmacologica Sinica 2007年第3期28卷 327-333页

作者： Yi CHANG~(2,3) George HSIAO~4 Seu-hwa CHEN~4 Yi-cheng CHEN~4 Jiing-han LIN~4 Kuang-hung LIN~4 Duen-suey CHOU~4 Joen-rong SHEU~(4,5)2 Department of Anesthesiology,Shin Kong Wu Ho-Su Memorial Hospital,Taipei 110,Taiwan,China 3 School of Medicine,Fu-Jen Catholic University,Taipei,110,Taiwan,China 4 Graduate Institute of Medical Sciences,Taipei Medical University,Tuipei 110,Taiwan,China Department of Anesthesiology Shin Kong Wu Ho-Su Memorial Hospital Taipei China School of Medicine Fu-Jen Catholic University Taipei China Graduate Institute of Medical Sciences Taipei Medical University Taipei China

Aim:To examine the detailed mechanisms underlying the inhibitory effect oftetramethylpyrazine(TMPZ)in inflammatory and apoptotic responses inducedby middle cerebral artery occlusion(MCAO)in ***:MCAO-inducedfocal cerebral ischemia in rats was used in this *** hypoxia-induciblefactor-1α(HIF-1α),activation of caspase-3,and TNF-αmRNA transcription inischemic regions were detected by immunoblotting and RT-PCR,***-oxidative activity was investigated using a thiobarbituric acid-reactive sub-stance(TBARS)test in rat brain homogenate ***:We showedthe statistical results of the infarct areas of solvent-and TMPZ(20 mg/kg)-treatedgroups at various distances from the frontal pole in MCAO-induced focal cerebralischemia in *** with TMPZ(20 mg/kg)markedly reduced the infarctarea in all regions,especially in the third to fifth ***-induced focalcerebral ischemia was associated with increases in HIF-lαand the activation ofcaspase-3,as well as TNF-αtranscription in ischemic *** expressionswere markedly inhibited by treatment with TMPZ(20 mg/kg).However,TMPZ(0.5-5mmol/L)did not significantly inhibit TBARS reaction in rat brain ***:The neuroprotective effect of TMPZ may be mediated at least by aportion of the inhibition of HIF-1αand TNF-αactivations,followed by the inhibi-tion of apoptosis formation(active caspase-3),resulting in a reduction in theinfarct volume in ischemia-reperfusion brain ***,TMPZ treatment mayrepresent an ideal approach to lowering the risk of or improving function in is-chemia-reperfusion brain injury-related disorders.

关键词： tetramethylpyrazine middle cerebral artery occlusion HIF-Iα caspase-3 TNF-α thiobarbituric acid-reactive substance

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以“五维一体”“内外兼顾”全力打造“川销新兵”成长新路径

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石油组织人事 2024年第7期 56-59页

作者：无何俊周武迪胡超逸杨钦夏成筱中国石油四川销售公司中国石油四川销售党委组织部中国石油四川销售党委组织部人才工作组中国石油四川销售技能人才评价中心中国石油四川销售广元分公司党群工作站

四川销售立足新员工职业成长与企业转型升级需求,积极探索新员工培养的有效路径,聚焦“培训深化、轮岗锻炼、导师引领、平台建设、情感关怀”五个维度协同发力,全方位提升新员工素质。对内持续关注新员工的思想动态,激发其内在动力;对... 详细信息

四川销售立足新员工职业成长与企业转型升级需求,积极探索新员工培养的有效路径,聚焦“培训深化、轮岗锻炼、导师引领、平台建设、情感关怀”五个维度协同发力,全方位提升新员工素质。对内持续关注新员工的思想动态,激发其内在动力;对外着重提升新员工的专业技能与知识储备,搭建干事创业一流平台。通过内外兼修、统筹兼顾的方式,确保新员工扎根企业、发挥所长,实现企业发展与员工成长的同频共振。

关键词：新员工培养五维一体成长成才平台建设

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An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data

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Protein & Cell 2015年第12期6卷 919-923页

作者： Jia Wang (1) (2) (3) Weiguang Wang (1) (2) Wen Song (2) (3) (4) Zhifu Han (2) (3) (4) Heqiao Zhang (2) (3) (4) Jijie Chai (2) (3) (4) Hongwei Wang (2) (3) (4) Jiawei Wang (1) (2) 1.State Key Laboratory of Membrane Biology School of Life Sciences Tsinghua University Beijing 100084 China 2.Center for Structural Biology School of Life Sciences Tsinghua University Beijing 100084 China 3.Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China 4.Ministry of Education Key Laboratory of Protein Science School of Life Sciences Tsinghua University Beijing 100084 China

Cryo-electron microscopy （cryo-EM） and macromolecular crystallography （MX） both allow the creation of three-dimensional images of biological macromolecules. EM data usually provide access to three-dimensional reconstructions of large biological complexes at low resolution, whereas MX usually delivers atomic or quasi-atomic resolution structures （1-3 A）.

关键词： Phase Error Molecular Replacement Histogram Match TLR13 Molecule Solvent Flatten

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Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration

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Acta Pharmacologica Sinica 2005年第4期26卷 492-499页

作者： Qing-hui MENG~2 Li-xin ZHOU~3 Jia-lin LUO~4 Jian-ping CAO~4 Jian TONG~4 Sai-jun FAN~(2,4,5) 2 Department of Oncology, Lombardi Comprehensive Caneer Center,Georgetown University,Washington DC 20057,USA 3 Institute of Medicine and Biotechnology,Chinese Academy of Medical Sciences,Beijing 100050,China 4 School of Radiation Medicine and Public Health,Soochow University,Suzhou 215007,China Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA Institute of Medicine and Biotechnology Chinese Academy of Medical Sciences Beijing China School of Radiation Medicine and Public Health Soochow University Suzhou China

Aim:To investigate the effect of 7-hydroxystaurosporine（UCN-01）,a selectiveprotein kinase C（PKC）inhibitor,on cell growth,migration,and invasion in inva-sive human glioblastoma U-87MG ***:PKC activity was determinedbased on the PKC-catalyzed transfer of the32p-phosphate group from[g-32p]ATPinto a PKC-specific peptide *** viability was measured by MTT *** invasion and migration were evaluated by a Boyden chamber assay andscratch wound assay,*** expression was analyzed using West-ern blot *** formation of 3-dimensional cellular aggregates was examinedby a cell-cell aggregation ***:UCN-01 treatment resulted in concen-tration-and time-dependent inhibition of U-87MG cell growth at higher doses（>100 nmol/L）,and reduced cell invasion and migration capability at less cytotoxicdoses（<100 nmol/L）.UCN-01 significantly repressed PKC *** this result,UCN-01 blocked cell invasion stimulated by phorbel 12-myristate-13-acetate（PMA）and ethanol（EtOH）,2 PKC *** expression ofthe tumor suppressor genes BRCA1 and PTEN increased the anti-invasion poten-tial of *** to UCN-01 caused a dose-dependent increase in celladhesion molecule *** effect of UCN-01 on the formation of cell-cellaggregation was significantly reduced by the addition of an ***:UCN-01 inhibits the invasion and migration of humanglioma ***,UCN-01 can have potential clinical applications for thetreatment of human glioma metastasis.

关键词： 7-hydroxystaurosporine protein kinase C cell movement cadherins BRCA1 protein

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