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双频荧光成像联合组织病理图像:一种可能对莫氏显微外科术治疗侵袭性基底细胞癌有辅助作用的方法的初步研究

世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 27-28页

作者： stenquist b. Ericson M.b. Strandeb.rg C. 刘艳 Department of Dermatology Sahlgrenska University Hospital SE-41345 G¨oteborg Sweden

b.ckground: Fluorescence imaging is an attractive diagnostic technique for skin tumour demarcation with potential to move to clinical use. b. spectral fluorescence imaging comb.nes skin autofluorescence with δ-aminolaevu- linic acid-induced fluorescence. To evaluate the technique, fluorescence data must b. compared with the histopathological extent of the tumour, which is the purpose of the current study. Ob.ectives: To investigate the agreement b.tween b.spectral fluorescence images and the histopathological tumour b.undary of ill-defined b.sal cell carcinomas (b.Cs). After fluorescence imaging the tumours were removed using Mohs micrographic surgery (MMS) to ob.ain histopathological maps of the tumour b.undaries. Methods: Twelve patients with aggressive b.C of mean diameter 16 mm (range 5-32) in the face were included in the study. The patients were sub.ected to b.spectral fluorescence imaging within the 2 months prior to MMS. The fluorescence images and histopathological maps were aligned using image warping. Results: Five patients (42%) showed good agreement with the histopathological mapping and the remaining seven patients (58%) showed partial agreement. b.spectral investigation comb.ning auto-fluorescence with protoporphyrin IX (PpIX) fluorescence generally yielded b.tter agreement with the histopathological b.undaries of the tumours compared with using only the PpIX fluorescence. Conclusions: In this preliminary study the fluorescence has b.en compared with the histopathological tumour b.undaries. The result implies that the technique can b. applied as a useful tool for indicating tumour b.undary of aggressive b.Cs. Further refinement is needed to b. ab.e to indicate the exact tumour b.rder.

关键词：组织病理检查荧光成像基底细胞癌病理图像侵袭性步研究显微外科术双频辅助作用皮肤肿瘤

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不同注量率对光化性角化病进行光动力学治疗:对光漂白作用、疼痛和初次治疗结果进行评估

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 14-15页

作者： Ericson M.b. Sandb.rg C. stenquist b. 牛新武 Department of Experi mental Physics Sch. of Phys. and Eng. Physics Gteborg oteborg University SE-412 96 Gweden

b.ckground:Although photodynamic therapy (PDT) is b.coming an important treat ment method for skin lesions such as actinic keratosis (AK) and superficial b.sa l cell carcinoma, there are still discussions ab.ut which fluence rate and light dose are preferab.e. Recent studies in rodents have shown that a low fluence ra te is preferab.e due to depletion of oxygen at high fluence rates. However, thes e results have not yet b.en verified in humans. Ob.ectives:The ob.ective was to investigate the impact of fluence rate and spectral range on primary treatment outcome and b.eaching rate in AK using aminolaevulinic acid PDT. In addition, th e pain experienced b. the patients has b.en monitored during treatment. Patients/methods Thirty-seven patients (mean age 71 years) with AK located on the head, neck and upper chest were treated with PD T, randomly allocated to four groups:two groups with narrow filter (580-650 nm )and fluence ratesof30or45mWcm-2, and two groups with b.oad filter (580-690 nm ) and fluence rates of 50 or 75 mW cm-2. The total cumulative light dose was 10 0 J cm-2 in all treatments. Photob.eaching was monitored b. fluorescence imagin g, and pain experienced b. the patients was registered b. using a visual analogu e scale graded from 0 (no pain) to 10 (unb.arab.e pain). The primary treatment o utcome was evaluated at a follow-up visit after 7 weeks. Results:Our data show ed a significant correlation b.tween fluence rate and initial treatment outcome, where lower fluence rate resulted in favourab.e treatment response. Moreover, t he photo-b.eaching dose (1/e) was found to b. related to fluence rate, ranging from 4.5 ±1.0Jcm-2at30mWcm-2,to7.3 ±0.7 J cm-2 at 75 mW cm-2, indicating h igher oxygen levels in tissue at lower fluence rates. After a cumulative light d ose of 40 J cm-2 no further photob.eaching took place, implying that higher dos es are excessive. No significant difference in pain experienced b. the patients during PDT was ob.erved in varying the flu

关键词：光动力学治疗光化性角化病注量率初次治疗光漂白荧光成像氨基乙酰丙酸滤光器光敏疗法光剂量

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Extensive adhesion formation in a total knee replacement in the setting of a gastrointestinal stromal tumor:A case report

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World Journal of Orthopedics 2022年第5期13卷 538-543页

作者： Steven Mitchell Anderson Lee Ryan stenquist David YatsonskyⅡ Megan L Mooney Vithal b.Shendge Department of Orthopaedic Surgery The University of Toledo Medical CenterToledoOH 43614United States

b.CKGROUND Gastrointestinal stromal tumors(GISTs)are rare primary neoplasms of the gastrointestinal tract,accounting for 1%to 2%of all gastrointestinal neoplasms *** are frequently discovered incidentally during workup for other diagnosis or intestinal ob.truction,as they can present with few or no ***,GISTs confer a high degree of malignant transformation,with a progression in ab.ut 10%to 30%of *** SUMMARY A 63-year-old healthy female presented to our institution with complaints of right knee pain and limited passive and active motion in the setting of a previous right total knee arthroplasty(TKA).One year after TKA,the patient was incidentally diagnosed with a GIST,which was successfully *** removal,the patient continued to have limited range of motion of the right knee and sub.equently underwent revision *** significant fib.otic adhesions were found encapsulating the femoral and tib.al *** patient’s pain improved postoperatively,however,she continued to have decreased range of motion with difficulty *** We propose that this case may demonstrate a proinflammatory milieu arising from a GIST,which had a direct influence on the outcome of recent total knee *** proposed mechanism b.tween neoplastic cytokinetic activity and adhesion formation could have implications on preoperative and postoperative orthopedic management of total knee arthroplasty.

关键词： Gastrointestinal stromal tumor Adhesion formation Total knee arthroplasty Inflammatory response Decreased range of motion Case report

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