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Vitamin d deficiency and metabolic syndrome:The joint effect on cardiovascular and all-cause mortality in the United States adults

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World Journal of Cardiology 2022年第7期14卷 411-426页

作者： longjian liu Saishi Cui stella l volpe Nathalie S May Deeptha Sukumar Rose Ann DiMaria-Ghalili Howard J Eisen Department of Epidemiology and Biostatistics Dornsife School of Public HealthDrexel UniversityPhiladelphiaPA 19104United States Department of Human Nutrition Foodsand ExerciseVirginia Polytechnic Institute and State UniversityBlacksburgVA 24061United States Department of Medicine College of MedicineDrexel UniversityPhiladelphiaPA 19102United States Department of Nutrition Sciences College of Nursing and Health ProfessionsDrexel UniversityPhiladelphiaPA 19102United States Department of Graduate Nursing College of Nursing and Health ProfessionsDrexel UniversityPhiladelphiaPA 19102United States Division of Cardiology Heart and Vascular InstitutePennsylvania State UniversityHersheyPA 17033United States

BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of *** To test the hypotheses that lower serum 25 hydroxyvitamin D[25(OH)D]concentrations(a marker of vitamin D level)and MetS have a long-term impact on the risk of CVD and all-cause mortality,and individuals with vitamin D deficiency can be identified by multiple *** A sample of 9094 adults,20 to 90 years of age,who participated in the Third National Health and Nutrition Examination Survey(NHANES III,1988 to 1994)were followed through December 2015 was *** associations of serum 25(OH)D concentrations and MetS with CVD and all-cause mortality were analyzed longitudinally using Cox regression *** and regression tree(CART)for machine learning was applied to classify individuals with vitamin D *** Of 9094 participants,30%had serum 25(OH)D concentrationsl(defined as vitamin D deficiency),39%had serum 25(OH)D concentrations between 20 to 29 ng/ml(insufficiency),and 31%had serum 25(OH)D concentrations≥30 ng/ml(sufficiency).Prevalence of MetS was 28.4%.During a mean of 18 years follow-up,vitamin D deficiency and MetS were significantly associated with increased risk of CVD and all-cause *** with both vitamin D deficiency and MetS had the highest risk of CVD mortality(HR=1.77,95%CI:1.22-2.58)and all-cause mortality(HR=1.62,95%CI:1.26-2.09),followed by those with both vitamin D insufficiency and MetS for CVD mortality(HR=1.59,95%CI:1.12-2.24),and all-cause mortality(HR=1.41,95%CI:1.08-1.85).Meanwhile,vitamin D sufficiency significantly decreased the risk of CVD and all-cause mortality for those who even had *** the total study sample,CART analysis suggests that being non-Hispanic Black,having lower serum folate level,and being female were the first three predictors for those with serum 25(OH)D *** Vitamin D defic

关键词： Joint effect Serum 25 hydroxyvitamin D concentration Metabolic syndrome Cardiovascular and all-cause mortality Cox model and machine learning

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Multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Open Journal of Soil Science 2024年第4期14卷 237-268页

作者： Neil-Yohan Musadji Rolf Gaël Mabicka Obame Michel Mbina Mounguengui Jean Aubin Ondo lydie-stella Koutika Eric Ravire Claude Geffroy laboratoire De Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement Des Sciences Fondamentales De L&#8217Ing&#233nieur Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Institut De Chimie Des Milieux et Maté riaux De Poitiers (IC2MP) Universit&#233 De Poitiers Poitiers France laboratoire De Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement De Phytotechnologie Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Dé partement De G&#233ologie Facult&#233 Des Sciences Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon laboratoire Pluridisciplinaire Des Sciences Ecole Normale Sup&#233rieure Libreville Gabon Centre De Recherche Sur la Productivité et La Durabilit&#233 Des Plantations Industrielles Pointe Noire Republic of Congo Sucaf Gabon Somdiaa Franceville Gabon

Assessing soil quality is essential for crop management and soil temporal changes. The present study aims to evaluate soil quality in the Ferralitic soils context countrywide. This assessment was done using multivariate soil quality indice (SQI) models, such as additive quality index (AQI), weighted quality indexes (WQIadd and WQIcom) and Nemoro quality index (NQI), applied to two approaches of indicator selection: total data set (TDS) and minimum data set (MDS). Physical and chemical soil indicators were extracted from the ORSTOM’s reports resulting from a sampling campaign in different provinces of Gabon. The TDS approach shows soil quality status according to eleven soil indicators extracted from the analysis of 1,059 samples from arable soil layer (0 - 30 cm depth). The results indicated that 87% of all provinces presented a very low soil quality (Q5) whatever the model. Among soil indicators, exchangeable K+ and Mg2+, bulk density and C/N ratio were retained in MDS, using principal component analysis (PCA). In the MDS approach, 50 to 63% of provinces had low soil quality grades with AQI, WQIadd and NQI, whereas the total was observed with WQIcom. Only 25% of provinces had medium soil quality grades with AQI and NQI models, while 12.5% (NQI) and 25% (AQI) presented high quality grades. Robust statistical analyses confirmed the accuracy and validation (0.80 r P ≤ 0.016) of AQI, WQIadd and NQI into the TDS and MDS approaches. The same sensitivity index value (1.53) was obtained with AQI and WQIadd. However, WQIadd was chosen as the best SQI model, according to its high linear regression value (R2 = 0.82) between TDS and MDS. This study has important implications in decision-making on monitoring, evaluation and sustainable management of Gabonese soils in a pedoclimatic context unfavorable to plant growth.

关键词： Gabon Ferralitic Soil Soil Indicators Standard Score Function Soil Quality Indices Sustainable Soil Soil Management

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Characterization of the molecular dysfunctions occurring in Aicardi-Goutieres syndrome patients with mutations in ADAR1

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Genes & Diseases 2024年第3期11卷 116-119页

作者： Sofan Al wardat loredana Frasinlli Elisa Orecchini Federica Rey Silvia Anna Ciafre Silvia Galardi Jessica Garau stella Gagliardi Simona Orcesi Davide Tonduti Stephana Carelli Cristina Cereda Ernesto Picardi Alessandro Michienzi Department of Biomedicine and Prevention University of Rome Tor VergataRome 00133Italy Pediatric Clinical Research Center"Romeo ed Enrica Invernizzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children's HospitalMilano20154Italy Department of Child Neurology and Psychiatry IRccs Mondino FoundationPavia 27100Italy Unit of Pediatric Neurology C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Department of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostructures and Biosystems National Institute(INBB) Rome00136Italy Institute of Biochemistry and Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis.^(1) ADAR1,one of the genes mutated in AGS(AGS6),encodes for an enzyme that belongs to the ADAR family(ADAR1,ADAR2,and ADAR3)that catalyzes the conversion of adenosine to inosine within double-stranded RNAs(dsRNAs)(RNA editing A-to-1).

关键词： ADAR1 interferon res

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National Soil Organic Carbon Stocks Inventories under Different Mangrove Forest Types in Gabon

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Open Journal of Forestry 2024年第2期14卷 127-140页

作者： Rolf Gaël Mabicka Obame Neil-Yohan Musadji Jean Hervé Mve Beh lydie-stella Koutika Jean Aubin Ondo Farrel Nzigou Boucka Michel Mbina Mounguengui Claude Geffroy Dé partement de Phytotechnologie Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Dé partement des Sciences Fondamentales de l&#8217Ing&#233nieur Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut Agronomiques et Forestiè res Centre National des Recherches Scientifiques et Technologiques Libreville Gabon Research Centre on the Durability and the Productivity of Industrial Plantations (CRDPI) Pointe Noire Republic of Congo laboratoire Pluridisciplinaire des Sciences &#201cole Normale Sup&#233rieure Libreville Gabon Agence Gabonaise d’ &#201tude et d&#8217Observation Spatiale Immeuble les Arcades Libreville Gabon Dé partement de G&#233ologie Faculte des Sciences Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut de Chimie des Milieux et Maté riaux de Poitiers (IC2MP) Universit&#233 de Poitiers Poitiers France

Gabonese’s estuary is an important coastal mangrove setting and soil plays a key role in mangrove carbon storage in mangrove forests. However, the spatial variation in soil organic carbon (SOC) storage remain unclear. To address this gap, determining the SOC spatial variation in Gabonese’s estuarine is essential for better understanding the global carbon cycle. The present study compared soil organic carbon between northern and southern sites in different mangrove forest, Rhizophora racemosa and Avicennia germinans. The results showed that the mean SOC stocks at 1 m depth were 256.28 ± 127.29 MgC ha−1. Among the different regions, SOC in northern zone was significantly (p p layers contained higher SOC stocks (254.62 ± 128.09 MgC ha−1) than upper layers (55.42 ± 25.37 MgC ha−1). The study highlights that low deforestation rate have led to less CO2 (705.3 Mg CO2e ha−1 - 922.62 Mg CO2e ha−1) emissions than most sediment carbon-rich mangroves in the world. These results highlight the influence of soil texture and mangrove forest types on the mangrove SOC stocks. The first national comparison of soil organic carbon stocks between mangroves and upland tropical forests indicated SOC stocks were two times more in mangroves soils (51.21 ± 45.00 MgC ha−1) than primary (20.33 ± 12.7 MgC ha−1), savanna and cropland (21.71 ± 15.10 MgC ha−1). We find that mangroves in this study emit lower dioxide-carbon equivalent emissions. This study highlights the importance of national inventories of soil organic carbon and can be used as a baseline on the role of mangroves in carbon sequestration and climate change mitigation but the variation in SOC stocks indicates the need for further national data.

关键词： Mangroves Forest Soil Organic Carbon Stocks Rizophora Racemose Avicenia germinans Gabon

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Radioisotope production using lasers:From basic science to applications

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Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.D.Rodrigues A.Bonasera M.Scisciò J.A.Pérez-Hernández M.Ehret F.Filippi P.l.Andreoli M.Huault H.larreur D.Singappuli D.Molloy D.Raffestin M.Alonzo G.G.Rapisarda D.lattuada G.l.Guardo C.Verona Fe.Consoli G.Petringa A.McNamee M.la Cognata S.Palmerini T.Carriere M.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.Margarone l.Giuffrida D.Batani P.Nicolai K.Batani R.lera l.volpe D.Giulietti S.Agarwal M.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre lasers Intenses et Applications(CElIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ElI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

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Manifestations of type 2 diabetes in corneal endothelial cell density,corneal thickness and intraocular pressure

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The Journal of Biomedical Research 2016年第1期30卷 46-51页

作者： stella Briggs Uchechukwu l Osuagwu Essam M AlHarthi Department of Optometry College of Health SciencesUniversity of BuraimiAl BuraimiSultanate of Oman Department of Optometry and Vision Sciences Institute of Health and Biomedical Innovation(Chronic Disease and Ageing)Queensland University of TechnologyBrisbaneQueenslandAustralia AlHokama Eye Specialist Center Riyadh 11427Saudi Arabia

We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized *** measured ECD,CCT and IOP of125 patients with type 2 DM（mean age 57.1±11.5 years）and compared them with 90 age-matched *** parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for *** the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.

关键词： type 2 diabetes corneal endothelial cells central corneal thickness diabetes duration and control

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MicroRNA rules： Made to be broken

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Frontiers in Biology 2013年第5期8卷 468-474页

作者： P. Shannon PENDERGRAST Tom volpe Ymir Genomics 516 Green Street 1A Cambridge MA 02139 USA Department of Cell andMolecular Biology Feinberg School of Medicine Northwestern University 303 East Chicago Avenue Chicago 1L 60611 USA

MicroRNAs （miRNAs） are important post-transcriptional regulators of gene expression. For over a decade the deluge of research describing the biogenesis and activity of miRNAs has lead researchers to postulate rules to help make sense of the enormous amount of data produced. These rules are repeated in miRNA research papers and reviews. While these rules have been helpful one must be conscious of their limitations or risk missing future breakthroughs. Here we describe some of the most commonly stated rules, the reasoning behind their formation, their uses, and limitations.

关键词： microRNA post-transcriptional gene regulation mRNA 3' UTR conservation rule seed pairing rule biogenesis rule mechanism of action rule

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Spectroscopic investigations on the effect of humic acid on the formation and solubility of secondary solid phases of ln_2(CO_3)_3

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Journal of Rare Earths 2011年第6期29卷 516-521页

作者： stella Antoniou Ioannis Pashalidis Andre Gessner Michael U Kumke Department of Chemistry University of Cyprus P.O. Box 20537 1678 Nicosia Cyprus Chemistry Department/Physical Chemistry University of Potsdam Karl- Liebknecht-Str. 24-25 14476 Potsdam-Golm Germany

The formation of secondary ln（III） solid phases （e.g., Nd2（CO3）3 and Sm2（CO3）3） was studied as a function of the humic acid concentration in 0.1 mol/l NaClO4 aqueous solution in the neutral pH range （5–6.5）. The solid phases under investigation were prepared by alkaline precipitation under 100% CO2 atmosphere and characterized by attenuated total reflectance Fourier transform infrared spectroscopy （ATR-FTIR）, X-ray diffraction （XRD）, time-resolved laser fluorescence spectroscopy （TRlFS）, diffuse reflectance ultraviolet-visible （DR-UV-Vis）, Raman spectroscopy, and solubility measurements. The spectroscopic data obtained indicated that Nd2（CO3）3 and Sm2（CO3）3 were stable and remained the solubility limiting solid phases even in the presence of increased humic acid concentration （0.5 g/l） in solution. Upon base addition in the ln（III）-HA system, decomplexation of the previously formed ln（III）-humate complexes and precipitation of two distinct phases occurred, the inorganic （ln2（CO3）3） and the organic phase （HA）, which was adsorbed on the particle surface of the former. Nevertheless, humic acid affected the particle size of the solid phases. Increasing humic acid concentration resulted in decreasing crystallite size of the Nd2（CO3）3 and increasing crystallite size of the Sm2（CO3）3 solid phase, and affected inversely the solubility of the solid phases. However, this impact on the solid phase properties was expected to be of minor relevance regarding the chemical behavior and migration of trivalent lanthanides and actinides in the geosphere.

关键词： lanthanide ions humic acid solid phase solubility Raman TRlFS DR-UV-Vis rare earths

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Multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Open Journal of Soil Science（土壤科学期刊） 2024年第4期 237页

作者： Neil-Yohan Musadji Rolf Gaël Mabicka Obame Michel Mbina Mounguengui Jean Aubin Ondo lydie-stella Koutika Eric Ravire Claude Geffroy

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Single-stage tubular urethral reconstruction using oral grafts is an alternative to classical staged approach for selected penile urethral strictures

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Asian Journal of Andrology 2020年第2期22卷 134-139页

作者： Felix Campos-Juanatey Simon Bugeja Mariya Dragova Anastasia V Frost stella l Ivaz Daniela E Andrich Anthony R Mundy Reconstructive Urology Unit Institute of UrologyUniversity College London HospitalsLondon W1G 8PHUK Department of Urology Marques de Valdecilla University HospitalInstitute of Investigation Valdecilla(IDIVAL)Santander 39008Spain Urology Unit Mater Dei HospitalMsida MSD 2090Malta

Penile urethral strictures have been managed by a staged surgical *** selected cases,spongiofibrosis can be excised,a neo-urethral plate created using buccal mucosa graft(BMG)and tubularized during the same procedure,performing a“twoin-one”stage *** aim to identify stricture factors which indicate suitability for this two-in-one stage *** assess surgical outcome and compare with staged *** conducted an observational descriptive *** data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and *** minimum follow-up was 6 *** were assessed clinically,radiologically,and by flow-rate *** was defined as recurrent stricture or any subsequent surgical or endoscopic *** analysis of stricture characteristics and statistical comparison was made between *** 425 penile urethroplasties,139 met the inclusion criteria:59 two-in-one stage and 80 *** mean stricture length was 2.8 cm(single stage)and 4.5 cm(staged).Etiology was lichen sclerosus(lS)52.5%(single stage)and 73.8%hypospadias related(staged).40.7%of patients had previous failed urethroplasties in the single-stage group and 81.2%in the *** most common stricture locations were navicular fossa(39.0%)and distal penile urethra(59.3%)in the single-stage group and mid or proximal penile urethra(58.7%)in the staged *** rates were 89.8%(single stage)and 81.3%(staged).A trend toward a single-stage approach for select penile urethral strictures was *** conclude that a single-stage substitution penile urethroplasty using BMG as a“two-in-one”approach is associated with excellent functional *** most suitable strictures for this approach are distal,primary,and lS-related strictures.

关键词： anterior urethral stricture hypospadias lichen sclerosus oral mucosa reconstructive surgical procedures tissue transplants

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