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World Journal of Gastroenterology 2024年第9期30卷 1253-1256页

作者： Francesca Colapietro nicola Pugliese Antonio Voza Alessio Aghemo stella de nicola department of Biomedical Sciences Humanitas UniversityMilan 20072Italy Division of Internal Medicine and Hepatology Department of GastroenterologyHumanitas Research HospitalMilan 20089Italy department of Emergency Humanitas Research HospitalMilan 20089Italy

Hepatitis B virus(HBV)reactivation(HBVr)represents a severe and potentially life-threatening condition,and preventive measures are available through blood test screening or prophylactic therapy *** assessment of HBVr traditionally considers factors such as HBV profile,including hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen,along with type of medication(chemotherapy;immunomodulants).Nevertheless,consideration of possible patient’s underlying tumor and the specific malignancy type(solid or hematologic)plays a crucial role and needs to be assessed for decision-making process.

关键词： Chronic hepatitis B Reactivation Nucleoside analogue Tyrosine kinase inhibitors Onco-hematology

Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer

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World Journal of Gastroenterology 2017年第24期23卷 4399-4406页

作者： Cosimo Sperti Mario Gruppo stella Blandamura Michele Valmasoni Gioia Pozza nicola Passuello Valentina Beltrame Lucia Moletta departments of Surgery Oncology and Gastroenterology3rd Surgical ClinicUniversity of Padua departments of Medicine section of PathologyUniversity of Padua

To analyze the importance of para-aortic node status in a series of patients who underwent pancreaticoduodenectomy (PD) in a single Institution. METHODSBetween January 2000 and december 2012, 151 patients underwent PD with para-aortic node dissection for pancreatic adenocarcinoma in our Institution. Patients were divided into two groups: patients with negative PALNs (PALNs-), and patients with metastatic PALNs (PALNs+). Pathologic factors, including stage, nodal status, number of positive nodes and lymph node ratio, invasion of para-aortic nodes, tumor’s grading, and radicality of resection were studied by univariate and multivariate analysis. Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test: significance was considered as P des was 26 (range 14-63). Twenty-five patients (16.5%) had para-aortic lymph node involvement. Thirty-three patients (23%) underwent R1 pancreatic resection. One-hundred forty-one patients recurred and died for tumor recurrence, one is alive with recurrence, and 9 are alive and free of disease. Overall survival was significantly influenced by grading (P = 0.0001), radicality of resection (P = 0.001), stage (P = 0.03), lymph node status (P = 0.04), para-aortic nodes metastases (P = 0.02). Multivariate analysis showed that grading was an independent prognostic factor for overall survival (P = 0.0001), while grading (P = 0.0001) and radicality of resection (P = 0.01) were prognostic parameters for disease-free survival. Number of metastatic nodes, node ratio, and para-aortic nodes involvement were not independent predictors of disease-free and overall survival. CONCLUSIONIn this experience, lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis, but they were not independent prognostic factors.

关键词： Lymphadenectomy Pancreas Pancreatic cancer Pancreatectomy Lymph node metastasis Para-aortic nodes Survival

H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease

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World Journal of Gastroenterology 2006年第48期12卷 7815-7820页

作者： Cristina Lenzi Alberto Palazzuoli nicola Giordano Giuliano Alegente Catia Gonnelli Maria stella Campagna Annalisa Santucci Michele Sozzi Panagiotis Papakostas Fabio Rollo Ranuccio Nuti Natale Figura department of In-ternal Medicine Endocrine-Metabolic Sciences and Biochemistry University of Siena Siena Italy Unit of Microbiology General Hospital Siena Italy department of Molecular Biology University of Siena Siena Italy Unit of Gastroenterology and Digestive Endos-copy General Hospital Trieste Italy

AIM: To determine the overall prevalence of H pylori and CagA positive H pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (CHD), and the potential role of anti-heat-shock protein 60 (Hsp60) anti- body response to these proteins in increasing the risk of CHD development. METHODS: Eighty patients with CHD and 160 controls were employed. We also compared the levels of anti- heat-shock protein 60 (Hsp60) antibodies in the two groups. The H pylori infection and the CagA status were determined serologically, using commercially available enzyme-linked immunosorbent assays (ELISA), and a Western blotting method developed in our laboratory. Systemic antibodies to Hsp60 were determined by a sandwich ELISA, using a polyclonal antibody to Hsp60 to sensitise polystyrene plates and a commercially available human Hsp60 as an antigen. RESULTS: The overall prevalence of H pylori infec- tion was 78.7% (n = 63) in patients and 76.2% (n = 122) in controls (P = 0.07). Patients infected by CagA- positive (CagA+) H pylori strains were 71.4% (n = 45) vs 52.4% of infected controls (P = 0.030, OR = 2.27). Sys-temic levels of IgG to Hsp60 were increased in H pylori- negative patients compared with uninfected controls (P development of CHD; high levels of anti- Hsp60 antibodies may constitute a marker and/or a con- comitant pathogenic factor of the disease.

关键词： H pylori Coronary heart disease CagA protein Heat shock protein 60 Antibody response

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明日风尚 2010年第6期 82-85页

作者： Tan nicola Lai

01Szenfeld式瑞典时尚>说起瑞典的时装设计师,想到的名字并不多,Bea Szenfeld是其中一位。生于波兰其后移民瑞典,在瑞典接受时装设计教育,2003年在Beckman’s College完成了设计课程后,赢得英国时装设计真人秀节目Fashion House的第一... 详细信息

01Szenfeld式瑞典时尚>说起瑞典的时装设计师,想到的名字并不多,Bea Szenfeld是其中一位。生于波兰其后移民瑞典,在瑞典接受时装设计教育,2003年在Beckman’s College完成了设计课程后,赢得英国时装设计真人秀节目Fashion House的第一名而崭露头角,Bea Szenfeld借此得到了在stella McCartney工作室的实习机会。

关键词：时装设计师真人秀节目实习机会 STYLE NOTEBOOK 鞋款紫罗一名希区柯克美国好莱

TNF-α inhibitors and tocilizumab do not influence hepatic steatosis in patients with rheumatoid arthritis

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World Journal of Rheumatology 2014年第1期4卷 1-5页

作者： Paola Sessa Matteo nicola Dario Di Minno Rosella Tirri Carmine Finelli Gabriele Valentini Giovanni Tarantino Rheumatology Unit Second University of Naples 80131 NaplesItaly department of Clinical Medicine and Surgery Federico Ⅱ University Medical School of Naples80131 Naples Italy Center of Obesity and Eating Disorders Stella Maris Mediterraneum FoundationC/da S. LuciaChiaromonte80035 Potenza Italy National Cancer Institute "Pascale Foundation" IRCSS Mercogliano (AV)80131 Naples Italy

AIM: To investigate the influence, if any, of tumor necrosis factor(TNF)-α inihibitors and Tocilizumab, on hepatic steatosis(HS) in rheumatoid arthritis(RA) patients in the light of the known role of TNF-α and interleukin-6, which are key-cytokines in the pathogenesis of RA, in inducing HS in general ***: We retrospectively reviewed the clinical charts of 36 RA patients, out of whom 12 had been treated with Methotrexate(MTX), 12 with TNF inhibitors ± MTX and 12 with Tocilizumab ± MTX. The 3 subgroups of patients matched each other for sex, age, body mass index, metabolic syndrome(MS) and other risk factors for atherosclerosis. At baseline and after 12 mo each patient underwent an abdominal ultrasonog-raphy for the assessment of presence of HS and the evaluation of its ***: No difference was detected either in the prevalence of HS or in that of its distinct grades between the 3 groups of patients at baseline. After 12 mo, the HS grade unchanged in 20 patients(7 subjects treated with MTX, 7 with TNF-α inhibitors ± MTX and 6 Tocilizumab ± MTX); increased in 12 patients(4 subjects treated with MTX, 4 TNF-α blockers ± MTX and 4 Tocilizumab ± MTX); decreased in 4(1 treated with MTX, 1 with anti-TNF-α + MTX and 2 with TCZ ± MTX(P = 0.75). No correlation was found between getting remission or low disease activity and the course of either MS or ***: We failed to detect any influence of MTX ± TNF-α inhibitors or Tocilizumab in reducing MS and HS. A prospective study is needed to clarify the topic.

关键词： Steatosis Rheumatoid arthritis Biological agents