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Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： chin-Heng Lu Hung-Min Chang Kuang-Hsi Chang Yen-Chuan Ou Chao-Yu Hsu Min-Che Tung Frank Cheau-Feng Lin stella chin-shaw tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong Hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHI<5 events/h,5 events/hAHI<15 events/h,15 events/hAHI<30 events/h,and AHI30 events/h,defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,PSG parameters,International Prostate Symptom Scores(IPSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(p<0.001),awake time(p=0.025),stage 1 sleep(p=0.033),and sleep latency(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

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Prostaglandin E2 inhibits phagocytosis of macrophages via downregulation of CD36 in endometriosis

Prostaglandin E2 inhibits phagocytosis of macrophages via do...

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The First Asian Conference on Endometriosis(ACEⅠ)

作者： Pei-chin Chuang Meng-Hsing Wu Yiu-Juian Lin Yutaka Shoji Lih-Yuh C.Wing shaw-Jenq tsai Department of Physiology National Cheng Kung University Medical CollegeDepartment of Nursing Department of Obstetrics & Gynecology National Cheng Kung University Medical CollegeDepartment of Nursing

Endometriosis,which affects more than 10% of women of reproductive age,is a complex disease and a major public health *** immune dysfunction was thought to play important roles in endometriosis development,the pathogenesis is still ***,we showed that prostaglandin E2 (PGE2) inhibited phagocytic ability of macrophages via downregulation of

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Biomimetic strategies for tendon/ligament-to-bone interface regeneration

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Bioactive Materials 2021年第8期6卷 2491-2510页

作者： Tingyun Lei Tao Zhang Wei Ju Xiao Chen Boon chin Heng Weiliang Shen Zi Yin Dr.Li Dak Sum&Yip Yio chin Center for Stem Cell and Regenerative Medicine and Department of Orthopedic Surgery of Sir Run Run shaw Hospital School of MedicineZhejiang UniversityHangzhou310058China Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province School of MedicineZhejiang UniversityHangzhou310058China Department of Orthopedic Surgery of The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou310052China Department of Sports Medicine School of MedicineZhejiang UniversityHangzhou310058China china Orthopedic Regenerative Medicine Group(CORMed) Hangzhou310058China Peking University School of Stomatology BeijingChina

Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure,composition,cell population and mechanics of the *** rapid advances in tissue engineering,a variety of strategies including advanced biomaterials,bioactive growth factors and multiple stem cell lineages have been developed to facilitate the healing of this tissue *** the important role of structure-function relationship,the review begins with a brief description of enthesis structure and ***,the biomimetic biomaterials including decellularized extracellular matrix scaffolds and synthetic-/natural-origin scaffolds are critically ***,the key roles of the combination,concentration and location of various growth factors in biomimetic application are *** that,the various stem cell sources and culture systems are *** last,we discuss unmet needs and existing challenges in the ideal strategies for tendon/ligament-to-bone regeneration and highlight emerging strategies in the field.

关键词： Tendon/ligament-to-bone interface Tissue engineering Biomaterial Growth factor Stem cell

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Hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombosis

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World Journal of Gastroenterology 2003年第12期9卷 2666-2670页

作者： Yung-Chih Lai Cheng-Yen Shih chin-Ming Jeng Sien-Sing Yang Jui-Ting Hu Yung-Chuan Sung Han-Ting Liu shaw-Min Hou Chi-Hwa Wu Tzen-Kwan Chen Department of Internal Medicine Cathay General HospitalTaipeiTaiwanChina Department of Radiology Cathay General HospitalTaipeiTaiwanChina Department of Surgery Cathay General HospitalTaipeiTaiwanChina

AIM: Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is associated with poor prognosis. The aim of this prospective study was to evaluate the efficacy of hepatic arterial infusion chemotherapy (HAIC) for patients with this ***: Eighteen HCC patients with PVTT were treated with HAIC via a subcutaneously implanted injection port. A course of chemotherapy consisted of daily cisplatin (10 mg for one hour) followed by 5-fiuorouracil (250 mg for five hours) zfor five continuous days within a given week. The patients were scheduled to receive four consecutive courses of *** were defined in whom either a complete or partial response was achieved, while non-responders were defined based on stable or progressive disease status. The prognostic factors associated with survival after treatment were ***: Six patients exhibited partial response to this form of HAIC (response rate = 33 %). The 3, 6, 9, 12 and 18-month cumulative survival rates for the 18 patients were 83 %, 72 %, 50 %, 28 %, and 7 %, respectively. Median survival times for the six responders and 12 non-responders were 15.0 (range, 11-18) and 7.5 (range, 1-13) months,respectively, It was demonstrated by both univariate and multivariate analyses that the therapeutic response and hepatic reserve function were significant prognostic ***: HAIC using low-dose cisplatin and 5-fluorouracil may be a useful alternative for the treatment of patients with advanced HCC complicated with PVTT. There may also be survival-related benefits associated with HAIC.

关键词：肝动脉灌注化疗门静脉肿瘤栓塞肝细胞癌影像学检查临床研究

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Petrogenesis of Cenozoic Basaltic Rocks from Jiangsu Province,china:Evidence from Geochemical Constraints

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Acta Geologica Sinica(English Edition) 2013年第1期87卷 102-117页

作者： Yung-Tan LEE Ju-chin CHEN Jyh-Yi SHIH Kung-Suan HO Huai-Jen YANG Meng-Lung LIN Yen-Tsui HU ching-Hsing CHIU Tourism School of Aletheia University Institute of Oceanography National Taiwan University National Museum of Natural Science Department of Earth Sciences National Cheng Kung University Sinotech Engineering Consultants Inc. Department of Tourism Management Shih Chien University

Cenozoic （Miocene to Pleistocene） basaltic rocks in Jiangsu province of eastern china include olivine tholeiite and alkali basalt. We present major, trace element and Sr-Nd isotopic data as well as Ar-Ar dating of these basalts to discuss the petrogenesis of the basalts and identify the geological processes beneath the study area. On the basis of chemical compisitions and Ar-Ar dating of Cenonoic basaltic rocks from Jiangsu province, we suggest that these basalts may belong to the same magmatic system. The alkali basalts found in Jiangsu province have higher ~FeO, MgO, CaO, Na20, TiO2 and P205 and incompatible elements, but lower A1203 and compatible elements contents than olivine tholeiite which may be caused by fractional crystallization of olivine, pyroxene and minor plagioclase. In Jiangsu basaltic rocks the incompatible elements increase with decreasing MgO/~FeO ratios. The primitive mantle-normalized incompatible elements and chondrite-normalized REE patterns of basaltic rocks found in Jiangsu province are similar to those of OIB. Partial loss of the mantle lithosphere accompanied by rising of asthenospheric mantle may accelerate the generation of the basaltic magma. The 143Nd/144Nd vs. S7Sr/S6Sr plot indicates a mixing of a depleted asthenospheric mantle source and an EM1 component in the study area. According to shaw＇s equation, the basalts from Jiangsu province may be formed by 1%-5% partial melting of a depleted asthenospheric mantle source. On the basis of Ar-Ar ages of this study and the fractional crystallization model proposed by Brooks and Nielsen （1982）, we suggest that basalts from Jiangsu province may belong to a magmatic system with JF-2 as the primitive magma which has undergone fractional crystallization and evolved progressively to produce other types of basalts.

关键词： Cenozoic basalts geochemistry Jiangsu Province mantle process Ar-Ar dating

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20国集团时代非洲加勒比地区发展与安全的前景(英文)

20国集团时代非洲加勒比地区发展与安全的前景(英文)

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北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： Timothy M shaw

The global financial crisis at the turn of the decade has generated regional divergences with long-term global implications,symbolised by the fast-tracked establishment of the G20(Cooper & Subacchi 2010).But is this an association of regional powers by contrast to the G3 of emerging states?This paper suggests that,in terms of prospects for both North,including a diminished Anglo-American centre & an EU of the PIIGS,and the‘global South ’,we need to distinguish between‘emerging powers’(shaw,Cooper & chin 2009),‘emerging societies’ (Pieterse & Rehbein 2009) &‘emerging economies’or companies(Goldstein 2007);ie varieties of capitalisms(Bruff 2008)& of civil societies which impact national & regional *** the BRICs become alternative centres of attraction,other regions like Africa & the Caribbean

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EXPERIMENTAL STUDY ON DARCY′S LAW IN HELE-shaw CELLS

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Transactions of Nanjing University of Aeronautics and Astronautics 2003年第2期20卷 134-139页

作者：孙建红许金造南京航空航天大学人机与环境工程系香港科技大学机械工程系

The basic physics of unsteady Hele-shaw flow at high Reynolds numbers is mainly studied by an experimental measurement. In order to confirm the Darcy′s law in Hele-shaw cell, since there is an analogy between flow in cells and that in porous media, progressive water waves are utilized to build an unsteady flow in a Hele-shaw cell, and which complex wave number is measured by a wave height gauge. Meanwhile, theoretical analyses are used to compare with experimental data. Result shows Darcy′s Law is not exactly correct for unsteady Hele-shaw flows, and it is expected to conduct a modified Darcy′s Law.

关键词： Hele-shaw cell surface water wave Darcy′s law

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Ⅷ.O-乙基N,N-二乙氨基一(或二)硫代磷酸钠的制备及其化学反应

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化学学报 1965年第5期 406-412页

作者：楊石先陈天池王琴孙金桂玉邵瑞鏈刘綸祖南开大学元素有机化学研究所南开大学元素有机化学研究所南开大学化学系

1.本文报告以O-乙基N,N-二乙氨基硫代磷酰氯(Ⅲ)为原料,合成O-乙基N,N-二乙氨基一(或二)硫代磷酸钠(Ⅰ)、(Ⅱ)的方法。 2.Ⅰ和Ⅱ分别与卤代烷反应,得到相应的酯(Ⅴ),(Ⅵ)。Ⅰ和Ⅱ在低温下用稀盐酸酸化则转化成相应的酸(Ⅶ)和(Ⅷ),后者... 详细信息

1.本文报告以O-乙基N,N-二乙氨基硫代磷酰氯(Ⅲ)为原料,合成O-乙基N,N-二乙氨基一(或二)硫代磷酸钠(Ⅰ)、(Ⅱ)的方法。 2.Ⅰ和Ⅱ分别与卤代烷反应,得到相应的酯(Ⅴ),(Ⅵ)。Ⅰ和Ⅱ在低温下用稀盐酸酸化则转化成相应的酸(Ⅶ)和(Ⅷ),后者分别与碘乙烷、重氮甲烷、环己胺等作用得到相应的酯(Ⅸ)和铵盐(Ⅺ)。 3.Ⅱ与卤素(溴或碘)反应形成二硫化物(Ⅻ),后者与等量氯反应得到磷酰氯(Ⅲ)。

关键词：硫代磷酸钠 N,N 乙醚提取乙基链烷基固体物实验值计算值碘乙烷乙基碘环己胺环己烷重氮甲烷叠氮甲烷重氮化合物二硫代磷酸卤代烷烷基卤硫氢化钠反应熔点熔解温度二乙氨基

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脑心通胶囊中水蛭的特异性DNA鉴别

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中山大学学报（自然科学版） 2020年第1期59卷 114-124页

作者：朱晓枭胡恺恩邵鹏柱彭维苏薇薇中山大学生命科学学院/广东省中药上市后质量与药效再评价工程技术研究中心广东广州510275 香港中文大学李达三叶耀珍中医药研究发展中心香港沙田

建立正品水蛭(宽体金线蛭、日本医蛭)的DNA分子鉴别方法。基于线粒体细胞色素c氧化酶亚基Ⅰ(COⅠ)基因序列,分别设计了针对宽体金线蛭和日本医蛭的特异性引物,将其应用于水蛭药材正品、常见伪品菲牛蛭以及含水蛭的中成药脑心通胶囊的PC... 详细信息

建立正品水蛭(宽体金线蛭、日本医蛭)的DNA分子鉴别方法。基于线粒体细胞色素c氧化酶亚基Ⅰ(COⅠ)基因序列,分别设计了针对宽体金线蛭和日本医蛭的特异性引物,将其应用于水蛭药材正品、常见伪品菲牛蛭以及含水蛭的中成药脑心通胶囊的PCR技术检测。结果显示单独使用引物WF1R2或WF2R2均可以特异性扩增宽体金线蛭的DNA,产生大小为200 bp左右的条带;而引物HF1R2则可以特异性扩增日本医蛭,产生大小为142 bp的条带;这3对引物在伪品菲牛蛭中均无扩增条带。且用引物WF1R2和WF2R2均在脑心通胶囊中检测到宽体金线蛭,与胶囊所用投料药材一致。结果表明这3对引物可以分别对宽体金线蛭和日本医蛭进行特异性鉴别,且无需测序;而引物WF1R2和WF2R2可直接用于脑心通胶囊中所用水蛭正品的检控。该DNA分子鉴定方法简便、准确,特异性强且灵敏度高,可作为对传统基原鉴定方法的补充,进一步提高水蛭药材及含水蛭的中成药脑心通胶囊的质量控制水平。

关键词：水蛭脑心通胶囊基原鉴定 DNA分子鉴定 COⅠ基因

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脑心通胶囊中全蝎的特异性DNA鉴别

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中南药学 2019年第12期17卷 2015-2020页

作者：朱晓枭胡恺恩邵鹏柱彭维苏薇薇中山大学生命科学学院//广东省中药上市后质量与药效再评价工程技术研究中心广州510275 香港中文大学李达三叶燿珍中医药研究发展中心香港抄田999077

目的建立正品全蝎(东亚钳蝎)的特异性DNA分子鉴别方法。方法采用DNA条形码技术,基于线粒体细胞色素c氧化酶亚基Ⅰ(COⅠ)基因序列,设计全蝎的特异性引物,对全蝎药材及含全蝎的中成药脑心通胶囊进行PCR扩增及测序,将获得的序列在GenBank... 详细信息

目的建立正品全蝎(东亚钳蝎)的特异性DNA分子鉴别方法。方法采用DNA条形码技术,基于线粒体细胞色素c氧化酶亚基Ⅰ(COⅠ)基因序列,设计全蝎的特异性引物,对全蝎药材及含全蝎的中成药脑心通胶囊进行PCR扩增及测序,将获得的序列在GenBank数据库中应用BLAST进行结果判定,结果中相似性最高的序列对应物种为待测样品最接近的物种。结果引物SF1R1和SF2R4均可特异性扩增东亚钳蝎的DNA,产生大小为250~260 bp的条带;且应用这两对引物均在脑心通胶囊中检测到东亚钳蝎,与胶囊所用投料药材一致。结论基于COⅠ序列的DNA条形码技术可用于全蝎药材及脑心通胶囊中全蝎的鉴定,该方法准确、简便、具有高特异性和灵敏度,具有实际应用价值。

关键词：全蝎脑心通胶囊 DNA条形码 COⅠ基因基原鉴定

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