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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 58-58页

作者： steinauer j. Drey E.A. Lewis R. 高雪莲 Department of Obstetr ics Gynecology and Reproductive Sciences 1001 Potrero Avenue San Francisco CA 94110 United States Dr.

OBj.CTIVE: To evaluate obstetrics and gynecology resident satisfaction with a comprehensive, integrated abortion rotation. METHODS: The University of Californ ia, San Francisco obstetrics and gynecology residency program includes a 6-week PGY-3 family planning rotation at an in-hospital clinic where abortions are p rovided up to 23 weeks of gestation. Residents annually evaluate the educational value of all clinical rotations on a 5-point Likert scale, with 5 indicating " maximum value," and 1 "no value." Using data from 1998-2003, we compared rating s of the family planning rotation with all other PGY-3 rotations. We also surve yed residents 1 to 3 years after graduation to assess the rotation qualitatively and quantitatively. RESULTS: Forty residents completed the abortion training, n one opted out of training, and all completed the evaluations. Of all rotations i n the third year, the family planning rotation was the highest rated (4.70), was similar in value to a high-volume surgical rotation (4.51, P >.10) and the ele ctive rotation (4.45, P >.05), and surpassed the average score for all inpatient rotations (4.00, P < .001), continuity clinic (4.10, P < .001), and outpatient clinical experiences (4.06, P < .01). According to residency graduates, the fami ly planning rotation was rated 4.8 (where 5 indicates “far greater value”than other rotations), and 85%of respondents rated it of “maximum learning value.” CONCLUSION: Obstetrics and gynecology residente place high value in the Universi ty of California, San Francisco PGY-3 family planning rotation during their tra ining and in their first years of practice.

关键词：意度住院医师教学价值一所尼亚定量评价实践评价

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New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins

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Frontiers in Biology 2016年第4期11卷 285-304页

作者： j.an Li Chun Guo Nickolas steinauer j.nsong Zhang Department of Pharmacology and Physiology Saint Louis University School of Medicine St. Louis Missouri 63104 USA

BACKGROUND： Nearly 15% of acute myeloid leukemia （AML） cases are caused by aberrant expression of AML 1-ETO, a fusion protein generated by the t（8;21） chromosomal translocation. Since its discovery, AML 1-ETO has served as a prototype to understand how leukemia fusion proteins deregulate transcription to promote leukemogenesis. Another leukemia fusion protein, E2A-Pbx 1, generated by the t（1; 19） translocation, is involved in acute lymphoblastic leukemias （ALLs）. While AML 1 - ETO and E2A-Pbxl are structurally unrelated fusion proteins, we have recently shown that a common axis, the ETO/E-protein interaction, is involved in the regulation of both fusion proteins, underscoring the importance of studying protein-protein interactions in elucidating the mechanisms of leukemia fusion proteins. OBj.CTIVE： In this review, we aim to summarize these new developments while also providing a historic overview of the related early studies. METHODS： A total of 218 publications were reviewed in this article, a maj.rity of which were published after 2004. We also downloaded 3D structures of AML1-ETO domains from Protein Data Bank and provided a systematic summary of their structures. RESULTS： By reviewing the literature, we summarized early and recent findings on AML 1-ETO, including its protein-protein interactions, transcriptional and lenkemogenic mechanisms, as well as the recently reported involvement of ETO family corepressors in regulating the function of E2A-Pbxl. CONCLUSION： While the recent development in genomic and structural studies has clearly demonstrated that the fusion proteins function by directly regulating transcription, a further understanding of the underlying mechanisms, including crosstalk with other transcription factors and cofactors, and the protein-protein interactions in the context of native proteins, may be necessary for the development of highly targeted drugs for leukemia therapy.

关键词： AML1-ETO E2A-Pbxl E-proteins chromosomal translocation transcription leukemia

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