检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工业液压的未来:从“恐龙”到“金独角兽”

液压与气动 2023年第8期47卷 1-7页

作者： steffen Haack 博世力士乐德国巴伐利亚美因河畔洛尔97816

传统液压技术将在未来十年内发生重大变化。电气自动化、数字化和IT技术的新发展将使工业液压系统的集成变得更加容易,并使其更具竞争力。综合剖析了工业液压所面临的市场挑战,与电传动技术在未来的竞争关系,以及在关键细分市场的发展... 详细信息

传统液压技术将在未来十年内发生重大变化。电气自动化、数字化和IT技术的新发展将使工业液压系统的集成变得更加容易,并使其更具竞争力。综合剖析了工业液压所面临的市场挑战,与电传动技术在未来的竞争关系,以及在关键细分市场的发展趋势。通过分析当前和未来的技术发展,结合产品和应用案例,提出了工业液压技术转型的方向、要点和解决方案。

关键词：工业液压数字化能效未来的可行性预测性维护

Knock-out of BnHva22c reduces the susceptibility of Brassica napus to infection with the fungal pathogen Verticillium longisporum

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2024年第2期12卷 503-514页

作者： Wanzhi Ye Roxana Hossain Michael Prbsting Abdallah Abdelmegid Mohamed Ali Lingyue Han Ying Miao steffen Rietz Daguang Cai Dirk Schenke Department of Molecular Phytopathology and Biotechnology Institute of PhytopathologyChristian-Albrechts-University of KielKielGermany Institut für Zuckerrübenforschung GöttingenGermany Plant Pathology Department Faculty of Agriculture and Natural ResourcesAswan UniversityAswanEgypt Fujian Provincial Key Laboratory of Plant Functional Biology College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Hohenlieth-Hof NPZ Innovation GmbHHoltseeGermany

Verticillium longisporum(Vl43)is a soilborne hemibiotrophic fungal pathogen causing stem striping on oilseed rape(OSR)and severe yield *** for resistant varieties is the most promising approach to control this ***,we report the identification of Hva22c as a novel susceptibility factor and its potential for improving OSR ***22c is a member of the Hva22 gene family,originally described for barley(Hordeum vulgare).Several Hva22 members have been located at the endoplasmic ***22c is up-regulated in response to Vl43 in both Arabidopsis and *** demonstrate that knock-out of Hva22c in OSR by CRISPR/Cas9 and its homolog in Arabidopsis by T-DNA insertion reduced plants’susceptibility to Vl43 infection and impaired the development of disease *** understand the underlying mechanism,we analysed transcriptomic data from infected and non-infected roots of hva22c knock-out and wild type *** identified a homozygous mutant with frame-shifts in all four BnHva22c loci displaying a vastly altered transcriptional landscape at 6 ***,a large set of genes was suppressed under mock conditions including genes related to the endomembrane *** the up-regulated genes we found several defense-related and phytohormone-responsive genes when comparing mutant to the wild *** results demonstrate that Hva22c is functionally required for a fully compatible plant-fungus *** loss of function reduces plant susceptibility,most likely due to endoplasmatic reticulum and Golgi dysfunction accompanied by additionally activated defense *** findings can help improve OSR resistance to *** infection.

关键词： Hva22c Susceptibility factor CRISPR/Cas9 Brassica napus Arabidopsis Verticillium longisporum Resistance breeding

Artificial intelligence for closed-loop ventilation therapy with hemodynamic control using the open lung concept

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Intelligent Computing and Cybernetics 2015年第1期8卷 50-68页

作者： Anake Pomprapa Danita Muanghong Marcus Köny steffen Leonhardt Philipp Pickerodt Onno Tjarks David Schwaiberger Burkhard Lachmann Helmholtz-Institute for Biomedical Engineering RWTH Aachen UniversityAachenGermany Department of Anesthesiology and Intensive Care Medicine Charité–University Medicine BerlinBerlinGermany

Purpose–The purpose of this paper is to develop an automatic control system for mechanical ventilation therapy based on the open lung concept(OLC)using artificial *** addition,mean arterial blood pressure(MAP)is stabilized by means of a decoupling controller with automated noradrenaline(NA)dosage to ensure adequate systemic perfusion during ventilation therapy for patients with acute respiratory distress syndrome(ARDS).Design/methodology/approach–The aim is to develop an automatic control system for mechanical ventilation therapy based on the OLC using artificial *** addition,MAP is stabilized by means of a decoupling controller with automated NA dosage to ensure adequate systemic perfusion during ventilation therapy for patients with ***–Thisinnovativeclosed-loop mechanicalventilation system leadsto a significant improvement in oxygenation,regulates end-tidal carbon dioxide for appropriate gas exchange and stabilizes MAP to guarantee proper systemic perfusion during the ventilation *** limitations/implications–Currently,this automatic ventilation system based on the OLC can only be applied in animal trials;for clinical use,such a system generally requires a mechanical ventilator and sensors with medical approval for *** implications–For implementation of a closed-loop ventilation system,reliable signals from the sensors are a prerequisite for successful ***/value–Theexperiment with porcine dynamics demonstrates thefeasibility and usefulness of this automatic closed-loop ventilation therapy,with hemodynamic control for severe ***,this pilot study validated a new algorithm for implementation of the OLC,whereby all control objectives are fulfilled during the ventilation therapy with adequate hemodynamic control of patients with ARDS.

关键词： Artificial intelligence Acute respiratory distress syndrome(ARDS) Closed-loop mechanical ventilation Electrical impedance tomography(EIT) Hemodynamic control Open lung concept

Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第43期25卷 6430-6439页

作者： Julian Nikolaus Bucher Marcus Hollenbach steffen Strocka Gereon Gaebelein Michael Moche Thorsten Kaiser Michael Bartels Albrecht Hoffmeister Department of Surgery Munich University Hospital at GroβhadernBavariaMunich 81377Germany Medical Department Ⅱ-Gastroenterology HepatologyInfectious DiseasesPulmonologyUniversity of Leipzig Medical CenterSaxonyLeipzig 04103Germany Department of Diagnostic and Interventional Radiology University of Leipzig Medical CenterSaxonyLeipzig 04103Germany Department of General VisceralVascular and Pediatric SurgeryUniversity of SaarlandSaarlandHomburg 66421Germany Department of Diagnostic and Interventional Radiology BavariaNuernberg 90411Germany Institute of Laboratory Medicine Clinical Chemistry and Molecular DiagnosticsUniversity of Leipzig Medical CenterSaxonyLeipzig 04310Germany Department for General and Visceral Surgery Helios Park-Klinikum LeipzigSaxonyLeipzig 04289Germany Medical Department Ⅱ-Gastroenterology HepatologyInfectious DiseasesPulmonologyUniversity of Leipzig Medical CenterLeipzig 04103SaxonyGermany

BACKGROUND Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt(TIPS)(SIC-T),is a rare complication of this technique and only referred by case ***,we conducted a systematic,retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct *** To assess prevalence and outcome of SIC-T in a large *** In this retrospective cohort study,we screened the institutional databases for all consecutive patients that were treated by TIPS-placement or TIPS-revision between January 2005 and August *** analyzed radiologic images for signs of biliary *** that were indicative of SIC-T were reviewed by two independent radiologists and additional patient data was *** statistics of patient demographics,indications for TIPS and procedural details were *** regression analysis was performed to identify predictors for the development of *** We analyzed 135 cirrhotic patients who underwent TIPS(mean age 55 years,79%male gender).Etiology of cirrhosis was alcohol in most cases and indications for TIPS were mainly refractory ascites and recurrent variceal *** revision was necessary in 31 *** identified 4 cases(2.9%)of SIC-T in direct proximity of the *** was confirmed by CT-scan,MRI or endoscopic retrograde cholangio pancreaticography(ERCP).In two patients TIPS was implanted via the right and in one through the medial hepatic *** patient received TIPS-prolongation by multiple *** patients were asymptomatic but one cholangitic abscess necessitated a transhepatic *** regression analysis identified TIPS-placement other than from medial hepatic vein to right portal vein as risk factor(OR 21.0)for *** SIC-T ads to(mostly late)complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic ***

关键词： Transjugular intrahepatic portosystemic shunt Cirrhosis Ascites Bleeding Cholestasis Biliary congestion

Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第16期26卷 1962-1970页

作者： Timo Rath Lukas Pfeifer Clemens Neufert Andreas Kremer Moritz Leppkes Arthur Hoffman Markus F Neurath steffen Zopf Department of Internal Medicine 1 Division of GastroenterologyLudwig Demling Endoscopy Center of ExcellenceFriedrich-Alexander-UniversityErlangen NuernbergErlangen 91054Germany Department of Internal Medicine Division of GastroenterologyKlinikum AschaffenburgAschaffenburg 63739Germany Department of Internal Medicine Division of GastroenterologyKlinikum FürthFürth 90766Germany

BACKGROUND The adenoma detection rate(ADR)is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening ***,adenoma miss rates reach up to 26%and studies have shown that a second inspection of the right colon in retroflected view(RFV)can increase *** To assess whether inspection of the whole colon in RFV compared to standard forward view(SFV)can increase *** Patients presenting for screening or surveillance colonoscopy were invited to participate in this randomized controlled trial and randomized into two *** RFV arm colonoscopy was initially performed with SFV,followed by a second inspection of the whole colon in *** the SFV arm first withdrawal was performed with SFV,followed by a second inspection of the whole colon again with ***,size and morphology of polyps found during first and second inspection in each colonic segment were recorded and all polyps were removed and sent for histopathology in separate *** Two hundred and five patients were randomly assigned to the RFV(n=101)and SFV(n=104)*** the RFV arm,both polyp detection rate(PDR)and ADR were increased under second inspection in RFV(PDR 1st SFV:39.8%,PDR 2nd RFV:46.6%;ADR 1st SFV:35.2%,ADR 2nd RFV:42%).Likewise,in the SFV arm,PDR and ADR were increased under second inspection(PDR 1st SFV:37.5%,PDR 2nd SFV:46.6%;ADR 1st SFV:34.1%,ADR 2nd SFV:44.3%)with no significant differences in ADR and PDR between the SFV and RFV *** number of adenomas per patient(APP)was increased in the RFV and SFV(APP RFV arm:1st SFV:1.71;2nd RFV:2.38;APP SFV arm:1st SFV:1.83,2nd SFV:2.2).The majority of adenomas additionally found during second inspection in RFV or in SFV were located in the transverse and left-sided colon and were>5 mm in *** Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and ***,increased detection is mos

关键词： Colorectal cancer Adenoma Adenoma detection rate Colonoscopy

Comparison of Hemospray~? and Endoclot? for the treatment of gastrointestinal bleeding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第13期25卷 1592-1602页

作者： Francesco Vitali Andreas Naegel Raja Atreya steffen Zopf Clemens Neufert Juergen Siebler Markus F Neurath Timo Rath Ludwig Demling Endoscopy Center of Excellence Division of Gastroenterology Friedrich-Alexander-University

BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent "touch-free" *** To analyze short term(ST-within 72 h-) and long-term(LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray(HS) and Endoclot(EC).METHODS HP was applied in 154 consecutive patients(mean age 67 years) with GI *** were followed up for 1 mo(mean follow-up: 3.2 mo).RESULTS Majority of applications were in upper GI tract(89%) with following bleeding sources: peptic ulcer disease(35%), esophageal varices(7%), tumor bleeding(11.7%), reflux esophagitis(8.7%), diffuse bleeding and erosions(15.3%). Overall ST success was achieved in 125 patients(81%) and LT success in 81 patients(67%). Re-bleeding occurred in 27% of all patients. In 72 patients(47%), HP was applied as a salvage hemostatic therapy, here ST and LT success were 81% and64%, with re-bleeding in 32%. As a primary hemostatic therapy, ST and LT success were 82% and 69%, with re-bleeding occurring in 22%. HS was more frequently applied for upper GI bleeding(P = 0.04)CONCLUSION Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding.

关键词： Hemostatic powder Gastrointestinal bleeding Hemospray Endoclot Haemostasis

From Industry 4.0 to Research 4.0. Development of High Performance Fibers in the Light of Digitization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料科学与工程（中英文B版） 2018年第4期8卷 161-177页

作者： steffen Müller-Probandt Dienes Apparatebau GmbH Development of special machines for synthetic fiber spinning Philipp-Reis-Str. 16 D-63165 Mühlheimam Main Germany

We associate a variety of innovations with the term ＂Industry 4.0＂. The pioneer of many 4.0 modifications forms the basisfor the trend towards the integrated digitization of many areas of life. The field of research requires from the pilot plants to developnew pioneering fibers high flexibility of its experimental facilities to allow new insights in the laboratory and prototype facilities at areasonable cost. Added to this is the desire to closely track all process data and prepare it in a timely manner. Mobile devices nowallow the researcher to vary parameters close to the process during observation. In the following lecture the question will bediscussed which of the many definitions and varieties of ＂Industry 4.0＂ can be meaningfully transferred to the field of research. Indoing so, we are guided by the findings that have been gained with modularized spinning systems in recent years. The respectivespinning processes require different analysis focuses and different conversion options. The digital world must follow the realdemands of the analog world. In addition to the elegance functions, it must be ensured that the control functions of the process meetthe requirements of machine safety. Digitization allows intelligent analyzes to be developed independently of the various spinningprocesses and can be flexibly adapted to the respective process conditions. The variability of spin systems depends on the intelligentmodularization of individual functions and the physics that require the spinning conditions. Finally, some examples of modularprototype systems are presented, and the limits of variability are discussed.

关键词： Industry 4.0 internet of things modularization innovation research prototype spinning machines high performancefibers carbon fibers cyber physical production systems

Importance,Organization and Evaluation of Interlaboratory Tests

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China's Refractories 2018年第2期27卷 1-6页

作者： Gerhard URBANEK steffen UHLIG RHI AG Leoben A-8700Austria QuoData GmbH Freising D-85356Germany

The importance of ＂precise＂ test values and their verification is growing in every industry throughout the world, lnterlaboratory studies constitute a basis for this. The high expenses and mathematical work required to carry out proper interlaboratory studies are frequently considered reasons not to conduct such studies. This makes it all the more important to emphasize the various advantages of an accurate interlaboratory study. In addition to providing precision data for the test method, it is also possible to carry out laboratory evaluations, which is important for accredited test laboratories. Furthermore, existing test methods can be optimized, refer- ence material can be obtained, and test methods can be compared. Optimized test instructions can also be generated using the findings and precision data. These advantages will be described in detail by means of examples below.

关键词： interlaboratory study round Robin tests test methods precision of test methods ISO 5725 standards

Highly sensitive electrochemical detection of living cells based on diamond microelectrode arrays

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第6期29卷 919-921页

作者： Jun Ruan Wenbo Zhang Hang Zhang Yun Chen Fawad Ur Rehman Hui Jiang steffen Strehle Alberto Pasquarelli Xuemei Wang State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory) School of Biological Science and Medical Engineering Southeast University Institute of Electron Devices and Circuits Ulm University

We designed boron-doped nanocrystalline diamond microelectrode arrays（BNCD-MEAs） with 16 channels for the bioanalysis of multicellular samples, which could be readily adapted for a highly sensitive detection of H2 O2[2_TD$IF]released from stimulated cells by ascorbic acid（AA）. Our observations demonstrated that the as-prepared diamond microelectrode arrays could be utilized to distinguish cancer cells from normal cells, and the amperometric study showed the considerable differences in the currents, indicating that the related Hep G2 cancer cells could release more H2 O2 than that of L02 normal cells. This supports the possibility to use diamond-based MEAs for rapid cancer cell detection in future clinic applications.

关键词： BNCD-MEAs 16 Channels Bioanalysis Stimulated cells H2O2 detection