检索结果-南通市图书馆

Clinical benefit of left atrial appendage closure in octogenarians

Journal of Geriatric Cardiology 2021年第11期18卷 886-896页

作者： Yamen Mohrez steffen gloekler steffen Schnupp Wasim Allakkis Xiao-Xia Liu Monika Fuerholz Johannes Brachmann Stephan Windecker Stephan Achenbach Bernhard Meier Caroline Kleinecke Department of Cardiology Klinikum CoburgCoburgGermany Cardiovascular Department University Hospital of BernBernSwitzerland Department of Cardiology Klinikum HochrheinWaldshut-TiengenGermany Depart-ment of Cardiology Beijing Anzhen HospitalBeijingChina Department of Cardiology Friedrich-Alexander Uni-versity Erlangen-NuernbergErlangenGermany

OBJECTIVES Whether left atrial appendage closure(LAAC)in octogenarians yield similar net clinical benefit compared to younger patients,was the purpose of the present *** Two real-world LAAC registries,enrolling 744 consecutive Amplatzer and Watchman patients from 2009 to 2018,were retrospectively *** All events are reported per 100 *** hundred and sixty one octogenarians and 483 non-octogenarians with a mean follow-up of 1.7±1.3 and 2.3±1.6 years,and a total of 1,502 patient-years were *** had a higher risk for stroke(CHA2DS2-VASc score:5.2±1.2 vs.4.3±1.7,P<0.0001)and bleeding(HAS-BLED score:3.3±0.8 vs.3.1±1.1,P=0.001).The combined safety endpoint of major periprocedural complications and major bleeding events at follow-up was comparable(30/446,6.7%vs.47/1056,4.4%;hazard ratio[HR]=1.2;95%confidence interval[CI]:0.73−1.98;P=0.48)between the *** efficacy endpoint of all-cause stroke,systemic embolism,and cardiovascular/unexplained death occurred more often in octogenarians(61/446,13.7%vs.80/1056,7.6%;HR=7.0;95%CI:4.53−10.93;P<0.0001).Overall,octogenarians had a lower net clinical benefit,i.e.,the composite of all above mentioned hazards,from LAAC compared to younger patients(82/446,18.4%vs.116/1056,11.0%;HR=4.6;95%CI:3.11−7.0;P<0.0001).Compared to the anticipated stroke rate,the observed rate de-creased by 41%in octogenarians and 53%in *** observed bleeding rate was reduced by 10%octogenarians and 41%*** LAAC can be performed with similar safety in octogenarians as compared to younger *** the long-term,it both reduces stroke and bleeding events,although to a lesser extent than in non-octogenarians.

关键词： atrial closure younger

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：