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Modern diagnostic approaches to cholangiocarcinoma

Hepatobiliary & Pancreatic Diseases international 2012年第4期11卷 349-359页

作者： Larisa E Vasilieva stefanos i papadhimitriou Spyros P Dourakis Second Department of internal Medicine University of Athens Medical SchoolHippokration General Hospital114 Vas Sofias AvenueAthens 11527Greece Molecular Cytogenetics Unit Haematology Laboratory"G.Genimatas" Regional General HospitalAthensGreece

BACKGROUND:Cholangiocarcinoma is a very aggressive tumor with poor ***,early diagnosis and surgical resection are of paramount *** diagnosis is difficult because access to the tumor is not *** is possible only for intrahepatic cholangiocarcinoma,which accounts for 10% of *** brush cytology from endoscopic retrograde cholangiopancreatography(ERCP) has a high specificity of 100% but unfortunately a low sensitivity of 30%.in this review we briefly describe new diagnostic techniques applicable to ERCP brush cytology specimens and targeting the genetic background of the disease,in particular fluorescence in situ hybridization(FiSH) and digital image analysis(DiA).DATE SOURCES:The PubMed database up to 2011 was used for the retrieval of relevant *** search terms FiSH,fluorescence in situ hybridization,DiA,digital image analysis and cholangiocarcinoma were *** original and review articles were ***:FiSH identifies cells with chromosomal abnormalities,mainly numerical aberrations,using a mixture of fluorescencelabeled *** offers a higher sensitivity than routine cytology,retaining a high level of *** DiA criterion for malignancy is demonstration of *** technique increases the sensitivity to 40%,but the specificity remains *** data from application to other tumors suggest that combination of FiSH and DiA may be of further ***:The new techniques offer a significantly enhanced diagnostic efficacy in the evaluation of ERCP brush *** from contributing to a more timely diagnosis,their wider application to cholangiocarcinoma may also facilitate the genetic study of the disease and add to our understanding of oncogenesis at the molecular level,with the prospect of identifying targets for novel therapeutic interventions.

关键词： cholangiocarcinoma fluorescence in situ hybridization digital image analysis

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