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Calcium supplementation for the prevention of colorectal adenomas: a systematic review and meta-analysis of randomized controlled trials

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World Journal of Gastroenterology 2016年第18期22卷 4594-4603页

作者： stefanos bonovas Gionata Fiorino Theodore Lytras Alberto Malesci Silvio Danese Department of Gastroenterology Humanitas Clinical and Research Center 20089 Rozzano Milan Italy Department of Experimental and Health Sciences Universitat Pompeu Fabra 08003 Barcelona Spain Centre for Research in Environmental Epidemiology 08003 Barcelona Spain Hellenic Center for Disease Control and Prevention 15123 Athens Greece Department of Medical Biotechnology and Translational Medicine University of Milan 20129 Milan Italy Department of Biomedical Sciences Humanitas University 20089 Rozzano Milan Italy

AIM: To determine the efficacy of calcium supplementation in reducing the recurrence of colorectal ***: We conducted a systematic review and meta-analysis of published studies. We searched PubMed, Scopus, the Cochrane Library, the WHO International Clinical Trials Registry Platform, and the *** website, through December 2015. Randomized, placebo-controlled trials assessing supplemental calcium intake for the prevention of recurrence of adenomas were eligible for inclusion. Two reviewers independently selected studies based on predefined criteria, extracted data and outcomes (recurrence of colorectal adenomas, and advanced or “high-risk” adenomas), and rated each trial’s risk-of-bias. Between-study heterogeneity was assessed, and pooled risk ratio (RR) estimates with their 95% confidence intervals (95%CI) were calculated using fixed- and random-effects models. To express the treatment effect in clinical terms, we calculated the number needed to treat (NNT) to prevent one adenoma recurrence. We also assessed the quality of evidence using ***: Four randomized, placebo-controlled trials met the eligibility criteria and were included. Daily doses of elemental calcium ranged from 1200 to 2000 mg, while the duration of treatment and follow-up of participants ranged from 36 to 60 mo. Synthesis of intention-to-treat data, for participants who had undergone follow-up colonoscopies, indicated a modest protective effect of calcium in prevention of adenomas (fixed-effects, RR = 0.89, 95%CI: 0.82-0.96; random-effects, RR = 0.87, 95%CI: 0.77-0.98; high quality of evidence). The NNT was 20 (95%CI: 12-61) to prevent one colorectal adenoma recurrence within a period of 3 to 5 years. On the other hand, the association between calcium treatment and advanced adenomas did not reach statistical significance (fixed-effects, RR = 0.92, 95%CI: 0.75-1.13; random-effects, RR = 0.92, 95%CI: 0.71-1.18; moderate quality of evidence).CO

关键词： Calcium Colorectal adenoma Recurrence Cancer chemoprevention Colorectal cancer Systematic review Meta-analysis Polyp

Modeling and optimization of non-isothermal convective drying process of Lavandula×allardii

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Information Processing in Agriculture 2024年第1期11卷 1-13页

作者： Vasileios Chasiotis Konstantinos-stefanos Nikas Andronikos Filios Laboratory of Thermo Fluid Systems(LTFS) Department of Mechanical EngineeringUniversity of West AtticaAncient Olive Grove CampusThivon Str.250GR12244 EgaleoGreece

Non-isothermal convective drying schemes were examined for Lavandula×allardii leaves and *** process parameters were optimized using response surface methodology(RSM)to ensure the peak operational *** effects of temperature increase rate(2–4°C/h)and the airflow velocity(1–3 m/s)on the essential oil yield,drying duration and consumption,were investigated.A face-centered central composite design was deployed and the experimental data was adapted to the most suitable polynomial models,as determined by the regression *** of variance was applied to assess the effects of the process variables,their interactions and the statistical significance of the examined *** factors of temperature increase rate and airflow velocity had a significant impact on the drying *** velocity had a greater effect on leaves’essential oil yield and inflorescences’process energy consumption,whereas the rates of temperature increase had a greater influence on the inflorescences’essential oil yield and leaves’energy *** minimum drying duration and energy consumption were obtained for the maximum temperature increasing rate at 3 and 1 m/s airflow velocities respectively;and the highest essential oil yield was obtained for the least rate of temperature increase and airflow velocity for both leaves and *** optimization was performed for minimizing drying duration and energy consumption by maximizing the essential oil *** rate of temperature increases of 4°C/h and the airflow velocity of 1 m/s,were proposed as the optimum non-isothermal drying conditions for both leaves and inflorescences of Lavandula×*** values of essential oil content have been 1.387/3.05 mL/g,4.21/4.18 h drying time and 0.809/0.732 kWh energy consumption at the optimum operation point for leaves and inflorescences,*** resulted optimized non-stationary temperature scheme considerably improved the drying

关键词： Convective drying Non-isothermal drying Lavender Essential oil Process optimization

Nanoindentation responses of NiCoFe medium-entropy alloys from cryogenic to elevated temperatures

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Journal of Iron and Steel Research International 2024年第8期31卷 2068-2077页

作者： Qin-qin Xu Kamran Karimi Amirhossein H.Naghdi Wen-yi Huo Chong Wei stefanos Papanikolaou NOMATEN Centre of Excellence National Centre for Nuclear ResearchOtwock 05-400MazowszePoland College of Mechanical and Electrical Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Science and Technology on Thermo Structural Composite Materials Laboratory Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

NiCoFe alloy,a medium-entropy alloy,shows potential for applications in extreme ***,there is a theoretical barrier concerning the unclear understanding of its high-temperature dislocation motion *** load response exhibits distinct signatures relevant to thermal activation,most notably a decrease in critical force(i.e,softening)from cryogenic to elevated temperatures,e.g.,from 200 to 1000 *** onset of plasticity is characterized by the nucleation of stacking faults and prismatic loops at low temperatures,whereas the surface nucleation of Shockley partial dislocations dominates plasticity at elevated *** show that thermal effects lead to non-uniform atom pile-ups and control the rate of phase transformation with increasing indentation *** findings in this work extend the understanding of the mechanical response of NiCoFe alloys under indentation at different temperatures,shedding light on the underlying dislocation motion mechanisms and surface deformation *** observed transformation-induced plasticity mechanism has implications for the properties of medium-entropy alloys and their potential applications in extreme environments.

关键词： Orientation Dislocations Mechanical behaviors Phase transition

Transcranial direct current stimulation efficacy in trigeminal neuralgia

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World Journal of Clinical Cases 2024年第5期12卷 1036-1038页

作者： Theodoros Fasilis Stylianos Gatzonis Panayiotis Patrikelis stefanos Korfias Athanasia Alexoudi 1^(st) Department of Neurosurgery National and Kapodistrian University of AthensAthens 10676Greece Department of Neurology Neurological Institute of AthensAthens 10676Greece

Trigeminal neuralgia is a severe,disabling pain and its deafferentation remains a challenge for health *** direct current stimulation is a non-invasive stimulation technique which finds new utility in managing ***-fore,the introduction of alternative,non-invasive,safe,and effective methods should be considered in treating patients with trigeminal neuralgia unresponsive to conventional treatment.

关键词： Trigeminal neuralgia Patient-controlled intravenous analgesia Neuromodulation Transcranial direct current stimulation

Reliability of the K-Force Muscle Controller Dynamometer on Eccentric and Isometric Hip Adduction Strength

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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 224-235页

作者： Christos Pippas Antonis Emmanouilidis stefanos Karanasios George Koumantakis George Gioftsos Department of Physiotherapy University of West Attica Athens Greece

Hip adduction strength tests are commonly used in clinical practice to provide an accurate diagnosis of groin injuries. Athletes with reduced adductor muscle strength are at risk of developing groin injuries. Our study aimed to evaluate the relative and absolute test-retest reliability of the side-lying eccentric hip adduction strength test and the long-lever adduction squeeze test using the K-Force hand-held dynamometer. Twenty physically active male individuals with a mean age (±SD) of 30.7 (±7.3) years were included. Both tests presented excellent test-retest reliability (Intraclass Correlation Coefficient: 0.77 - 0.95). The best and mean scores of the eccentric and isometric tests presented the smallest test-retest variation (MDC%: 12.8 - 14.9 and MDC%: 14.6 - 18.7, respectively). Our study showed that the K-Force dynamometer has excellent reliability for assessing hip adduction strength in two different testing positions. We suggest the best and mean of three repetitions for clinical practice as they present the lowest variability. Further research evaluating its clinimetric properties in different populations and gender is recommended.

关键词： Adductor Groin Strength Testing Dynamometer Reliability

Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1017-1029页

作者： Savvas Symeonidis Ioannis Mantzoros Elissavet Anestiadou Orestis Ioannidis Panagiotis Christidis stefanos Bitsianis Vasiliki Bisbinas Konstantinos Zapsalis Trigona Karastergiou Dimitra Athanasiou Stylianos Apostolidis Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece ENT Department Royal Cornwall Hospitals NHS TrustCornwall TR13LJUnited Kingdom 1^(st)Propedeutic Surgical Department University Hospital of ThessalonikiAristotle University of ThessalonikiThessaloniki 54636Greece

Laparoscopic cholecystectomy(LC)remains one of the most commonly performed procedures in adult and paediatric *** the advances made in intraoperative biliary anatomy recognition,iatrogenic bile duct injuries during LC represent a fatal complication and consist an economic burden for healthcare systems.A series of methods have been proposed to prevent bile duct injury,among them the use of indocyanine green(ICG)*** most commonly reported method of ICG injection is the intravenous administration,while literature is lacking studies investigating the direct intragallbladder ICG *** narrative mini-review aims to assess the potential applications,usefulness,and limitations of intragallbladder ICG fluorescence in *** screened the available international literature to identify the reports of intragallbladder ICG fluorescence imaging in minimally invasive cholecystectomy,as well as special issues regarding its *** search retrieved four prospective cohort studies,three case-control studies,and one case *** the three case-control studies selected,intragallbladder near-infrared cholangiography(NIRC)was compared with standard LC under white light,with intravenous administration of ICG for NIRC and with standard intraoperative cholangiography(IOC).In total,133 patients reported in the literature have been administered intragallbladder ICG administration for biliary mapping during *** includes several reports of intragallbladder ICG administration,but a standardized technique has not been established *** data suggest that NIRC with intragallbladder ICG injection is a promising method to achieve biliary mapping,overwhelming limitations of IOC including intervention and radiation exposure,as well as the high hepatic parenchyma signal and time interval needed in intravenous ICG ***-based guidelines on the role of intragallbladder ICG fluorescence in LC require the assessment of furth

关键词： Minimally invasive cholecystectomy Laparoscopic cholecystectomy Biliary tract mapping Indocyanine green Near-infrared fluorescent cholangiography Intracystic indocyanine green Intragallbladder indocyanine green Bile duct injury

Translation and cross-cultural adaptation of the Kidney Transplant Questionnaire 25 to Greek

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World Journal of Transplantation 2024年第2期14卷 148-154页

作者： Vasileios Koutlas Eirini Tzalavra Vasileios Tatsis Charalampos Pappas Stavroula Vovlianou stefanos Bellos Anila Duni Eleni Stamellou Konstantinos I Tsamis Michail Mitsis Evangelia Dounousi Department of Surgery and Kidney Transplant Unit University Hospital of IoanninaIoannina 45500EpirusGreece Department of Surgery Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology University Hospital of IoanninaIoannina 45500EpirusGreece Department of Nephrology General Hospital of KavalaKavala 65500Greece Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece

BACKGROUND Kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients(KTRs)and has been established as the treatment of choice for patients with end-stage kidney ***-related quality of life(HRQoL)has become an important outcome *** is highly important to develop reliable methods to evaluate HRQoL with disease-specific *** To translate the disease-specific instrument Kidney Transplant Questionnaire 25(KTQ-25)to the Greek language and perform a cross-cultural *** The translation and adaptation of the original English version of the KTQ-25 to the Greek language were performed based on the International Quality of Life RESULTS Eighty-four KTRs(59 males;mean age 53.5±10.7 years;mean estimated glomerular filtration rate 47.7±15.1 mL/min/1.73 m2;mean transplant vintage 100.5±83.2 months)completed the Greek version of the KTQ-25 and the 36-item Short-Form Health Survey,and the results were used to evaluate the reliability of the Greek *** Cronbach alpha coefficients for all the KTQ-25 dimensions were satisfactory(physical symptoms=0.639,fatigue=0.856,uncertainty/fear=0.661,appearance=0.593,emotions=0.718,total score=0.708).The statistically significant correlation coefficients among the KTQ-25 dimensions ranged from 0.226 to *** correlation coeffi-cients of the KTQ-25 dimensions with the SF-36 physical component summary(PCS)ranged from 0.196 to 0.550;the correlation coefficients of the KTQ-25 with the SF-36 mental component summary(MCS)ranged from 0.260 to 0.655;and the correlation coefficients of the KTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613,*** According to the findings,the Greek version of the KTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.

关键词： Kidney Transplant Questionnaire 25 Kidney transplantation Kidney transplant recipients Health-related quality of life Quality of life

Experimental models of high-risk bowel anastomosis in rats:A systematic review

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World Journal of Experimental Medicine 2024年第2期14卷 114-131页

作者： Georgios Ntampakis Manousos-Georgios Pramateftakis Elissavet Anestiadou stefanos Bitsianis Orestis Ioannidis Chryssa Bekiari George Koliakos Maria Karakota Anastasia Tsakona Angeliki Cheva Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Laboratory of Anatomy and Histology School of Veterinary MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece Experimental and Research Center Papageorgiou General Hospital of ThessalonikiThessaloniki 56403Greece Laboratory of Biochemistry Faculty of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Department of Pathology Faculty of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of *** studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further *** drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk *** the advances in experimental protocols and techniques,designing a high-quality study is still challenging for the investigators as there is a plethora of different models *** To review current state of the art for experimental protocols in high-risk anastomosis in *** This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** identify eligible studies,a comprehensive literature search was performed in the electronic databases PubMed(MEDLINE)and Scopus,covering the period from conception until 18 October *** From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk *** of assessing anastomotic healing were extracted and were individually *** Anastomotic healing studies have evolved over the last decades,but the findings are yet to be translated into human *** is a need for high-quality,well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.

关键词： High-risk anastomosis Rats Experimental models Bowel Colon Anastomotic leak Colon resection Inflammatory bowel disease Intra-abdominal sepsis Bursting pressure

Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2679-2688页

作者： Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis Dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-Georgios Pramateftakis Efstathios Kotidis Barbara Driagka Ourania Kerasidou Savvas Symeonidis stefanos Bitsianis Freideriki Sifaki Konstantinos Angelopoulos Haralabos Demetriades Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Department of ENT Royal Cornwall Hospitals NHS TrustCornwall TR13LJUnited Kingdom

BACKGROUND Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative *** particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherapy *** To investigate whether GH can improve the healing of a colonic anastomosis following the adverse effects of intraperitoneal administration of 5-fluorouracil(5-FU),bleomycin and *** Eighty Wistar rats underwent laparotomy and a 1 cm-resection of the transverse colon,followed by an end-to-end anastomosis under general *** rats were blindly allocated into four equal groups and administered a different daily intraperitoneal therapeutic regimen for 6 *** control group(A)received normal *** B received chemotherapy with 5-FU(20 mg/kg),bleomycin(4 mg/kg)and cisplatin(0.7 mg/kg).Group C received GH(2 mg/kg),and group D received the aforementioned combination chemotherapy and GH,as *** rats were sacrificed on the 7th postoperative day and the anastomoses were macroscopically and microscop-ically *** weight,bursting pressure,hydroxyproline levels and inflammation markers were *** All rats survived until the day of sacrifice,with no infections or other complications.A decrease in the body weight of group D rats was observed,not statistically significant compared to group A(P=1),but significantly different to groups C(P=0.001)and B(P<0.01).Anastomotic dehiscence rate was not statistically different between the *** pressure was not significantly different between groups A and D(P=1.0),whereas group B had a significantly lower bursting pressure compared to group D(P<0.001).All groups had significantly more adhesions than group ***,as a measurement of collagen deposition,was significantly higher in group D compared to group B(P<0.05),and higher,but not statistically significant,compared to group *** changes in group D were recorded,compared to group A

关键词： Growth hormone Colonic anastomosis Adhesion Bursting pressure Collagen Hydroxyproline Inflammation Neoangiogenesis Chemotherapy