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Histopathology and immunophenotyping of late onset cutaneous manifestations of COVID-19 in elderly patients: Three case reports

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World Journal of Clinical Cases 2021年第20期9卷 5744-5751页

作者： Maria Mazzitelli stefano dastoli Chiara Mignogna Luigi Bennardo Elena Lio Maria Chiara Pelle Enrico Maria Trecarichi Branca Isabel Pereira Steven Paul Nisticò Carlo Torti Department of Medical and Surgical Sciences Infectious and Tropical Disease UnitMagna Graecia UniversityCatanzaro 88100Italy Department of Health Sciences Magna Graecia Universitàof CatanzaroCatanzaro 88100Italy Interdipartimental Service Center Pathology UnitPugliese Ciaccio HospitalCatanzaro 88100Italy Department of Health Sciences Magna Graecia UniversityCatanzaro 88100Italy Department of Medical and Surgical Sciences Magna Graecia Universitàof CatanzaroCatanzaro 88100Italy HIV/GUM Directorate Chelsea and Westminster Hospital Foundation TrustLondon SW109NHUnited Kingdom

BACKGROUND Several cutaneous manifestations such as urticarial rash,erythematous patches and chilblain-like lesions have been described in young adults with coronavirus disease 2019(COVID-19)and are present in up to 20%patients,but few reports exist describing histopathological and immunophenotypic characteristics of dermatological lesions in older *** aim was to characterize skin lesions in elderly patients during late stages of COVID-19 from clinical,histological and immunophenotypic *** SUMMARY Three patients,admitted for COVID-19,and who developed cutaneous manifestations underwent skin *** analysis for CD20,CD3,CD4 and CD8 was performed on skin biopsies to assess immune cell ***1a was used as a marker of Langerhans cells,and CD31 as a marker of endothelial *** the three study patients,cutaneous manifestations were evident in the late-stage of COVID-19(mean time from the first positive severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)swab to rash onset was 35 d).Skin biopsies showed a similar pattern of T lymphocyte infiltration in all ***,a chronic dermatitis with perivascular lymphocytic infiltrate was observed with predominance of CD3+T-cell(CD3+).CONCLUSION Our study confirms previous *** and immunophenotypic patterns in our patients confirm results described in the two previous reported *** pattern is similar to what is found in some lympho-proliferative ***,since these findings are non-specific,SARS-CoV-2 infection should be suspected.

关键词： COVID-19 SARS-CoV-2 Rash T-helper infiltrates Cutaneous manifestation Case report

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