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Autoimmune liver diseases and SARS-CoV-2

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World Journal of Gastroenterology 2023年第12期29卷 1838-1851页

作者： Costantino Sgamato Alba Rocco Debora Compare stefano Minieri stefano Andrea Marchitto Simone Maurea Gerardo Nardone Department of Clinical Medicine and Surgery University of Naples Federico ⅡNaples 80131Italy Department of Advanced Biomedical Sciences University of Naples Federico ⅡNaples 80131Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing coronavirus disease 2019(COVID-19),can trigger autoimmunity in genetically predisposed individuals through hyperstimulation of immune response and molecular *** we summarise the current knowledge about autoimmune liver diseases(AILDs)and SARS-CoV-2,focusing on:(1)The risk of SARS-CoV-2 infection and the course of COVID-19 in patients affected by AILDs;(2)the role of SARS-CoV-2 in inducing liver damage and triggering AILDs;and(3)the ability of vaccines against SARS-CoV-2 to induce autoimmune responses in the *** derived from the literature suggest that patients with AILDs do not carry an increased risk of SARS-Cov-2 infection but may develop a more severe course of COVID-19 if on treatment with steroids or *** SARSCoV-2 infection can lead to the development of several autoimmune diseases,few reports correlate it to the appearance of de novo manifestation of immunemediated liver diseases such as autoimmune hepatitis(AIH),primary biliary cholangitis(PBC)or AIH/PBC overlap *** case series of an AIHlike syndrome with a good prognosis after SARS-CoV-2 vaccination have been *** the causal link between SARS-CoV-2 vaccines and AIH cannot be definitively established,these reports suggest that this association could be more than coincidental.

关键词： Autoimmune liver disease SARS-CoV-2 COVID-19 COVID-19 vaccine Autoimmune hepatitis

A Software-in-the-Loop Implementation of Adaptive Formation Control for Fixed-Wing UAVs

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IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1230-1239页

作者： Jun Yang Ximan Wang Simone Baldi Satish Singh stefano Fari Systems Engineering Research Institute China State Shipbuilding CorporationBeijing 100094China Delft Center for Systems and Control (DCSC) TU Delft2628CD DelftThe Netherlands School of Mathematics Southeast University211189 NanjingChinaand also with DCSCTU Delft2628CD DelftThe Netherlands German Aerospace Center (DLR) Institute of Space SystemsD-28359 BremenGermanyand was with Politecnico di MilanoItaly and also with DCSCTU DelftThe Netherlands

This paper discusses the design and software-in-theloop implementation of adaptive formation controllers for fixedwing unmanned aerial vehicles(UAVs) with parametric uncertainty in their structure, namely uncertain mass and inertia. In fact, when aiming at autonomous flight, such parameters cannot assumed to be known as they might vary during the mission(*** on the payload). Modeling and autopilot design for such autonomous fixed-wing UAVs are presented. The modeling is implemented in Matlab, while the autopilot is based on ArduPilot, a popular open-source autopilot suite. Specifically, the ArduP ilot functionalities are emulated in Matlab according to the Ardupilot documentation and code, which allows us to perform software-in-the-loop simulations of teams of UAVs embedded with actual autopilot protocols. An overview of realtime path planning, trajectory tracking and formation control resulting from the proposed platform is given. The software-inthe-loop simulations show the capability of achieving different UAV formations while handling uncertain mass and inertia.

关键词： ArduPilot adaptive formation control Fixed-wing UAVs software-in-the-loop simulations

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Simultaneous removal of critical rare earth elements and chalcogen oxyanions by anaerobic granular sludge

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Rare Metals 2024年第9期43卷 4595-4611页

作者： Chiara Belloni Mohanakrishnan Logan stefano Papirio Piet N.L.Lens University of Galway Galway H91 TK33Ireland Department of Civil Architectural and Environmental EngineeringUniversity of Naples Federico II80125 NaplesItaly

Conventional mining of economically and strategically important critical rare earth elements(REEs)(such as neodymium,lanthanum and dysprosium),and chalcogens(such as selenium and tellurium)are associated with a huge economic and environmental ***,the need to recover REEs as well as chalcogens from different waste streams including wastewaters is becoming *** assays on synthetic chalcogen/REE-laden wastewater showed that the presence of REEs significantly improved the tellurite removal rate(>80%)and enhanced selenate removal by 66%±10%.Three 3.9 L continuous upflow anaerobic granular sludge bed(UASB)reactors were operated at a hydraulic retention time of 24 h and 30℃.Selenate reduction was achieved with a removal efficiency of~98% with an influent p H of 4.0 for more than 28 *** effect of REEs on tellurite removal in the UASB bioreactor could not be clearly established since a soluble tellurium removal efficiency of more than 98%was observed already before the addition of REEs at elevated tellurite *** complete REE removal in both batch assays and UASB reactors at higher pH(7.0±0.5)was attributed to precipitation,whereas chalcogen oxyanions removal was due to microbial ***,at acidic p H,biosorption was responsible for REE's removal,and the Se-enriched sludge exhibited a superior REE's removal efficiency than the non-enriched and Te-enriched sludge.

关键词： Rare earth elements Selenium Tellurium Bioreduction Adsorption

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A SCHEME FOR EVALUATING THE MEAN MERIDIONAL CIRCULATION OF THE ATMOSPHERE

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Science China Chemistry 1988年第10期31卷 1235-1244页

作者：吴国雄,stefano TIBALDI Institute of Atmospheric Physics Academia Sinica Beijing European Centre for Medium-Range Weather Forecasts Reading U. K.

Based on the continuity of the atmosphere, a new scheme is developed to diagnose the atmospheric mean meridional circulations. ECMWF analyses four times per day of January 1982 were retrieved to evaluate the global mean meridional circulation. Investigations and calculations show that this new scheme produced more reasonable results in comparison with the traditional scheme. The existence of the double Hadley cell in the winter hemisphere is confirmed as well.

关键词： mean meridional circulation double Hadley cell

Direct-acting antivirals and risk of hepatocellular carcinoma: from genetic signature to metabolic risk factors

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Hepatoma Research 2020年第5期6卷 27-35页

作者： stefano Gitto Erica Villa Department of Experimental and Clinical Medicine University of FlorenceFlorence 50121Italy Department of Medical Specialties Gastroenterology UnitUniversity of Modena&Reggio EmiliaModena 41124Italy

Hepatocellular carcinoma(HCC)is the fifth most common malignancy and the second leading cause of cancerrelated *** C virus and mainly hepatitis C virus-related cirrhosis is the chief risk factor for *** direct-acting antivirals are available for the eradication of hepatitis C virus with remarkable results in terms of virological response and with optimal safety ***,some authors have suggested that viral eradication due to these new drugs might favor both occurrence and recurrence of *** exact biological mechanisms of carcinogenesis in this specific setting have not been well identified,but it has been suggested that adjustments in immune surveillance and increase in vascular endothelial growth factor expression could have a chief ***,after publication of many large studies and meta-analyses,we can affirm that there is no increased risk on a population ***,on an individual basis,sustained virological response due to direct-acting antivirals may facilitate HCC onset in some specific subgroups of *** them,we could point out patients with activated neoangiogenesis but also subjects with particularly severe metabolic imbalance.

关键词： Direct-acting antivirals hepatocellular carcinoma carcinogenesis

Characterization of ultrafine particles from hardfacing coated brake rotors

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Friction 2023年第1期11卷 125-140页

作者： Yezhe LYU Ankur SINHA Ulf OLOFSSON stefano GIALANELLA Jens WAHLSTRÖM Department of Mechanical Engineering Sciences Lund UniversityLund SE-22100Sweden Department of Machine Design KTH Royal Institute of TechnologyStockholm SE-10044Sweden Department of Industrial Engineering University of TrentoTrento 38123Italy

Automotive brake rotors are commonly made from gray cast iron(GCI).During usage,brake rotors are gradually worn off and periodically ***,replaced brake rotors are mostly remelted to produce brand-new cast iron products,resulting in a relatively high energy consumption and carbon footprint into the *** addition,automotive brakes emit airborne *** of the emitted particles are categorized as ultrafine,which are sized below 100 nm,leading to a series of health and environmental *** this study,two surface treatment techniques are applied,ie.,high-velocity oxygen fuel(HVOF)and laser cladding(LC),to overlay wear-resistant coatings on conventional GCI brake rotors in order to refurbish the replaced GCI brake rotor and to avoid the remelting *** two coating materials are evaluated in terms of their coefficient of friction(CoF),wear,and ultrafine particle emissions,by comparing them with a typical GCI brake *** results show that the CoF of the HVOF disc is higher than those of the GCI and LC ***,HVOF disc has the lowest wear rate but results in the highest wear rate on the mating brake pad *** LC disc yields a similar wear rate as the GCI *** ultrafine particles from the GCI and LC discs appeared primarily in round,chunky,and flake *** HVOF disc emits unique needle-shaped *** the ultrafine particle range,the GCI and HVOF discs generate particles that are primarily below 100 nm in the running-in period and 200 nm in the steady ***,the LC disc emitted particles that are primarily~200 nm in the entire test run.

关键词： ultrafine particle high-velocity oxygen fuel laser cladding brake particle size distribution particle morphology

Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa Moni Daniele Di stefano Silvia Giordani Renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

Enhanced recovery pathways in pancreatic surgery: State of the art

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World Journal of Gastroenterology 2016年第28期22卷 6456-6468页

作者： Nicolò Pecorelli Sara Nobile stefano Partelli Luca Cardinali stefano Crippa Gianpaolo Balzano Luigi Beretta Massimo Falconi Division of Pancreatic Surgery Pancreas Translational and Clinical Research Center San Raffaele Scientific Institute "Vita-Salute" University Department of Surgery Università Politecnica delle Marche Department of Anesthesiology San Raffaele Scientific Institute "Vita-Salute" University

Pancreatic surgery is being offered to an increasing number of patients every year. Although postoperative outcomes have significantly improved in the last decades, even in high-volume centers patients still experience significant postoperative morbidity and full recovery after surgery takes longer than we think. In recent years, enhanced recovery pathways incorporating a large number of evidence-based perioperative interventions have proved to be beneficial i n t e r m s o f i m p rove d p o s t o p e ra t i ve o u t c o m e s, and accelerated patient recovery in the context of gastrointestinal, genitourinary and orthopedic surgery. The role of these pathways for pancreatic surgery is still unclear as high-quality randomized controlled trials are lacking. To date, non-randomized studies have shown that care pathways for pancreaticoduodenectomy and distal pancreatectomy are safe with no difference in postoperative morbidity, leading to early discharge and no increase in hospital readmissions. Hospital costs are reduced due to better organization of care and resource utilization. However, further research is needed to clarify the effect of enhanced recovery pathways on patient recovery and post-discharge outcomes following pancreatic resection. Future studies should be prospective and follow recent recommendations for the design and reporting of enhanced recovery pathways.

关键词： Pancreas surgery Perioperative care Length of stay Postoperative complications Pancreatic neoplasms Evidence-based medicine

Guided resonance in negative index photonic crystals: a new approach

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Light(Science & Applications) 2014年第1期3卷 365-369页

作者： Silvia Romano stefano Cabrini Ivo Rendina Vito Mocella CNR-IMM-Unita di Napoli 80131 NapoliItaly Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCAUSA

The behavior of a negative refraction photonic crystal slab irradiated with out-of-plane incident beam is an unexplored *** such an experimental configuration,guided mode resonance appears in the reflection *** show that,in this case,the light coupled inside the photonic crystal is backpropagating.A relationship with the negative index properties is established using a new approach in which the guided resonance is recovered by modeling the photonic crystal layer with a simple Lorentz resonator using the Fresnel reflection formula.

关键词： diffraction gratings guided mode resonance negative index photonic crystals