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What is a reliable CT scan for diagnosing splenosis under emergency conditions?

World Journal of Gastroenterology 2009年第29期15卷 3684-3686页

作者： Francesco Giuseppe Garaci Michele Grande Massimo Villa stefano mancino Daniel Konda Giovanni Simonetti Grazia Maria Attinà Gabriele Galatà Department of Diagnostic Imaging and Interventional Radiology University Hospital of Tor Vergata viale Oxford 81 00133 Rome Italy Department of Surgery University Hospital of Tor Vergata viale Oxford 81 00133 Rome Italy

Splenosis is a condition in which splenic tissue is present in a non-anatomical position. Implants of splenic tissue can mimic neoplasms and only specific examinations can confirm the correct diagnosis. Here we report a case of a 23-year-old male patient with a history of surgical splenectomy during childhood after trauma. He was admitted to the emergency department with acute bowel obstruction. An abdominalpelvic computed tomography (CT) scan revealed small bowel obstruction and the presence of two rounded, solid masses located in the rectal-vescical pouch. Quantitative analyses of the different density values in the arterial phase and early portal venous phase demonstrated that these lesions were highly vascularised (92 and 97 Hounsfield Units, respectively). The hypothesis of an ectopic splenic mass was made after evaluation of the CT images and clinical history. The acute bowel obstruction caused by adhesive intestinal syndrome was resolved by surgical adhesiolysis. The smallest mass adherent to the rectum was removed. Histopathologic examination confirmed the benign nature of the lesion, which consisted of splenic tissue.

关键词： CT扫描脾脏紧急情况诊断计算机断层扫描肠梗阻扫描显示 CT图像

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Role of microRNAs in translation regulation and cancer

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World Journal of Biological Chemistry 2017年第1期8卷 45-56页

作者： Stefania Oliveto Marilena mancino Nicola Manfrini stefano Biffo INGM National Institute of Molecular Genetics“Romeo ed Enrica Invernizzi” Department of Biosciences University of Milan

MicroRNAs(miRNAs) are pervasively expressed and regulate most biological functions. They function by modulating transcriptional and translational programs and therefore they orchestrate both physiological and pathological processes, such as development, cell differentiation, proliferation, apoptosis and tumor growth. miRNAs work as small guide molecules in RNA silencing, by negatively regulating the expression of several genes both at mRNA and protein level, by degrading their mRNA target and/or by silencing translation. One of the most recent advances in the field is the comprehension of their role in oncogenesis. The number of miRNA genes is increasing and an alteration in the level of miRNAs is involved in the initiation, progression and metastases formation of several tumors. Some tumor types show a distinct miRNA signature that distinguishes them from normal tissues and from other cancer types. Genetic and biochemical evidence supports the essential role of miRNAs in tumor development. Although the abnormal expression of miRNAs in cancer cells is a widely accepted phenomenon, the cause of this dysregulation is still unknown. Here, we discuss the biogenesis of miRNAs, focusing on the mechanisms by which they regulate protein synthesis. In addition we debate on their role in cancer, highlighting their potential to become therapeutic targets.

关键词： MicroRNA 翻译癌症 OncomiR 肿瘤 suppressor

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