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Population Structure and Sexual Maturity of the Pufferfish Lagocephalus sceleratus （Osteichthyes, Tetraodontidae） in the Lebanese and Syrian Marine Waters （Eastern Mediterranean）

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Journal of Earth Science and Engineering 2014年第4期4卷 236-244页

作者： Gaby Khalaf Adib Saad Sherif Jemaa Waad Sabour Myriam Lteif stefano lelli National Centre for Marine Sciences CNRS (National Council for Scientific Research) Batroun 534 Lebanon Faculty of Agricultural Engineering Tishreen University Lattakieh 1408 Syria

The pufferfish Lagocephalus sceleratus is an invasive Lessepsian species of Indo-Pacific origin that has established an increasing population over the past decade in the Levantine basin of the Mediterranean. Besides its toxicity due to the accumulation of tetrodotoxin in its body, it is causing damage to fishing gears and fishermen＇s catches. This study aims to provide data on the population structure and sexual maturity of this species in the eastern basin of the Mediterranean. A total of 214 individuals were collected in the coastal marine waters of Lebanon and Syria, between January 2012 and June 2013 by means of different types of nets and lines, on soft bottoms, at depths ranging from 10 m to 170 m. The TL （total length） of the samples varies between 10.8 cm and 71 cm. The most common size classes, represented by 125 individuals, are the ones between 30 cm and 50 cm TL, with a bulge at 40 cm, represented by 44 individuals. The average TL is 43.99 cm （standard deviation： SD = 17.65） for both males and females. The TW （total weight） of the specimens ranges between 14 g and 4,603 g with an average value of 1,458.52 g （SD = 1,329.49）. The sex ratio （M/F） is 1：1.35 with a total number of 87 males, 118 females and nine unidentified individuals. The weight-length relationship （TW = aTLb） shows a negative allometric growth with b = 2.9481 and R2 = 0.9806. The condition factor （K） is close to one for all samples. The average value of the GSI （gonadosomatic index） shows a substantial increase from winter to spring. The spawning takes place between April and June.

关键词： Lagocephalus sceleratus Lessepsian species population structure eastern Mediterranean.

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Novel mutation in the ligand-binding domain of the androgen receptor gene （1790p） associated with complete androgen insensitivity syndrome

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Asian Journal of Andrology 2008年第4期10卷 687-691页

作者： Florina Raicu Rossella Giuliani Valentina Gatta Chiara Palka Paolo Guanciali Franchi Pierluigi lelli-Chiesa stefano Tumini Liborio Stuppia Department of Clinical Sciences and Imaging G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Department of Biomedical Sciences G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Aging Research Center G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Division of Pediatric Surgery G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Department of Pediatrics and Gynecology G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Institute of Molecular Genetics National Research Council IGM-CNR Bologna 40100 Italy Carol Davila University of Medicine and Pharmacy Bucharest 020027 Romania

Mutations in the X-linked androgen receptor （AR） gene cause androgen insensitivity syndrome （AIS）, resulting in an impaired embryonic sex differentiation in 46,XY genetic men. Complete androgen insensitivity （CAIS） produces a female external phenotype, whereas cases with partial androgen insensitivity （PALS） have various ambiguities of the genitalia. Mild androgen insensitivity （MAIS） is characterized by undermasculinization and gynecomastia. Here we describe a 2-month-old 46,XY female patient, with all of the characteristics of CAIS. Defects in testosterone （T） and dihydrotestosterone （DHT） synthesis were excluded. Sequencing of the AR gene showed the presence in exon 6 of a T to C transition in the second base of codon 790, nucleotide position 2369, causing a novel missense Leu790Pro mutation in the ligand-binding domain of the AR protein. The identification of a novel AR mutation in a girl with CAIS provides significant information due to the importance of missense mutations in the ligand-binding domain of the AR, which are able to induce functional abnormalities in the androgen binding capability, stabilization of active conformation, or interaction with coactivators.

关键词： androgen receptor novel androgen receptor gene mutation complete androgen insensitivity syndrome

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