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Emerging issues in peripheral nerve repair

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Neural Regeneration Research 2012年第29期7卷 2267-2272页

作者： stefano Geuna Pierluigi Tos Bruno Battiston Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) & Department of Clinical and Biological Sciences University of TurinTorino 10043 Italy Department of Traumatology Microsurgery UnitC.T.O. HospitalTorino 10126Italy

It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.

关键词： nerve reconstruction tissue engineering cell and tissue transplantation gene therapy biomaterials peripheral nervous system microsurgery artificial hollow tubes muscle-vein-combined tubes non-nervous guides neural regeneration

Not only myelination: the immune-inflammatory functions of oligodendrocytes

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Neural Regeneration Research 2022年第12期17卷 2661-2663页

作者： Marta Boccazzi stefano Raffaele Marta Fumagalli Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanItaly

Oligodendrocytes(OLs)are highly specialized cells of the central nervous system(CNS).Their primary and most investigated role is to form myelin,a multilamellar fatty membrane that enwraps axons ensuring their insulation and the saltatory conduction of nerve *** formation of myelin is a complex process during which the OL precursor cells(OPCs,also known as NG2-glia)become mature OLs through a highly regulated program of *** addition,OPCs persist in the adult grey and white matter parenchyma,representing approximately 6%of the total number of CNS *** their role in myelin generation and turn-over,it is now clear that OPCs have the capability to control tissue homeostasis and to sense and react to inflammation which characterizes many neurological diseases.

关键词： myelin cytes homeostasis

Virtual earth cloud: a multi-cloud framework for enabling geosciences digital ecosystems

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International Journal of Digital Earth 2023年第1期16卷 43-65页

作者： Mattia Santoro Paolo Mazzetti stefano Nativi National Research Council of Italy Institute of Atmospheric Pollution Research-Unit of FlorenceRomaItaly Joint Research Centre of the European Commission B6 UnitIspraltaly

Humankind is facing unprecedented global environmental and social challenges in terms of food,water and energy security,resilience to natural hazards,*** address these challenges,international organizations have defined a list of policy actions to be achieved in a relatively short and medium-term *** development and use of knowledge platforms is key in helping the decision-making process to take significant decisions(providing the best available knowledge)and avoid potentially negative impacts on society and the *** knowledge platforms must build on the recent and next coming digital technologies that have transformed society–including the science and engineering *** Earth Data(BED)science aims to provide the methodologies and instruments to generate knowledge from numerous,complex,and diverse data *** science requires the development of Geoscience Digital Ecosystems(GEDs),which bank on the combined use of fundamental technology units(*** data,learning-driven artificial intelligence,and network-based computing platform)to enable the development of more detailed knowledge to observe and test planet Earth as a *** manuscript contributes to the BED science research domain,by presenting the Virtual Earth Cloud:a multi-cloud framework to support GDE implementation and generate knowledge on environmental and social sustainability.

关键词： Earth observation geosciences digital ecosystem virtual cloud big earth data multi-cloud interoperability science

Mapping of Tonoplast Intrinsic Proteins in Maturing and Germinating Arabidopsis Seeds Reveals Dual Localization of Embryonic TIPS to the Tonoplast and Plasma Membrane

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Molecular Plant 2011年第1期4卷 180-189页

作者： stefano Gattolin Mathias Sorieul Lorenzo Frigerio Department of Biological Sciences University of Warwick Coventry CV4 7AL UK

We have mapped the expression of the tonoplast intrinsic protein （TIP） gene family members in Arabidopsis seeds by fluorescent protein tagging of their genomic sequences and confocal microscopy. Three isoforms （TIP1;1, TIP2;1, and TIP2;2） have distinct patterns of expression in maternal tissues （outer integument and placento-chalazal region）. Two isoforms, TIP3;1 and the previously uncharacterized TIP3;2, are the only detectable TIPs in embryos during seed maturation and the early stages of seed germination. Throughout these developmental stages, both isoforms co-locate to the tono- plast of the protein storage vacuoles, but also appear to label the plasma membrane. Plasma membrane labeling is specific to TIP3;1 and TIP3;2, is independent of the position of the fluorescent protein tag, and appears to be specific to early seed maturation and early germination stages. We discuss these results in the context of the predicted distribution of aquaporins in Arabidopsis seeds.

关键词： Aquaporin vacuole tonoplast intrinsic protein Arabidopsis seed embryo protein storage endosperm endoplasmic reticulum fluorescent protein.

From Decision to Commitment： The Molecular Memory of Flowering

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Molecular Plant 2009年第4期2卷 628-642页

作者： Jessika Adrian stefano Torti Franziska Turck Max Planck Institute for Plant Breeding Research Carl von Linne Weg 10 50829 Koln Germany

During the floral transition the shoot apical meristem changes its identity from a vegetative to an inflorescence state. This change in identity can be promoted by external signals, such as inductive photoperiod conditions or vernalization, and is accompanied by changes in expression of key developmental genes. The change in meristem identity is usually not reversible, even if the inductive signal occurs only transiently. This implies that at least some of the key genes must possess an intrinsic memory of the newly acquired expression state that ensures irreversibility of the process. In this review, we discuss different molecular scenarios that may underlie a molecular memory of gene expression.

关键词： Memory floral commitment floral transition chromatin Polycomb group transcription regulatory network motif.

Design of deformable mirrors for high power lasers

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High Power Laser Science and Engineering 2016年第2期4卷 68-74页

作者： stefano Bonora Jan Pilar Antonio Lucianetti Tomas Mocek CNR-IFN HiLASE Centre Institute of Physics AS CR Department of Physical Electronics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in Prague

We present the workflow of the design, realization and testing of deformable mirrors suitable for high power diode pumped solid-state lasers. It starts with the study of the aberration to be corrected, and then it continues with the design of the actuators position and characteristic. In this paper, we present and compare three deformable mirrors realized for multi-J level laser facilities. We show that with the same design concept it is possible to realize deformable mirrors for other types of lasers. As an example, we report the realization of a deformable mirror for femtosecond lasers and for a CW CO_2 laser.

关键词： adaptive optics closed loop deformable mirror high power lasers

Assessing n-type organic materials for lithium batteries:A techno-economic review

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InfoMat 2023年第11期5卷 1-24页

作者： Alessandro Innocenti Henry Adenusi stefano Passerini Helmholtz Institute Ulm(HIU)Electrochemical Energy Storage UlmGermany Karlsruhe Institute of Technology(KIT) KarlsruheGermany Department of Chemistry The University of Hong KongHong Kongthe People's Republic of China Hong Kong Quantum AI Lab Hong Kongthe People's Republic of China Department of Chemistry Sapienza University of RomeRomeItaly

The high demand for critical minerals such as lithium,copper,nickel,and cobalt,required for lithium-ion batteries,has raised questions regarding the feasibility of maintaining a steady and affordable supply of raw materials for their *** the last years,researchers have shifted their attention toward organic materials,which are potentially more widely available,affordable,and sustainable due to the ubiquitous presence of the constituent organic *** n-type materials have a redox mechanism analogous to that of lithium-ion cathodes and anodes,hence they are suitable for a meaningful comparison with the state-of-the-art *** many reviews have evaluated the properties of organic materials at the material or electrode level,herein,the properties of n-type organic materials are assessed in a complex system,such as a full battery,to evaluate the feasibility and performance of these materials in commercial-scale battery *** most relevant cathode materials for organic batteries are reviewed,and a detailed cost and performance analysis of n-type material-based battery packs using the BatPaC 5.0 software is *** analysis considers the influence of electrode design choices,such as the conductive carbon content,active material mass loading,and electrode density,on energy density and *** potential of n-type organic materials as a low-cost and sustainable solution for energy storage applications is highlighted,while emphasizing the need for further advancements of organic materials for energy storage applications.

关键词： batteries cost-performance analysis lithium-ion organic review

Sharing the post-earthquake situation for emergency response management in transborder areas: The e-Atlas tool

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Journal of Safety Science and Resilience 2022年第1期3卷 72-86页

作者： stefano Grimaz Petra Malisan Andrea Pividori SPRINT-Lab Polytechnic Department of Engineering and ArchitectureUniversity of Udine33100UdineItaly

Usually,the response after a disastrous event requires decision-makers in emergency operative rooms to quickly outline and understand the current post-event situation,for planning and defining strategies for a contextualized ***,in many cases,disastrous events affect cross-border territories and/or involve multiple orga-nizations in responding to the demand generated by the *** cases require a harmonized and coordinated response by all the institutions/subjects involved in emergency *** address this challenge,this pa-per proposes the e-Atlas(emergency atlas)tool for showing and sharing information that embraces a response management perspective to explicitly support decision-makers in managing the criticalities of a post-earthquake *** e-Atlas has been designed and tested to:i)acquire sensible information for allowing decision-makers to understand in almost real-time the post-earthquake situational picture,and ii)share the representation of the situational picture among different users,allowing each of them to use it according to its specific *** of the tool are illustrated,to show how it is used in a transborder context in the North-East area of Italy.

关键词： Emergency response management GIS Seismic emergency Decision-making support e-Atlas

Unsupervised Electric Motor Fault Detection by Using Deep Autoencoders

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IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 441-451页

作者： Emanuele Principi Damiano Rossetti stefano Squartini Francesco Piazza the Department of Information Engineering Università Politecnica delle Marche Loccioni Group Angeli di Rosora IEEE

Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literature for detecting faults automatically. Deep neural networks have been successfully employed for this task, but, up to the authors' knowledge, they have never been used in an unsupervised scenario. This paper proposes an unsupervised method for diagnosing faults of electric motors by using a novelty detection approach based on deep autoencoders. In the proposed method, vibration signals are acquired by using accelerometers and processed to extract LogMel coefficients as features. Autoencoders are trained by using normal data only, i.e., data that do not contain faults. Three different autoencoders architectures have been evaluated: the multilayer perceptron(MLP) autoencoder, the convolutional neural network autoencoder, and the recurrent autoencoder composed of long short-term memory(LSTM) units. The experiments have been conducted by using a dataset created by the authors, and the proposed approaches have been compared to the one-class support vector machine(OC-SVM) algorithm. The performance has been evaluated in terms area under curve(AUC) of the receiver operating characteristic curve, and the results showed that all the autoencoder-based approaches outperform the OCSVM algorithm. Moreover, the MLP autoencoder is the most performing architecture, achieving an AUC equal to 99.11 %.

关键词： Autoencoder convolutional neural networks electric motor fault detection long short-term memory neural networks novelty detection