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德语人文研究 2004年第5期 43-48页

作者： stefanie Eschenlohr TestDaF Institut Representative in P.R. China Dr.

Diploid species phylogeny and evolutionary reticulation indicate early radiation of Ephedra in the Tethys coast

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Journal of Integrative Plant Biology 2023年第12期65卷 2619-2630页

作者： Qiong Yu Fu-Sheng Yang Ya-Xing Chen Hui Wu stefanie M.Ickert-Bond Xiao-Quan Wang State Key Laboratory of Plant Diversity and Specialty Crops Institute of Botanythe Chinese Academy of SciencesBeijing100093 China China National Botanical Garden Beijing100093 China College of Life Sciences University of Chinese Academy of SciencesBeijing100049 China Department of Biology and Wildlife&UA Museum of the North University of Alaska Fairbanks(UAF)FairbanksAK99775 USA

Reconstructing a robust species phylogeny and disentangling the evolutionary and biogeographic history of the gymnosperm genus Ephedra,which has a large genome and rich polyploids,remain a big *** we reconstructed a transcriptome-based phylogeny of 19 diploid Ephedra species,and explored evolutionary reticulations in this genus represented by 50 diploid and polyploid species,using four low-copy nuclear and nine plastid *** diploid species phylogeny indicates that the Mediterranean species diverged first,and the remaining species split into three clades,including the American species(Clade A),***,and all other Asian species(Clade B).The single-gene trees placed *** sister to Clade A,Clade B,or Clades A+B in similar proportions,suggesting that radiation and gene flow likely occurred in the early evolution of *** addition,reticulate evolution occurred not only among the deep nodes,but also in the recently evolved South American species,which further caused difficulty in phylogenetic ***,we found that allopolyploid speciation was pervasive in *** study also suggests that Ephedra very likely originated in the Tethys coast during the late Cretaceous,and the South American Ephedra species have a single origin by dispersal from Mexico or North America.

关键词： allopolyploidy biogeography Ephedra phylogenomics phylogeny reticulate evolution

Testing experimentally the effect of soil resource mobility on plant competition

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Journal of Plant Ecology 2014年第3期7卷 276-286页

作者： stefanie Wilberts Matthias Suter Nina Walser Peter J.Edwards Harry Olde Venterink Dieter Ramseier Department of Biology/Chemistry Division of EcologyUniversity of OsnabrückBarbarastrasse 13Osnabrück 49076Germany Forage Production and Grassland Agroscope Reckenholz-TänikonReckenholzstrasse 1918046 ZurichSwitzerland Institute of Integrative Biology ETH ZurichUniversitätstrasse 16Zürich 8092Switzerland Plant Biology and Nature Management Vrije Universiteit BrusselPleinlaan 21050 BrusselsBelgium

Aims The volume of soil beyond a plant’s roots from which that plant is able to acquire a particular nutrient depends upon the mobility of that nutrient in the *** this reason it has been hypothesized that the strength of competitive interactions between plants vary with soil nutrient *** aimed to provide an experimental test of this *** We devised two experimental systems to investigate specifically the effect of nutrient transport rates upon intraspecific *** the first,the exchange of rhizosphere water and dissolved nutrients between two connected pots,each containing one plant,was manipulated by alternately raising and lowering the *** the second experiment,the roots systems of two competing plants were separated by partitions of differing porosity,thereby varying the plants’access to water and nutrients in the other plant's *** this second experiment,we also applied varying amounts of nutrients to test whether higher nutrient input would reduce competition when competition for light is avoided,and applied different water levels to affect nutrient concentrations without changing nutrient *** findings In both experiments,lower mobility reduced competitive effects on plant biomass and on relative growth rate(RGR),as *** the second experiment,however,competition was more intense under high nutrient input,suggesting that low nutrient supply rates reduced the strength of the superior *** effects on RGR were only evident under the low water level,suggesting that under lower nutrient concentrations,competitive effects might be less *** together,our results provide the first direct experimental evidence that a reduction in nutrient mobility can reduce the intensity of competition between plants.

关键词： belowground competition nutrient transport soil water relative growth rate

A New Immunostimulatory Proteoglycan-GLIS from Ganoderma lucidum

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A New Immunostimulatory Proteoglycan-GLIS from Ganoderma luc...

Acupuncture treatment in gastrointestinal diseases: A systematic review

2002国际灵芝专题研讨会

作者： Martin Zimmerman-Kordmann Werner reutter Institut für Molekularbiologie und Biochemie Freie Universitt Berlin Amimallee 22 D-14195 Berlin-Dahlem Germany Institut für Molekularbiologie und Biochemie Freie Universitt Berlin Amimallee 22 D-14195 Berlin-Dahlem Germany

A bioactive fraction (GLIS) was isolated from the fruiting body of the fungus Ganoderma lucidiun using successive chromatographic steps. GLIS is a proteoglycan and has a carbohydrate : protein in a ratio of 11.5 :1. The carbohydrate portion is composed of seven different monosaccharides, predominantly D-galactose, D-glueose and D-mannose in the molar ratio of 1 : 3.8 : *** stimulated the proliferation of normal mouse and tumor bearing mouse spleen lymphocytes. The proliferation by the factor 4.0 in MSL and the factor 2.5 in MSB. By analysis of flow cytometry and im-munofluorescenee microscope, it was found that the B cells were enlarged and expressed CD71 and CD25 on the cell surface, this mean that GLIS activated mouse spleen lymphocytes. In addition most of the activated cells were found to be B cells by double staining with CD19/CD25 and CD19/CD71. Lymphocytes also showed a significantly increased production of IL-2, whereas the secretion of IL-4 was not influenced by GLIS. Furthermore, GLIS did not influence the intracellular Ca2+ concentration of lymphocytes, but it enhanced the expression of protein kinase C a and protein kinase C γin B cells. According to our results GLIS is a new B cell-stimulating factor.

关键词： Ganoderma lucidum (GL), imrnunoaetivation, B cells, pmteoglycan, anticancer

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World Journal of Gastroenterology 2007年第25期13卷 3417-3424页

作者： Antonius Schneider Konrad Streitberger stefanie Joos University Hospital Heidelberg Department of General Practice and Health Services Research Germany University Hospital Heidelberg Department of Anaesthesiology Germany

The purpose of this work was to assess the evidence for effectiveness of acupuncture （AC） treatment in gastrointestinal diseases. A systematic review of the Medline-cited literature for clinical trials was performed up to May 2006. Controlled trials assessing acupuncture point stimulation for patients with gastrointestinal diseases were considered for inclusion. The search identified 18 relevant trials meeting the inclusion criteria. Two irritable bowel syndrome （IBS） trials, 1 Crohn＇s disease and 1 colitis ulcerosa trial had a robust random controlled trial （RCT） design. In regard to other gastrointestinal disorders, study quality was poor. In all trials, quality of life （QoL） improved significantly independently from the kind of acupuncture, real or sham. Real AC was significantly superior to sham acupuncture with regard to disease activity scores in the Crohn and Colitis trials. Efficacy of acupuncture related to QoL in IBS may be explained by unspecific effects. This is the same for QoL in inflammatory bowel diseases （IBD）, whereas specific acupuncture effects may be found in clinical scores. Further trials for IBDs and in particular for all other gastrointestinal disorders would be necessary to evaluate the efficacy of acupuncture treatment. However, it must be discussed on what terms patients benefit when this harmless and obviously powerful therapy with regard to QoL is demystified by further placebo controlled trials.

关键词： Irritable bowel syndrome Inflammatorybowel disease Gastrointestinal disease Placebo Acupuncture

A comparison of perspectives on costs in emergency care among emergency department patients and residents

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World Journal of Emergency Medicine 2017年第1期8卷 39-42页

作者： stefanie K.Gilbert Leana S.Wen Jesse M.Pines Department of Emergency Medicine The George Washington UniversityWashingtonDC 20037USA

BACKGROUND: Costs of care are increasingly important in healthcare policy and, more recently, in clinical care in the emergency department(ED). We compare ED resident and patient perspectives surrounding costs in emergency ***: We conducted a mixed methods study using surveys and qualitative interviews at a single, academic ED in the United States. The two study populations were a convenience sample of adult ED patients(>17 years of age) and ED residents training at the same institution. Participants answered open- and closed-ended questions on costs, medical decision making, cost-related compliance, and communication about costs. Closed-ended data were tabulated and described using standard statistics while open-ended responses were analyzed using grounded ***: Thirty ED patients and 24 ED residents participated in the study. Both patients and residents generally did not have knowledge of medical costs. Patients were comfortable discussing costs while residents were less comfortable. Residents agreed that doctors should consider costs when making medical decisions whereas patients somewhat disagreed. Additionally, residents generally took costs into consideration during clinical decision-making, yet nearly all residents agreed that they had too little education on ***: There were several notable differences in ED patient and resident perspectives on costs in this U.S. sample. While patients somewhat disagree that cost should factor into decision making, generally they are comfortable discussing costs yet report having insuf? cient knowledge of what care costs. Conversely, ED residents view costs as important and agree that cost should factor into decision making but lack education on what emergency care costs.

关键词： Emergency medicine Clinical decision-making Cost Communication Residency education

Ionomic Profiling of Rice Genotypes and Identification of Varieties with Elemental Covariation Effects

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Rice science 2022年第1期29卷 76-88,I0026-I0030页

作者： ZHANG Chengming Nobuhiro TANAKA Maria stefanie Dw IYANTI Matthew SHENTON Hayato MARUYAMA Takuro SHINANO CHU Qingnan XIE Jun Toshihiro WATANABE Research Faculty of Agriculture Hokkaido UniversitySapporo 060-8589Japan Institute of Crop Science National Agriculture and Food Research OrganizationTsukuba 305-8518Japan Graduate School of Agricultural and Life Sciences The University of TokyoTokyo 113-8657Japan College of Resources and Environment Southwest UniversityChongqing 400715China

Ionomic profiles are primarily influenced by genetic and environmental *** ionomic responses to varietal effects is necessary to understand the ionomic variations among species or subspecies and to potentially understand genetic effects on ionomic *** cultivated 120 rice(Oryza sativa)varieties to seedling stage in identical hydroponic conditions and determined the concentrations of 26 elements(including 3 anions)in the shoots and roots of *** the subspecies effects were limited by the genus Oryza pre-framework and its elemental chemical properties,we found significant differences in ionomic variations in most elements among the aus,indica and japonica *** component analysis of the correlations indicated that variations in the root-to-shoot ionomic transport mechanisms were the main causes of ionomic differences among the ***,the correlations were primarily associated with the screening of varieties for elemental covariation effects that can facilitate breeding biofortified rice varieties with safe concentrations of otherwise toxic *** japonica subspecies exhibited the strongest elemental correlations and elemental covariation effects,therefore,they showed greater advantages for biofortification than the indica and aus subspecies,whereas indica and aus subspecies were likely safer in metal(loid)polluted *** also found that geographical and historical distribution significantly defined the ionomic ***,the results of this study provided a reference for further association studies to improve the nutritional status and minimize toxicity risks in rice production.

关键词： ionomic profile rice genotype elemental covariation correlation principal component analysis

The mutational dynamics of the SARS-CoV-2 virus in serial passages in vitro

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Virologica Sinica 2022年第2期37卷 198-207页

作者： Sissy Therese Sonnleitner stefanie Sonnleitner Eva Hinterbichler Hannah Halbfurter Dominik BCKopecky Stephan Koblmüller Christian Sturmbauer Wilfried Posch Gernot Walder Dr.Gernot Walder GmbH Medical LaboratoryDepartment of VirologyAusservillgraten9931Austria Division of Hygiene and Medical Microbiology Medical University of InnsbruckInnsbruck6020Austria Institute of Biology University of GrazGraz8010Austria

Since its outbreak in 2019,Severe Acute Respiratory Syndrome Coronavirus 2(SARS-Co V-2)keeps surprising the medical community by evolving diverse immune escape mutations in a rapid and effective *** gain deeper insight into mutation frequency and dynamics,we isolated ten ancestral strains of SARS-Co V-2 and performed consecutive serial incubation in ten replications in a suitable and common cell line and subsequently analysed them using RT-q PCR and whole genome *** those lines we hoped to gain fundamental insights into the evolutionary capacity of SARS-Co V-2 in *** results identified a series of adaptive genetic changes,ranging from unique convergent substitutional mutations and hitherto undescribed *** region coding for spike proved to be a mutational hotspot,evolving a number of mutational changes including the already known substitutions at positions S:484 and S:*** discussed the evolution of all specific adaptations as well as possible reasons for the seemingly inhomogeneous potential of SARS-Co V-2 in the adaptation to cell *** combination of serial passage in vitro with whole genome sequencing uncovers the immense mutational potential of some SARS-Co V-2 *** observed genetic changes of SARS-Co V-2 in vitro could not be explained solely by selectively neutral mutations but possibly resulted from the action of directional selection accumulating favourable genetic changes in the evolving variants,along the path of increasing potency of the *** among a high number of quasi-species in the SARS-Co V-2 in vitro population gene pool may reinforce directional selection and boost the speed of evolutionary change.

关键词： SARS-CoV-2 Whole genome sequencing(WGS) Mutational dynamics Adaptation Serial passage in vitro

Gene Expression Profiling of the Mouse Pancreas during the Secondary Transition in the Organogenesis of the Pancreatic Gland*

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Journal of Diabetes Mellitus 2021年第1期11卷 1-9页

作者： stefanie J. Willmann TUM Munich Germany

Diabetes mellitus is a chronic disease that impacts the homeostasis of blood sugar levels caused by loss or defect of insulin-producing β-cells in the Islets of Langerhans. Type 1 diabetes (T1D) is caused by auto-immune mediated destruction of β-cells, whereas in T2D, insulin is produced but used inefficiently. T2D accounts for 90% of people with diabetes worldwide (WHO 1999) and is the fastest increasing disease worldwide (https://***/en/). For an improved understanding of the pathomechanism of diabetes, profound knowledge of pancreas organogenesis and the associated gene regulatory networks is required. Therefore, we dissected and profiled the pancreatic endodermal and non-endodermal compartment between the embryonic stages (E) 12.5 and E 15.5 when progenitor cells commit to their different pancreatic lineages.

关键词： Gene Expression Profile Pancreas Organogenesis Single-Nucleotide Polymorphism Type 1 Diabetes Type 2 Diabetes

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纽马格推动客户BCF生产

合成纤维 2005年第12期34卷 49-50页

作者： Arnd Luppold Martin Rademacher Tilman reutter

地毯和地毯纱市场总是充满着挑战,新的需求不断地出现.地毯业的时尚潮流在快速地变化着,同时全球性的压力也在稳步增长.地毯业在这样的竞争环境中必须找到能够保持成功的途径.在这种情况下,工艺链前期的BCF技术对地毯纱和地毯生产是否... 详细信息

地毯和地毯纱市场总是充满着挑战,新的需求不断地出现.地毯业的时尚潮流在快速地变化着,同时全球性的压力也在稳步增长.地毯业在这样的竞争环境中必须找到能够保持成功的途径.在这种情况下,工艺链前期的BCF技术对地毯纱和地毯生产是否成功起着决定性的作用.

关键词： BCF 生产客户地毯纱竞争环境全球性决定性工艺链需求