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现代制造 2024年第9期 34-36页

作者： stefanie Wenzel 不详

Sanitar-heinze公司在很短的时间里就实现了数字化仓库管理的最高效率。过去以纸张为主的物流过程现在都在全新的WMS仓库管理系统中实现了全面的数字化管理。而数字化管理带来的结果就是:物流工作流程更加透明,降低了失误率、物流职工... 详细信息

Sanitar-heinze公司在很短的时间里就实现了数字化仓库管理的最高效率。过去以纸张为主的物流过程现在都在全新的WMS仓库管理系统中实现了全面的数字化管理。而数字化管理带来的结果就是:物流工作流程更加透明,降低了失误率、物流职工的工作效率更高。物流中心的仓储运输能力也成为企业价值增值链中的一个重要环节。

关键词：仓储运输物流过程数字化管理物流中心失误率价值增值链工作效率工作流程

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Stimulation of p38 MAPK by hormal preconditioning with atrial natriuretic peptide

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World Journal of Gastroenterology 2002年第4期8卷 707-711页

作者： Alexandra K. Kiemer stefanie kul.anek-heinze Tobias Gerwig Alexander L. Gerbes Angelika M. Vollmar Department of Pharmacy Center of Drug ResearchUniversity of MunichGermany Department of Medicine ⅡKlinikum GrosshadernUniversity of MunichGermany Department of Medicine Ⅱ Klinikum GrosshadernUniversity of MunichGermany Department of Pharmacy Center of Drug ResearchUniversity of MunichGermany

AIM：Stress-activated signaling pathways responsible for hepatic ischemia reperfusion injury and their modulation by protective interventions are widely *** of rat livers with Atrial Natriuretic Peptide(ANP)attenuates ischemia reperfusion injury(Gerbes et ***1998,18:1309-1317),SinANP has recently been shown to be a regulator of the p38MAPKpathway in endothelial cells(Kiemer et ***2002,90:874-881).aim of this thudy was to investigate activities of MAPK during ischemia and reperfusion and effects of ANP on ***:Rat livers were perfused with KH-buffer in the presence or absence of ANP for 20min,kept in cold UWsloution for 24h,and reperfused forupto120min,Activities of p38MAPKand JNKwas determined by in vitro phosphorylation assays using MBP and c-jun as *** SDS/PAGE electrophoresis,gels were quantified by ***:Activity of p38MAPKin control organs decreased in the course of ischemia and reperfusion by85%,whereas ANPincreased p38 activity by up to *** of control livers increased in the course of ischemia and reperfusion by up to *** increase in JNK activrity was slightly elevated in ANP preconditioned ***:This work represents a systematic investigation of MAPK activation during liver ischemia and *** ANP,for the first time a pharmacological approach to modulate these central signal transduction molecules is presented.

关键词：血浆心纳素 p38MAPK 缺血预处理肝脏缺血

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Organic carbon dynamics and enzyme activities in agricultural soils amended with biogas slurry, liquid manure and sewage sludge

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Agricultural Sciences 2012年第1期3卷 104-113页

作者： Britta Stumpe Steffen Werner Robert Jung stefanie heinze Elisabeth Jüschke Christian Strippel Bernd Marschner Department Soil Science/Soil Ecology Institute of Geography Ruhr-University Bochum Bochum Germany

The application of organic soil amendments is a common practice for increasing soil fertility and soil organic carbon (SOC) content. In recent years, a new product from biogas production, biogas slurry is increasingly applied to agricultural soils, although little is known about its effects on soil properties. In this study, the influence of this new product in comparison with liquid manure and sewage sludge on the organic carbon dynamics and enzyme activities were investigated in two different agricultural soils in short-term incubation studies. As a control, biologically inert sand was also amended with these organic wastes. In sand, biogas slurry degraded to 10.4% within 14 days, while no differences were found between the degradability of liquid manure and sewage sludge with 6.6% and 5.4%, respectively. However, although the degradability of biogas slurry was highest among the organic amendments, liquid manure application resulted in the highest respiration rates in the soil samples. This was likely due to the organic waste borne easily decomposable substrates which were most dominant in liquid manure. Organic waste applications were found to generally increase the activity of numerous enzymes but did not change the soil enzyme patterns. Thus, in general it was shown that the microbial population of the organic wastes will not become prominent when introduced with the manures to soils. Thus, an inoculation with organic waste borne microorganisms could likely be neglected when discussing the extent of organic carbon dynamics after organic waste application to agricultural soils.

关键词： Biogas Slurry Organic Wastes Organic Carbon Dynamics Enzyme Activity Priming Effects

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Hepatocyte cytoskeleton during ischemia and reperfusion -influence of ANP-mediated p38 MAPK activation

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World Journal of Gastroenterology 2005年第47期11卷 7418-7429页

作者： Melanie Keller Alexander L Gerbes stefanie kul.anek-heinze Tobias Gerwig Uwe Grützner Nico van Rooijen Angelika M Vollmar Alexandra K Kiemer Department of Pharmacy Centre of Drug ResearchUniversity of MunichButenandtstr. 5-1381377 MunichGermany Department of Medicine Ⅱ Klinikum GroβhadernUniversity of MunichMarchionistr. 1781377 MunichGermany Angelika M Vollmar Alexandra K KiemerDepartment of PharmacyCentre of Drug ResearchUniversity of MunichButenandtstr. 5-1381377 MunichGermany Department of Pharmacy Centre of Drug ResearchUniversity of MunichButenandtstr. 5-1381377 MunichGermany Department of Medicine ⅡKlinikum GroβhadernUniversity of MunichMarchionistr. 1781377 MunichGermany Institute for Surgical Research Klinikum GroβhadernUniversity of MunichMarchionistr. 1781377 MunichGermany Vrije Universiteit VUMCDepartment of Molecular Cell BiologyFaculty of Medicine1081 BT AmsterdamThe Netherlands

AIM： To determine functional consequences of this activation, whereby we focused on a potential regulation of the hepatocyte cytoskeleton during ischernia and reperfusion. METHODS： For in vivo experiments, animals received ANP （5 μg/kg） intravenously. In a different experimental setting, isolated rat livers were perfused with KH-buffer ＋ANP （200 nmol/L）＋SB203580 （2 μmol/L）. Livers were then kept under ischernic conditions for 24 h, and either transplanted or reperfused. Actin, Hsp27, and phosphorylated Hsp27 were determined by Western blotting, p38 MAPK activity by in vitro phosphorylation assay. F-actin distribution was determined by confocal microscopy. RESULTS： We first confirmed that ANP preconditioning leads to an activation of p38 MAPK and observed alterations of the cytoskeleton in hepatocytes of ANP- preconditioned organs. ANP induced an increase of hepatic F-actin after ischemia, which could be prevented by the p38 MAPK inhibitor SB203580 but had no effect on bile flow. After ischemia untreated livers showed a translocation of Hsp27 towards the cytoskeleton and an increase in total Hsp27, whereas ANP preconditioning prohibited translocation but caused an augmentation of Hsp27 phosphorylation. This effect is also mediated via p38 MAPK, since it was abrogated by the p38 MAPK inhibitor SB203580. CONCLUSION： This study reveals that ANP-mediated p38 MAPK activation leads to changes in hepatocyte cytoskeleton involving an elevation of phosphorylated Hsp27 and thereby for the first time shows functional consequences of ANP-induced hepatic p38 MAPK activation.

关键词： Hormonal preconditioning Atrial natriuretic peptide Hsp 27 Actin Polymerization

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Organic carbon dynamics and enzyme activities in agricultural soils amended with biogas slurry,liquid manure and sewage sludge

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Agricultural Sciences（农业科学） 2012年第1期

作者： Britta Stumpe Steffen Werner Robert Jung stefanie heinze Elisabeth Jüschke Christian Strippel Bernd Marschner

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