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Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

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Liver Research 2020年第3期4卷 145-152页

作者： Melissa M.Clemens Joel H.Vazquez stefanie kennon-mcgill Sandra S.McCullough Laura P.James Mitchell R.mcgill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockARUSA Interdisciplinary Graduate Program in Biomedical Sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockARUSA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockARUSA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockARUSA Center for Dietary Supplement Research University of Arkansas for Medical SciencesLittle RockARUSA

Background and aim:Acetaminophen(APAP)overdose is a major cause of acute liver injury,but the role of macrophages in the propagation of the hepatotoxicity is *** research revealed that macrophage inhibitors protect against APAP ***,later work demonstrated that macrophage ablation by acute pre-treatment with liposomal clodronate(LC)exacerbates the *** our surprise,during other studies,we observed that pre-treatment twice with LC seemed to protect against APAP hepatotoxicity,in contrast to acute *** aim of this study was to confirm that observation and to explore the ***:We treated mice with empty liposomes(LE)or LC twice per week for 1 week before APAP overdose and collected blood and liver tissue at 0,2,and 6 h *** then measured liver injury(serum alanine aminotransferase activity,histology),APAP bioactivation(total glutathione,APAP-protein adducts),oxidative stress(oxidized glutathione(GSSG)),glutamate-cysteine ligase subunit c(Gclc)mRNA,and nuclear factor erythroid 2-related factor(Nrf2)*** also confirmed the ablation of macrophages by F4/80 ***:Pre-treatment twice with LC dramatically reduced F4/80 staining,protected against liver injury,and reduced oxidative stress at 6 h post-APAP,without affecting APAP ***,Gclc mRNA was higher in the LC group at 0 h and total glutathione was higher at 2 h,indicating accelerated glutathione re-synthesis after APAP overdose due to greater basal glutamate-cysteine *** stress was lower in the LC groups at both time ***,total Nrf2 immunofluorescence was higher in the LC ***:We conclude that multiple pre-treatments with LC protect against APAP by accelerating glutathione re-synthesis through glutamate-cysteine *** using twice or possibly more LC pre-treatments to deplete macrophages,including peritoneal macrophages,should be aware of this poss

关键词： Acetaminophen(APAP) Acute liver failure(ALF) Damage-associated molecular patterns(DAMPs) Drug-induced liver injury Liposomal clodronate(LC) Kupffer cells Nuclear factor erythroid 2-related factor(Nrf2) Sterile inflammation Stress response

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Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3836-3846页

作者： Melissa M.Clemens stefanie kennon-mcgill Joel H.Vazquez Owen W.Stephens Erich A.Peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SMcCullough Laura P.James Brian N.Finck Mitchell R.mcgill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Interdisciplinary Graduate Program in Biomedical Sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Winthrop P.Rockefeller Cancer Institute University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR2205USA Division of Geriatrics and Nutritional Sciences Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63110USA Center for Dietary Supplement Research University of Arkansas for Medical SciencesLittle RockAR 72205USA

We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)***,we hypothesized that exogenous PA is also *** test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)*** then collected blood and liver at 6,24,and 52 ***-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC ***,PA did not affect canonical mechanisms of APAP ***,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the *** with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated ***,PA failed to protect against APAP in IL-6-deficient ***,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating ***,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short *** data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model.

关键词： Acute liver injury Acute liver failure Adipokine Cytokine Dietary supplement Drug-induced liver injury Hepatotoxicity Lipid

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更高效的数字化仓库管理

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现代制造 2024年第9期 34-36页

作者： stefanie Wenzel 不详

Sanitar-Heinze公司在很短的时间里就实现了数字化仓库管理的最高效率。过去以纸张为主的物流过程现在都在全新的WMS仓库管理系统中实现了全面的数字化管理。而数字化管理带来的结果就是:物流工作流程更加透明,降低了失误率、物流职工... 详细信息

Sanitar-Heinze公司在很短的时间里就实现了数字化仓库管理的最高效率。过去以纸张为主的物流过程现在都在全新的WMS仓库管理系统中实现了全面的数字化管理。而数字化管理带来的结果就是:物流工作流程更加透明,降低了失误率、物流职工的工作效率更高。物流中心的仓储运输能力也成为企业价值增值链中的一个重要环节。

关键词：仓储运输物流过程数字化管理物流中心失误率价值增值链工作效率工作流程

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自动化:撬动灵活生产的杠杆

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现代制造 2024年第2期 37-38页

作者： stefanie Michel 不详

第41届国际装配自动化展览会的展示核心是从零部件到组件和子系统直至完整的全套系统。工厂企业的设计师、决策者和采购人员都可以在这一会展中找到符合自己需求的最佳解决方案。2023年10月10~13日,著名的国际生产和装配自动化技术展Mo... 详细信息

第41届国际装配自动化展览会的展示核心是从零部件到组件和子系统直至完整的全套系统。工厂企业的设计师、决策者和采购人员都可以在这一会展中找到符合自己需求的最佳解决方案。2023年10月10~13日,著名的国际生产和装配自动化技术展Motek会展与国际粘合剂及密封技术博览会Bondexpo会展同时拉开帷幕。

关键词：装配自动化最佳解决方案采购人员密封技术会展粘合剂博览会

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不“只是”CAM软件

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现代制造 2024年第7期 38-39页

作者： stefanie Michel 不详

近几年来,Delcam公司的产品已经成为了Autodesk公司软件中的一部分。数控加工编程软件Powermill是如何发展成为CAM计算机辅助制造软件的?为什么CAM也可以在Autodesk Fusion计算机绘图软件中使用?本文采访了Autodesk公司软件产品管理和... 详细信息

近几年来,Delcam公司的产品已经成为了Autodesk公司软件中的一部分。数控加工编程软件Powermill是如何发展成为CAM计算机辅助制造软件的?为什么CAM也可以在Autodesk Fusion计算机绘图软件中使用?本文采访了Autodesk公司软件产品管理和营销经理Clinton Perry先生。

关键词：计算机辅助制造计算机绘图软件 CAM软件 Autodesk 营销经理软件产品数控加工编程 Fusion

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精确运动控制的驱动系统

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现代制造 2024年第5期 42-43页

作者： stefanie Michel 不详

作为一个系统来讲,电动机和运动控制器不仅仅是一系列元器件的总和。Faulhaber公司就用自己的产品展示了只有使用合适的运动控制器才能可靠地驱动小型电动机实现自动化。在自动化控制领域中,机械设备的运动通常都要精确地、动态地和灵... 详细信息

作为一个系统来讲,电动机和运动控制器不仅仅是一系列元器件的总和。Faulhaber公司就用自己的产品展示了只有使用合适的运动控制器才能可靠地驱动小型电动机实现自动化。在自动化控制领域中,机械设备的运动通常都要精确地、动态地和灵活地予以控制。例如,没有人愿意让不安全的机器人给自己做微创手术。即便是在CNC数控机床加工过程中数控机床的刀具和材料供给也都必须做到非常精确,只有这样才能确保零件的加工精度。但如果没有合适的驱动装置就无法完成此类任务。

关键词：运动控制器 CNC数控机床小型电动机产品展示零件的加工加工过程驱动装置机械设备

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The early development of face processing——What makes faces special?

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Neuroscience Bulletin 2012年第6期28卷 765-788页

作者： stefanie Hoehl stefanie Peykarjou Department of Psychology University of HeidelbergHauptstr47-51 Heidelberg 69117Germany

In the present article we review behavioral and neurophysiological studies on face processing in adults and in early development. From the existing empirical and theoretical literature we derive three aspects that distinguish face processing from the processing of other visual object categories. Each of these aspects is discussed from a developmental perspective. First, faces are recognized and represented at the individual level rather than at the basic level. Second, humans typically acquire extensive expertise in individuating faces from early on in development. And third, more than other objects, faces are processed holistically. There is a quantitative difference in the amount of visual experience for faces and other object categories in that the amount of expertise typically acquired for faces is greater than that for other object categories. In addition, we discuss possible qualitative differences in experience for faces and objects. For instance, there is evidence for a sensitive period in infancy for building up a holistic face representation and for perceptual narrowing for faces of one＇s own species and race. We conclude our literature review with questions for future research, for instance, regarding the exact relationship between behavioral and neuronal markers of face processing across development.

关键词： face processing development infants visual expertise holistic processing event-related potential

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Simultaneous determination of five anti-epilepsy drugs in human plasma using liquid chromatography-mass spectrometry

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Science China Chemistry 2010年第11期53卷 2373-2378页

作者： stefanie WeiBig Institute of Pharmaceutical Analysis College of PharmacyWuhan University

A new liquid chromatography-mass spectrometry method for the determination of carbamazepine,clonazepam,alprazolam,estazolam and phenytoin in human plasma has been developed by using diazepam as an internal *** separation was performed on a Zorbax SB-C18 column(30 mm × 2.1 mm,3.5 ?m) with a mobile phase consisting of methanol and aqueous 25 mM ammonium acetate using gradient elution.A diethyl ether extraction method was used for the extraction of five anti-epilepsy *** final extract was injected for analysis by LC-MS/*** method was validated within the concentration range of 50-5000 ng mL-1 for five anti-epilepsy *** precision of the assay(RSD%) was less than 10% at all concentration levels within the tested *** method recoveries for all samples were more than 90%.The results indicate that the method is specific,sensitive and accurate,and suitable to study the pharmacokinetics,to adjust the dosage for individual administration,and to monitor the drug-concentration and drug abuse of the five anti-epilepsy drugs.

关键词： liquid chromatography-mass spectrometry anti-epilepsy drugs plasma concentration

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View on microRNAs as a potential tool to fight blindness: focus on Müller glia and gliosis

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Neural Regeneration Research 2022年第7期17卷 1501-1502页

作者： stefanie Gabriele Wohl The State University of New York College of OptometryDepartment of Biological and Vision SciencesNew YorkNYUSA

The neural retina is a part of the central nervous *** it lacks regenerative capacity,in an event of injury or disease,neuronal loss leads to visual impairment and often to ***,Müller glia(MG),the predominant glia in the retina,undergo a variety of molecular and cellular changes and discontinue to carry out their important regular functions in the tissue(e.g.,maintaining tissue homeostasis and nurturing neurons).

关键词： homeostasis predominant carry

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Review on Efficacy and Health Services Research Studies of Complementary and Alternative Medicine in Inflammatory Bowel Disease

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Chinese Journal of Integrative Medicine 2011年第6期17卷 403-409页

作者： stefanie Joos Department of General Practice and Health Services Research University Medical Hospital Heidelberg Voβstrasse 2 69120 HeidelbergGermany

Objective：To assess the evidence of the use and efficacy for complementary and alternative medicine（CAM） in inflammatory bowel disease（IBD）. Methods：A systematic literature search in MEDLINE was performed for randomized controlled trials（RCTs） in Crohn＇s disease and ulcerative ***,a selective literature search for health services research studies on the use of CAM in patients with IBD was ***：Health services research studies showed a high use of CAM in adult and pediatric patients with IBD *** contrast to the high use among IBD patients,there was a lack of high-quality data for many of the used CAM *** most of the studies showed positive results,the methodological quality of most studies was rather low;therefore,the results had to be interpreted with *** there were many studies for probiotics and fish oil,RCTs for the highly used method homeopathy, for most herbal products,and for traditional Chinese medicine methods apart from acupuncture RCTs were completely ***：The lack of high-quality studies might be the consequence of the problems associated with the funding of clinical trials involving ***,having the high user rates in mind,high-quality studies assessing efficacy and safety of those methods are urgently ***,there is a need for better representation of CAM in undergraduate and postgraduate medical education.

关键词： complementary and alternative medicine inflammatory bowel disease Crohn's disease ulcerative colitis health services research health services research

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