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A new general index of home range overlap and segregation:the Lesser Kestrel in Southern Italy as a case study

Avian Research 2021年第1期12卷 108-117页

作者： Alessandro Ferrarini Giuseppe Giglio stefania caterina pellegrino Marco Gustin Conservation Department LIPU-BirdLife Italy(Lega Italiana Protezione Uccelli)Via Udine 3/a43122 ParmaItaly

Background:There is increasing interest in evaluating home-range overlap(or,otherwise,segregation)between bird species,and between or within bird populations,to inform spatial *** far,studies of home-range overlap typically make use of comparisons between pairs of individuals,populations or species,and return a matrix of pairwise overlaps(e.g.,percent overlaps).However,when the number of individuals,populations or species to be compared is elevated,an overlarge overlap matrix is difficult to interpret from an ecological ***:We propose here a new,conceptually simple and computationally efficient index(general overlap index;GOI)for the ready computation within GIS of home range overlap of an arbitrarily large number(i.e.,n≥2)of individuals,populations or *** the number of home ranges to be compared,GOI always returns a single score between 0 and *** a case study,we applied our index to 24,074 GPS points of 10 Lesser Kestrels(Falco naumanni)in order to estimate within-colony and between-colony overlaps in two neighboring colonies in Southern ***:Within-colony overlap was elevated for both colonies(96.41%at Cassano delle Murge,n=5 individuals;81.38%at Santeramo in Colle,n=5 individuals),while between-colony overlap was low(19.12%;n=2 colonies)and,after a randomization procedure,more spatially-segregated than expected by ***:Modern biotelemetry offers huge amounts of data describing the space use of animal *** use of intuitive and straightforward indices,like GOI,can be useful to promptly extract ecological information from such an amount of data(*** change in space use over successive years,evaluating the reliability of various home-range estimators).

关键词： Between-colony overlap Falco naumanni Home range randomization Overlap estimator Spatial segregation Within-colony overlap

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A new methodology for computing birds＇ 3D home ranges

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Avian Research 2018年第2期9卷 168-173页

作者： Alessandro Ferrarini Giuseppe Giglio stefania caterina pellegrino Anna Grazia Frassanito Marco Gustin Conservation Department LIPU - BirdLife (Lega Italiana Protezione Uccelli) Via Udine 3/a 43122 Parma Italy Alta Murgia National Park Via Firenze 10 70024 Gravina in Puglia Bari Italy.

Background： So far, studies of avian space use are mostly realized in 2D, with the vertical dimension ignored. We propose here a new, relatively simple and computationally reasonable method for the estimation of volumetric （i.e. 3D） avian home ***： Through accurate GPS data-loggers, we collected 25,405 GPS points on Lesser Kestrels＇（Fdlco noumonni） space use during the nestling period in one main colony in *** applied our 3D home range estimator to the whole GPS dataset, and also separately to diurnal and nocturnal GPS ***： The 3D colony home range resulted equal to 28.12 km3. By considering daytime and night-time separately, the volumetric home ranges resulted considerably ***： Our 3D home range estimator, because of its intuitive and straightforward properties, can easily capi-talize on the datasets offered by modern biotelemetry （data-loggers, light detection and LIDAR sensors） and enhance conservation strategies for mitigating anthropogenic impacts on bird species. Its applications embrace, but are not limited to, more accurate estimates of collision risk with power lines, aircrafts and wind farms, and increased knowledge of birds＇space requirements in order to persist in their distribution areas.

关键词： Avian space use Biotelemetry GPS data-loggers Vertical dimension Volumetric home range

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Dengue and falciparum malaria co-infection in travelers returning from Burkina Faso:Report of two cases in Northeastern Italy

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Asian Pacific Journal of Tropical Medicine 2023年第3期16卷 139-142页

作者： Antonio Mastroianni caterina Vocale Vittorio Sambri Tiziana Lazzarotto Paolo Gaibani Giada Rossini stefania Varani Infectious&Tropical Diseases Unit Department of Specialty Medicine“Annunziata”Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly Infectious&Tropical Diseases Unit Department of Specialty Medicine“G.B.Morgagni-L.Pierantoni”HospitalForlìItaly Microbiology Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Medicine and Surgery University of BolognaBolognaItaly Great Romagna Hub Laboratory Unit of MicrobiologyPievesestinaCesenaItaly

Rationale: Malaria and dengue are the most prevalent vector-borne diseases in tropical countries. Plasmodium parasite and dengue virus(DENV) concurrent infection is possible and often under-recognized in geographical areas where these infections are both *** concern and diagnosis: We describe the first two cases of Plasmodium falciparum and DENV-3 co-infection in travelers returning to northeastern Italy from Burkina Faso during ***: Malaria infection in both patients was treated with mefloquine. Due to the persistence of symptoms despite of the antimalaria treatment, dengue was also investigated;the treatment of dengue was ***: The patients were discharged in good general ***: The need for surveillance of potential malaria and dengue co-infection in travelers returning to Europe from endemic areas is highlighted, as infection with Plasmodium does not exclude arboviral co-infection.

关键词： Dengue virus Falciparum malaria Travelers infection Co-infection Arbovirus

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TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype

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World Journal of Gastroenterology 2016年第38期22卷 8509-8518页

作者： caterina Sagnelli Marco Merli caterina Uberti-Foppa Hamid Hasson Anna Grandone Grazia Cirillo stefania Salpietro Carmine Minichini Mario Starace Emanuela Messina Patrizia Morelli Emanuele Miraglia Del Giudice Adriano Lazzarin Nicola Coppola Evangelista Sagnelli Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. LanzaraSecond University of Naples 80131 Naples Italy Department of Infectious Diseases Vita-Salute University San Raffaele Scientific Institute 20127 Milan Italy Department of Pediatrics Second University of Naples 80131 Naples Italy Department of Mental Health and Public Medicine Section of Infectious Diseases Second University of Naples 80131 Naples Italy

AIM To evaluate the impact of the Glu167Lys(E167K) transmembrane 6 superfamily member 2(TM6SF2) variant on the biochemical and morphologic expression of liver lesions in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) co-infected *** The study comprised 167 consecutive patients with HIV/HCV coinfection and biopsy-proven chronic hepatitis. A pathologist graded liver fibrosis and necroinflammation using the Ishak scoring system, and steatosis using Kleiner's scoring system. Patients were genotyped for TM6SF2 E167K(rs58542926) by real-time Polymerase chain reaction. The 167 patients, 35 therapy-naive and 132 receiving ART, were prevalently males(73.6%), the median age was 40.7 years and the immunological condition good(median CD4+ cells/mm3 = 505.5).RESULTS The 17 patients with the TM6SF2 E167 K variant, compared with the 150 with TM6SF2-E/E, showed higher AST(P = 0.02) and alanine aminotransferase(P = 0.02) and higher fibrosis score(3.1 ± 2.0 vs 2.3 ± 1.5, P = 0.05). In a multivariate analysis, TM6SF2 E167 K was independently associated with severe fibrosis. The same analysis showed that HCV-genotype 3, present in 42.2% of patients was an independent predictor of severe steatosis. The association of TM6SF2 E167 K with severe steatosis, absent for the whole group of 167 patients, was re-evaluated separately for HCVgenotype 3 and non-3 patients: No factor was independently associated with severe steatosis in the HCV-genotype-3 subgroup, whereas an independent association was observed between severe steatosis and TM6SF2 E167 K in non-3 HCV genotypes. No association between the TM6SF2 E167 K variant and severe liver necroinflammation was *** In HIV/HCV coinfection the TM6SF2 E167 K variant is an independent predictor of severe fibrosis, but appears to be independently associated with severe steatosis only for patients with a non-3 HCV genotype.

关键词： Human immunodeficiency virus/hepatitis C virus co-infection TM6SF2 Liver histology Liver steatosis Liver biopsy

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CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not

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Cellular & Molecular Immunology 2015年第4期12卷 474-482页

作者： Maria Neve Polimeno caterina Ierano Crescenzo D'Alterio Nunzia Simona Losito Maria Napolitano Luigi Portella Giosuè Scognamiglio Fabiana Tatangelo Anna Maria Trotta Steven Curley Susan Costantini Raffaele Liuzzi Francesco Izzo stefania Scala Oncological Immunology Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"-IRCCS-ITALIA Naples Italy. Pathology Unit Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"-IRCCS-ITALIA Naples Italy. Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston TX USA. CROM-Centro Ricerche Oncologiche Mercogliano Mercogliano (AV) Italy. Institute of Biostructure and Bioimaging (IBB) of the Italian National Research Council Naples Italy. Hepato-Biliary Surgery Unit Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"-IRCCS-ITALIA Naples Italy.

Hepatocellular carcinoma （HCC） is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expression was analyzed by immunohistochemistry in 86 HCC patients （training cohort） and validated in 42 unrelated HCC patients （validation cohort）. CXCR4 levels were low in 22.1% of patients, intermediate in 30.2%, and high in 47.7%, whereas CXCR7 levels were low in 9.3% of patients, intermediate in 44.2% and high in 46.5% of the patients in the training cohort. When correlated to patient outcome, only CXCR4 affected overall survival （P=-O.03）. CXCR4-CXCL12-CXCR7 mRNA levels were examined in 33/86 patients. Interestingly, the common CXCR4-CXCR7 ligand CXCL12 was expressed at significantly lower levels in tumor tissues compared to adjacent normal liver （P=0.032）. The expression and function of CXCR4 and CXCR7 was also analyzed in several human HCC cell lines. CXCR4 was expressed in Huh7, Hep3B, SNU398, SNU449 and SNU475 cells, whereas CXCR7 was expressed in HepG2, Huh7, SNU449 and SNU475 cells. Huh7, SNU449 and SNU475 cells migrated toward CXCL12, and this migration was inhibited by AMD3 lO0/anti-CXCR4 and by CCX771/anti-CXCR7. Moreover, SNU449 and Huh7 cells exhibited matrix invasion in the presence of CXCL12 and CXCL11, a ligand exclusive to CXCR7. In conclusion, CXCR4 affects the prognosis of HCC patients but CXCR7 does not. Therefore, the CXCR4-CXCL12-CXCR7 axis plays a role in the interaction of HCC with the surrounding normal tissue and represents a suitable therapeutic target.

关键词： CXCR4 CXCR7 CXCL12 hepatocellular carcinoma prognosis

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Si/Ga埃尼碳硅酸盐的合成与表征（英文）

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催化学报 2015年第6期36卷 813-819页

作者： Giuseppe Bellussi Angela Carati stefania Guidetti caterina Rizzo Roberto Millini Stefano Zanardi Erica Montanari Wallace O'Neil Parker Jr. Michela Bellettato Eni s.p.a. Development Operations & Technology Downstream R&D

Phenylene-gallosilicates were prepared with the same crystalline structure as their aluminum analogues. The new Ga-Eni Carbon Silicates(Ga-ECS) phases were investigated by X-ray diffraction, scanning electron microscopy, nuclear magnetic resonance and thermogravimetric analysis, which demonstrated that gallium isomorphously replaced aluminum in the framework of the organic-inorganic hybrids similar to the case of classical zeolites. Hybrid ECS materials were obtained with different types of bridged silsesquioxane precursors that maintained the aluminum-silicate nature of the inorganic moiety. This work confirms a new level of crystal chemistry versatility for this class of materials, and demonstrates the possibility to tailor also the inorganic part of the framework by changing the nature of the trivalent heteroatom.

关键词：硅酸盐扫描电子显微镜 Si 合成表征 GA 碳 X射线衍射

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Biochemical sensing exploiting plasmonic sensors based on gold nanogratings and polymer optical fibers

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Photonics Research 2021年第7期9卷 1397-1408页

作者： FRANCESCO ARCADIO LUIGI ZENI DOMENICO MONTEMURRO caterina ERAMO stefania DI RONZA CHIARA PERRI GIROLAMO D’AGOSTINO GUIDO CHIARETTI GIOVANNI PORTO NUNZIO CENNAMO Department of Engineering University of Campania Luigi VanvitelliAversa 81031Italy Department of Physics E.Pancini University of Naples Federico IINaples 80126Italy Moresense Srl Filarete FoundationMilan 20139Italy

In this work,we present a novel biochemical sensing approach based on a plasmonic sensor chip,combined with a specific receptor,excited and interrogated via a custom 3D-printed holder through a transmission-based experimental setup,exploiting polymer optical fibers. The setup is designed to measure a disposable plasmonic chip based on a gold nanograting fabricated on a polymethylmethacrylate substrate. The examined sensor configurations here presented are simulated,realized,and experimentally tested. More specifically,first,a numerical analysis is carried out by changing several sensor parameters,then an experimental optical characterization of different sensor configurations is reported. Finally,to test the biosensing capabilities of the proposed method,as a proof of concept,we deposit on the best sensor configuration a biomimetic receptor specific for bovine serum albumin detection. The experimental results demonstrate that the proposed sensor shows an ultra-low limit of detection,equal to about 37 pmol/L.

关键词： exploit optical polymer

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Hepatitis B virus and hepatitis C virus infection inhealthcare workers

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World Journal of Hepatology 2016年第5期8卷 273-281页

作者： Nicola Coppola stefania De Pascalis Lorenzo Onorato Federica Calò caterina Sagnelli Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples80131 NaplesItaly Department of Clinical and Experimental Medicine and Surgery“F.Magrassi e A.Lanzara” Second University of Naples80131 NaplesItaly

Approximately 3 million healthcare workers per year receive an injury with an occupational instrument, with around 2000000 exposures to hepatitis B virus(HBV) and 1000000 to hepatitis C virus(HCV). Although an effective HBV vaccine has been available since the early eighties, and despite the worldwide application of universal vaccination programs started in the early nineties, HBV still remains a prominent agent of morbidity and mortality. There is no vaccine to limit the diffusion of HCV infection, which progresses to chronicity in the majority of cases and is a major cause of morbidity and mortality worldwide due to a chronic liver disease. Healthcare workers are frequently exposed by a mucosal-cutaneous or percutaneous route to accidental contact with human blood and other potentially infectious biological materials while carrying out their occupational duties. Mucosal-cutaneous exposure occurs when the biological material of a potentially infected patient accidentally comes in contact with the mucous membranes of the eyes or mouth or with the skin of a healthcare worker. Percutaneous exposure occurs when an operator accidentally injures himself with a sharp contaminated object, like a needle, blade or other sharp medical instrument. About 75% of the total occupational exposure is percutaneous and 25% mucosal-cutaneous, the risk of infecting a healthcare worker being higher in percutaneous than in mucosal-cutaneous exposure. All healthcare workers should be considered for HBV vaccination and should meticulously apply the universal prophylactic measures to prevent exposure to HBV and HCV.

关键词： Hepatitis B virus infection Hepatitis C virusinfection Needle-stick injury Healthcare workers

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Plasma small-extracellular vesicles enriched in miR-122-5p promote disease aggressiveness in pediatric anaplastic large-cell lymphoma

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Cancer Communications 2023年第5期43卷 630-634页

作者： Carlotta caterina Damanti Lavinia Ferrone Enrico Gaffo Anna Garbin Anna Tosato Giorgia Contarini Ilaria Gallingani Roberta Angioni Barbara Molon Giulia Borile Elisa Carraro Marta Pillon Federico Scarmozzino Angelo Paolo Dei Tos Marco Pizzi Francesco Ciscato Andrea Rasola Alessandra Biffi stefania Bortoluzzi Federica Lovisa Lara Mussolin Maternal and Child Health Department Pediatric Hematology Oncology and Stem Cell Transplant CenterUniversity of PaduaPaduaItaly Pediatric Research Institute“Cittàdella Speranza” PaduaItaly Department of Molecular Medicine University of PaduaPaduaItaly Department of Biomedical Sciences University of PaduaPaduaItaly General Pathology and Cytopathology Unit Department of Medicine-DMEDUniversity of PaduaPaduaItaly

Dear Editor,Anaplastic lymphoma kinase-positive(ALK+)anaplastic large cell lymphoma(ALCL)is an aggressive peripheral Tcell lymphoma representing 10%-15%of pediatric lymphoid *** constitutively activated nucleophosmin-ALK(NPM-ALK)fusion protein is the main driver of ALK+ALCL oncogenesis[1].Current clinical protocols can achieve high cure rates,with 75%event-free survival(EFS)at 5 years[2],but the patients’outcome with relapsed/refractory disease still remains poor[3].Liquid biopsy is widely applied for the prognostic and therapeutic stratification of onco-hematological *** a non-invasive procedure,it can be used to identify several biomarkers,such as small extracellular vesicles(S-EVs)[4].S-EVs are stable carriers of molecules that mediate genetic exchange between distant cells,alter the microenvironment,facilitate cancer cell progression and promote drug resistance[5].

关键词： lymphoma pediatric neoplasms

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Nuclear imaging in detection and monitoring of cardiotoxicity

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World Journal of Radiology 2014年第7期6卷 486-492页

作者： Carmen D’Amore Paola Gargiulo stefania Paolillo Angela Maria pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi Department of Advanced Biomedical Sciences Federico II University SDN Foundation Institute of Diagnostic and Nuclear Development

Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and *** coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor *** ventricular dysfunction is the most typical manifestation and can lead to heart *** ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial *** non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic *** echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical *** aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity.

关键词： Cardiotoxicity Cardiac nuclear imaging Early diagnosis Scintigraphy Positron emission tomography

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