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In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy

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World Journal of Gastroenterology 2011年第5期17卷 677-680页

作者： Giovanni D De Palma stefania staibano Saverio Siciliano Francesco Maione Maria Siano Dario Esposito Giovanni Persico Department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgerySection of Diagnostic and Therapeutic EndoscopyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly

Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was *** this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in *** study involved a patient presenting long-standing *** imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological *** mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination.

关键词： Colonoscopy Confocal laser endomicros-copy Chronic ulcerative colitis Dysplasia-associatedlesional mass Histology

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Diagnostic accuracy of confocal laser endomicroscopy in diagnosing dysplasia in patients affected by long-standing ulcerative colitis

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 414-420页

作者： Antonio Rispo Fabiana Castiglione stefania staibano Dario Esposito Maria Siano Francesco Maione Francesca Salvatori stefania Masone Marcello Persico Giovanni Domenico De Palma Gastroenterology University 'Federico Ⅱ'of Naples80131 NaplesItaly Gastroenterology University 'Federico Ⅱ' of Naples80131 NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity 'Federico Ⅱ' of Naples80131 NaplesItaly Surgery and Advanced Technologies-University 'Federico Ⅱ' of Naples 80131 NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity'Federico Ⅱ'of Naples80131 NaplesItaly Surgery and Advanced Technologies-University 'Federico Ⅱ'of Naples 80131 NaplesItaly

AIM:To evaluate the diagnostic accuracy of confocal laser endomicroscopy(CLE) for the detection of dysplasia in long-standing ulcerative colitis(UC).METHODS:We prospectively performed a surveillance colonoscopy in 51 patients affected by long-standing ***,in the presence of macroscopic areas with suspected dysplasia,both targeted contrasted indigo carmine endoscopic assessment and probe-based CLE were *** mucosal biopsies and histology,utilised as the gold standard,were assessed randomly and on visible lesions,in accordance with current ***:Fourteen of the 51 patients(27%) showed macroscopic mucosal alterations with the suspected presence of dysplasia,needing chromoendoscopic and CLE *** 5 macroscopically suspected cases,the presence of dysplasia was confirmed by histology(3 flat dysplasia;2 DALMs).No dysplasia/cancer was found on any of the outstanding random *** diagnostic accuracy of CLE for the detection of dysplasia compared to standard histology was sensitivity 100%,specificity 90%,positive predictive value 83% and negative predictive value 100%.CONCLUSION:CLE is an accurate tool for the detection of dysplasia in long-standing UC and shows optimal values of sensitivity and negative *** scheduled combined application of chromoendoscopy and CLE could maximize the endoscopic diagnostic accuracy for diagnosis of dysplasia in UC patients,thus limiting the need for biopsies.

关键词： Ulcerative colitis Cancer Confocal Surveillance

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